Articles tagged with Micronuclei
Research reveals that micronuclei uptake regulates microglial morphology and gene expression, influencing neurogenesis, neural networks, and cerebrovascular function. This mechanism is crucial for the postnatal brain's development and function.
Researchers question whether micronuclei activate the cGAS-STING pathway, a key innate immune response to foreign nucleic acids. The study found that MN more commonly recognizes DNA during cell division without triggering STING activation.
A graduate student's curiosity uncovers a previously unknown link between chromosomal instability and epigenetic alterations in cancer. The study, led by MSK researchers, reveals that chromosomal instability can drive epigenetic changes without requiring gene mutations, shedding light on the biology of advanced, drug-resistant cancers.
Researchers developed a simple and inexpensive technique to assess genetic toxicity in bats, highlighting the need for monitoring wildlife health due to declining biodiversity. The study found higher levels of micronuclei frequency in bats roosting near agricultural lands.
The study revealed that loss of Lamin A/C acetylation results in softened nuclei prone to mechanical pressure and eventual breaking. Nuclear blebs and micronuclei are more likely to form under these conditions, posing a risk to genetic material integrity.
A new study has found a link between high levels of arsenic in rice and elevated genetic damage in humans. Researchers discovered that people consuming rice with more than 0.2 mg/kg arsenic showed higher frequencies of micronuclei, a sign of chromosomal damage.
A team of scientists at the Salk Institute found that disrupted micronuclei, which can trigger massive DNA damage on chromosomes, might play an active role in carcinogenesis. They also identified biomarkers to detect these structures, suggesting a new tool for cancer diagnosis.
Researchers at Dana-Farber Cancer Institute discovered a mechanism by which micronuclei disrupt chromosomes, leading to cancer-causing gene mutations. The findings suggest that whole chromosome aneuploidy may promote cancer in a similar way to other genomic alterations.