Articles tagged with Genome Sequencing
Children's Mercy researchers developed STAT-Seq, a 50-hour whole genome sequencing approach, to diagnose critically ill infants. The technology could reduce hospitalization and costs by quickly identifying genetic diseases, with potential benefits for up to one-third of NICU patients.
Biologists at Ruhr-Universität used a combination of laser microdissection and RNA-seq to analyze gene activity in the entire genome of certain fungi. They found that gene expression differs between tissue types, with some genes active only in specific tissues.
A genomic sequencing project funded by community donations has published the first sequence of the critically endangered Puerto Rican Parrot. The project, led by Dr. Taras Oleksyk, covers nearly 76% of the parrot's genome and has found similarities to zebra finches and chickens.
The University of New Hampshire will receive two new instruments, a DNA sequencer and a computer cluster, to advance its genome studies and space science research. The new equipment will enable researchers to study emerging diseases, environmental changes, and space weather with greater precision.
Researchers have discovered that the malaria-causing parasite Plasmodium vivax shares the same genetic variations despite being found on different continents. The sequencing of its genome could help understand how the parasite lives and causes malaria, and may lead to new treatments for drug-resistant strains.
A team of neuroscientists discovered a signature of disease that may help explain the relationship between transposons and neurodegenerative disorders. They found that TDP-43 normally functions to silence or repress potentially harmful transposons, but when its function is compromised, these elements become overexpressed.
A deadly outbreak of antibiotic-resistant bacteria at NIH's Clinical Center was quelled through collaboration with genomic experts. Genome sequencing revealed the outbreak had a single source, and targeted interventions stopped its spread.
A novel arenavirus has been identified as the possible cause of inclusion body disease in snakes, a devastating illness that spreads easily among boas and pythons in captivity. The discovery may lead to the development of diagnostic tools and treatments to eradicate the disease from snake collections worldwide.
A new study on malaria genomes reveals significant genetic diversity in Plasmodium vivax, a species of malaria that affects humans outside Africa, making it adept at evading drugs and vaccines. The research also sequenced the genome of Plasmodium cynomolgi, a close relative that infects Asian monkeys.
A team of citizen scientists, led by Dr Andy Grierson, analyzed human genome data to identify new clues on the Y chromosome, revealing a detailed family tree for Western European men. This community-led approach has the potential to facilitate rapid progress in understanding historical human migrations and paternal lineages.
A new DNA study provides clues about the species' evolution, suggesting that climate change and genetic exchange with brown bears helped create the polar bear as we know it today. The research found evidence of fluctuating population sizes over the past million years, growing during cooling periods and shrinking in warmer times.
A new technique links agronomic traits in crops with active genomic regions, identifying expressed genes. This allows plant breeders to develop markers based on these genes, accelerating breeding through marker-assisted selection.
Belgian scientists have developed a simple assay to track 'superparasites', a type of Leishmania parasite that causes deadly visceral leishmaniasis. This breakthrough could help monitor the spread and emergence of these drug-resistant microbes, contributing to better control of the disease.
Researchers at Stanford University School of Medicine have successfully sequenced a fetus's genome using only a maternal blood sample. The new approach, published in Nature, has significant implications for prenatal diagnosis and could bring genetic testing one step closer to routine clinical use.
Researchers have successfully sequenced the parrot genome using single molecule sequencing, allowing for a better understanding of the genetic mechanisms behind vocal learning. The breakthrough could lead to insights into speech development in humans and the study of cancer and brain functions.
The melon genome consists of 450 million base pairs and 27,427 genes, with seven varieties sequenced. Key findings include genes related to disease resistance and the ripening process, offering potential for improving crop yields and quality.
New research suggests that short stretches of piRNA evaluate cells' genetic history by recognizing sequences that have been expressed before. The study found that the silencing pattern is permanent and passed stably between generations, with each individual establishing its own pattern.
A study suggests that the evolution of fungi capable of breaking down lignin may have played a key role in ending coal deposits. The findings propose that this ability allowed for the complete breakdown of dead plant matter into carbon dioxide, releasing it into the atmosphere instead of accumulating as coal.
A study published in PNAS found two distinct strains of Vibrio cholerae bacteria that may have contributed to the 2010 Haitian cholera outbreak. The genomic diversity of Haitian isolates revealed significant complexity and relationship to past epidemics.
Researchers used whole-genome sequencing to distinguish between related MRSA strains, potentially shortening outbreak duration. The study identified genetic differences between strains that current methods couldn't detect.
