Articles tagged with Tissue Samples
Researchers identified 13 gene groups common to all three mental disorders, including those involved in protein production, immune response and brain cell communication. The study suggests that targeting these shared pathways could lead to new treatment strategies.
Scientists have identified two distinct genetic subtypes in Crohn's disease patients, each with unique patterns of gene expression and clinical features. This discovery could lead to more effective treatment strategies tailored to individual patients' needs.
A study found that at least 1 in 3 gene expression studies contain mislabeled samples, leading to incorrect conclusions. Researchers used a sex-specific gene expression approach to detect mislabeling and found that 46% of human tissue datasets contained discrepancies.
Researchers use nanosensors to detect genetic mutations in tissue samples from patients with malignant melanoma. This enables the identification of specific mutations and targeted treatment, significantly extending patients' life expectancy. The new method detects changes quickly and easily using coated microcantilevers.
Researchers investigate the link between diet, obesity-linked Type 2 diabetes, and intervertebral disc degeneration. They suspect that a diet high in processed fats and sugars causes inflammation and modification of disc tissue, leading to degeneration.
A University of Colorado Cancer Center study found that only 4.6% of cases had discrepancies between initial and final evaluations, with most being due to process errors or interpretation errors. The study aimed to reduce discrepancy rates by identifying trends and implementing changes.
A new technique called magnified analysis of proteome (MAP) allows scientists to image brain tissue at multiple scales, preserving proteins within cells and connectivity between neurons. The method enables high-resolution imaging with a resolution as high as 60 nanometers, tracing connections in the human brain more accurately.
Scientists have identified a new species of beaked whale using DNA analysis, with eight known specimens found across the Pacific Ocean. The new species is darker and smaller than the more common Baird's beaked whale, and its genetic differences suggest it represents a distinct species.
The Penn researchers have developed a placenta-on-a-chip that accurately models the transport of nutrients across the placental barrier. This innovation has the potential to revolutionize research on preterm birth by providing a unique capability to mimic and study the function of the human placenta.
A new study uses computer learning to create a standardized atlas that can automatically annotate samples, including lost metadata such as tissue type. By combining data from over 7,000 samples and 200 labs, the work represents a way to leverage publically available 'omics data while improving quality control.
Researchers found that chorus frogs now form hybrids across a broader area of Louisiana and Mississippi, with the hybrid zone expanding over time. The study's use of 40-year-old tissue samples preserved at the LSU Museum of Natural Science highlights the importance of museum collections in understanding biodiversity and speciation.
A team of scientists at Helmholtz Munich developed a protocol to analyze metabolite composition in fixed tissues using mass spectrometry imaging. This method allows for the study of spatial distribution of molecules with high precision, enabling the identification of new predictive, diagnostic and prognostic markers.
Researchers at MIT have developed a new microscopy technique that enables precise visualization of RNA molecules in intact tissues. By expanding the tissue sample before imaging, they can obtain high-resolution images of RNA distribution using ordinary microscopes. This breakthrough could help scientists study gene expression and disea...
Inflammatory myofibroblastic tumors (IMTs) are linked to a deficiency in nonsense-mediated RNA decay (NMD), which deactivates the cell's quality control system and leads to increased inflammation. This finding may lead to new treatments for rare masses of immune cells.
Scientists at Massachusetts General Hospital developed a new procedure to generate and expand airway stem cells from lung tissue samples, allowing for multiple generations of cultures. This breakthrough may lead to improved treatments for airway diseases like asthma and COPD.
A national assessment of metal contamination in bats reveals high levels of metals such as lead, copper, and cadmium that can cause toxic effects in bat populations. Around 21% of sampled bats contained residues of at least one metal above toxic thresholds, indicating a significant proportion may be affected by metal exposure.
Researchers found simultaneous changes in response to obesity in almost all tissues studied, including the digestive system and internal organs. The study highlights the burden of overweight and obesity on these systems and may lead to personalized care.
Researchers at Max-Planck-Institute for Intelligent Systems have discovered a new reversible adhesive using gallium that can be controlled by temperature changes. The adhesive has potential applications in various fields such as biological samples handling and industrial pick-and-place processes.
A PhD student at OIST Graduate University created a plastic insert that modifies the pathways of the electric current in a circular shape, making each current path of the same distance. This design enables researchers to study cells in a uniform electric field, even in circular-shaped environments like petri dishes.
