Articles tagged with Hepatocytes
Researchers at OHSU's Oregon Stem Cell Center have discovered that macrophages, not stem cells, can fuse with diseased liver cells to correct genetic liver disease in mice. This finding suggests that transplantation of macrophages alone may be a more targeted and effective treatment approach than traditional stem cell therapy.
Researchers found that bone marrow stem cells can differentiate into liver cells within days, restoring liver function in injured mice. The study suggests a new approach to treating chronic diseases like diabetes and cirrhosis of the liver.
A recent study published in Hepatology suggests that using nitric oxide during liver reperfusion can protect transplanted livers from cell death, improving survival rates. Researchers found that nitric oxide blocks mitochondrial damage, a key factor in organ rejection and failure.
Researchers have identified a potential new source of stem cells for treating liver damage, offering hope for improved care. The study found that umbilical cord blood cells may differentiate into functional liver cells after transplantation, providing a promising therapeutic avenue for acute and chronic liver injury therapy.
A newly discovered gene, Pcsk9, has been found to regulate the uptake of bad cholesterol from the blood by affecting liver cells' LDL receptors. This study provides a potential therapeutic approach to treating high blood cholesterol levels, a major risk factor for heart disease.
A major study at Cedars-Sinai Medical Center found that a bioartificial liver significantly reduced mortality among patients with acute liver failure. The treatment showed a 44% reduction in mortality rates compared to standard supportive care, offering new possibilities for treating this life-threatening condition.
A new toxicity test uses human growth hormone-secreting cell lines to detect toxic compounds, reducing the need for animal testing. The test, developed by Italian researchers, can identify low concentrations of chemicals that current methods may miss.
Researchers found that stem cell factor (SCF) levels change significantly after partial hepatectomy, and SCF administration restores hepatocyte proliferation in mice with IL-6 knockout. This suggests SCF plays a crucial role in liver regeneration.
A UCSF-led study found no evidence of trans-differentiation when bone marrow-derived cells fused with damaged tissue in mice, casting doubt on their potential as a treatment for brain and heart diseases. The researchers suggest that cell fusion might be a physiological mechanism for repairing damaged cells, but more research is needed.
A new nanotech strategy creates a precise architectural framework for liver or kidney cells to sustain viability for at least one week. Experiments show 96% of kidney cells and 95% of liver cells survived with the device, paving the way for whole, functional organs
Research found that alcohol consumption increases hepatitis C virus replication by upregulating nuclear factor kappa B, a key cellular regulator of immune pathways. Alcohol also inhibits the anti-HCV effect of interferon-alpha therapy. Treatment with naltrexone abolishes alcohol actions.
Researchers have made a breakthrough in treating liver disease by using bone marrow stem cells from matched donors. The study found that these stem cells can form liver-like cells in damaged livers, producing human albumin and showing promise as a potential treatment for liver disease.
Researchers at Baylor College of Medicine have made a breakthrough in developing a gene therapy that can cure diabetes in mice. The treatment uses the NeuroD gene to induce liver cells to produce insulin and other hormones associated with the pancreas' endocrine system.
Scientists have discovered that bone marrow-derived stem cells can fuse with liver cells to form healthy, functional cells. This process, called cell fusion, reverses liver damage in mice with a genetic disease, paving the way for potential human treatments.
The University of North Carolina at Chapel Hill is conducting a clinical trial on a bio-artificial technology called ELAD, which uses functioning human hepatocytes to help patients with acute liver failure. The device has shown promising results in extending the lives of those awaiting a donor liver and may even allow the damaged liver...
Researchers at UNC School of Medicine successfully transdifferentiated rat stem cells into functional new tissue, including platelets, red blood cells, and heart muscle cells. This breakthrough finding may provide clues to the therapeutic potential of human adult stem cells for tissue repair.
Scientists at Oregon State University have made a groundbreaking discovery about the role of micro-RNA in regulating gene expression. Micro-RNAs are found to cut messenger-RNAs in half, interfering with their function and controlling the process of cell differentiation.
Researchers at Stanford University Medical Center have identified genes needed by cancerous liver cells but ignored or used at different levels by normal liver cells. This discovery could lead to more effective treatments and screening tests for liver cancer in Asian populations, who are 10 times more likely to develop the disease due ...
Researchers have discovered that adult bone marrow stem cells can differentiate into liver cells, secreting key proteins and enzymes. This breakthrough could lead to the development of bio-artificial livers and improved treatment options for patients with genetic liver diseases.
Researchers have found that protease inhibitors used in AIDS treatment can lead to severe cardiovascular problems by accumulating a certain apolipoprotein in liver cells. This accumulation causes the liver cell to release excessive lipoprotein particles into the bloodstream, increasing the risk of heart disease.
Scientists at UIC found that increasing FoxM1B gene expression restored liver cell growth rates and division activity in aged mice, potentially treating aging-related diseases such as cancer and Alzheimer's. This breakthrough could lead to new therapies for the elderly using gene therapy.
Researchers reexamine the process of reverse cholesterol transport, a critical mechanism for removing excess cholesterol from peripheral tissues. The study reveals that this process may have both protective and detrimental effects on cardiovascular health.
Researchers discovered that bone marrow-derived stem cells can generate mature liver cells in humans. This groundbreaking finding has the potential to revolutionize treatment options for liver damage and disease.
Dr. Achilles A. Demetriou will present information on the bioartificial liver (BAL), an external device that cleanses blood plasma through synthetic and biologic materials, during Digestive Disease Week. The BAL has completed a Phase I clinical trial at Cedars-Sinai and is now in a large multi-center study.
Researchers found that TRAIL causes catastrophic damage to human liver cells, but not to liver cells from mice and nonhuman primates. The study's findings indicate that results of standard preclinical tests may mislead investigators about an agent's safety for use in humans.
Researchers at the University of Pittsburgh Medical Center discovered that bone marrow-derived cells can differentiate into functional liver cells, potentially repairing or replacing damaged livers. This breakthrough challenges traditional scientific dogma and opens up new possibilities for treating liver diseases.
A team of physicians and scientists successfully demonstrated the long-term function of transplanted human liver cells in a patient with Crigler-Najjar Syndrome Type I. The procedure reduced the patient's daily phototherapy needs from 12 hours to six hours, significantly improving her quality of life.