Biopsies may overlook esophagus disease
Researchers mapped eosinophil distribution in esophagus, showing current biopsies may under- or misdiagnose eosinophilic esophagitis. The study suggests new diagnostic methods could be available in five years.
Tissue Samples
Articles tagged with Tissue Samples
A diet high in choline during pregnancy may mean less stress for baby
A diet high in choline during pregnancy may lower the risk of high blood pressure and diabetes in offspring. Choline, found in eggs, helps protect against prenatal stress effects on fetal development.
Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
The European Society of Human Reproduction and Embryology announces a breakthrough in fertility preservation, with Italy's first successful pregnancy and live birth after cryopreserving ovarian tissue. The technique has shown promising results, even after lengthy storage periods.
BUSM researchers identify role of FOXO1 gene in Parkinson's disease
Researchers at BUSM found increased expression of FOXO1 gene in Parkinson's disease brain tissue samples. Two single-nucleotide polymorphisms associated with age at onset were also discovered, providing new insights into the genetic mechanisms of Parkinson's.
Gone fishing: Researchers' imaging technique trolls in quiet cellular seas
A new microscopy technique called trolling AFM allows researchers to study soft biological samples in liquid with high resolution and high quality. The technique uses a thin, long nanoneedle to extend the tip of an atomic force microscope, reducing hydrodynamic drag and allowing for minimal disturbance of the sample.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNanotechnology·DateJun 14, 2012
Handheld probe shows great promise for oral cancer detection
A portable, miniature microscope has been developed to detect oral cancer in real-time, offering a significant improvement over traditional biopsy methods. The handheld probe uses a laser and micromirror technology to create full 3D images of tissue samples, providing high accuracy and potentially reducing treatment costs.
New software opens the door to wider use of 3-D imaging in the study of disease
Researchers developed a novel system for 3D reconstruction and examination of tissues at microscopic resolution, enhancing the study of normal and disease processes. The new approach uses conventional histopathological methods and can be used by technical or medical staff without input from computing specialists.
Stanford scientists search public databases, flag novel gene's key role in type 2 diabetes
Researchers used public databases to find a novel gene associated with type-2 diabetes, which shows increased activity in fat tissue. The findings suggest that CD44, a cell-surface receptor, plays a major causal role in the disease's development.
UCF scientists use nanotechnology to hunt for hidden pathogens
Researchers at UCF have developed a novel technique using nanoparticles coated with DNA markers to detect pathogens in human tissue, potentially giving doctors a faster and more accurate tool. The new method is effective at picking up even small amounts of a pathogen and takes hours instead of weeks or months to deliver results.
From beaker to bits: Collaboration creates computational model of human tissue
Researchers have developed a computational model called 'cell graphs' that links the structure of human tissue to its corresponding biological function. This new tool uses graph theory and can be used to determine whether a tissue sample is cancerous or not, eliminating differences of opinion between doctors.
Immune system implicated in prematurity complication
A study by Vanderbilt University Medical Center researchers has found that disruptions in the immune system's regulation may play a role in necrotizing enterocolitis (NEC), a deadly disease affecting premature infants. The findings suggest a new target for therapeutic interventions to prevent NEC.
Scientists learn how to 'out run damage' with imaging technique
Researchers at Arizona State University have created an imaging technique that allows for atomic-level resolution without damaging biological samples. This breakthrough enables the use of high-intensity X-rays, previously limited by damage caused by the radiation.
Why looks can be deceiving
Researchers at McGill University have identified two brain regions critical for recognizing facial expressions and emotions. Damage to these areas can lead to difficulties in understanding social signals, impacting daily life.
Ferroelectric switching discovered for first time in soft biological tissue
Engineers at the University of Washington have discovered ferroelectricity in the walls of arteries, a finding that could have significant biomedical implications. The study found clear evidence of ferroelectric switching in a sample of pig aorta, which may also apply to human tissue.
Parabens in breast tissue not limited to women who have used underarm products
Research found parabens in breast tissue of all study participants, regardless of underarm product use, indicating alternative sources. The study detected five common paraben esters in 60% of samples and high levels of n-propylparaben near the armpit.
Bacteria in the gut of autistic children different from non-autistic children
Researchers found that autistic children with gastrointestinal problems harbor a specific type of bacteria, Sutterella, which is not detected in non-autistic children. The study used tissue samples from the guts of patients and suggests that these differences may play a role in the development of autism.
