Articles tagged with Tissue Samples
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Researchers used shotgun metagenomics to sequence DNA from a calcified nodule in a 700-year-old skeleton, recovering the genome of Brucella melitensis, a disease causing fevers and arthritis. The ancient strain was closely related to recent strains found in Italy, providing insights into medieval infections.
Researchers have developed a single-pixel optical system that can overcome light scattering in tissue, enabling transmission of images through scattering media. The technique uses compressive sensing to compress large data files as they are measured, allowing it to reconstruct the image and penetrate deeper into tissue.
University of Washington researchers have confirmed the presence of ferroelectric switching in biological tissues, particularly in proteins found in organs that repeatedly stretch and retract. This phenomenon may help build and support healthy connective tissues in mammals and potentially detect early stages of hardening of arteries.
Cryoprobes surpassed traditional forceps in collecting larger, higher-quality samples for diagnosing interstitial lung diseases. Larger multicenter trials are needed to confirm the benefits and safety profile of this technique.
The challenges in cancer molecular testing require effective communication between oncologists and pathologists. Close communication, systems approaches, and new institutional protocols can help ensure efficient testing and optimal patient outcomes.
Researchers use NMR spectroscopy to enrich a mouse's carbon isotopes, enabling the growth of biological tissue in the lab. The technique has huge potential for scientific and medical breakthroughs, including replacing heart valves.
Researchers found that long noncoding RNAs distinguish between two major types of heart failure and change expression patterns after LVAD support. These RNA molecules may play a role in coordinating the regulation of multiple genes involved in heart function.
A new study by Lars Fändriks and Herbert Helander reveals the inner surface area of the gastro-intestinal tract in healthy adults is between 30-40 square meters. This is significantly smaller than previous estimates, which ranged from 180 to 300 square meters.
Researchers develop composite material with improved impact resistance and toughness inspired by mantis shrimp's club, which accelerates underwater faster than a 22-caliber bullet. The new design structure shows less external damage and increased residual strength after impact compared to standard aerospace materials.
Researchers at Case Western Reserve University have developed a new method to isolate single immune cells from the mouth, allowing them to study how these cells fight diseases. The method successfully isolated over 94% of the cells, enabling researchers to gain insights into treating oral cancers and other health issues.
Researchers developed a new adaptive optics technology that rapidly corrects for light-bending distortions in microscopic images. The technique, inspired by astronomy and ophthalmology, brings into focus fine structures and subcellular organelles in nerve cells deep within living brain tissue.
A team of researchers has demonstrated the advantages of the HOPE fixation strategy, which preserves tissue structure while allowing modern analysis techniques like proteomics and phospho-proteomics. This breakthrough enables personalized medicine and opens up new opportunities for disease research and therapy.
Researchers at MIT analyzed the shells of a sea creature to determine why they are exceptionally tough and optically clear. The shells' unique properties emerge from a specialized nanostructure that allows optical clarity, as well as efficient energy dissipation and localized deformation.
Physicist Premi Haynes has made a groundbreaking discovery about the cellular structure of the human heart, particularly related to heart failure. She found that different regions of the left ventricular wall have unique cellular patterns of mechanical properties, with the middle being a better
A multi-institutional study found that newly diagnosed Crohn's disease patients have an imbalance in their intestinal microbial population, with increased levels of harmful bacteria and decreased levels of beneficial bacteria. This imbalance is associated with the development of symptoms and may be exacerbated by antibiotic use.
Researchers have discovered that genes expressed in the nasal passages can serve as accurate proxies for those expressed deeper in the lungs. This breakthrough allows for less invasive and more affordable genetic profiling of asthmatic patients, potentially leading to improved treatment options and better understanding of the disease.
Researchers have developed a graphene water balloon to visualize hydrated protein molecules without freezing or slicing them. This technique allows for the capture of high-resolution images of ferritin, a protein critical for human health, which may lead to new treatments for diseases like Alzheimer's and cancer.
Researchers developed a method using Raman spectroscopy to distinguish normal brain tissue from brain tumor tissue, achieving up to 99.5% accuracy in distinguishing between the two. The technique has the potential to improve outcomes for patients undergoing surgery to remove glioblastoma multiforme (GBM), a deadly type of brain tumor.
Patients with celiac disease who experience persistent villous atrophy have a heightened risk of hip fractures, according to research. A gluten-free diet may help minimize tissue damage and reduce the risk of complications.
