Articles tagged with Bioinformatics
Researchers developed a novel, more accurate classification system for gliomas using molecular profiles of 1122 cells. The study identified seven categories for tumor progression assessment, providing a more precise way to predict patient outcomes and treatment responses.
A recent study found that mildly deleterious mutations evolve as neutral during early human migrations out of Africa, while very harmful mutations are found at similar frequencies globally. This suggests a maximum threshold for human tolerance to genetic damage.
The book 'Video Bioinformatics: From Live Imaging to Knowledge' bridges the gap between life sciences and computer science. It provides breakthrough capabilities in understanding continuous life processes through intelligent analysis of live imaging data.
The researchers have developed a new model that allows atomic-level simulations of DNA dynamics, achieving extraordinary accuracy in just 5 years of work. The data is stored in a public website with over 4 Terabytes of information.
The Genome Analysis Centre has achieved a major milestone in wheat research by assembling the genome into larger and more complete chunks. This breakthrough, made possible by improved sequencing technology, will enable researchers to develop new insights into wheat genes and breeding programmes.
Researchers have developed methods to overcome technical limitations in studying the immune system, allowing for investigation of interdependent components and their impact on functions at the systems level. The new book provides valuable insights into team science and the application of computational tools to model immunity.
Researchers developed computational models to study cancer cells' genome structure, improving understanding of genetic changes. The approach uses statistical methods to reconstruct chaotic genomes and identify structural changes in tumour DNA.
Dr. Prerna Dua, associate professor of health informatics and information management at Louisiana Tech University, has been honored with the AHIMA Triumph Award for her research expertise in healthcare and decision support. The award recognizes her dedication to enriching the field of health information management.
Two NIH grants will support Cathy Wu's work on protein ontology and big data analysis to improve understanding of human disease and identify potential diagnostic targets. Researchers will use natural language processing tools to retrieve targeted therapy information from scientific literature and clinical trials.
A group of scientists from seven international laboratories failed to replicate the STAP study, which claimed to turn ordinary cells into pluripotent stem cells. Computational analysis revealed significant genomic inconsistencies, including different genders and mixtures of embryonic and placental stem cells in some experiments.
The UK10K project analyzed nearly 10,000 individuals to understand the contribution of rare genetic variants to various diseases. The study identified new genetic variants and genes underlying disease risk, increasing the resolution of genetic discoveries.
An international team of researchers identified key opportunities in nutrition science to close a major gap between available and projected food by 2050. The researchers proposed eight axes of research, including sustainability, food safety, and big data analysis, to improve nutrition as a science.
A new project aims to characterise the genetic diversity of traditional Vietnamese rice varieties using genomic markers for disease resistance and salt tolerance. Bioinformatics capacity will be built in Vietnam through training workshops and data sharing.
A new bioinformatics approach has been developed to identify associations between molecules from vast data sources, resulting in more accurate results than current methods. This technique improves the detection of genes related to lipid metabolism by 15% on a mouse nutritional study.
Researchers at the University of Michigan have identified the genetic blueprint of a bacteria that produces ET-743, a compound extracted from a marine invertebrate. This discovery expands understanding of the microbe and could lead to lab-grown production of the cancer-fighting drug.
A UK-China consortium, funded by the BBSRC, will host training workshops to support scientists in managing and sharing their metabolomics data and analyses. The partnership, involving EMBL-EBI, universities, and GigaScience, aims to improve data sharing in metabolomics, promoting better quality data and efficient research.
A high demand for bioinformatics training is driven by the increasing use of big data in life sciences. The Global Organisation for Bioinformatics Learning, Education & Training (GOBLET) aims to develop a global community-centred training portal with comprehensive resources and courses.
A novel online tool, PolyMarker, has been developed to automate primer design for multiple genome species, significantly reducing turnaround time. This innovation enables the identification of genetic markers associated with desirable traits in crops, such as high yield or disease resistance.
The Aquaria project has created a powerful web resource that simplifies the process of gleaning insight from 3D protein structures. The tool offers around 46 million computer models, allowing users to view additional information such as genetic differences mapped onto 3D structures.
A landmark study published by an international team of over 100 researchers reconstructs the insect tree of life, answering longstanding questions about their origins and evolution. The study reveals that insects originated at the same time as early terrestrial plants and developed wings 400 million years ago.