CCNY's Robert Alfano wins first biomedical optics award
Robert Alfano, CUNY Distinguished Professor of Science and Engineering at CCNY, receives the Britton Chance Biomedical Optics Award for developing non-invasive optical biopsy methods that provide molecular information on cancer cells. His techniques can eliminate wait times and reduce physical trauma of surgery.
Light can detect pre-cancerous colon cells
Researchers at Duke University have developed a technology that uses angle-resolved low coherence interferometry to detect pre-cancerous cells in the colon. The device shines short bursts of light into tissue samples and analyzes scattered light for signs of dysplasia, with an accuracy rate of 85%.
New chemical reagent turns mouse brain transparent
Researchers at RIKEN have developed a new aqueous reagent, Scale, which renders biological tissue transparent, allowing for vivid 3D images of neurons and blood vessels deep inside the mouse brain. The reagent's unique properties enable visualization of fluorescently-labeled samples at unprecedented depths and levels of spatial detail.
New microscope might see beneath skin in 4-D
Researchers developed a new type of laser scanning confocal microscope that can gather spectrographic information from every point in a sample at a wide range of wavelengths in a single scan. This allows for high-resolution pictures and potential detection of early signs of melanoma.
Genomewide mapping reveals developmental and environmental impacts
A study published in PLOS Genetics found that thousands of genes affect plant adaptation to environmental challenges. The researchers used a genomewide association mapping approach to identify key genes involved in defense metabolism, revealing significant influences from both internal growth and external environments.
Children's National collaborates with NIH researchers to identify gene variant in Proteus syndrome
A team of researchers at Children's National Medical Center has identified the genetic mutation causing Proteus syndrome, a rare disorder characterized by excessive tissue and bone growth. The study found that a point mutation in the AKT1 gene activates sporadic tissue growth associated with Proteus syndrome.
NIH researchers identify gene variant in Proteus syndrome
Researchers identified the genetic mutation causing Proteus syndrome, leading to spontaneous tissue and bone growth. The discovery offers hope for potential drug therapies and confirms the disease's cause, previously unknown.
SourceNIH/National Human Genome Research Institute·JournalNew England Journal of Medicine·DateJul 27, 2011
Public prefers limited informed consent process for biobanks
Most study participants preferred an opt-in consent process, while 41% supported a broad description of how samples and health information might be used. The study suggests that public support and trust for biobanks can be built by implementing an informed consent process that meets formal requirements and standards.
Study suggests alternative treatment for bacteria in oysters
Researchers found that exposure to salty water reduces Vibrio vulnificus levels in oysters, potentially providing a low-cost solution to FDA regulations. The study suggests an 'oyster relay' method could be effective in minimizing the presence of the bacterium.
New imaging technique provides rapid, high-definition chemistry
A new synchrotron-based imaging technique provides high-resolution pictures of tissue molecular composition with unprecedented speed and quality. The IRENI facility cuts imaging time from hours to minutes while quadrupling sample size range, revealing detailed structure and chemistry.
Pathology study tracks uterine changes with mifepristone
A recent pathology study suggests that mifepristone could be a therapeutic option for women with severe uterine fibroid symptoms. The research confirms that the drug does not trigger cancerous lesions in the uterus, but rather causes benign changes such as fluid-filled glands and abnormal blood vessels.
U-M develops a potential 'game changer' for pathologists
A University of Michigan-led team has developed a potential game changer for pathologists using Spatially-Invariant Vector Quantization (SIVQ) to analyze digital images made from tissue slides. SIVQ can pinpoint cancer cells, calcifications and other critical features with high accuracy and speed.
SourceMichigan Medicine - University of Michigan·JournalJournal of Pathology Informatics·DateFeb 28, 2011
Lasers ID deadly skin cancer better than doctors
Researchers at Duke University developed a laser-based tool that can identify substantial chemical differences between cancerous and healthy skin tissues. The technique uses two lasers to pump energy into suspicious moles, analyzing the way it redistributes in the skin cells to pinpoint microscopic locations of different skin pigments.
Scientists develop method to keep surgically-removed prostate tissue alive and 'working' for week
Researchers at Johns Hopkins Medicine have developed a technique to culture normal and cancerous prostate tissue for up to a week, enabling accurate predictions of how living tissues respond to therapy. This breakthrough could lead to the creation of individualized medicines for prostate cancer patients.
Scientists target possible cause of 1 form of bowel disease
Researchers found a small piece of RNA that blocks glutamine production in the colon, leading to diarrhea, bloating, and abdominal pain. Silencing this RNA segment may open up a new approach to treating IBS symptoms.