Researchers have identified unique genetic markers that indicate higher stress tolerance in corals, enabling the development of novel reef restoration strategies. These markers can be used to create fine-scale distribution maps and guide selective breeding programs for more resilient corals.
Using ultrasonic signals, researchers demonstrated the possibility of high-definition video transmission through tissue for in-body communications with implanted medical devices. The study achieved data rates >30Mbps with low error rates, sufficient for real-time streaming.
A new timed amyloid seeding assay achieves or surpasses the sensitivity of currently available tests for transmissible spongiform encephalopathies, according to a report in The Journal of Molecular Diagnostics. This advanced assay offers better detection capabilities, allowing for clinical applications and surveillance programs.
A team of scientists at Linköping University has developed a molecular probe for early detection of amyloidosis, a rare disease affecting less than 200,000 people in the US. The probe detects small amyloid deposits that traditional methods miss, enabling earlier diagnosis and more effective treatment.
A new process for making brain tissue transparent has been developed at RIKEN Center for Developmental Biology, allowing for the creation of super-resolution 3-D images of delicate structures deep in the brain. This breakthrough enables researchers to visualize synaptic changes and neural structures with unprecedented detail.
Researchers have developed a new method to acquire three-dimensional atlases of tissue that provide much more information, incorporating data on tissue structure and molecular profile. The new technique enables doctors or researchers to peer into the tissue and identify specific proteins within cells throughout the whole tissue.
Researchers aim to improve measurement methods for amyloid-beta protein production outside the brain, a key area of study for Alzheimer's disease. They plan to develop innovative quantitative proteomics methods to analyze peripheral tissue changes and their relation to brain changes.
A team of Penn Medicine researchers successfully identified a pathogenic agent in a patient sample using PathoChip technology, which rapidly identifies elusive microorganisms. The breakthrough could lead to faster and more effective treatment for life-threatening infections in immunocompromised patients.
A new method using mass spectrometry measures hundreds of proteins in a single blood sample, enabling researchers to determine the severity of sepsis and which organs are damaged. This technique provides an understanding of molecular events during the course of a disease, with potential applications for studying other diseases.
Researchers developed a novel approach to collect healthy post-mortem blood and tissue samples from hundreds of donors for gene expression analysis. The GTEx Project provides valuable resources for understanding disease processes and developing treatments.
Researchers found that treetop leaves in tall trees like coast redwood and Japanese cedar act as a water supply tank, storing water to help maintain physiological functions. This discovery helps predict future changes in forest function and CO2 absorption in the face of climate change.
A novel method has been developed to examine protein structure and function at the cell level using formalin-fixed paraffin-embedded (FFPE) tissue. This allows for precise study of protein changes in Alzheimer's disease, a neurodegenerative condition.
Researchers detected parabens and their byproducts in tissues of marine mammals like dolphins, sea otters, and polar bears. High levels were found in some species, with tens of thousands of nanograms per gram of tissue.
Researchers analyzed breast tissue from 239 women, comparing samples with and without breast cancer for the presence of bovine leukemia virus. They found a significant association between BLV infection and an increased risk of breast cancer, with odds ratio higher than obesity, alcohol consumption, and post-menopausal hormone use.
A Penn study identified immunostimulatory defective viral genomes as a key player in eliciting an immune response against RSV. In human and mouse models, the presence of DVGs was correlated with improved immune function and reduced disease severity.
Researchers developed a faster method for classifying benign and malignant human breast tissues using fresh samples. This automated method eliminates the need for time-consuming tissue preparation and specialist assessment, potentially improving breast cancer management in developing countries.
Researchers at UGA's Savannah River Ecology Laboratory found toxic chemical Aroclor 1268 in egg and tissue samples of least terns across coastal Georgia, causing adverse effects. The contaminant has spread beyond the Superfund site via the food web, posing a risk to bird populations.
Researchers found that sleep loss for one night altered the regulation and activity of clock genes in human tissues, particularly in adipose tissue and skeletal muscle. This could suggest a link between disrupted circadian rhythms and impaired glucose tolerance and metabolic pathologies.
A Mayo Clinic study has identified abnormalities in the levels and processing of ribonucleic acids (RNA) in patients with sporadic and genetic forms of ALS. The findings, published in Nature Neuroscience, suggest that different factors may contribute to the development of ALS and highlight the need for tailored therapies.
Researchers at the University of Salzburg developed a new method to estimate time since death in humans, even up to 240 hours after death, by analyzing muscle proteins and enzymes in pigs. Initial results are promising for human samples, offering a simple and efficient approach with advantages over current methods.