Researchers decode Dekkera bruxellensis genome, gaining insights into its impact on wine taste. The study enables wine producers to control flavor development, leading to potential cost savings and new wine tastes.
The University of Oklahoma led a US-based team in sequencing the tomato genome, revealing new insights into fruit characteristics. The achievement has significant implications for developing more desirable strains with higher yields, increased disease resistance, and improved flavor.
The tomato genome sequence provides detailed information about its genes and chromosomes, enabling researchers to improve crop yields and quality. The full genome sequence allows for faster and less expensive sequencing of other varieties, with potential applications in improving taste, nutritional content and disease resistance.
The Tomato Genome Consortium has sequenced the genomes of domesticated tomatoes and its wild ancestor Solanum pimpinellifolium, revealing detailed insights into the plant's genetic makeup. The sequences provide a better understanding of how genetics and environmental factors interact to determine crop health and viability.
The Tomato Genome Consortium has sequenced and assembled the tomato genome, revealing two rounds of triplications that have impacted genes controlling texture, color, and maturation. This analysis provides key information for studying the evolution of this species and exploring methods to promote resistance to pests and water scarcity.
A 16th-century Korean child's mummified liver has revealed a unique hepatitis B virus (HBV) genotype C2 sequence common in Southeast Asia, providing insight into the virus's evolution and spread. The ancient genome is the oldest full viral genome described in scientific literature.
Scientists have determined the genetic sequences of all 12 available strains of vancomycin-resistant Staphylococcus aureus bacteria, which acquired resistance independently after acquiring a specific transposon. The findings may lead to new ways to prevent and treat infection by MRSA, VRSA, and VRE.
Scientists sequenced the Heliconius butterfly genome to understand wing pattern diversity, finding that different species copy each other's patterns by exchanging genes. This process allows hybrids to gain useful genes for adapting to changing conditions and survive.
Researchers from the Heliconius Genome Consortium sequenced the Postman butterfly's genome and found promiscuous sharing of large DNA regions among closely-related species. This study reveals how hybrids can introduce new genes that help populations adapt, changing our understanding of adaptation in evolution.
Researchers sequenced foxtail millet's genome to guide assembly of switchgrass genome, a perennial grass with multiple chromosome copies. The compact genome offers advantages for studying adaptation and developing genetic tools.
Researchers used next-generation sequencing to identify genetic causes of developmental delays and congenital abnormalities in seven out of twelve patients. The study found that the technology can provide a diagnosis about half of the time, motivating its use for patients with unknown genetic conditions.
Researchers have announced GenomeSpace, a software environment that brings together a wide range of genomic analysis tools and data sources. The platform enables seamless transitions between tools, allowing biologists to carry out projects from start to finish without manual conversions or programming skills.
Scientists sequenced the Tasmanian tiger genome, revealing extremely low genetic variability due to geographical isolation. This limited genetic makeup makes the species highly susceptible to diseases and extinction.
Researchers identified 147 genetic regions in sticklebacks that enable adaptation to marine and freshwater environments. Regulatory changes predominate, with most differences occurring in non-coding regions of the genome.
A new study by UCLA researchers has discovered a single instance of two independent mutations disrupting the SCN2A gene in affected siblings, confirming its importance. The study found multiple variations between unaffected and affected groups, making promising new candidates for autism susceptibility genes.
Researchers identified specific genomic changes that enable fish populations to adapt to new environments, revealing the importance of regulatory changes. The study also found that large DNA inversions can lead to the formation of separate species.
The study reveals that changes to both genes and DNA stretches controlling gene activity have driven sticklebacks' adaptation to fresh water. Reused genetic regions, including armor genes and those involved in metabolism and developmental signaling, helped remodel fish into forms better suited to freshwater environments.
A team of researchers has developed a new tool to identify conserved motifs in the genomes of trypanosomatids, a group of parasites that include the causing agents of leishmaniasis and Chagas disease. The tool, named LeischCICS, uses bioinformatics tools to pinpoint potentially functional and regulatory sequences.
Biobank researchers emphasize the need for defined systems to handle incidental findings and individual research results, aiming to ensure patient safety with genomic technologies
A group of specialists explored options for searching and reporting incidental genetic findings in clinical genome sequencing. The study found that while there was no perfect agreement among experts, the majority agreed that many incidental findings should be reported to clinicians. Specialists also differed on whether to disclose cert...
Researchers used whole genome sequencing to reveal that Chlamydia strains can swap DNA, making it harder to detect new strains and track re-infections. This knowledge is crucial for improving Chlamydia testing and implementing health policies to combat the spread of this common STI.
