Articles tagged with Genotoxic Stress
Researchers have developed a novel genome engineering method called prime assembly, which enables long DNA fragments to be stitched into precise target positions within living cells. This approach may allow for the development of universal gene therapies that can apply to many patients.
Researchers evaluated the safety profiles of ethylhexyl triazone (EHT) and diethylhexyl butamido triazone (HEB) using integrated genotoxicity and phototoxicity assessments. The studies found no significant increases in mutagenic or chromosomal damage, and only minor micronucleus increases at high concentrations.
Researchers found no significant genotoxic effects of triazine UV filters in bacterial reverse mutation, chromosomal aberration, and micronucleus assays. Phototoxicity assessments also confirmed safety using 3T3 neutral red uptake and guinea pig models. The results support the use of these filters in topical applications.
A new study in Addiction Biology suggests that cannabis use can cause chromosomal damage, leading to increased cancer risk and birth defects. This genotoxicity may be transmitted to offspring via damaged sperm or eggs.
A recent study identified three key DNA repair mechanisms that protect the genome from formaldehyde-induced damage during development, adulthood, and ageing. The researchers found that N-acetyl-L-cysteine can reverse most of the toxicity in animal models and human cells with altered DNA repair systems.
Experts propose a series of scientific principles and experimental approaches to assess potential carcinogenicity of gene therapies. Data transparency is crucial, with publicly accessible data from viral integrations site studies and clinical settings.
A new Australian study found a strong link between low magnesium levels and high homocysteine, leading to increased DNA damage and susceptibility to Alzheimer's, Parkinson's, gastrointestinal diseases, cancers, and diabetes. Wholegrains, dark leafy vegetables, nuts, beans, and dark chocolate are rich in magnesium.
Researchers found higher concentrations of genotoxic carbonyls in some packaged treats, exceeding the recommended threshold for potential health risks. The study suggests that these compounds likely formed during the baking process and highlight the importance of monitoring flavorings in food.
A new study by North Carolina State University researchers finds that sucralose-6-acetate, a chemical formed when we digest sucralose, is genotoxic and breaks up DNA. The chemical is also present in trace amounts in the sweetener itself, posing potential health risks.
Researchers at Tokyo Medical and Dental University identify a novel focal adhesion remodeling process that strengthens cell-matrix adhesion in response to genotoxic stress. This mechanism involves the replacement of FAK with FRNK, leading to increased firm cell attachment.
A new study finds that andiroba oil accelerates wound healing, increases contraction rates, and promotes local re-epithelialization. The oil also presents a similar potential to low-level laser therapy (LLLT) in treating oral mucositis, a common side effect of chemotherapy.
A recent study published in Applied In Vitro Toxicology found that tobacco-free nicotine pouches exhibit reduced levels of toxicants and biological activity compared to combustible cigarette smoke. The products, manufactured by Imperial Brands, showed substantially reduced genotoxicity and cytotoxicity in three toxicological assays.
A new study published in DNA Repair shows that hydroxychloroquine exhibits DNA-damaging and mutagenic effects at a clinically achievable dose. The findings suggest the possibility of additional side effects, particularly in patient populations, and emphasize the need for careful risk assessment and informed consent.
Researchers discovered a cell-to-cell communication network that instructs tumor cells in tissues to regrow after genotoxic therapy. The study found that elevated p53 levels and release of interleukin-6 signal cells to activate growth signals, leading to tumor regrowth.
Researchers developed a simple and inexpensive technique to assess genetic toxicity in bats, highlighting the need for monitoring wildlife health due to declining biodiversity. The study found higher levels of micronuclei frequency in bats roosting near agricultural lands.
A growing number of preclinical studies suggest that rAAV-mediated gene therapy may cause insertional mutagenesis and increase the risk of hepatocellular carcinoma. Research emphasizes the need for careful reconsideration of potential genotoxicity risks in human clinical applications.
A recent study reveals that disinfection by-products (DBPs) in water are toxic and genotoxic, causing DNA damage. DBPs from iodine-containing compounds and nitrogen-containing compounds are more toxic than regulated ones.
Researchers have identified a common intermediate to activate ATR in response to various forms of genotoxic stress, including UV-induced cross-links and oxidative damage. This discovery highlights the importance of proper DNA detection and response to prevent genome instability and cancer.
A recent study found that pregnant smokers have a higher rate of chromosomal abnormalities in their amniotic cells compared to non-smokers. The research, published in JAMA Network, also identified specific chromosomal regions affected by tobacco exposure.