Articles tagged with Tissue Samples
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Researchers found genes associated with B cell receptor signaling and activation in tolerant kidney transplant recipients, suggesting an active immune regulation of B cells. The study provides insights into the mechanisms behind tolerance induction in renal transplantation, potentially leading to minimization of immunosuppression.
Researchers detected abnormal prion protein in the skin of nearly two dozen CJD patients and found that healthy mice infected with skin extracts developed prion disease. The study raises questions about potential surgical instrument contamination and the use of skin samples as a diagnostic test for human and animal prion diseases.
Researchers developed a new tool to analyze cellular and molecular profiles of synovial tissue and peripheral blood, which may help unlock clues about rheumatoid arthritis. The study found that robust cell yield from synovial tissue enables mass and flow cytometric data.
Researchers have developed a new method to preserve tissue samples for rheumatoid arthritis research, allowing for the analysis of multiple samples in a uniform way. This approach has the potential to identify specific inflammatory pathways and guide treatment decisions.
NASA engineer Justin Jones used an industrial X-ray CT scanner to evaluate volcanic rocks and other specimens, revealing previously undetected minerals and 3D arrangements. The technology has potential applications in planetary exploration, including the analysis of samples from Mars and asteroids.
Researchers at Drexel University have identified microRNA miR-34a as the 'master regulator' involved in bronchopulmonary dysplasia (BPD), a chronic lung disease affecting up to 15,000 premature infants annually. Inhibiting miR-34a significantly reduces BPD in mice, suggesting a potential new treatment target.
Researchers analyzed blood and brain tissue data to find epigenetic marks that control gene expression, revealing key connections between genes and immune function. This study suggests that understanding epigenetic connections could lead to new treatments for autism by targeting specific biological pathways.
Scientists from the University of Geneva explore links between diseases and gene activity to build a model identifying specific sequences in the non-coding genome. The study reveals surprising results, including brain tissues being key contributors to schizophrenia risk and the small intestine playing a role in disease development.
Researchers have made the largest study on genetic patterns and molecular changes in specific tissues, showing tens of thousands of variants with detectable effects. The studies also identified rare genetic variants contributing to extreme changes in cellular markers.
A new study published in Nature and Nature Genetics describes a comprehensive atlas of gene expression across 42 tissue types, providing insights into the molecular origins of human disease. The study's findings allow researchers to identify genetic factors that cause changes in gene expression and relate them to human disease risk.
A genetic study aims to improve the tenderness and productivity of Brazilian beef cattle. Researchers bred over 800 animals to identify genomic areas associated with meat quality characteristics, revealing molecular processes related to muscle deposition and fat thickness.
Researchers found that drinking alcohol induces changes to a cholesterol-regulating gene, PCSK9, leading to differences in how cholesterol is processed. Higher methylation and gene expression of PCSK9 were associated with chronic heavy alcohol use, which can lead to lower PCSK9 protein levels due to liver damage.
Researchers developed CUBIC, a technique making human organs transparent for better pathological diagnosis. This method surpasses current methods in its ability to observe whole organs and detect metastatic carcinomas.
Researchers discovered N-glycolyl groups in ancient fossils, suggesting a link between glycans and the evolutionary history of Homo genus in Africa. The study also found degradation of sialic acid led to selective incorporation into chondroitin sulfate in human tissues.
A team of Penn researchers found a correlation between shorter telomeres and heart failure in human patients. Telomere length was directly related to cardiac function, with severely shortened telomeres indicating decreased cardiac performance.
A study led by researchers at Linköping University found that patients with IBS have a more sensitive intestinal mucosa to bacteria, allowing for faster passage of pathogens like Salmonella typhimurium and E. coli HS. Mast cells appear to play a significant role in regulating this process.
Scientists mapped B-cell clone populations across the human body, discovering two broad networks that influence immune responses. The findings provide a new foundation for infectious disease research and could lead to tissue-specific immune monitoring assays.
Researchers analyzed century-old seal pelts to investigate human impacts on the Antarctic ecosystem. They found that Weddell seals' diets have not changed significantly over the past hundred years, but significant change occurred in the phytoplankton community, likely due to climatic shifts.
Researchers developed DroNc-Seq, a method merging sNuc-Seq with microfluidics for parallel measurement of gene expression in complex tissues. The technique enables identification of unique expression signatures for cell types, including rare ones, and differentiation between closely related subtypes.
Researchers at Hokkaido University developed a nanosheet made of CYTOP to prevent drying and deformation of biological samples. The nanosheet retains water content and provides sufficient surface adhesion for fixing samples, resulting in high-resolution images.
