Articles tagged with Mammalian Cells
Researchers have identified distinct differences between heart muscle cells that fail and those that adapt to high blood pressure. Cells that adapted were thicker, needed more energy, and could keep the heart beating, while failing cells became stretched out and weak.
Engineers boosted cells' ability to produce unsaturated lipids, leading to increased membrane respiration and growth rate. This knowledge could improve biofuel production and develop new treatments for diseases like type 2 diabetes.
Researchers analyzed 250,000 cells from six mammalian species to chart the evolution of antiviral and antibacterial immunity. They found that genes involved in the immune response have highly variable activity in different cells within an individual's tissue.
Researchers induced a mild brain injury in mice and used neural precursor cells to show recovery of lesions and improved motor functions. The study suggests that these cells may enable the brain's own cells to repair damaged areas.
Researchers at UNIGE discovered that α and δ cells can take over insulin production when β cells are damaged, leading to a phenomenon of cell plasticity. This finding opens the door to new treatments by harnessing the body's regenerative capacities.
Warren Ruder, a Pitt engineer, has been awarded $1.5 million from the NIH Director's New Innovator Award to develop magnetically induced synthetic gene networks for cell and tissue therapies. His research combines biology and engineering to create new biomimetic systems that can regulate disease pathways.
Researchers discovered that cells in the cerebellum, or 'little brain', have unique metabolic needs. The study found that blocking an enzyme regulating mitochondria impairs cerebellar development more than other parts of the brain.
Scientists report that senescent cells accumulate in certain brain cells prior to cognitive loss, but eliminating them diminishes tau protein aggregation and memory loss. The study identifies two brain cell types, microglia and astrocytes, as prone to senescence.
In a mouse model, researchers found that dysfunctional regulatory T-lymphocytes contribute to sustained inflammation and cardiac enlargement. Removing these cells restored normal function and reversed disease progression. This therapeutic approach suggests a new target for treating human heart failure.
A genetic study reveals that Asian colobine monkeys have a poor sense of taste, particularly in regards to natural sugars. This is attributed to their diet consisting mainly of leaves, which are easily digestible and fibre-rich, rather than energy-rich fruits containing simple sugars.
Researchers have developed an assay that concurrently profiles the epigenome and transcriptome of each cell type, revealing how different cells interpret their genetic code. The study provides insights into the relationship between epigenome and transcriptome, as well as the regulation of gene expression across various cell types.
Researchers discover a new type of human brain cell that has never been seen in mice and other laboratory animals. These 'rosehip neurons' may play a role in fine-level control between regions of the human brain, and their absence in rodents suggests difficulties in modeling human brain diseases.
Researchers developed a new imaging tool to visualize metabolic activities in individual cells, tracking protein, lipid, and DNA production. The technique's potential applications include tumor removal, head injury detection, and developmental disorder diagnosis.
Scientists have created a comprehensive atlas of the mouse genome's regulatory landscape, revealing how DNA elements regulate cell type identity and identifying potential links to human diseases. The study cataloged over 400,000 regulatory elements and assigned most patterns to specific cell types.
Researchers identified a rare pulmonary ionocyte cell type in airway tissue, playing a key role in cystic fibrosis. The new cell subtype expresses CFTR at high levels, challenging previous assumptions about airway function.
Researchers at UCSF discovered thymic tuft cells play key role in preventing autoimmunity by displaying proteins to train T cells, similar to gut sensory cells. The finding could lead to better understanding of autoimmune diseases and potentially regulate thymus function.
Researchers found that injecting senescent cells into young mice results in physical dysfunction. Treating the mice with a combination of dasatinib and quercetin cleared senescent cells from tissues and restored function.
Researchers at Mayo Clinic found that senolytic drugs can significantly improve health span and life span in elderly mice by removing senescent cells. The study showed that administering senolytics orally improved physical function, increased daily activity, and extended remaining life span by 36 percent.
Scientists successfully regenerate skeletal muscle cells in mice with muscular dystrophy by using cells from animal teratomas. The study showed improved potential with 80% regeneration compared to the current 5-10%.
Researchers at University of California San Diego School of Medicine and University of Minnesota have developed a new CAR-T immunotherapy using natural killer cells engineered from human induced pluripotent stem cells. These cells demonstrated heightened activity against ovarian cancer with less toxicity, offering potential advantages ...
A study published in JNeurosci reveals how nicotine interacts with cells regulating the output of a brain region involved in habit formation. Nicotine reduces dorsal striatal output, an effect that persists even after the drug has been cleared from the brain, potentially underlining nicotine addiction.