The University of California, Los Angeles (UCLA) will develop new strategies for mining and understanding complex biomedical data sets. The center's findings will help shape guidelines for future data integration and use.
The new Competence Center for High Performance Computing in the Natural Sciences will facilitate interdisciplinary collaborations and provide improved HPC services. The center will focus on research and application optimization, with a strong emphasis on Big Data and hardware accelerators.
The special issue of Applications in Plant Sciences explores bioinformatic methods to analyze plant morphology. Researchers successfully applied automated classification and identification techniques, geometric morphometrics, and skeleton networks to examine plant form.
Researchers at A*STAR's Institute of Medical Biology have identified a biomarker, Lgr5, to detect ovarian cancer earlier. Bioinformatics analysis has also revealed genes whose mutation status can be used for prognosis and development of personalized treatment.
Researchers discovered a significant difference in the contents and distribution of mobile DNA elements between fruit fly populations on opposite sides of Evolution Canyon. The study found that these repetitive sequences are increasingly recognized as agents of adaptive change, influencing stress resistance and mating.
Researchers identified distinct genetic underpinnings for different manifestations of preeclampsia, including early vs. late timing and high severity levels. The study found unique sets of genes involved from both mother and fetus, suggesting specific biological contributions to the condition.
Researchers at Virginia Tech and MIT have developed a computer-aided design tool called GenoCAD to create genetic languages for designing biological systems. The tool helps capture biological rules to engineer organisms that produce useful products or healthcare solutions from inexpensive materials. GenoCAD enables the standardization ...
A team of scientists from Harvard University and Virginia Tech has established a reliable set of human genotypes to benchmark human genome sequencing. This will help researchers gain traction against human disease by refining genomic data. The findings are available online, enabling real-time benchmarking of DNA-sequencing methods.
Researchers have developed software that can learn from a patient's normal and seizure electrical activity to predict when another seizure may occur. This allows for an early warning system, potentially enabling people with epilepsy to live safer lives by avoiding hazardous situations before a seizure begins.
Professor Speed has developed tools to help biologists analyze and explain their results, making it possible to look at hundreds of genes in a DNA sequence at once to understand genetic changes involved in complicated diseases. He is also working on determining the genetic traits that make normal and cancerous cells different.
Researchers investigate protein diversity, finding that many small changes have no impact, but some can significantly affect functionality. The study suggests that the wide functional spectrum of proteins plays a key role in evolution, and may hold the key to personalized medicine.
A new bioinformatics software tool, DrGaP, has been developed to identify genetic mutations responsible for cancers. The tool combines statistical methods and bioinformatics tools to distinguish between driver mutations and passenger mutations, leading to a more complete identification of altered genes and signaling pathways in cancer.
The $11 million investment will support large-scale applied and small-scale innovative projects to develop new tools and methodologies. These innovations aim to improve cancer treatments, response to infectious disease outbreaks, food production, and more.
Researchers analyzed over 858,717 grant and contract summaries to identify potential instances of duplicate funding. They found strong evidence that tens of millions of dollars may have been spent on grants where at least a portion was already being funded.
The FASEB MARC Program has awarded $3,700 to two students and their faculty mentors at the ISCB Rocky 2012 meeting. The program aims to increase diversity in biomedical research by promoting participation of underrepresented minority students and scientists.
A new $2 million grant will support a pan-continental bioinformatics research network in Africa. The H3ABioNet project aims to aggregate and analyze large datasets, establish collaborations among preexisting centers, and train African students and scientists in bioinformatics.
A new approach combines pupillography with blinking assessment to measure alertness, sidestepping subjective assessment by healthcare workers. The method has been successfully tested on two groups of volunteers and links blink, pupillary indices and subjective sleepiness.
The National Science Foundation has awarded funding to the Gramene project for a 5-year period, supporting the development of a Plant Reactome. This will increase the functionality of Gramene, which already provides valuable comparisons across and within sequenced plant genomes.
Researchers from Jena University used Einstein's equation to calculate the optimal value of hematocrit, finding that it is around 40% in humans and many other vertebrates. This value may explain why similar levels of hemoglobin are found across species.
The journal Fundamenta Informaticae publishes a special issue commemorating Alan Turing's work on reaction-diffusion theory, which is considered a foundation of chaos theory and theoretical biology. The issue explores the applications of mathematical theories inspired by Turing's work to natural phenomena.
