Hidden infection shortens life
Researchers discovered that mild malaria infections in birds accelerated telomere shortening, leading to premature death. Infected individuals produced fewer offspring despite no visible symptoms.
Telomeres
Articles tagged with Telomeres
Telomere extension turns back aging clock in cultured human cells, Stanford study finds
A new procedure can increase the length of human telomeres by up to 1,000 nucleotides, allowing researchers to generate large numbers of cells for study or drug development. This breakthrough may lead to new ways to treat diseases caused by shortened telomeres.
Study identifies new targeted treatment strategy for some aggressive cancers
Researchers have identified a new potential treatment targeting the alternative lengthening of telomeres (ALT) pathway in cancer cells. Treatment with a small molecule inhibitor suppressed growth and survival of ALT-positive tumor cells.
Human exposure to metal cadmium may accelerate cellular aging
A new study finds that higher human exposure to cadmium can lead to significantly shorter telomeres, associated with cardiovascular disease and other diseases of old age. Cadmium exposure has been linked to premature aging of cells, kidney disease, and other health problems.
SourceGeorge Washington University Milken Institute School of Public Health·JournalAmerican Journal of Epidemiology·DateDec 11, 2014
Herpes virus rearranges telomeres to improve viral replication
Researchers found that herpes simplex virus 1 rearranges telomeres to improve viral replication, suggesting a molecular mechanism for viral efficiency. The study also highlights the role of telomere proteins in protecting against viral infection.
NSF funds Kent State study of human chromosome
Researchers will use techniques like molecular scalpels and laser tweezers to study G-quadruplex structures in human telomeres. The goal is to understand how these units are structured and distributed, which could lead to new anti-cancer drugs.
Mediterranean diet associated with longer telomeres
Researchers found that women who follow the Mediterranean diet have longer telomeres, which are repetitive DNA sequences at the ends of chromosomes. The study, published in The BMJ, suggests that adherence to this diet may help buffer telomere shortening and promote health and longevity.
Mediterranean diet linked to longer life
A Mediterranean diet high in fruits, vegetables, nuts, and olive oil has been associated with longer telomeres, a biomarker of slower aging. The study found that adherence to the diet was significantly linked to longer telomeres, corresponding to 1.5 years of telomere ageing.
Scientists uncover mechanism that controls the fitness of cells, impacting aging and disease
Researchers at UT Southwestern Medical Center found a novel looping mechanism involving DNA end caps that determines gene regulation, contributing to aging and disease. The study reveals how telomere length affects gene expression patterns, potentially influencing the onset of disease and optimizing fitness with age.
Research resolves contradiction over protein's role at telomeres
Research at Rockefeller University resolves the long-standing debate on Rap1's role at telomeres, revealing that human Rap1 plays a minor role in protecting telomeres. The study contradicts previous findings and sheds light on the protein's potential unrelated function.
Study shows clear new evidence for mind-body connection
A study has demonstrated a clear new evidence for mind-body connection in breast cancer survivors, showing that mindfulness meditation and support groups can influence telomere length. This suggests potential health benefits beyond the initial three-month period studied.
Sugared soda consumption, cell aging associated in new study
A new study by UCSF researchers found a significant association between sugared soda consumption and cell aging, as measured by telomere shortening in immune cells. The findings suggest that regular consumption of sugar-sweetened sodas may influence disease development through accelerated cellular aging.
SourceUniversity of California - San Francisco·JournalAmerican Journal of Public Health·DateOct 16, 2014
Gene mutation discovered in blood disorder
A gene mutation in ACD has been linked to aplastic anemia by disrupting telomere function and protecting cells from DNA damage. Researchers hope this discovery will lead to new treatments for the disease.
Melanoma risk found to have genetic determinant
A recent study published in the Journal of the National Cancer Institute has established a link between longer telomeres and increased melanoma risk. The research team identified seven genetic variations associated with telomere length and found that those with the longest telomeres are at a 30% increased risk of developing melanoma.