A new mass spectrometry-based technology enables rapid analysis of tissue samples, offering a faster and more accurate alternative to traditional methods. The automated droplet-based surface sampling probe reduces testing time for cancer diagnosis from 20-30 minutes to just 4-5 minutes.
Triceratops teeth have five layers of tissue, each with a unique function, allowing them to slice through dense material and vary their diet. The discovery reveals complex dental structures among dinosaurs, inspiring new engineering techniques.
Researchers have developed high-throughput techniques to quickly and easily give every cell in a sample a unique genetic barcode, enabling scientists to analyze complex tissues at the single-cell level. This breakthrough allows for deeper understanding of cell diversity and gene expression.
A new study led by Harvard T.H. Chan School of Public Health researchers found that adults over 50 with persistent depressive symptoms are twice as likely to have a stroke as those without depression. Even after depressive symptoms improve, stroke risk remains elevated, particularly for women.
The study develops a method for label-free chemical imaging using infrared spectroscopic imaging, allowing molecular stains to be reproduced without tissue damage. This approach enables multiplexed molecular analysis and could revolutionize pathology in research and clinical practice.
A study published by the GTEx Project Consortia reveals that gene expression variation differs more between organs than individuals, with over 750 genes linked to sex and ethnicity. The research also found that 2,000 genes vary with age, including those related to neurodegenerative diseases.
Researchers analyzed gene activity in over 1,600 tissue samples to understand how genomic variants control gene expression and predispose people to diseases like cancer, heart disease, and diabetes. They identified common eQTLs across tissues and found a large number of tissue-specific eQTL genes.
Researchers have identified a second possible specimen of the rare 'pocket shark,' measuring just 5.5 inches long, with distinct physiological features and an unhealed umbilical scar.
Scientists at the University of Manchester have made a groundbreaking discovery that could lead to an early test for kidney disease. They found significant differences in protein composition and structure between mice with different genetic backgrounds and sexes, which may contribute to susceptibility to kidney disease.
A new assay using RT-MLPA has been developed to differentiate between germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes of diffuse large B-cell lymphoma. The assay is accurate, simple, flexible, short turnaround time, low cost, and efficient.
Researchers have developed a new protocol to study clonal patterns in coast redwood clones, which could help forest management and preservation efforts. The method uses short repeating DNA sequences to identify distinct clones and has been tested on 770 coast redwoods.
Researchers developed a new imaging technique that enables fast and broad diagnostic assessments using infrared light, eliminating the need for chemical stains. This allows pathologists to obtain precise information from tissue samples without damaging them.
Researchers employ NMR spectroscopy and MRI to differentiate between two tanning methods used on ancient skins, revealing changes in chemistry and relaxation properties.
Research using 405 consumer product recalls found that corporate social media reduces negative price reactions to recall announcements. However, as social media evolves, firms lose control over online content and negative sentiment from disgruntled users exacerbates market reactions.
A recent NIH study found that Ebola virus can remain infectious in a body for at least seven days after death, with viral RNA detectable for up to 10 weeks. The research highlights the importance of safe handling practices and suggests oral swabbing as a reliable alternative for obtaining diagnostic samples.
A Michigan State University study found that most people are willing to donate bodily samples for medical research, but this willingness drops when specific projects are mentioned. The study suggests that biobanks should rethink their consent processes and be more transparent about the research they support.
A survey of nearly 1,600 individuals found that the majority were willing to donate tissue samples and medical information to a biobank. The researchers suggest that an adequate approach for dealing with donors' moral concerns may lie between blanket consent and specific consent.
Researchers from UCLA have created a device that can accurately detect cancer and cell abnormalities like pathology lab microscopes. The lens-free microscope uses holograms to create 3D images, making it easier to spot any issues.
A novel orthomyxovirus, Wellfleet Bay virus (WFBV), has been linked to cyclic mass mortality events in eider ducks on Cape Cod. The study found that WFBV is likely tick-borne and contributes to the deaths, but other factors such as parasitic worms and stress may also play a role.
The Scripps Research Institute team is investigating the deadly Lassa fever virus with a $6.6 million NIH grant. The five-year study aims to understand how the immune system fights off the virus and develops new treatments for the disease. Researchers will analyze cells, chemicals, and genetics of patients to uncover key findings.
A new study reveals that cold exposure can convert white fat tissue into calorie-burning beige fat, which can help prevent obesity. However, obese individuals exhibit a reduced ability to produce beneficial beige fat due to inflammation.