Next generation surgical robots: Where's the doctor?
Researchers at Duke University have demonstrated a robot's ability to locate and sample lesions in simulated human organs without human assistance. The robot uses artificial intelligence to process real-time data from ultrasound scans and perform tasks such as biopsies.
Scientists create 3-D models of whole mouse organs
Scientists at Yale University have developed a method to create high-resolution 3D models of intact mouse organs, allowing for non-invasive imaging and analysis. This breakthrough uses fluorescence microscopy and optical clearing to image tissues up to depths of over two millimeters, enabling the creation of virtual 3D biopsies.
Scientists grow new lungs using 'skeletons' of old ones
Researchers from the University of Texas Medical Branch at Galveston have successfully grown new lung tissue using embryonic stem cells and decellularized rat lungs. The breakthrough, published in Tissue Engineering Part A, paves the way for potential applications in treating severe lung disorders such as cystic fibrosis.
SourceUniversity of Texas Medical Branch at Galveston·JournalTissue Engineering Part A·DateJun 23, 2010
Pressure testing tiny cell samples
Researchers have developed a new technique to study the structural properties of tissues by sucking cells into a pipette, providing information on adhesion and elasticity. This approach complements existing methods and allows for measurements on living tissue in its natural environment.
A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
Researchers at Johns Hopkins Medicine found serum amyloid A as a key protein trigger for sarcoidosis, an inflammatory disease affecting hundreds of thousands of Americans. The discovery opens the path to developing drug treatments or vaccines to block inflammation.
SourceJohns Hopkins Medicine·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateMay 3, 2010
DNA barcoding reveals mislabeled cod and haddock in Dublin
Scientists used DNA barcoding to identify 25% of 'cod' and 'haddock' samples as genetically different species, highlighting a need for transparency in the seafood industry. The study found that smoked fish samples were incorrectly labeled at an 82.4% rate, with some species masquerading as cod or haddock.
SourceEcological Society of America·JournalFrontiers in Ecology and the Environment·DateApr 22, 2010
Mercury is higher in some tuna species, according to DNA barcoding
New research using DNA barcoding identifies specific tuna species with high mercury levels, which can pose a health risk to frequent fish eaters. The study suggests that consumers can minimize their mercury intake by choosing lower-mercury tuna options like yellowfin, and calls for clearer labeling of tuna species.
Increasingly threatened loggerheads follow their own paths in travel, eating
Researchers analyzed 15 female loggerheads' shells to discover their surprising dietary and travel habits. The findings suggest the turtles are surprisingly different in their range, diet, or both, with individualistic patterns revealed over a span of 12 years.
Indian spice may delay liver damage and cirrhosis
Curcumin reduces bile duct blockage, liver cell damage, and scarring in mice with chronic liver inflammation. The spice interferes with chemical signalling pathways involved in the inflammatory process, offering a promising alternative to current treatments like ursodeoxycholic acid.
Gluten intolerance in Finland has doubled
The occurrence of gluten intolerance has doubled in Finland, affecting 2% of adults and 1.5% of children. A new diagnosis method is needed to treat early stages of the condition, which may be symptom-free.
Blood clotting finding may lead to new treatments
Researchers at Imperial College London have made a groundbreaking discovery that could lead to new treatments for conditions like deep vein thrombosis and haemophilia A. The study found that factor VIII, a key protein in blood clotting, is produced by lung blood vessels rather than just the liver.
3 brain diseases linked by toxic form of same neural protein
A toxic form of the neural protein Elk-1 is linked to three degenerative brain disorders: Parkinson's disease, Alzheimer's disease, and Huntington's disease. The study found that this modified form of Elk-1 strongly associates with pathological markers present in diseased tissue from these diseases.
Early protein processes crucial to formation and layering of myelin membrane
Researchers from Boston College have made a significant discovery about myelin structure and stability using x-ray diffraction. They found that early protein processes are crucial to the proper formation and layering of the myelin membrane, which is critical for nerve conduction and nervous system function.
Africa's rarest monkey had an intriguing sexual past, DNA study confirms
A DNA study confirms that Africa's rarest monkey, the kipunji, had an intriguing sexual past with baboons. The results may help to set conservation priorities for this critically endangered species by highlighting the importance of protecting its habitat and preserving genetic diversity.
'Genome 10K' proposal aims to sequence 10,000 vertebrates
A new initiative aims to sequence the genomes of 10,000 vertebrates, including whales, dolphins, and porpoises, to gain better understanding of species diversity, evolution, and conservation. The project, called Genome 10K, has the potential to revolutionize our knowledge of cetaceans and inform effective conservation strategies.