A new web-based program called Spliceman predicts whether genetic mutations will disrupt mRNA splicing, a process crucial for gene expression. The software uses research to show that many disease-causing mutations occur due to faulty splicing instructions.
A new study in mBio reveals that microbes thriving on hot fluid methane and sulfur are replaced by those feeding on solid iron and sulfur when deep-sea vents go dormant. Researchers also explore genomic sequencing data to aid rapid detection of hospital-acquired infections caused by enterococci bacteria.
Researchers at Stanford University School of Medicine discovered that common baker's yeast has engaged in promiscuous mating in fermentation vats, leading to a genetic mash-up. This unexpected behavior affects the flavor of wine and makes tracing lineage difficult.
A team led by Rutgers University professor Debashish Bhattacharya has sequenced the genome of Cyanophora paradoxa, a one-celled alga that shed light on the evolution of photosynthesis. The study reveals that all plastids trace their origin to a single primary endosymbiosis, approximately 1.6 billion years ago.
Researchers at the University of Washington have advanced a technique called metagenomics, allowing them to single out a marine microorganism and map its genome even though it comprised only 7 percent of a water sample. The resulting genome offers hints that Euryarchaeota might serve as a cleanup crew after diatoms bloom and die.
Researchers at UCSF are sequencing the DNA of 4,000 people with various forms of epilepsy in a bid to identify the genetic causes of the disease. The study, funded by a $25-million grant, will also explore ways to treat people with epilepsy and uncover new patterns of genetics.
Researchers at UT-ORNL discovered that aquatic bacteria made the transition to land approximately 400 million years ago, rather than 2 billion years earlier. This finding has significant implications for bioenergy research, particularly in the development of cellulolytic enzymes for efficient plant growth and bioethanol production.
Whole genome sequencing technology has arrived, uncovering both useful and unwelcome medical results, including information on high-risk diseases like dementia. Regulation is crucial to ensure safe use, with a nuanced approach that balances paternalism with protection from potential harm.
The monarch butterfly's genome has been fully sequenced, offering insights into its long-distance migration. The study reveals genes responsible for vision, circadian clocks, and juvenile hormone synthesis, essential for extended lifespan and navigation.
Researchers at UMass Chan Medical School have sequenced the monarch butterfly genome, revealing an estimated 16,866 protein-coding genes involved in its seasonal migration. The study provides new insights into the genetic and regulatory elements underlying this remarkable journey.
Researchers are utilizing genomic data to create novel pest-control strategies, reducing reliance on chemical pesticides and environmental pollution. The study focuses on the biology of the two-spotted spider mite, exploring its ability to develop pesticide resistance and potential applications in crop protection.
The genome of Medicago, a legume model, reveals insights into the evolution of nitrogen-fixing symbioses that can be partly attributed to a 58 million-year-old genetic event. The study found additional genes specialized for root nodulation and interaction with symbiotic bacteria.
The US Department of Energy Joint Genome Project has selected two projects from the Danforth Plant Science Center to develop genetic resources for bioenergy grasses. The projects will focus on improving biomass production and stress tolerance in crops such as switchgrass, sorghum, and Miscanthus.
A Tel Aviv University researcher warns that live virus polio vaccine evolution can continue to threaten global eradication efforts. The expert recommends maintaining herd immunity, environmental surveillance, and switching to inactivated vaccines.
The US Forest Service's Northern Research Station is part of an international team sequencing 1,000 fungal genomes as part of the DOE's Community Sequencing Program. This project aims to create an encyclopedia of all fungi, which will help researchers understand their roles in ecosystems and develop new products.
The ICRISAT-led team has completed the genome sequence of pigeonpea, a legume crop grown by millions of poor farmers worldwide. With this breakthrough, scientists can now identify genes for drought tolerance and improve crop productivity, tackling pests and disease constraints in production.
The DOE JGI's 2012 Community Sequencing Program allocates over 30 trillion bases for researchers to study plant-microbe interactions and environmental genomics. This includes projects on rhizosphere microbial communities, Casuarina trees, and microbial communities in extreme environments.
A consortium led by Einstein researcher Nir Barzilai aims to sequence the complete genomes of 100 healthy centenarians in 30 days. This effort, backed by a $10 million 'X Prize,' seeks to uncover genetic advantages behind exceptional longevity and develop personalized medicine strategies.
Researchers have identified five high-priority drug targets for the parasitic disease ascariasis, caused by the giant intestinal roundworm Ascaris suum. The discovery provides new insights into treating the condition, which affects millions of people in developing countries and causes chronic effects in young children.