Articles tagged with Telomeres
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Researchers at the University of Michigan Comprehensive Cancer Center found that dysfunctional telomeres can trigger cancer mutations, even in the absence of shortening. The study used mice prone to develop cancer and found that deprotection alone is enough to trigger cancer.
A new study reinforces the importance of healthy living by finding that women with a healthy weight and lower perceived stress may have slower telomere shortening, potentially reducing breast cancer risk. The study suggests that duration of obesity and levels of perceived stress can impact telomere length, accelerating aging.
Researchers at UCLA discovered a chemical called TAT2 that can prevent or slow telomere shortening in immune cells, potentially making it a key weapon in the fight against HIV. The study found that TAT2 treatment prolonged the ability of killer T-cells to divide and inhibited HIV production.
A pilot study found that comprehensive lifestyle changes increased telomerase levels by 29% and improved telomere maintenance capacity in immune system cells. This suggests a potential link between healthy habits and slower cellular aging.
Researchers have discovered that a protein called Est3 recognizes where to report to work through a specific 3-dimensional shape displayed on its surface. This finding has propelled forward studies of Est3's role in elongating chromosome ends and saving cells from premature growth arrest.
A UCLA study identifies the mechanism behind the mind-body connection, finding that cortisol suppresses telomerase levels in immune cells. This leads to shorter telomeres and increased susceptibility to illness.
Researchers have found that double-strand DNA breaks occur more frequently in specific regions near telomeres and centromeres, increasing the likelihood of chromosome gene swapping. This discovery may lead to a better understanding of developmental chromosome abnormalities and birth defects.
A recent genetic study found that higher vitamin D levels are linked to improved genetic measures of lifelong aging and chronic stress. Vitamin D may also play a role in reducing the risk of heart disease and certain cancers.
Researchers found that younger patients with colon cancer have shorter telomeres than expected, suggesting a possible biomarker for early detection. The study also found gender differences in the incidence of colon cancer among young people.
Researchers discovered that telomeric RNA is transcribed from DNA on the telomere, challenging previous theories. This finding may uncover new targets for attacking telomere function in cancer cells.
Researchers discovered critical telomere length and chromosomal fusion, offering hope for an early warning test. Telomeres play a crucial role in cell division, and their dysfunction can lead to cancer formation.
Researchers found that chronic caregivers develop genetic and molecular changes that effectively age their bodies by four to eight years, resulting in a shortened lifespan. Caregivers also exhibit severe depression symptoms and weakened immune systems, contributing to the negative effects of chronic stress.
Researchers discover telomere shortening as a predictor of coronary heart disease in pre-diabetics and Type 2 diabetics. Early indication of telomeres starting to shorten may indicate the onset of diabetes and ultimately predict CAD.
Aging cells with dysfunctional telomeres can promote tumorigenesis, but p53-mediated senescence may suppress spontaneous cancer development. Activating the senescence pathway is sufficient to prevent tumorigenesis in mutant mice with dysfunctional telomeres.
Scientists at Johns Hopkins have identified genetic culprits triggering a fatal lung disease. Mutations in telomerase genes were found in 8% of patients with inherited idiopathic pulmonary fibrosis (IPF), leading to short telomeres and cell death.
Researchers at the Salk Institute have discovered a novel RPA-like complex that specifically targets the short single-stranded DNA tail end of yeast chromosomes. This complex helps maintain telomere integrity and prevent premature senescence or cancer development.
Scientists have linked telomere loss to both cancer and aging by visualizing chromosomes of cells from patients with Werner Syndrome. Rebuilding structures called telomeres significantly blocks genetic damage seen in cells of patients with Werner Syndrome.
A study found that middle-aged men with shorter telomeres were more likely to develop coronary heart disease. Statin treatment reduced the risk of heart disease in these individuals, suggesting a potential biomarker for personalized medicine.
Researchers at the Salk Institute reveal how cellular repair proteins recruit a second machinery to create a protective structure at chromosome ends, maintaining chromosomal stability. Telomeres exist to prevent damage and ensure cell division integrity.
A new study reveals a molecular mechanism underlying bone marrow failure in X-linked human disease, dyskeratosis congenita. Telomere maintenance defects are caused by reduced telomerase RNA, contradicting previous hypotheses about ribosome biogenesis.
