Articles tagged with Bioinformatics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A Medical College of Georgia bioinformatics expert has received a $15 million NIH grant to continue operating the Coordinating and Bioinformatics Unit. The grant will support the development of animal models for diabetic complications, including cardiovascular disease and kidney damage.
Researchers developed a detailed computational model to simulate AZT metabolism in mitochondria, exploring potential mechanisms of toxicity. The model may help minimize or eliminate toxic side effects of AZT in HIV-infected patients.
The study demonstrates an extremely high rate of prediction accuracy (95%) in a very complex pathogen, the vaccinia virus. Bioinformatics was able to reveal the vast majority of epitopes that trigger an effective immune response against the virus.
FELICS, a unique electronic infrastructure project funded by the European Union, offers unrestricted access to prominent biological databases. This initiative provides critical support for BRENDA and CheBI, facilitating navigation of the biological knowledge space for scientists.
Researchers at VBI will utilize the database to identify key genes involved in tomato metabolism and apply RNA interference technology. The project aims to enhance tomato cultivation and expand its application in biotechnology research programs.
A computer scientist has developed a system to analyze proposed drug names and rank them in terms of confusability, using techniques from linguistics and bioinformatics. The system, created in collaboration with the FDA, can identify sound-alike and look-alike drug names with great accuracy, reducing the risk of prescription errors.
Mohamad Halawi, a UH graduate, has been awarded multiple scholarships and a prestigious NIH fellowship to pursue his passion in cancer genomics research. With these honors, he aims to become a physician-scientist practicing in oncology.
A new XML-based architecture could improve access to chemical information in biomedical literature, reducing errors and increasing publication efficiency. The proposed system would link to open databases like PubChem, enabling readers to easily identify compounds mentioned in articles.
The University of Houston is developing DNA probes to detect emerging pathogens using advanced genomic computations and bioinformatics. The goal is to rapidly identify microorganisms and viruses that could be used in bioterrorism attacks.
The NIH has funded two new bioinformatics resources at UT Southwestern to improve drug discovery and vaccine development. The BioHealthBase will focus on understanding how microbes establish infections, while the ImmPort system will integrate data from different biomedical research areas to identify disease-causing genes and proteins.
PathPort is a life sciences interoperability framework providing access to biological characterizations of known pathogens and their near relatives. The project aims to aid in detection, identification, and analysis of high-priority pathogens using its analytical tools and data models.
A $18 million bioinformatics center will provide a single web-based entry point for infectious disease researchers to access data on hundreds of deadly microorganisms. The center aims to accelerate research into the biology and evolution of these pathogens, with a focus on eight key species.
A study published in Physical Review E found that a loss of just 2% of US power grid substations can cause catastrophic failure. Researchers identified high-load transmission substations as critical points, emphasizing the need for increased redundancy and distributed generation.
Researchers at Universitat Autonoma de Barcelona have developed the PDA web service, allowing scientists to analyze genetic diversity in different individuals and species. The server enables the search for small variations in genomes, providing valuable information for studying illnesses with a genetic origin.
The Virginia Tech National Bioinformatics Resource Center will focus on Brucella, Caliciviruses, hepatitis A, Rabiesvirus, and Coxiella burnetii/Rickettsias. The center will enable researchers to access, analyze, and study molecular data for these infectious diseases.
Researchers found a common genetic signature consisting of 67 genes that are abnormally expressed in all cancers. These genes are involved in cell cycle and proliferation, making the discovery logical despite its difficulty.
A Virginia Tech researcher has been awarded $1.8 million to investigate the Arabidopsis genome, a key plant model organism. The project aims to understand the function of SABATH faculty of methyltransferase genes in plants, which could lead to breakthroughs in plant physiology and reproduction.
The formation of wwPDB formalizes the global character of the Protein Data Bank, ensuring transparency and quality of data. The collaboration allows for individual creativity in presenting and making data available to the community.
The Virginia Bioinformatics Institute is at the forefront of a new regional center of excellence for biodefense and infectious disease research. This initiative aims to combat infectious diseases, including potential bioterrorism threats, by leveraging genomics, bioinformatics, and supercomputing capabilities.
The NIH award will focus on oxidative stress research in baker's yeast, with the goal of developing new strategies to combat neurodegenerative diseases. The grant also provides opportunities for high school and undergraduate students from economically-depressed areas to receive bioinformatics training.
The Early Detection Initiative aims to identify proteins that signify cancer presence or risk in human blood samples using proteomics techniques. Researchers will analyze data from large groups of individuals with known health histories and behaviors.
Researchers at Virginia Tech's Bioinformatics Institute will sequence the genomes of two Phytophthora species, including one that causes over $1 billion in soybean losses annually. The project aims to understand how these pathogens operate and develop strategies to control them, with potential benefits for marine species like diatoms.
The collaboration will focus on understanding infectious disease pathogens, host interactions, and environmental factors. Researchers will develop technologies for rapid detection, identification, and remediation of pathogens.
Yale University has been awarded a $1.3 million pre-center grant to prepare for the potential establishment of a Center of Excellence in Biomedical Computing. The grant aims to train new scientists in interdisciplinary areas of biomedical computing, addressing a critical shortage identified by NIH.
The NSF-funded Expresso project develops a computational system for microarray bioinformatics, enabling the automation of tedious methodological aspects. The project will be used for various experimental biology research projects, including Loblolly Pine tree drought resistance and human tissue analysis.
Researchers at VBI are developing software to integrate metabolomics data with gene expression and proteomics, enabling scientists to pinpoint the exact function of genes and proteins. The collaboration with Phenomenome aims to create a global understanding of biological systems from a dynamic perspective.
The Deutsche Forschungsgemeinschaft has chosen five locations to develop bioinformatics capabilities, focusing on Bielefeld, Munich, Leipzig, Saarbrücken, and Tübingen. The initiative aims to boost Germany's attractiveness in life sciences and academic research.