Researchers at the University of Saskatchewan have developed a powerful new tool for analyzing kinases, which are enzymes involved in various cellular processes. The software promises to improve data accuracy and understanding of biology, representing important treatment targets for diseases.
The study confirms that studying genes shared with other animals is a viable means of extrapolating information about human biology. Researchers analyzed 400,000 pairs of genes and found only a weak decrease in functional similarity between orthologs.
Researchers confirmed long-held belief that studying shared genes with other species is useful. They analyzed 400,000 gene pairs and found that studying orthologs is more relevant to understanding human biology than previously thought.
A study found that a simple genetic test can predict the aggressiveness of rhabdomyosarcoma tumours in children, allowing for tailored treatment and improved survival rates. The test identified a panel of genes whose altered activity levels could be used to predict patient response to treatment.
A study published in Clinical Nutrition found that patients with mild to moderate Crohn's disease showed significant improvement when taking supplementary CLA. The natural fatty acid has anti-inflammatory properties and may offer a safer alternative to synthetic drugs.
A new community resource, DGRP, provides the highest-resolution view to date of genome structure and variation in a population of fruit flies with diverse traits. The study has far-reaching effects on animal breeding, pesticide development, and personalized medicine.
Researchers at University of Oxford and Harvard Stem Cell Institute have developed a common standard to describe and integrate large datasets from various fields, enabling better coordination of findings. The ISA Commons platform allows small research groups to store laboratory data without dedicated bioinformatics support.
Despite efforts to identify and retract plagiarized papers, a significant percentage remain untagged, raising concerns about the prevalence of scientific plagiarism. Researchers like Harold Garner have called for improved detection systems to address this growing issue.
Researchers have developed a software package called PoPoolation2 to compare population data, facilitating the study of evolution and adaptation. The tool uses next-generation sequencing methods to determine allele frequencies between populations, providing insights into evolutionary processes.
A study using Quebec's BALSAC population database found that families on the edge of migration waves had more children and contributed more to the contemporary population's genetics. This phenomenon, known as 'gene surfing', may explain the elevated frequency of genetic diseases in certain regions.
Researchers analyzed genealogies of over one million individuals in Quebec to show that pioneers on the edge of colonization waves had a selective advantage. This advantage led to increased fertility and reproductive success, as well as a desire for exploration and colonization.
The Minimum Information about a Bioactive Entity (MIABE) standard aims to capture more information about bioactive compounds, enabling better analysis and design. By adopting this standard, researchers can analyze large datasets from various drug discovery programs, leading to improved understanding of successful drugs.
The new NSF grant will leverage Convey's hybrid-core platform and technologies to process vast amounts of biological data. Researchers can extract meaningful information from this environment using cutting-edge tools, leading to incredible breakthroughs in the biosciences.
The National Institutes of Health has renewed funding for a research project at Virginia Tech to develop computational models to assist policymakers and researchers in making better-informed decisions about emerging infectious diseases. The project aims to refine existing models to provide software tools that can help public health off...
Ralph Roskies, PSC's scientific co-director, has been appointed to the National Library of Medicine's Board of Regents for a four-year term. He brings expertise in bioinformatics and high-performance computing to the role.
Researchers in Germany sequenced and analyzed a draft genome sequence of an E. coli O104:H4 strain from the 2011 outbreak, identifying a new progenitor strain. The study's rapid sequencing technique has immediate implications for surveillance, diagnostics, and future therapies.
The open-source software, GenPlay, is designed to help biologists visualize, analyze and transform raw genomic data. Biologists can now analyze their own data using a user-friendly tool that provides continuous visual feedback, making it easier to make sense of the avalanche of new data.
A recent study suggests that successful genetic blueprints for mesodermal development are recycled by evolution, rather than being invented anew in different species. The researchers found highly conserved transcription factor binding sites across six fruit fly species, indicating a shared regulatory program.
Bhavnani's research uses advanced visual analytical methods to classify asthma patients, enabling targeted diagnosis and treatments. The study builds on molecular data from multiple institutions, demonstrating the potential of translational bioinformatics.
The FASEB MARC Program has awarded a travel grant of $1,650 to promote diversity in the field of bioinformatics. The award recognizes Cynthia N. Prudence's poster/platform presentation at the ISCB Great Lakes Bioinformatics Conference.