A population-based study found that people with hand osteoarthritis had significantly shorter white cell telomere lengths compared to those without the disease. Telomere length was also associated with the severity of osteoarthritis, suggesting a link between biological ageing and degenerative inflammatory bone disease.
A recent study published in Cell reveals that mice have two proteins working together to protect chromosome ends, suggesting rapid evolution. The findings identify the distinct functions of POT1a and POT1b proteins, which could impact human telomere biology.
Researchers found that Rad9 plays a crucial role in repairing DNA damage and protecting chromosome ends. Inactivating Rad9 in tumor cells could enhance the power of radiation treatments by making it easier for radiation to inflict fatal damage on cancerous genetic material.
Researchers at Howard Hughes Medical Institute have identified a crucial protein domain in telomerase, an enzyme that contributes to cancer growth. The discovery provides new insights into the mechanism of cancer development and may lead to the development of targeted therapies.
Researchers believe that understanding the structure of DNA end caps, called telomeres, can help develop new cancer treatments. They found that the rate of shortening is influenced by the length of the overhang and hope to manipulate it for therapeutic purposes.
Scientists found that RNAi machinery plays a role in maintaining telomere length by regulating retrotransposon transposition. Mutations in key components of the system increase telomere element transposition.
Researchers found that mice with half the normal amount of telomerase can't maintain their stem cells' chromosome ends, leading to early demise. The study suggests that inherited disease may be caused by inherited telomere length, not the status of the telomerase gene.
Researchers found that chromosome ends elicit a limited DNA damage response when exposed, but not during normal replication. This discovery highlights the importance of telomeres in preserving genome integrity and preventing cancer development.
Researchers at Salk Institute demonstrate that telomere length does not dictate aging and lifespan, contradicting previous assumptions. They found that non-dividing cells, such as nerve cells, play a crucial role in aging, and targeting telomeres alone is insufficient to prevent accelerated aging.
Researchers extended the lifespan of blood vessel cells from elderly donors, enabling successful culture of engineered blood vessels. This breakthrough advances tissue engineering towards treating vascular disease.
Researchers found that obesity and smoking accelerate aging by reducing telomere length, which decreases steadily with age. Smokers experience an average of 4.6 years of accelerated aging, while obese individuals see an additional 8.8 years of age loss compared to lean women.
Researchers have identified a novel protein, MKRN1, that regulates telomerase activity and maintains cellular telomere lengths. Increasing MKRN1 levels in cells promotes the degradation of telomerase enzyme hTERT, leading to decreased telomerase activity and shorter telomeres.
Researchers Elizabeth Blackburn and Janet Rowley have been awarded the Landon-AACR Prizes for Basic and Translational Cancer Research. Their work has led to a deeper understanding of telomeres, enzymes that play a role in cancer growth.
Researchers found that inhibiting tankyrase 1 enhances telomere shortening and accelerates cancer cell death when combined with telomerase inhibitors. This strategy may reduce drug treatment time and minimize acquired resistance.
Chronic stress, even in healthy women, can lead to shorter telomeres and increased oxidative stress, accelerating cellular aging. The study also found that caregivers of chronically ill children experienced more stress and shorter telomeres than controls.
Researchers at UCLA have discovered a protein that can keep HIV-fighting cells youthful and active, dividing endlessly and preventing telomeres from shortening. This breakthrough could lead to the development of new treatments for AIDS, cancer, and other diseases.
María Blasco, a Spanish scientist, was awarded the EMBO Gold Medal for her groundbreaking research on telomeres and cancer. Her work has led to significant discoveries on telomerase RNA component, interplay with DNA repair and cell cycle, and chromatin epigenetics.
Research suggests that telomere dysfunction may be a key component in the development of many epithelial cancers. Telomere length abnormalities were observed in 97% of precancerous lesions, with abnormally short telomeres found in 88%.
Researchers at Imperial College London have discovered a link between chromosome 'caps' and the prediction of rare bone marrow diseases. The study found that shorter telomeres in chromosomes can indicate an increased risk of disease severity and early onset, providing a potential new mechanism for understanding disease anticipation.
Researchers have found that the inheritance of a parental X chromosome is strongly correlated with similar telomere length between parents and children. This suggests that the process of ageing might be an X-linked trait.