Researchers found a strong negative correlation between pancreatic cell size and lifespan in 24 mammalian species. Animals with larger cells tend to age faster, while smaller cells are associated with longer lifespans.
Researchers have obtained key information about proteins in single human cells, revealing molecular happenings inside a cell. The nanoPOTS technology allows for the analysis of samples that are 500 times smaller than previously possible, providing vital insights into cellular behavior.
Researchers found that a protein called NS2B3 cleaves the STING protein in humans, but not in mice, allowing ZIKV to replicate. This study provides a molecular basis for the virus's restricted host tropism and may aid in developing novel drug and vaccine candidates.
Scientists created self-contained spaces inside mammalian cells using bacterial proteins, allowing for controlled enzymatic reactions and iron biomineralization. This technology could aid in cell therapy, gene reporting, and sorting, opening new avenues for biomedical research.
Researchers developed an artificial metalloenzyme that can penetrate a mammalian cell and accelerate hormone release, activating a gene switch to create a fluorescent protein. This breakthrough enables the modification of cell functions on a genetic level or the creation of drugs from harmless precursors.
The study identifies embryonic mammary gland progenitors as multipotent cells that can give rise to both basal and luminal lineages. The researchers developed a novel strategy to isolate these cells and assessed their molecular features, revealing a hybrid transcriptional signature.
Research on mice brain structure found substantial molecular differences between male and female mice, particularly in the locus coeruleus region. Female mice have higher abundance of EP3 receptor and elevated levels of Slc6a15 and Lin28b genes associated with major depressive disorder.
A ketogenic diet has been found to protect retinal cells from degeneration in a mouse model of glaucoma, increasing energy availability. The study suggests that a ketogenic diet may help maintain vision in patients with glaucoma.
Aging mice with fewer Merkel cells experience greater mechanically induced itch, suggesting a potential explanation for the loss of mechanical itch control under aging and chronic conditions. The study's findings contradict the intuitive notion that fewer sensory neurons would lead to weaker sensations.
Aging is associated with a decline in Merkel cells, which control the itch response. Researchers identified Piezo2 as a protein that plays a role in suppressing itch, providing hope for future treatments of touch-related itching.
Aging nerves are damaged by immune cells that drive degeneration, but a new treatment blocks these cells, restoring nerve structure and muscle strength. Treatment with a cytokine receptor inhibitor reduced macrophage numbers and improved grip force in aging mice.
Scientists have identified immune-related genes in Egyptian fruit bats that suggest a different approach to viral infections. The study found expanded and diversified natural killer cell receptors, MHC class I genes, and type I interferons in bats, which may enable them to tolerate viruses without symptoms.
Researchers found norovirus infects tuft cells, which multiply virus quickly and set off severe infections. Targeting these cells with a vaccine or drug may prevent or treat norovirus infections.
Researchers at UCSB discovered that syntaxin 3S, a soluble form of SNARE protein, regulates gene expression in the nucleus, potentially playing a role in cancer progression. This finding opens up a new field of research into the moonlighting properties of proteins.
Mice prenatally exposed to valproic acid showed greater seizure severity and reduced neural migration. Voluntary exercise alleviated VPA-induced effects, suggesting potential therapeutic strategies for prenatal VPA-exposed individuals with neurological disorders.
A new messenger protein named GPS2 enables mitochondrial stress signals to reach the nucleus, affecting cell survival and metabolism. The discovery holds promise for understanding and treating mitochondrial diseases, as well as improving insulin sensitivity and combating obesity.
The new TILT3D microscope produces clear 3-D images of structures and individual molecules within a cell, overcoming existing illumination techniques' limitations. Researchers can track the 3-D movement of molecules over time with high precision, enabling detailed studies of cellular structures.
ILC2 cells play a crucial role in preventing or slowing metastasis in lung and prostate cancer by unleashing the killing power of T-cells. Researchers have concluded that ILC2 cells may be a potent weapon in stopping cancer from spreading, offering potential treatment for blood-borne and solid tumours.
New research reveals that all-trans-retinoic acid regulates immune system responses in the mouse intestine by controlling expression of HIC1 protein in innate lymphoid cells. This finding could lead to new strategies to protect against infection and intestinal imbalance.
Researchers have developed a new synthetic bioluminescence system that allows for imaging of cells from outside the body. The bioengineered light source enables tracking of cancer cells in mice and brain-cell activity in monkeys, with potential applications beyond lab research.
