Articles tagged with Chromosome Conformation Capture
Researchers at the University of Pittsburgh School of Medicine discovered an unexpected chromosome interaction between telomeres and centromeres in some aggressive cancers. This interaction creates a genetic signature that could help identify ALT-positive tumors, which are often challenging to treat due to genomic instability.
The study created a critical framework for understanding the architecture of the genome and its association with gene function in cells. The 4DN Consortium integrated data from over a dozen techniques to compile an extensive catalogue of looping interactions between genes and regulatory elements.
A new approach for understanding chromatin's 3D structure and its influence on gene regulation has been developed by scientists at Sanford Burnham Prebys. The method measures a genomic region's proximity to the isolated center of a chromatin clump, revealing that surface regions are more active than core regions.
The Gerlich Group at IMBA found that histone acetylation establishes a sharp surface boundary on chromosomes, resisting microtubule perforation. Chromatin phase separation and DNA looping by condensin cooperates to build mitotic chromosomes with unique physical properties.
The researchers reported a reference sequence for the supernumerary B chromosome in maize, with key properties such as its origin and molecular mechanism remaining unclear. The study found that the current gene content is a result of continuous transfer from the A chromosomal complement over an extended evolutionary period.