Articles tagged with Insulin Like Growth Factor
A new study has identified a deficit in the placental expression of IGFBP1 and low circulating levels as associated with insulin resistance during pregnancy. The findings suggest that measuring IGFBP1 levels could help identify people at risk of developing gestational diabetes early in pregnancy.
New research from University of Illinois Chicago identifies a potential 'stop growing' switch triggered by steroid hormone ecdysone in fruit flies, which may relate to human puberty. The study's findings have implications for understanding the growth-stopping process in humans, particularly given recent changes in puberty onset.
Research reveals a local mechanism in neurons that enables insulin-like growth factors to facilitate brain plasticity. IGF release is necessary for activating the IGF1-Receptor during synaptic plasticity, leading to neuron growth and strengthening.
Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
The research reveals PAPP-A's heart-shaped structure and its interaction with STC2, a key regulator of IGF conversion. The study suggests that complex formation between PAPP-A and STC2 is highly regulated, influencing height by up to 2.1 cm.
A new study published in the Journal of Dairy Science finds that feeding transition milk to neonatal Holstein calves instead of milk replacer improves health scores and stimulates intestinal development. The researchers found increased weight gain and improved gut health, with benefits seen in all sections of the small intestine.
Researchers identified nutraceuticals that mimic caloric restriction effects by modulating insulin-like growth factor 1 receptor signaling and sirtuin activity. These compounds promote longevity and healthspan without malnutrition.
Researchers at Rutgers University have identified a new factor essential for maintaining stem cells in the brain and gut, whose loss contributes to anxiety and cognitive disorders. The study reveals that this gene product supports multiple types of adult stem cells, including those critical for cognitive function and intestinal renewal.
A study published in PLOS Genetics reveals that insulin and IGF1/IGF2 growth factors play a vital role in sexual development. In the absence of these hormones, embryos fail to differentiate into male or female, highlighting their essential role in primary sex determination.
A team of researchers has created a new in vitro model for studying the effects of light on wound healing. They found that exposure to blue-violet light increases mitochondrial activity, cell proliferation, and growth factor secretion in human epidermal keratinocytes. These results suggest that blue light may be useful in enhancing epi...
Researchers have identified SHP-2 as a crucial mediator of insulin-like growth factors' effects on stimulating placental growth. This discovery may lead to new treatments for growth restriction of babies in the womb, improving their health outcomes.
Researchers found that IGF-I stimulates aggressive tumor growth and DNA repair regulation, leading to poor outcomes. The study identifies a gene signature linked to patient responses to breast cancer treatments, offering potential biomarkers for targeted therapies.
A research team has discovered the first functional insulin-like growth factor binding protein (IGFBP) ortholog in invertebrates. The newly identified protein, called imaginal morphogenesis protein-late 2 (Imp-L2), binds to insulin and inhibits its growth-promoting function, regulating growth control and insulin signaling.
A new study reveals that growth factors and the environment work together to accelerate brain maturation, particularly in visual system development. Insulin-like growth factor I (IGF-I) is identified as a key mediator of this process.
Investigators at LA BioMed found evidence linking insulin-like growth factor receptor (IGF-1R) to the development of Graves' disease, a common cause of hyperthyroidism. The discovery suggests a potential therapeutic strategy for autoimmune diseases.
Dr. Berrino suggests that dietary factors play a major role in breast cancer prevention, particularly for women carrying BRCA mutations. By adopting a healthier diet, these women can reduce their risk of developing the disease.
Dr. Stephen B. Trippel's research involves articular cartilage repair through the use of a naturally occurring growth factor, with laboratory results encouraging for repairing musculo-skeletal tissue. The technique combines gene therapy and tissue engineering to stimulate cartilage-cell growth.
IGFBP-5 promotes osteoblast function and bone formation in a manner distinct from IGF-I. The protein interacts with a receptor on osteoblasts to regulate cell growth and activity.