Articles tagged with Chromatin
Researchers developed new tools to infer context-specific regulatory networks from paired expression and chromatin accessibility data. This approach recovers significant information on binding locations and chromatin states, enabling accurate inferences for gene regulatory relationships.
Scientists at UNC discovered a cascade of molecular signals that program gene activity to drive fruit fly maturation, involving alterations to DNA packaging and chromatin accessibility. This basic biology finding may hold significance for understanding how cancers arise in humans.
Scientists have discovered that the 3D organisation of the genome arises when the first zygotic genes are transcribed, and these boundaries are maintained throughout development. This finding helps explain why the TAD organisation of genomes is similar across tissue types and evolutionary conserved regions between species.
Researchers developed a new technique to study three-dimensional genome organization in individual cells, revealing differences between maternal and paternal genomes. The study provides insights into the earliest stages of embryogenesis and may help understand totipotency and reprogramming of somatic cells.
LJI researchers identified key factors controlling T cell fate, shedding light on molecular mechanisms behind T cell exhaustion. This study offers new approaches to clinical intervention strategies to modulate T cell activity and improve immune function.
A low-carbohydrate ketogenic diet has been shown to alleviate symptoms of a rare inherited intellectual disability in mice genetically engineered with a Kabuki syndrome-like condition. The study suggests that correcting an imbalance in chromatin's open and closed states may improve mental function, offering new hope for treatment.
Researchers at University of Illinois discovered that mechanical force can directly trigger gene expression by stretching chromatin, a condensed DNA and protein mixture. The study found that the degree of stretching affects gene expression, with varying effects based on the direction of the force in relation to the cell's cytoskeleton.
Researchers used assortativity to analyze DNA interactions and identify proteins mediating chromatin contact networks. This approach helps understand genome organization and its relationship with gene expression regulation.
Researchers at CRG have discovered an active repression mechanism involving the progesterone receptor in hormone-dependent breast cancer cells, affecting 650 genes. The study identifies a protein FOXA1 that signals genes for repression by compacting chromatin and restricting gene access.
Researchers used computer simulations to model chromosomes and found that reorganization occurs only on small spatial scales and short time scales. The study aims to develop new methodologies for visualizing genome distances smaller than 0.1 Mbp, improving our understanding of chromatin behavior during interphase.
Researchers at Center for Genomic Regulation discover a new pathway generating energy in the cell nucleus to deal with stressful situations and high levels of DNA damage. The key enzyme NUDIX5 is identified as crucial for nuclear ATP synthesis, which could lead to targeted cancer medicine and biomarker development.
A small portion of the maize genome holds vast amounts of information controlling traits like plant size and stress response. This discovery could greatly accelerate crop improvement by allowing researchers to pinpoint specific genetic changes.
Researchers at Cornell University and Florida State University identified a tiny percentage of regulatory DNA in the maize genome that accounts for roughly half of the variation in observable traits found in corn. This discovery enables breeders to focus on these areas for more efficient plant breeding.
Researchers develop approach to understand chromatin regulators, which modify DNA to alter gene expression. They found that regulators control the probability of gene expression in a population, not just individual cells.
Researchers at Princeton University have discovered the two-step process that activates Suv39h1, an essential enzyme responsible for organizing large portions of human DNA. The study reveals how the enzyme employs a positive feedback loop to chemically tag unnecessary regions of DNA.
A new method called 'ADPr-ChAP' allows researchers to identify chromatin sites modified by ADP-ribosylation in response to cell stress, enabling a better understanding of the cellular stress reaction. This breakthrough could lead to new ways of intervening in disease-making processes such as chronic inflammation and cancer.
Researchers at Rockefeller University have identified pivotal changes in epigenetic pathway genes required for forming the cerebellum's circuitry. The study reveals that specific epigenetic regulators are crucial for neuronal connections and ion channel expression.
Researchers at MSU have discovered the mechanisms of self-organization in living cells, revealing the role of topologically associated domains (TADs) in compacting DNA into three-dimensional structures. This knowledge may lead to new approaches for understanding and treating diseases related to gene regulation.
Researchers at the University of Pennsylvania have identified a hormone-mediated 'chromatin switch' that directs plants to form flowers in response to auxin. This finding could lead to increased flower formation and potentially boost agricultural yields.
Researchers found that chromatin marks are irrelevant for regulating genes expressed in specific tissues during development. The study challenges current beliefs about epigenetics and offers new insights into gene expression.