Researchers at the University of Southern Denmark have developed a new, safer, and noninvasive diagnostic technique for stomach ulcers. The technique makes the ulcer-causing bacteria in the gut light up in fluorescent green, allowing doctors to detect ulcers instantly without taking tissue samples.
A new method for analyzing biological samples based on their chemical makeup is set to transform the way medical scientists examine diseased tissue. The technology uses mass spectrometry imaging (MSI) to identify tissue types, providing more detailed information than standard histological tests.
Researchers at Penn have developed a dynamic model of tissue failure that takes into account the complex feedback effects of cells' molecular motors. The study reveals how myosin activity contributes to tissue instability and provides insights for designing more accurate models to predict tissue behavior.
A non-invasive alternative to liver biopsy, the French-made FibroScan, has been proven very reliable in a national multi-center study. The device measures liver stiffness to assess fibrosis and guide treatment, providing quick and painless results.
A UCLA study has identified a biological clock embedded in the human genome that can accurately measure the age of diverse organs, tissues, and cell types. The clock found that some parts of the anatomy, like breast tissue, age faster than the rest of the body.
A study found nearly 170 significant gene expression changes in patients with pouchitis, increasing to over 1,000 in those progressing to Crohn's-like changes. These alterations involved genes in inflammatory processes and metabolic pathways.
Research reveals lithium's unique mode of action in treating depression and bipolar disorders. Lithium accumulation in white matter suggests a new target for psychotropic drugs.
Researchers at Sam Houston State University are investigating new methods to preserve tissue samples and speed up the DNA identification process after mass disasters. The goal is to improve DNA preservation and processing, enabling faster victim identification and closure for families.
Researchers at NASA and the University of Florida create single fixation protocol to study plant growth in space, allowing analysis of both molecular and morphological features. The new method uses RNA later and low-temperature scanning electron microscopy to preserve tissues without damage.
Scientists have developed a new way to analyze archived biopsy samples for exposure to carcinogenic substances, providing insights into the role of environment in cancer risk. The breakthrough enables broader use of stored tissue samples to study human exposure and DNA damage.
Researchers developed a method to extract information from soil surrounding bodies, allowing for insight into the day before death. High mercury concentrations in soil suggest exposure occurred within hours or days prior to death.
A new protocol has been developed to decontaminate human fetal tissues used for cell transplantation, reducing the risk of brain infections. The technique was tested on laboratory animals and shown to be effective in eliminating microbial contamination.
Researchers have developed a novel protocol for detecting basil downy mildew, enabling early identification and facilitating timely disease control. The method uses Visikol, a proprietary solution that replaces chloral hydrate, allowing for quick detection using a hand magnifying glass.
Researchers at RIKEN have developed a new sugar and water-based solution called SeeDB that turns tissues transparent in just three days without disrupting their shape or chemical nature. This technique enables the visualization of neuronal circuitry inside a mouse brain, revealing detailed wiring patterns and single-fiber resolution.
The BigBrain model is based on data from over 7,400 tissue samples and provides a detailed understanding of the normal structure of different functional areas of the brain. The high-resolution model will contribute to precise identification and evaluation of changes in the brains of patients with neurodegenerative diseases.
Scientists analyzed DNA from a New Zealand museum specimen to determine if it represents a new type of killer whale. The study found that the specimen separated from other killer whales approximately 390,000 years ago, suggesting it may be a separate subspecies or species.
Researchers at Rockefeller University have developed a multicolor fluorescence labeling method to visualize miRNAs in tissue sections, enabling the identification of tumor-specific miRNAs and distinguishing between different tumor types. This technology shows promise as a molecular diagnostic tool for clinical settings.
Researchers found that purified ginger components can work synergistically with beta-agonists to relax airway smooth muscle and improve breathing. The most effective component was 6-shogaol, which dissolves F-actin filaments and inhibits phosphodiesterase4D.
A genetic mutation in gene GNAQ on chromosome 9q21 is identified as the cause of Sturge-Weber syndrome and port-wine birthmarks. The discovery opens up new avenues for targeted therapies and offers renewed hope to families affected by the conditions.
Researchers at Johns Hopkins University have successfully performed biopsies using hundreds of tiny, untethered grippers that can collect tissue samples without batteries or wires. The microgrippers, activated by the body's heat, hold promise for more effective cancer detection and disease diagnosis.