A new method using molecular spectroscopy enables researchers to extract biochemical profiles containing information about disease progression. The method facilitates improved understanding of the mechanistic processes on molecular and cellular levels that are key to developing diabetes.
A recent study analyzed feral pigs, gray squirrels, and waterfowl from uncontaminated and contaminated habitats to assess environmental contamination. Many waterfowl tissues exceeded safe consumption levels, posing health concerns for both birds and humans.
Researchers have developed a new microscope technique that allows for the first time to produce 3D images of live embryos in cattle, enabling the selection of healthy embryos before in vitro fertilization. This breakthrough could significantly improve IVF success rates and reduce costs.
A team of international researchers developed a bioprinted 3D vascularized liver tissue model that mimics in vivo drug administration, providing a more accurate system for drug toxicity testing. The new model's endothelial layer delays drug diffusion response, offering a potential mechanism to optimize drug absorption.
Marine biologists analyzed three dolphin species' diets, revealing overlap in feeding ecology despite differences in hunting strategies. The research provides valuable insights for conservation and management of dolphin populations worldwide.
Researchers at MIT and Harvard Medical School have devised a way to image biopsy samples with much higher resolution, revealing detailed information about disease. The new technique expands tissue samples before imaging, allowing for the detection of features that can only be seen with high-resolution electron microscopes.
Researchers from Imperial College London have used a new technique called 'optical clearing' to image adult heart tissue in 3D, revealing intricate networks of tiny blood vessels and collagen scaffold. This breakthrough could help doctors monitor the spread of stiff scar tissue and track patient responses to treatments.
Researchers found that patients with diabetes have lower levels of substance P in their tears, indicating corneal nerve damage. Substance P measurement may become a non-invasive test to assess the risk of diabetic neuropathy.
Researchers found that the AEP enzyme trims alpha-synuclein into toxic pieces, similar to its effect on tau in Alzheimer's disease. This discovery offers a potential drug target for Parkinson's disease.
A new microscope can rapidly image tumor margins during surgery, reducing the need for second surgeries. It also enables pathologists to view tissue in 3D, potentially leading to improved diagnosis and treatment decisions.
Researchers at Stanford University have developed a way to retrofit OCT machines with off-the-shelf components, increasing resolution by several-fold. This improvement enables physicians to perform virtual biopsies and detect retinal and corneal damage, incipient tumors, and more with enhanced accuracy.
Researchers discovered changes in bacteria in the mucus lining of the intestine that could lead to earlier diagnosis and better management of inflammatory bowel diseases. This breakthrough study found these changes occurred 12 weeks before they were detectable in stool samples.
Researchers from Lomonosov Moscow State University discovered that ancient ground squirrels in the Indigirka river basin are closely related to present-day Beringian ground squirrels in Kamchatka. The study revealed that these animals have a complex migration history, with multiple colonization events in Eurasia.
A new method called Bone CLARITY enables the observation of stem cells within intact bones, facilitating research into osteoporosis and bone interactions with other organs. Researchers used this technique to test a new drug developed for treating osteoporosis, revealing increased stem cell proliferation in response to the treatment.
A new algorithm, CYCLOPS, can detect and characterize molecular rhythms in human cells. The tool has the potential to improve dosing for many existing medications by identifying optimal times for administration.
Researchers found that low levels of the 'memory protein' NPTX2 are associated with reduced levels of cognition and memory loss in Alzheimer's disease. The study suggests that the combination of low NPTX2 and amyloid plaques disrupts neural activity, leading to cognitive failure.
Scientists have discovered that nearly half of the mammoths' bones show signs of serious pathologies, including 'articular mouse' disease and abnormal vertebrae. These findings support the hypothesis that geochemical stress led to the mass extinction of mammoths.
Mini Das, assistant professor of physics at UH, aims to develop fast, low-radiation, high-resolution X-ray microscopy to study tissues and materials without slicing or killing samples. Her project will test new detecting methods, algorithms, and instrumentation.
MIT researchers have developed a way to make extremely high-resolution images of tissue samples, allowing scientists to see complex patterns in brain synapses and potentially map neural circuits. The new technique uses a tissue-expansion technique to boost resolution to about 25 nanometers.
Researchers found that gonorrhea infects the female reproductive tract by breaking connections between cells that normally form a protective barrier. The study uses tissue samples from human endocervix and reveals how Neisseria gonorrhoeae promotes activation of non-muscle myosin II to induce cell shedding and penetration.
