Articles tagged with Mammalian Cells
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Researchers have identified a distinct subset of hematopoietic stem cells capable of fully repopulating the bone marrow after transplantation. These cells, marked by specific surface markers, were found to be essential for successful bone marrow transplantation in nonhuman primates and show promise for human applications.
Researchers at the University of Minnesota have created lab-grown blood vessel replacements that are non-living yet can be repopulated with cells by the recipient's own cells. The grafts performed well in a recent study with adult baboons, showing healthy cell growth and resistance to infection.
Researchers identified a sulfur metabolite with antioxidant activity that supports mitochondrial energy metabolism, a crucial process for cellular function. This finding highlights the potential of enzymes involved in sulfur respiration to treat diseases such as diabetes and cardiovascular disease.
Researchers found that antimicrobial peptide R-Spondin1 stimulates intestinal stem cells to differentiate into Paneth cells, which secrete alpha-defensins with strong antimicrobial activity. Administration of R-Spondin1 restored gut microbiota in mice with graft-versus-host disease, preventing depletion of Paneth cells and dysbiosis.
Researchers will count and catalog cell types in mouse brain using single-cell transcriptomics, aiming to build a comprehensive atlas of cell types that can be applied to the human brain.
The NIH BRAIN Initiative has launched a major effort to discover and catalog the brain's diverse cell types. The BICCN will generate knowledge that is prerequisite to solving the mysteries of brain disorders such as schizophrenia, Alzheimer's disease, and autism spectrum disorder.
Researchers will systematically identify and catalog cell types across the mammalian brain using molecular signatures and genetic targeting. The project aims to better understand brain function and dysfunction, with potential applications for therapeutic uses in humans.
Researchers found a link between sugar consumption and cancer development through yeast cell research, clarifying the Warburg effect. The study suggests that high sugar metabolism in cancer cells stimulates tumor growth.
Researchers found that new mutations in iPS cells are concentrated in non-transcriptional regions of the genome, which are sensitive to oxidative stress. This suggests that these mutations may not lead to cancer-related adverse effects.
Altered MAIT cell concentration and function are linked to T1D pathogenesis, compromising gut mucosa homeostasis and favoring autoimmune responses.
A comprehensive study mapped specific cell types in mouse brains, revealing three major inhibitory cell types vary across cortical areas, and female brains have more modulatory neurons in certain subcortical regions. The study provides insights into brain function and has potential applications for understanding psychiatric disorders.
Researchers discovered a chemical tag added to RNA during embryonic development regulates the early brain's growth. The study found that m6A-tagging is essential for proper brain cell development, with dysregulation linked to psychiatric disorders.
Researchers at St. Jude Children's Research Hospital found that hundreds of precursor cells, not just a handful, are involved in establishing the blood system before birth. This discovery has clinical implications, as understanding how the blood system emerges can help unravel the origins of disease and identify susceptible cells.
Scientists have successfully transplanted human stem cells into monkeys with Parkinson's disease, showing long-term benefits. The quality of donor cells, particularly the Dlk1 gene, played a crucial role in determining cell survival. This study brings iPS cell-based therapy closer to clinical trials.
Researchers at UMass Amherst have found that layered black phosphorous (BP) nanoparticle toxicity is dependent on particle size and concentration. The study reveals that BP's cytotoxicity is based on reactive oxygen species generation, disrupting cell membrane integrity in a particle-size-dependent manner.
New research shows that injured mouse eyes can regenerate neurons, integrating them into the eye's circuitry. The study uses a zebrafish clue to discover cues that reprogram Müller glia into retinal neurons, opening new approaches for treating eye trauma and retinal disease.
A new study finds that quaternary ammonium compounds (quats) inhibit mitochondria, the powerhouses of cells, and estrogenic functions. This raises concern about their impact on human health and potential reproductive harm.
A recent study by Cold Spring Harbor Laboratory reveals the intricate interactions between chandelier cells and pyramidal neurons in the cerebral cortex. The research shows that these inhibitory cells can receive information from hundreds of excitatory cells, influencing their firing patterns and local circuit activity.
Researchers discovered a causal link between senescent cells and age-related bone loss in mice. Targeting these cells increased bone mass and strength. The study's findings suggest that senolytic drugs may have widespread application in treating multiple chronic diseases, including osteoporosis.
Researchers reprogrammed cells carrying an extra chromosome in mice, resulting in the loss of the extra chromosome. This technique, known as trisomy-biased chromosome loss, successfully generated fertile offspring and offers a potential solution to infertility related to extra chromosomes.