Gene mutation may reveal clues for treating lung diseases
Researchers have identified a genetic mutation linked to premature lung development and severe respiratory complications. The mutation, found in four children born with multiple abnormalities, may provide insight into potential treatments for newborn lung distress and COPD.
Hyper-SAGE boosts remote MRI sensitivity
A new technique called Hyper-SAGE amplifies MRI signals by up to 10,000 times, allowing for the detection of low concentrations of cancers and other clinical targets. This breakthrough enhances the sensitivity of Magnetic Resonance Imaging (MRI) technology.
SourceDOE/Lawrence Berkeley National Laboratory·JournalProceedings of the National Academy of Sciences·DateOct 9, 2009
NHLBI awards $11 million for molecular roadmap to chronic lung diseases
Researchers will create a genetic and molecular treasure trove to redefine COPD and pulmonary fibrosis. The project aims to identify individuals at risk, diagnose earlier and develop personalized treatments.
New lab-on-a-chip technique developed at U of T
Researchers have created a new technology that analyzes tiny blood and breast tissue samples to detect increased estrogen levels, which may indicate breast cancer. This breakthrough could lead to faster screening for high-risk populations and improved diagnosis.
Novel breast tissue feature may predict woman's cancer risk
Mayo Clinic researchers found that certain structural features within breast tissue can indicate a woman's individual cancer risk. The percentage of acini present per lobule at a given age indicates cancer risk. This method is more accurate in predicting risk for an individual than the Gail model.
Measuring nitrate concentrations in leafy green vegetables
A recent study published by the American Society for Horticultural Science found that conventional methods for measuring nitrate concentrations in plant tissue are often time-consuming, expensive, and impractical. The researchers developed a new method using rapid potentiometric and colorimetric techniques to measure nitrate concentrat...
Human Tissue Act may have helped research, says study
A new study from the University of Leicester suggests that the Human Tissue Act 2004 may have facilitated medical research by giving Research Ethics Committees clearer guidance. The study analyzed letters written by ethics committees before and after the Act's implementation, concluding that committees were less likely to raise concern...
Scientists take early steps toward mapping epigenetic variability
Scientists at Brown University have completed a study mapping variations in epigenomic structure using over 200 human tissue samples. The research reveals wide epigenetic variation linked to aging and smoking, which may increase susceptibility to diseases like cancer.
Study reveals major genetic differences between blood and tissue cells
Researchers at McGill University discovered significant genetic disparities between blood and tissue cells, undermining the validity of genome-wide association studies. This finding has implications for vascular diseases, such as abdominal aortic aneurysms, where tissue samples are often used.
Ben-Gurion U. researchers identify how stressed fat tissue malfunctions
Ben-Gurion University researchers have identified a key signaling pathway in intra-abdominal fat that contributes to obesity-related disorders. The study found that this pathway is activated in response to fat accumulation in the abdomen, correlating with increased cardio-metabolic risk and whole-body insulin resistance.
SourceAmerican Associates, Ben-Gurion University of the Negev·JournalJournal of Endocrinology and Metabolism·DateJul 14, 2009
Colon cancer screening technique shows continued promise in new study
A new colon cancer screening technique created by Northwestern University researchers has shown a high sensitivity in detecting precancerous lesions, potentially rivaling the effectiveness of colonoscopy. The technique uses optical technology to analyze tissue samples, identifying the 'fingerprint' of carcinogenesis.
University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease
Scientists at the University of Saskatchewan and Canadian Light Source have identified a chemical fingerprint associated with Barrett's Esophagus, a precursor to esophageal cancer. The discovery uses infrared microscopy to detect biomarkers in individual cells, offering a new diagnostic tool for detecting the condition.
New strategy developed to diagnose melanoma
A UCSF research team has developed a technique to diagnose melanoma by measuring differences in levels of genetic markers, with a success rate higher than 90 percent. The new strategy distinguished between benign and malignant skin lesions, shedding light on difficult-to-diagnose cases.
SourceUniversity of California - San Francisco·JournalProceedings of the National Academy of Sciences·DateMar 30, 2009
Social isolation makes strokes more deadly, study finds
Researchers found that socially isolated mice suffered more brain damage and higher inflammation levels after a stroke compared to paired mice. Social support was shown to reduce damaging inflammatory responses and increase anti-inflammatory cytokines in the brain.