Articles tagged with Thymocytes
Researchers have developed a new organoid model to study the thymus and its function in training T cells. The model enables long-term culture of TECs, which could lead to new insights into treating patients with impaired thymus function.
The study found a loop of physical signals, resembling a double-handed handshake, that encourages cell suicide. This discovery could lead to new immune-regulating therapies and understanding the mechanisms that ensure T cells aggressively pursue hordes of infectors but not damage healthy human tissue.
A Brazilian research team used CRISPR/Cas9 to investigate the Aire gene, which plays a crucial role in controlling aggressive autoimmunity. The study found that Aire-mutant mTECs were worse at adhering to thymocytes and losing their original function.
A new study by UC Irvine researchers reveals the crucial role of glycosylation in determining how T cells are created and selected. The findings provide insight into a vital process that determines the body's ability to fight infection.
A new study by Dr. Guyden and colleagues reveals that thymic nurse cells regulate T cell development by selecting thymocytes to live or die. The findings suggest that these cells have the capacity to internalize both non-functional and positively selected thymocytes, leading to a revised understanding of their function.
Researchers used two-photon microscopy to visualize thymocyte migration in intact thymuses. The study found that positively selected T cells follow a clear directional course to the medulla, suggesting long-range signaling cues guide this process.
The study reveals how SATB1 regulates gene transcription by remodeling chromatin and positioning nucleosomes. In thymocytes, SATB1 brings specific enzymes to the IL-2Ra gene site, regulating its activation and repression.