Articles tagged with Bioinformatics
A three-year, $2.4 million grant will develop a systems biology approach to combat the effects of drought on staple food crops like maize, wheat, and rice. The project aims to identify key regulatory genes and signaling pathways that can improve drought resistance.
The National Science Foundation has awarded a grant to develop GenoCAD, a web-based Computer Assisted Design environment for synthetic biology. The platform allows users to design complex DNA sequences in minutes and will support teams of undergraduate students enrolled in iGEM.
Researchers demonstrate that Affymetrix Gene platform can analyze differential splicing activity, comparable to Exon arrays, providing added value to existing data. The new statistical method, FIRMAGene, uses adjacent poorly fitting probes to calculate differential expression.
Researchers developed AssociationViewer to analyze genetic differences and uncover new genetic markers for diseases. The software displays SNPs on a large scale, enabling scientists to visualize significant variations in the genomic context.
The University of Southern California will be the central clearing house for a national project to collect and integrate biomedical data, facilitating access to physicians and researchers. BIRNCC aims to create a nationwide computer network that accelerates collaborative biomedical research and translates basic science into treatments.
Researchers Edgar de Graaf and Jeroen De Knijf analyzed patterns in web surfing behavior to reduce the number of results and improve efficiency in data mining. They developed methods to detect relevant patterns quickly and effectively within large quantities of semi-structured data.
Researchers at Virginia Tech will develop high-performance computer modeling tools to design efficient wireless spectrum markets. The goal is to create a robust, economically viable and efficient Dynamic Spectrum Access architecture for cellular networks.
The Swiss Institute of Bioinformatics has produced an encyclopaedic knowledge capturing the functions and interactions of human proteins. The dataset covers 20,325 human proteins and will speed up scientific work aimed at improving quality of life, particularly in combating genetic-based diseases.
Dr. Joseph DeRisi receives the Heinz Award for his pioneering work in viral detection platforms, including the ViroChip that detects new viruses and characterizes malaria parasites' life cycles. His open access approach to science enables free sharing of research and software.
A new approach, MisPred, uses five principles to identify suspect proteins with abnormal or incomplete annotations in public databases. The majority of errors are attributed to the absence of expected signal peptides and domain integrity violations.
The MIBBI initiative brings together grassroots standardisation groups to create a unified framework for high-throughput biology. By sharing minimal information standards, researchers can increase data reproducibility and analysis power.
Researchers at Virginia Tech developed guidelines for designing and managing next-generation databases of biological parts. The study identified key needs for improvement, including standardization of DNA clones and quality control measures.
A team of undergraduate students from UC San Diego has developed a new area of bioinformatics called comparative proteogenomics, which analyzes multiple genomes and proteomes simultaneously. This approach improves genomic and proteomic annotations, unlocking biological mysteries and addressing difficult problems in the field.
Researchers used metabolomics to identify groups of relevant biomarkers of disease in healthy and diabetic mice. The study found that the ratios between certain metabolite concentrations were more informative than their absolute concentrations.
A new EC-funded project aims to unite Europe's biological data resources into a sustainable, integrative network for life sciences research. The European Life-science Infrastructure for Biological Information (ELIXIR) project will provide a secure funding mechanism and protect valuable data from insecure or short-term funding.
The study provides a global analysis of human proteins interacting with viral and bacterial proteins, revealing possible intervention points for future therapeutics. Pathogens preferentially target high-impact human proteins called hubs and bottlenecks, which are involved in cancer pathways.
Bowling Green State University biology undergraduates will contribute to the Microbial Genome Annotation research program, analyzing microorganisms' genomes and gaining skills in genomics and bioinformatics. The project aims to sequence the genomes of all cultured bacteria and archaea, with BGSU students providing valuable input.
The UC Irvine Institute for Genomics and Bioinformatics has received a $5.6 million grant to expand its Biomedical Informatics Training program, which trains graduate students in the intersection of life sciences and computational technologies. The program, one of only 18 nationwide, provides specialized training in molecular biology, ...
Nicholas Tan Xue-Wei, an 18-year-old Singaporean student, will present his research paper on stem cells at two international conferences in the US and UK. He was nominated for a Best Paper Award at WCE 2007 for his work on growing Mesenchymal Stem Cells in a serum-free medium.
Researchers at UC San Diego and University of Hawaii will analyze avian flu genomes using bioinformatics software and a computational grid. The project aims to combat emerging bird flu pandemic threats using reverse genetics techniques and promotes global cooperation in case of a flu pandemic.
Researchers have developed a new classification system for Rickettsia bacteria, highlighting the importance of plasmids in virulence traits and host recognition. The study provides insight into the evolutionary origin of rickettsiae and has implications for the development of diagnostics and vaccines.
Researchers have discovered that two alphaproteobacteria lack the universal extra guanylate nucleotide typically found in transfer RNA molecule tRNAHis, which assists in incorporating amino acid histidine into new proteins. This finding suggests a radical departure from previously known identity rules for histidine-carrying tRNAs.
Scientists from IRB Barcelona have published a dynamic map of protein behavior, enabling the prediction of protein structures and interactions. The study, part of the MoDel project, aims to establish a 'fourth dimension' for protein structures, facilitating the design of new drugs and understanding of protein functions.
A Medical College of Georgia bioinformatics expert has received a $15 million NIH grant to continue operating the Coordinating and Bioinformatics Unit. The grant will support the development of animal models for diabetic complications, including cardiovascular disease and kidney damage.