Daily changes in nuclear positioning of circadian genes regulate their activity with a 24-hour period. Researchers identified two proteins PARP1 and CTCF that bring genes to the periphery, promoting silent state.
Researchers discovered that genetic variation impacts multiple, separated gene regulatory elements simultaneously, revealing a harmonized and synergistic behavior. This study sheds light on fundamental aspects of genome biology and its role in complex diseases such as cancer and diabetes.
A team of researchers at the IRCM has made a breakthrough discovery about how DNA is organized in our cells. They found that two specific proteins play an essential role in maintaining the proper structure of chromatin.
A study published in Nature Communications reveals that the protein dDsk2, a ubiquitin receptor, plays a key role in regulating gene expression. This discovery opens up new avenues for understanding the link between dDsk2 and neurodegenerative diseases such as Alzheimer's and Huntington's.
Scientists have mapped the physical structure of the nuclear landscape to understand changes in genomic interactions during cell senescence and ageing. They reconciled two models of ageing, finding that SAHF domains show a dramatic loss of local interconnectivity and internal structure in senescent chromatin.
Researchers find that embryonic stem cells can modify their metabolism to keep their entire genome accessible, allowing them to renew themselves. This discovery could lead to breakthroughs in regenerative medicine and a better understanding of cancer.
A team of researchers at Florida State University has made a groundbreaking discovery in the field of plant genetics, shedding light on how plants regulate their genetic material. The study found that certain regions of DNA are hypersensitive to enzymes, allowing scientists to identify new biochemical signatures and gain a better under...
Researchers have successfully treated a genetic form of intellectual disability in mice using an anticancer drug, suggesting a potential new approach for the human condition. The study's findings indicate that altering the balance between chromatin's open and closed states could be key to treating Mendelian disorders of the epigenetic ...
Three analyses compare how human, worm, and fruit fly genomes are read out and organized into chromosomes, adding billions of entries to a publicly available archive. Scientists discovered common features that apply to all organisms, offering insights into human development and disease.
Researchers at Duke University discovered that the host determines which genes are open in the gut, while microbes regulate their usage, indicating a cooperative environment where both parties interact to thrive. This study has significant implications for understanding the intricate relationships between hosts and microbiomes.
A study sequencing the exome of 231 schizophrenia patients and their unaffected parents found that collective damage across several genes contributes to the disease. This discovery could lead to early detection and treatment strategies.
Researchers at Cold Spring Harbor Laboratory discovered a protein called Chd5 that plays a crucial role in chromatin remodeling during sperm development. The team found that Chd5 is essential for maintaining the genetic information of male fertility, and its absence can lead to infertility and increased risk of disease.
Researchers identify machinery of epigenetic inheritance, a process by which traits are passed between generations without DNA sequence changes. The discovery reveals that chemical marks on chromatin serve as molecular memory, allowing cells to recognize and remember to silence specific genes in each new generation.
Researchers identified an enzyme called TLK1 that regulates the transport of histones to DNA copying hubs, crucial for maintaining normal gene function. The study found that TLK1 boosts the supply of histones at critical time points, ensuring correct chromatin architecture and cellular identity.
Researchers found that ANP32E strips histone H2A.Z from DNA, altering gene expression and leading to improper chromatin structure in cells lacking the protein. This discovery could reveal novel therapeutic strategies for diseases and cancers.
Researchers present new pain management treatment for SCD patients using selectin inhibitors, while also exploring targeted gene therapy strategies to produce healthy hemoglobin. These advances aim to improve the long-term outlook and quality of life for hundreds of thousands of patients worldwide.
A study from the University of Pennsylvania School of Medicine reveals that epigenetic factors play a role in senescence, a process linked to normal aging and tumor suppression. The researchers found large-scale changes in gene expression and chromatin architecture when a nuclear protein called lamin B1 is deleted in senescent cells.
The study reveals HDAC3 plays a key role in regulating gene expression, chromatin structure, and genome stability. Disruption of HDAC3 expression leads to impaired hematopoiesis, highlighting its importance in stem cell functions and bone marrow failure syndromes.
Researchers found that actin's monomeric form interacts with chromatin to regulate gene expression and genome stability. The discovery challenges the dogma that actin functions through polymerization, revealing a novel mechanism for nuclear actin.
Researchers at CSHL have discovered how Chd5 exerts its beneficial effects by binding to histone H3, preventing cancer initiation and promoting tumor suppression. This finding has important implications for treating diverse human cancers.