Researchers from the University of Notre Dame have created a method using environmental DNA (eDNA) and Light Transmission Spectroscopy (LTS) to detect invasive aquatic species in real-time. This innovative approach enables rapid identification of high-risk species before they cause significant damage.
Researchers have developed a novel procedure to isolate DNA from cactus tissue using cactus spines, overcoming challenges posed by polysaccharide-based mucilage content. This method simplifies genetic work and is less invasive than traditional sampling methods.
Researchers at the University of Wisconsin-Madison have developed a new technique to accelerate protein analysis, allowing for the simultaneous identification of proteins in multiple samples. This breakthrough could lead to faster diagnosis of cancer and the discovery of novel drug targets.
Scientists have developed wavelength-modulated Raman spectroscopy to overcome challenges in using the method in a clinical setting. The technique enables clean extraction of Raman signals even with high auto-fluorescence backgrounds and ambient light.
Scientists at Queen Mary University of London identified a gene linked to resistance in melanoma tumour cells. The gene TP63 was found to correlate significantly with a worse prognosis in melanoma patients.
Hyejin Moon's novel microfluidic devices improve accurate images and conditions of huge numbers of samples, enabling quicker disease biomarker identification. The technology has applications for speedier drug development and may lead to the development of devices used by patients in their own homes.
Researchers found that breast cancer tissue has a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This discovery may help improve breast cancer diagnosis and therapy by identifying potential for cancer spread. The study used advanced microscopy techniques to analyze tissue properties at the nanoscale.
Donors to biobanks have a moral stake in what happens to their tissue samples, requiring ongoing updates and protection of their rights. Tomlinson recommends biobanks provide donors with plain language summaries of research projects and inform them about potentially controversial uses.
Researchers have found that the human papillomavirus 16 (HPV16) is present in the brains of individuals with a common form of childhood epilepsy. The discovery suggests that the virus may play a role in the development of the condition, and could lead to new therapeutic options related to HPV.
A recent study published in Genome Medicine found great diversity in biobanks, with varying organizational structures, specimen types, and purposes. The research emphasizes the need for standardized policies to govern these collections and make samples available for research.
Scientists at the University of Manchester have developed a camera that takes powerful three-dimensional colour X-ray images, enabling rapid detection of contraband, corrosion, and cancer. The technology uses hyperspectral imaging to identify chemicals and compounds within large objects, reducing scanning time by minutes.
Columbia University researchers have created the first-ever atlas of immune cells in the human body, providing a unique view of T lymphocyte distribution and function. The study found that T cells are highly compartmentalized, with each tissue having its own complement of T cells.
Using LCLS at SLAC National Accelerator Laboratory, researchers successfully stripped most electrons from xenon atoms, creating a highly charged state. This discovery could aid in studying extreme states of matter or avoiding damage in samples.
Researchers developed a new optical imaging technique that uses tissue-penetrating laser light to analyze ultra-thin collagen fibers in breast tumor tissue samples. The study found that women with denser fiber patterns were more likely to need lymph node biopsy and removal, reducing the risk of unnecessary surgeries.
Researchers found that UVB exposure changes the structure of skin cells, making them more prone to tearing under pressure and increasing the risk of cracking and chapping. Wearing sunscreen can help protect the skin's integrity.
A recent study has confirmed that an association between XMRV and prostate cancer was due to laboratory contamination. The researchers found that the virus was introduced into prostate tissue samples through contact with a different cell line, which had been contaminated with XMRV in the 1990s.
Researchers mapped eosinophil distribution in esophagus, showing current biopsies may under- or misdiagnose eosinophilic esophagitis. The study suggests new diagnostic methods could be available in five years.
A diet high in choline during pregnancy may lower the risk of high blood pressure and diabetes in offspring. Choline, found in eggs, helps protect against prenatal stress effects on fetal development.
The European Society of Human Reproduction and Embryology announces a breakthrough in fertility preservation, with Italy's first successful pregnancy and live birth after cryopreserving ovarian tissue. The technique has shown promising results, even after lengthy storage periods.
Researchers at BUSM found increased expression of FOXO1 gene in Parkinson's disease brain tissue samples. Two single-nucleotide polymorphisms associated with age at onset were also discovered, providing new insights into the genetic mechanisms of Parkinson's.
A new microscopy technique called trolling AFM allows researchers to study soft biological samples in liquid with high resolution and high quality. The technique uses a thin, long nanoneedle to extend the tip of an atomic force microscope, reducing hydrodynamic drag and allowing for minimal disturbance of the sample.