Researchers at CNIO have developed a way to stabilize haploidy in animal cells, overcoming the issue of quick loss of genetic stability. By removing the p53 tumor suppressor gene, the group increases the survival rate of these cells, thereby stabilizing their haploid state.
A new study by Cedars-Sinai Medical Center suggests that cardiac stem cell infusions could reverse aging in the human heart. Cardiosphere-derived cells secrete tiny vesicles containing RNA and proteins, which may turn back the clock for age-related heart conditions.
A new study reveals that regulatory T cells can either suppress or reactivate latent cytomegalovirus in different mouse tissues, such as the spleen and salivary gland. Depletion of these immune cells reduced viral load in the spleen but increased it in the salivary gland.
A study found that a single injection of the longevity hormone klotho fragment improved spatial and working memory, strengthened neuron connections, and countered cognitive deficits in mice. The treatment lasted for several weeks and showed promise as a potential therapy for neurodegenerative diseases.
Dr. Warren Ruder is developing microparticles carrying engineered bacteria known as 'smart biomaterials' to reprogram mammalian cell signaling and influence disease outcomes. His goal is to use these hybrid biomaterials to better understand how cell signaling works and affect many diseases.
Researchers from Osaka University have found that the interaction between M18BP1/KNL2 and CENP-A proteins is crucial for cell division in various species except mammals, including humans. This essential protein interaction allows new CENP-A deposition into centromeres to maintain genome information equally during mitosis.
Researchers at LMU present a new theoretical model for the origin of grid cells in the brain, assigning a crucial role to the timing of signals from neurons called place cells. The model suggests that grid cells are generated through synaptic plasticity and transform temporal coordinated signaling into hexagonal patterns.
Researchers have discovered that mammalian cells can build an embryo by making four simple decisions, including counting their neighboring cells. This simplified understanding of embryonic development challenges traditional theories and offers new insights into evolution.
Researchers have developed a new technique to create miniature human hearts by introducing human cells into the matrix of a whole rat heart, preserving the lining and circulation. This method allows for the confirmation of basic science findings and testing of potential new heart drugs with improved accuracy.
Researchers from Kyoto University developed a new method to transfer genes into cancer cells using gold nanorods coated with oleate and DOTAP. The nanorods are activated by near-infrared laser heat, inducing cell death in surrounding cancer cells.
Researchers have discovered significant differences in G protein-coupled receptor expression between humans and mice, highlighting the need for new approaches to develop effective diabetes drugs.
Researchers developed a new method to target select cells in adult brains, using an optogenetic technique. By altering the function of brain circuits and changing behavior, scientists can better understand the roles of specific cell types in the complex brain circuitry.
Naoki Yamanaka, the first researcher at UC Riverside to receive a Pew scholarship, will pursue foundational research using state-of-the-art techniques. His research focuses on identifying chemicals that interrupt steroid hormone entry into cells, which could lead to novel means of manipulating steroid-related processes.
Researchers at Newcastle University have identified a mechanism that causes fatty liver disease and successfully reversed it using a pharmacological approach. By eliminating senescent cells, the build-up of unwanted fat in the liver was reduced, restoring liver function to normal.
Research from the University of Rochester Medical Center suggests that preterm infants may be more susceptible to lung diseases due to a lack of alveolar type II cells. These cells play a crucial role in rebuilding lung tissue after damage and producing pulmonary surfactant, a vital compound for healthy lungs.
Researchers have developed a novel photoswitch that restores visual function in blind mice by activating retinal neurons. The light-sensitive molecule, DAD, targets bipolar cells, offering advantages over previous approaches. This breakthrough provides a promising alternative for treating vision loss.
Scientists have discovered a simple code for facial identity in the primate brain, allowing them to reconstruct faces from neural activity. By analyzing electrical signals from specific nerve cells, researchers can create a multidimensional face space and decode additional faces.
Researchers at Gladstone Institutes have discovered the key protein CTCF plays a crucial role in controlling DNA organization, reevaluating the cause of certain cancers and developmental defects. The study sheds new light on gene regulation and provides insights into fundamental genome organization processes.
Researchers discovered that normal cells recognize and attack transformed cells through metabolic changes, including mitochondrial dysfunction and elevated glucose uptake. These changes play a crucial role in eliminating early-stage cancer cells.
A recent study found that plant and animal stem cells exhibit similar interaction patterns, explaining why plant cells can reprogram more easily. Researchers developed mathematical equations to analyze protein interactions, revealing key differences in cellular flexibility.