Researchers developed a detailed computational model to simulate AZT metabolism in mitochondria, exploring potential mechanisms of toxicity. The model may help minimize or eliminate toxic side effects of AZT in HIV-infected patients.
The study demonstrates an extremely high rate of prediction accuracy (95%) in a very complex pathogen, the vaccinia virus. Bioinformatics was able to reveal the vast majority of epitopes that trigger an effective immune response against the virus.
FELICS, a unique electronic infrastructure project funded by the European Union, offers unrestricted access to prominent biological databases. This initiative provides critical support for BRENDA and CheBI, facilitating navigation of the biological knowledge space for scientists.
Researchers at VBI will utilize the database to identify key genes involved in tomato metabolism and apply RNA interference technology. The project aims to enhance tomato cultivation and expand its application in biotechnology research programs.
A computer scientist has developed a system to analyze proposed drug names and rank them in terms of confusability, using techniques from linguistics and bioinformatics. The system, created in collaboration with the FDA, can identify sound-alike and look-alike drug names with great accuracy, reducing the risk of prescription errors.
Mohamad Halawi, a UH graduate, has been awarded multiple scholarships and a prestigious NIH fellowship to pursue his passion in cancer genomics research. With these honors, he aims to become a physician-scientist practicing in oncology.
A new XML-based architecture could improve access to chemical information in biomedical literature, reducing errors and increasing publication efficiency. The proposed system would link to open databases like PubChem, enabling readers to easily identify compounds mentioned in articles.
The University of Houston is developing DNA probes to detect emerging pathogens using advanced genomic computations and bioinformatics. The goal is to rapidly identify microorganisms and viruses that could be used in bioterrorism attacks.
The NIH has funded two new bioinformatics resources at UT Southwestern to improve drug discovery and vaccine development. The BioHealthBase will focus on understanding how microbes establish infections, while the ImmPort system will integrate data from different biomedical research areas to identify disease-causing genes and proteins.
PathPort is a life sciences interoperability framework providing access to biological characterizations of known pathogens and their near relatives. The project aims to aid in detection, identification, and analysis of high-priority pathogens using its analytical tools and data models.
A $18 million bioinformatics center will provide a single web-based entry point for infectious disease researchers to access data on hundreds of deadly microorganisms. The center aims to accelerate research into the biology and evolution of these pathogens, with a focus on eight key species.
A study published in Physical Review E found that a loss of just 2% of US power grid substations can cause catastrophic failure. Researchers identified high-load transmission substations as critical points, emphasizing the need for increased redundancy and distributed generation.
Researchers at Universitat Autonoma de Barcelona have developed the PDA web service, allowing scientists to analyze genetic diversity in different individuals and species. The server enables the search for small variations in genomes, providing valuable information for studying illnesses with a genetic origin.
The Virginia Tech National Bioinformatics Resource Center will focus on Brucella, Caliciviruses, hepatitis A, Rabiesvirus, and Coxiella burnetii/Rickettsias. The center will enable researchers to access, analyze, and study molecular data for these infectious diseases.
Researchers found a common genetic signature consisting of 67 genes that are abnormally expressed in all cancers. These genes are involved in cell cycle and proliferation, making the discovery logical despite its difficulty.
A Virginia Tech researcher has been awarded $1.8 million to investigate the Arabidopsis genome, a key plant model organism. The project aims to understand the function of SABATH faculty of methyltransferase genes in plants, which could lead to breakthroughs in plant physiology and reproduction.
The formation of wwPDB formalizes the global character of the Protein Data Bank, ensuring transparency and quality of data. The collaboration allows for individual creativity in presenting and making data available to the community.
The Virginia Bioinformatics Institute is at the forefront of a new regional center of excellence for biodefense and infectious disease research. This initiative aims to combat infectious diseases, including potential bioterrorism threats, by leveraging genomics, bioinformatics, and supercomputing capabilities.
The NIH award will focus on oxidative stress research in baker's yeast, with the goal of developing new strategies to combat neurodegenerative diseases. The grant also provides opportunities for high school and undergraduate students from economically-depressed areas to receive bioinformatics training.
The Early Detection Initiative aims to identify proteins that signify cancer presence or risk in human blood samples using proteomics techniques. Researchers will analyze data from large groups of individuals with known health histories and behaviors.
Researchers at Virginia Tech's Bioinformatics Institute will sequence the genomes of two Phytophthora species, including one that causes over $1 billion in soybean losses annually. The project aims to understand how these pathogens operate and develop strategies to control them, with potential benefits for marine species like diatoms.
The collaboration will focus on understanding infectious disease pathogens, host interactions, and environmental factors. Researchers will develop technologies for rapid detection, identification, and remediation of pathogens.
Yale University has been awarded a $1.3 million pre-center grant to prepare for the potential establishment of a Center of Excellence in Biomedical Computing. The grant aims to train new scientists in interdisciplinary areas of biomedical computing, addressing a critical shortage identified by NIH.
The NSF-funded Expresso project develops a computational system for microarray bioinformatics, enabling the automation of tedious methodological aspects. The project will be used for various experimental biology research projects, including Loblolly Pine tree drought resistance and human tissue analysis.
Researchers at VBI are developing software to integrate metabolomics data with gene expression and proteomics, enabling scientists to pinpoint the exact function of genes and proteins. The collaboration with Phenomenome aims to create a global understanding of biological systems from a dynamic perspective.
The Deutsche Forschungsgemeinschaft has chosen five locations to develop bioinformatics capabilities, focusing on Bielefeld, Munich, Leipzig, Saarbrücken, and Tübingen. The initiative aims to boost Germany's attractiveness in life sciences and academic research.