Researchers at Linköping University developed a non-invasive magnetic resonance spectroscopy test to diagnose fatty liver disease. The new method can detect liver damage with as little as 3% fat content, increasing sensitivity and accuracy.
Researchers have confirmed that resveratrol metabolites can be detected in ocular tissues, including the conjunctiva and aqueous fluid. This finding opens up new avenues for exploring the therapeutic potential of resveratrol in human eye health.
Researchers successfully grow human heart cells on spinach leaves by perfusing fluids and microbeads through the plant's vascular system, paving the way for using multiple leaves to treat heart attack patients. The technique could also be adapted for other tissues, such as bone engineering.
Researchers have identified mutations in the SF3B1 gene present in 37% of mucosal melanoma samples, which could lead to novel therapies. The study highlights the potential of targeting this gene in patients with advanced mucosal melanoma.
Researchers successfully rewarmed large-scale animal heart valves and blood vessels preserved at low temperatures using a revolutionary new method. The discovery has the potential to increase organ availability for transplantation, potentially eliminating transplant waiting lists within two years.
A new study reveals that nanotechnology can be used to rapidly rewarm cryogenically treated samples without damaging delicate frozen tissues. This technology may help make organ cryopreservation a reality, eliminating transplant waiting lists and reducing rejection rates.
Researchers at Johns Hopkins Medicine found no evidence of cytomegalovirus (CMV) infection in tumor tissues from 125 patients with aggressive brain cancers. The study suggests that targeting the virus may not be effective in treating glioblastoma and other high-grade gliomas, which are common primary brain cancers in adults.
Scientists analyzed microRNAs from Ötzi's skin, stomach, and stomach contents to determine their stability over time. They found some molecules were present predominantly in ancient tissues, while others were not detectable.
Researchers at Max Planck Institute for Chemical Ecology have developed a new technique to visualize molecular distributions on rippled, hairy, or bulgy surfaces. The 'corrective glass' method uses laser ablation electrospray ionization (LAESI) to correct for surface topography and provide accurate chemical imaging.
A Duke University study has found elevated selenium levels in fish from three North Carolina lakes receiving power plants' coal ash waste, contaminating aquatic ecosystems and posing health risks. The study highlights the ongoing issue of continuous contamination of aquatic resources from hundreds of coal ash ponds across the country.
Researchers at Tohoku University identified a new mechanism producing low-energy free electrons from X-ray absorption in matter. The process, known as Electron Transfer Mediated Decay, involves rapid charge redistribution over multiple atomic sites.
Radiation damage hinders SAXS experiments' success due to protein aggregation and fragmentation. A new software, RADDOSE-3D extensions, calculates doses for SAXS experiments, reducing manual burden and assessing radioprotectant efficacy.
A Joslin researcher will study how exercise affects the body at a molecular level to develop individually targeted exercise recommendations and help people with mobility issues. The project aims to provide valuable insights into harnessing these molecular changes to benefit patients with type 1 and 2 diabetes.
A new procedure using a 22-gauge needle improves the diagnosis of autoimmune pancreatitis (AIP) through microscopic examination of tissue samples. Researchers successfully diagnosed AIP in 58% of patients using this method, offering a solution for distinguishing AIP from pancreatic cancer.
Researchers have created a new culture model of the human intestine where living tissue from a patient biopsy can be preserved and studied for days. The model enables studies of complex interactions between host cells, mucus production, and gut microbes.
Researchers identified 13 gene groups common to all three mental disorders, including those involved in protein production, immune response and brain cell communication. The study suggests that targeting these shared pathways could lead to new treatment strategies.
Scientists have identified two distinct genetic subtypes in Crohn's disease patients, each with unique patterns of gene expression and clinical features. This discovery could lead to more effective treatment strategies tailored to individual patients' needs.
A study found that at least 1 in 3 gene expression studies contain mislabeled samples, leading to incorrect conclusions. Researchers used a sex-specific gene expression approach to detect mislabeling and found that 46% of human tissue datasets contained discrepancies.
Researchers use nanosensors to detect genetic mutations in tissue samples from patients with malignant melanoma. This enables the identification of specific mutations and targeted treatment, significantly extending patients' life expectancy. The new method detects changes quickly and easily using coated microcantilevers.
Researchers investigate the link between diet, obesity-linked Type 2 diabetes, and intervertebral disc degeneration. They suspect that a diet high in processed fats and sugars causes inflammation and modification of disc tissue, leading to degeneration.