The Center for Excellence in Engineering Biology has awarded a $500,000 grant to Columbia University to develop human cells that can grow with reduced external nutrients, known as prototrophy. This pilot project is part of the Genome Project-write (GP-write) Grand Challenge, aiming to deepen an understanding of life and develop pragmat...
Researchers have discovered that excessive DNA replication can lead to cell malignancy but also offers a potential approach against cancer. By exploiting the cooperation of proteins CDC6 and CDT1, scientists aim to induce lethal DNA re-replication selectively in cancer cells.
Researchers developed fCLIP-seq to analyze DROSHA's impact on miRNA fragments, revealing hundreds of new cleavage sites and alternative processing patterns. The study uncovers additional end modifications important for miRNA biogenesis, shedding light on its regulation in diseases like cancer.
A Johns Hopkins Medicine study found that air pollution directly causes inflammation in the nasal and sinus tissues of mice. The researchers exposed mice to polluted air for 16 weeks, showing increased white blood cells and biomarkers of inflammation.
Researchers at UT Southwestern Medical Center successfully corrected Duchenne muscular dystrophy using the gene-editing enzyme CRISPR-Cpf1. The treatment restored production of the missing dystrophin protein, providing a promising new tool for treating this progressive disease.
Researchers identified R-LA induced cellular changes, inhibiting glucose production from non-carbohydrate sources. This study suggests a potential therapeutic approach for liver cancer treatment.
Scientists uncovered a genetic fossil record of extinct retroviruses in modern organisms, revealing how our ancestors eradicated an ancient retrovirus around 11 million years ago. The study analyzed human endogenous retrovirus T (HERV-T) fossils to understand the elimination process.
Salk scientists have discovered a chemical cocktail that enables cultured mouse and human stem cells to generate both embryonic and extra-embryonic tissues. This breakthrough could lead to better disease modeling, drug discovery, and tissue regeneration, particularly in the field of organ regeneration.
A new study by Boston University engineer Wilson Wong outlines a simplified platform to target and program mammalian cells as genetic circuits, enabling researchers to make complex computations. The BLADE platform uses DNA recombinases to allow for more targeted manipulation of cells and their behavior.
Researchers found that common cancer drugs increase blood sugar levels, which can damage healthy cells and make them more vulnerable to chemotherapy. Fasting or glucose reduction reversed this increase in toxicity in mice.
Researchers identified a novel coronavirus in a Ugandan bat that is 87% identical to MERS-CoV and 91% identical to NeoCoV. However, the virus has significant differences in its spike gene, making it unlikely to spread to humans.
A novel coronavirus found in a Ugandan bat is 87% identical to the one causing MERS, but lacks key proteins allowing it to infect humans. Researchers say the virus is unlikely to spread to humans, despite its similarities.
Researchers at Boston University School of Medicine studied Zika virus-infected cells using light and electron microscopy, revealing dramatic changes in cell architecture. These findings support the development of new therapeutics targeting both Zika and related viruses like Dengue.
A peptide targeting senescent cells has shown evidence of improving healthspan in naturally-aged mice and mice genetically engineered to rapidly age. The approach reverses age-related loss of fur, poor kidney function, and frailty by blocking the ability of a protein implicated in senescence.
Researchers identify complementary roles played by mitral and tufted cells in processing olfactory information. Active learning enhances distinctiveness between similar smells through separate neural networks.
Researchers found that mammalian cells can respond to changes in gravitational conditions extremely quickly, recovering full function within 42 seconds. This rapid adaptation challenges previous assumptions about cell behavior in space, providing good news for manned space flight.
A new study suggests that a fasting-mimicking diet can reprogram pancreas cells in diabetic mice, enabling them to produce insulin and repair themselves. The researchers found that the diet triggered developmental reprogramming in the pancreas, rebuilding damaged areas and restoring function.
A fasting-mimicking diet has been shown to reverse diabetes in mice by promoting the growth of new insulin-producing pancreatic cells. In humans, the diet also increased expression of a protein that accelerates insulin production in type 1 diabetes patients, suggesting potential for alleviating symptoms.
Scientists have successfully converted mouse alpha cells into insulin-producing beta cells by blocking the expression of two specific genes. The research suggests that this natural flexibility in cell fate may be exploited to develop a new therapeutic approach for Type 1 diabetes.
Researchers identified cardiolipin, a mitochondrial lipid, as a potential target for reducing Parkinson's symptoms. Blocking the FASN protein increased cardiolipin levels and improved mitochondrial function, providing new insights into the disease.