A study published in Cell Reports found that the position of a gene within chromatin affects its expression, contradicting the concept of a singular 'histone code'. The researchers inserted the same gene into 90 different locations in yeast chromosome and discovered significant differences in gene activity.
Researchers identified hundreds of regions in the human genome with unique chromatin structures that control cognitive behavior and expression. These findings provide new insights into diseases like Alzheimer's and autism.
Researchers identified a new mechanism allowing the toxic DUX4 protein to be produced in skeletal muscle, causing progressive muscle weakness. Mutations in the SMCHD1 gene cause chromatin relaxation, leading to DUX4 production.
Researchers have made a breakthrough in nuclear reprogramming by identifying histone H3.3 as a key player in reverting nuclei to a pluripotent state, capable of becoming any cell type. This discovery has significant implications for regenerative medicine and cancer treatment.
A study reveals that repressor proteins like Set2 recruit de-acetylases and chromatin remodelers Isw1 to block histone exchange and prevent erroneous transcription. This mechanism is crucial for maintaining accurate gene expression, which is often disrupted in diseases such as cancer.
Researchers discovered a 'switch' called MOZ that modifies the Tbx1 gene, essential for normal heart development, to explain variations in DiGeorge syndrome severity. The study found that MOZ activity can be influenced by environmental factors, such as diet, particularly vitamin A, which can exacerbate birth defects.
Researchers at Stowers Institute for Medical Research reveal that histone exchange occurs over a large proportion of genes, controlling gene expression. They also find that the Set2 protein plays a complex role in regulating transcription, preventing cryptic RNA transcripts and maintaining chromosomal stability.
Researchers at Children's Hospital of Philadelphia have developed approaches to control long-range genomic interactions during gene expression. By identifying a looping factor, they showed that chromatin looping is a cause, not an effect, of gene transcription.
Weill Cornell Medical College researchers discovered that a chromosomal rearrangement in prostate cancer cells creates a new 'fusion' gene, warping DNA structure and triggering abnormal growth. The study suggests a model for how other chromosomal translocations contribute to cancer formation.
Scientists have identified PRC2, a chromatin regulator, as a promising therapeutic target in acute myeloid leukemia. Blocking PRC2 halts uncontrolled proliferation and reactivates anti-tumor pathways, offering a potential new treatment option.
Researchers have elucidated the crystal structure of Alba2-DNA complex in archaea, revealing a hollow pipe-like structure that compacts DNA. This discovery provides valuable clues into the evolution of chromatin structure and its connection to diseases.
Scientists at EMBL have developed a new method to observe enhancer activity during development, showing that specific chromatin modifications trigger gene expression. This breakthrough provides cell-type specific information on enhancer activity and gene status in multicellular embryos.
Researchers at Max Planck Institute discovered that plant seed cells contract their nuclei and condense chromatin to resist dehydration, enabling seeds to survive harsh conditions. This mechanism allows seeds to prepare for germination when environmental conditions improve.
Researchers at USC's Keck School of Medicine discovered how estrogen activates genes in breast-cancer cells through a protein called TIP60, which recognizes methylation signals in chromatin. This finding builds upon previous work and has broader implications for gene regulation and potentially global significance.
A Stanford University School of Medicine study found that modifying proteins in a laboratory roundworm increases the life span of both the original animal and its descendants, even when the modification is no longer present. This suggests that longevity can be inherited in a non-genetic manner over several generations.
A recent study published in Nature Cell Biology has discovered that bookmarking genes before cell division accelerates their reactivation afterwards. By analyzing the kinetics of gene activation, researchers found that a histone molecule undergoes chemical modification and is preserved during mitosis, allowing for rapid reactivation.
Researchers at Stanford University School of Medicine have developed a new technique that allows them to pinpoint the exact DNA sequences and locations bound by regulatory RNAs. The study reveals the intricate world of gene expression and how RNA molecules control neighboring and distant genes.
A recent NIH award of $1.39M will support a study led by Dr. Lori A. Pile to investigate the alteration of chromatin structure during cell division, which is crucial for normal cell growth and cancer development. The findings aim to refine cancer treatments currently undergoing clinical trials.
The University of Colorado Cancer Center has successfully genetically sequenced the most prevalent type of bladder cancer, urothelial carcinoma. The team discovered mutations in genes responsible for chromatin remodeling, which are similar to those found in other cancers.
A study published in Nature Genetics identified 49 new significantly mutated genes associated with TCC, including eight genes related to chromatin remodeling. These genetic aberrations were found in 59% of individuals with TCC, suggesting a potential role for UTX gene in bladder cancer classification and diagnosis.