Telomeres protect chromosome ends, but when they're short, enzymes called exonucleases nibble away, causing gene loss. This discovery challenges the long-held assumption that chromosome fusion is the primary mechanism behind genomic instability.
Researchers found that patients with smoking-related cancers had shorter telomeres than those without cancer, and that short telomeres were associated with a greater cancer risk. Smoking status significantly influenced the effect of short telomeres on cancer risk.
A new study suggests that telomere dysfunction may play a causal role in human intraepithelial neoplasia (IEN) found in precancers. Short telomeres were found in the majority of precursor lesions across various types of cancers, indicating potential early molecular mechanisms underlying cancer development.
A study of 143 individuals over 60 years old found that those with longer telomeres lived four to five years longer than those with shorter ones. People with shorter telomeres had significantly higher mortality rates from heart disease and infectious diseases.
A recent study found that a rare genetic disease is caused by the shortening of telomeres, leading to premature aging symptoms like hair loss and slow wound healing. The researchers discovered that telomere dysfunction disrupts chromosome function, resulting in cellular chaos and organ failure.
Researchers discovered that telomere shortening is a common feature in high-grade prostatic intraepithelial neoplasia (HGPIN), the precursor to prostate cancer. Shortened telomeres were found in 93% of HGPIN lesions, suggesting their role as potential biomarkers for early detection and prevention.
Cancer cells have evolved to continually activate telomerase, keeping telomeres intact and enabling rapid division. Researchers at UC Berkeley are now searching for proteins and signals involved in telomerase shuttling around the cell nucleus to develop new therapeutic strategies.
Researchers at Princeton University discovered a new activator protein Est1 that plays a key role in telomere capping. This finding contradicts existing theories and may offer a new target for cancer treatment. Est1 works by sweeping in with precise timing to activate the telomere-building process.
Aging cells retire when their telomeres become too short to function, according to a new Rockefeller University study. The researchers found that protein TRF2 helps critically short telomeres function better, allowing old cells to live longer.
The study found that critically short telomeres signal cells to arrest or die, rather than average length. Turning on telomerase can restore function without significantly increasing overall telomere length, offering new insights into cancer treatment options.
Biologists discovered that chromosomes fuse together due to telomere replication and distinct protein functions. The study found two types of telomeres and the roles of proteins in normal cell function.
Research suggests that telomere shortening is associated with atherosclerosis, potentially linking it to premature ageing. Patients with severe coronary artery disease showed shorter telomeres compared to healthy controls, indicating accelerated cellular ageing.
Researchers found that the Ku protein plays a key role in mediating mammalian telomere capping, preventing chromosomal fusion. The discovery sheds light on cellular growth control and aberrations leading to cancer. Mouse cells lacking Ku develop chromosome fusions.
A new study finds that the 'cell crisis' theory explains why certain cancers become more common with age. Genetic mutations cause cells to divide uncontrollably after telomeres shorten, leading to cancer development.
A Princeton scientist has discovered a naturally occurring protein that inhibits telomerase, which replicates and lengthens chromosome ends. The protein, Pif1p, acts directly on the chromosome ends to keep the lengthening process in check.
Researchers found that cow clones exhibit youthful telomeres, indicating a potential for increased lifespan, whereas normal cells age prematurely. This breakthrough erases doubts about cloning's utility by showing it doesn't rob cells of their normal lifespan.
Fox Chase Cancer Center molecular biologist Dominique Broccoli has been awarded a $100,000 V Foundation Scholarship to investigate the role of telomeres in cellular aging. Her research aims to understand how telomere length limits cell growth and renewal, potentially leading to new approaches for limiting tumor growth.
Researchers at Johns Hopkins describe fundamental shape of telomerase molecule in mammals and other vertebrates, identifying four common areas highly involved with the enzyme's working. This new information may prompt approaches to inhibit the enzyme, which is active in cancer cells and contributes to their continuous cell division.
Scientists find that telomerase enzyme contributes to chromosome stability beyond telomere length, offering a new target for extending cell life span and combating cancer. The discovery suggests a novel approach to manipulating the enzyme for therapeutic purposes.
Mice lacking a gene for making telomeres displayed symptoms of aging, including graying hair and increased tumor incidence. However, the study reveals that telomere loss is not solely responsible for aging, suggesting other mechanisms at play.