Researchers at Kumamoto University successfully grafted human iPS cell-derived inner ear cells into embryonic mice, expressing key proteins essential for hearing development. The study's findings suggest that these cells may compensate for missing proteins and improve hearing loss in hereditary cases.
Researchers investigated naked mole rats' cellular senescence mechanism, finding unique features that contribute to their cancer resistance and longevity. Despite exhibiting senescence similar to mice, naked mole rats display a more structured response to senescence, which may be beneficial for longevity.
Researchers discovered specific cells in the hippocampus that fire when animals are anxious, triggering anxiety-related behaviors. The findings suggest a direct pathway to respond to anxiety-provoking environments, opening up new areas for exploring treatment ideas.
Researchers at Oregon State University have developed a new method of cell preservation using desiccation, which shows promise as an alternative to cryopreservation via liquid nitrogen. The method involves removing water from cells, resulting in a stable solid that can be stored in conventional freezers or refrigerators.
Scientists have identified a key role for protein MIRO1 in attaching peroxisomes to molecular motors, enabling movement and membrane dynamics in human cells. This discovery has provided new insights into the molecular mechanisms determining peroxisome number and shape.
Researchers have created the world's first monkey clones using somatic cell nuclear transfer (SCNT), a technique that made Dolly the sheep. The cloned monkeys, Zhong Zhong and Hua Hua, are genetically identical long-tailed macaques born recently at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai.
Researchers at Harvard's Wyss Institute have developed an immune-mimicking biomaterial that can amplify patient-specific T cells outside the body, increasing efficiency of cancer immunotherapies. The new approach mimics the process by which antigen-presenting cells stimulate T cells to expand and stay alive.
Researchers have identified a crucial role for myeloid-derived suppressor cells (MDSCs) in regulating inflammation in newborns. These immature immune cells help control the inflammatory response during the first weeks of life, and their accumulation is linked to milk feeding.
Researchers found that TRPM4 performs a similar role to TRPM5 in the taste system, enabling the detection of sweet, bitter and umami foods. This discovery challenges existing dogma and has implications for understanding human health and regulating appetite.
UC San Francisco bioengineers develop a method to create complex tissue shapes, such as bowls and coils, by patterning cells on thin layers of extracellular matrix fibers. This approach mimics natural developmental processes and offers new insights into the fundamental biology of tissue assembly.
Researchers at the Salk Institute have discovered a multifunctional role for the protein nup98 in blood cell development, enabling immature stem cells to differentiate into specialized mature cell types. The findings also shed light on the mechanism of leukemia formation and its potential treatment.
Scientists discovered a complex color vision circuit in mice involving the M5 cell, which may process color information and lead to new treatments for humans. This finding expands our understanding of color vision and its relationship with other types of vision.
Nanotexturing creates a surface that kills bacteria while not harming mammalian cells, improving corrosion resistance. The process could be used to attack microbial contamination on implantable medical devices and food processing equipment.
Researchers at German Cancer Research Center prove grid cells measure distances and enable path integration in mice, aiding spatial orientation. This innate behavior helps animals find the most direct route from A to C without learning or visual cues.
Scientists in Canada converted adult mouse respiratory tract cells into large populations of induced progenitor-like cells using an interrupted reprogramming strategy. These cells retained a residual memory of their parental cell lineage and showed potential as a cell replacement therapy in mice with cystic fibrosis.
Researchers from Wake Forest Institute for Regenerative Medicine discovered that sodium percarbonate and calcium peroxide improved insulin-producing cell function and viability in lab-built bioartificial pancreas. Oxygen-generating materials could potentially supplement cells' high oxygen needs, aiding in diabetes treatment.
Researchers at ETH Zurich have developed a method to compress and decompress DNA, enabling the efficient transfer of large amounts of genetic information into cells. This innovation has potential applications in synthetic biology, biotechnology, and cancer research, improving diagnosis accuracy and treatment outcomes.
Researchers identified a reversible 'master switch' that regulates developmental genes in fruit flies, providing a conceptually simple explanation for how different cell types are formed. This discovery could lead to a better understanding of cancer mutations and the development of new therapeutic strategies.
A team of researchers at the Broad Institute has created a high-resolution census of the small intestine's cellular composition, revealing new insights into gut biology and its connection to diseases such as inflammatory bowel disease and food allergies. The atlas uses single-cell RNA sequencing and provides a reference for studying th...