Articles tagged with Pleiotropy
Researchers have defined what a premature aging disease is and developed tools to diagnose progeria patients, allowing them to identify new syndromes. The study also identified correlations between progeroid syndromes and other conditions, providing a significant step forward in understanding premature aging.
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
Researchers identified high expression of glypican-1 in primary solid tumors, correlating with poor prognosis in various cancer types. Suppression of GPC1 attenuated cancer cell proliferation, suggesting its potential as a novel diagnostic tool and target for therapy.
Researchers created a network of interacting proteins to understand the function of genes and link specific biological processes to diseases. They identified groups of proteins interacting with genes linked to over 1,000 human traits, providing insights into new targets for drug discovery and potential repurposing opportunities.
Researchers from the Chinese Academy of Sciences have developed a method to overcome the tradeoff between rice yield component traits, including panicle number and size. By modifying the cis-regulatory region of the Ideal Plant Architecture 1 gene, they increased grain yield by 15.9% while maintaining tiller number.
Researchers uncover the pleiotropic functions of hnRNPK in regulating skeletal muscle cell differentiation, including inhibition of myoblast differentiation and suppression of genes involved in endoplasmic reticulum stress. The study suggests that targeting hnRNPK could be a potential therapeutic strategy for treating human disorders.
A combination therapy with PCSK9-inhibitors and lipoprotein-apheresis (LA) is proposed as a potential treatment for Homozygous Familial Hypercholesterolaemic (HoFH) patients. LA has potent therapeutic effects on inflammation and related mediators.
A common genetics study method called Mendelian randomization has been found to be distorted by a phenomenon called horizontal pleiotropy in nearly 50% of its studies. This distortion can lead to false positive causal relationships and affects the accuracy of drug discovery and disease management.
Research reveals antagonistic pleiotropy is very common in yeast, where genes can harm or benefit depending on environment. The study's findings have broad implications for human genetics and disease treatment.
A recent study by Duke University researchers has identified pleiotrophin as a protein that can promote the growth of blood stem cells. The finding may lead to new treatments for patients undergoing chemotherapy or bone marrow transplants, enabling them to quickly regenerate healthy blood levels.
A new analysis by Jianzhi Zhang and coworkers reveals flaws in models predicting the cost of complexity and finds that moderate complexity best enables organisms to adapt. The study challenged assumptions underlying traditional mathematical models, suggesting that a moderate amount of complexity is beneficial for adaptation.
Scientists at Duke University Medical Center have discovered a new growth factor that stimulates the expansion and regeneration of hematopoietic stem cells. The growth factor, pleiotrophin, has been shown to increase the numbers of human cord blood stem cells in culture capable of engraftment in immune-deficient mice.
Researchers found that pleiotrophin expression activates stromal cells to remodel the tumor microenvironment, inducing tumor angiogenesis and aggressive breast cancers. PTN secretion from human breast cancer cells may be sufficient to shift progression to a more aggressive form of breast cancer.