SourceThe Geisel School of Medicine at Dartmouth·JournalJNCI Journal of the National Cancer Institute·DateSep 18, 2014
Chromosome buffers hold key to better melanoma understanding
A new study from the University of Leeds has uncovered a genetic risk factor for melanoma, with longer telomeres associated with a higher risk. The research found that individuals with shorter telomeres are at a 30% increased risk of developing melanoma.
Curb sitting time to protect aging DNA and possibly extend lifespan
Reducing sedentary activity appears to lengthen telomeres, which cap chromosomes in cells. A reduction in sitting hours was significantly associated with telomere lengthening in blood cells.
CNIO experts discover the genomic origin of telomere protectors
Researchers have identified the specific chromosomes where telomere-protecting RNAs (TERRAs) originate from. The study reveals that TERRAs exclusively come from chromosome 18 and to a lesser extent from chromosome 9. This discovery will help design tools to study their role in telomere biology and disease.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalNature Communications·DateSep 3, 2014
Healthy lifestyle may buffer against stress-related cell aging, study says
A new UC San Francisco study shows that maintaining healthy behaviors can reduce telomere shortening, a marker of cellular aging. The researchers found that post-menopausal women who exercised, slept well and ate well had less telomere shortening than those with poor lifestyles.
Longer telomeres linked to risk of brain cancer
Research by UCSF scientists reveals two gene variants associated with longer telomeres also increase the risk of developing gliomas. Despite being carried by a majority of people, these genetic variants may promote overall health due to their protective effect on cells from aging.
Arizona State University scientists take steps to unlock the secrets to the fountain of youth
Researchers at Arizona State University have published an atomic-level look at the telomerase enzyme that may hold secrets to the fountain of youth. Telomeres protect genetic data and are linked to aging and cancer.
A protein required for integrity of induced pluripotent stem cells
A study reveals that SIRT1 is required for correct and safe cell reprogramming, ensuring healthy functioning of induced pluripotent stem cells. The protein helps maintain telomeres and prevents chromosome aberrations and DNA damage.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalStem Cell Reports·DateApr 21, 2014
Stressful environments genetically affect African-American boys
A study of 40 black boys aged 9 found that those from disadvantaged environments had shorter telomeres, a biomarker for aging, than their advantaged peers. Boys with genetic sensitivities to stress also showed accelerated telomere shortening.
SourcePrinceton School of Public and International Affairs·JournalProceedings of the National Academy of Sciences·DateApr 9, 2014
Loneliness impacts DNA repair
A study by Denise Aydinonat and Dustin Penn found that solitary African grey parrots have shorter telomeres than those housed with mates, regardless of age. This suggests that both extreme social conditions can accelerate cellular aging and may serve as a biomarker for chronic stress.
Combo of overweight, high sodium intake speeds cell aging in teens
A recent study found that high sodium intake in teenagers can lead to faster cell aging, with overweight and obese teens showing the most significant effects. Researchers analyzed data from 766 people aged 14-18 and discovered that those who consumed more salt had shorter telomeres, which protect chromosomes from damage.
Cells do not repair damage to DNA during mitosis because telomeres could fuse together
Research reveals cells shut down DNA repair processes during cell division to prevent chromosome fusions, a process that could lead to cancer. Telomeres fuse together when DNA repair is re-activated, causing defective chromosomes.
Coffee or beer? The choice could affect your genome
A Tel Aviv University study found that moderate caffeine consumption shortens telomeres, a key indicator of aging and cancer risk, while moderate alcohol consumption lengthens them. The research suggests that environmental factors can impact telomere length, which could inform the prevention and treatment of human diseases.
Long-term unemployment may accelerate aging in men
A new study has found that long-term unemployment may accelerate aging in men by shortening their telomeres, which protect genetic code from degradation. This association was found in a study of over 5,600 Finnish men born in 1966.
Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find
Carnegie Mellon researchers found an association between childhood socioeconomic status and adult telomere length, which affects cold susceptibility. Participants with parents of lower socioeconomic status had shorter telomeres and were more likely to develop the common cold.
Scientists discover new role for cell dark matter in genome integrity
Researchers at the University of Montreal have discovered a new role for non-coding RNA molecule TERRA in maintaining telomere length and protecting against cancer. By tracking telomerase molecules with TERRA, scientists found that this 'dark matter' plays a crucial role in regulating telomerase activity.
In prostate cancer prognosis, telomere length may matter
Researchers found that men with variable telomere length in cancer cells and shorter telomeres in stromal cells were more likely to develop metastatic disease and die sooner from their prostate cancer. This combination could be a marker for prostate cancer prognosis.
New research on inherited herpesvirus may have implications for transplantation
A recent study found that inherited human herpesvirus 6 in telomeres can lead to unstable viral genomes and increased risk of reactivation. This research has significant implications for transplant patients who are often immunosuppressed, highlighting the need for screening donors for this inherited form of HHV-6.
Study reveals first ever data indicating that positive lifestyle changes may reverse aging on a cellular level
A pilot study found that comprehensive lifestyle changes increased telomere length by an average of 10%, while control group telomeres decreased by 3%. The study suggests that such lifestyle changes may significantly reduce the risk of diseases and premature mortality.
Lifestyle changes may lengthen telomeres, a measure of cell aging
A pilot study shows that comprehensive lifestyle changes can increase telomere length by up to 10%, potentially reducing the risk of chronic diseases. The study, conducted over five years, involved 35 men with prostate cancer who followed a plant-based diet and engaged in moderate exercise, stress reduction, and social support.
Newly discovered weakness in cancer cells make them more susceptible to chemotherapy
Scientists discovered a new weakness in cancer cells that makes them more susceptible to chemotherapy by targeting the HDAC5 protein. Cancer cells with longer telomeres tend to be resistant to therapies, while shorter telomeres make them more vulnerable to treatment.
SourceFederation of American Societies for Experimental Biology·JournalThe FASEB Journal·DateAug 29, 2013
Statins may slow human aging by protecting against telomere shortening: A feature of senescent cells
Researchers found that statins can activate telomerase, slowing down senescent cells and potentially leading to healthy lifespan extension. The study suggests that statins could be used as an anti-aging therapy, mitigating age-related diseases like heart disease and cancer.
SourceFederation of American Societies for Experimental Biology·JournalThe FASEB Journal·DateAug 29, 2013
Critical pathway in cell cycle may lead to cancer development
A team of scientists at the Salk Institute for Biological Studies has identified a critical pathway in cell cycle control that, when disrupted, leads to cancer cell proliferation. Shortened telomeres, which occur with cellular aging, activate a DNA damage response that arrests cell growth.
New mouse model reveals a mystery of Duchenne muscular dystrophy, Stanford scientists say
Researchers at Stanford University School of Medicine developed a mouse model that accurately mimics the course of Duchenne muscular dystrophy in humans. The study demonstrates a molecular basis for the cardiac defect and provides evidence for a potential treatment to prolong heart function.
Telomere length influences cancer cell differentiation
Researchers discovered that forced telomere elongation promotes cancer cell differentiation, suppressing genes involved in tumor malignancy. Telomeres may modulate cell behavior by controlling gene expression, potentially leading to new cancer treatments.
CNIO researchers discover a new gene involved in obesity
Researchers at the Spanish National Cancer Research Centre (CNIO) have discovered a link between telomere protection and obesity, with the RAP1 gene playing a key role. The study found that mice lacking RAP1 gained weight and developed metabolic syndrome, highlighting a new potential mechanism in human obesity.
Institute funded to evaluate leukocyte telomere length, personality traits, & health outcomes
A study funded by the National Institute of Aging investigates the link between personality traits and telomere length, a measure of cellular aging. The research examines whether personality traits influence telomere length through healthy lifestyle and traumatic life events.
CNIO researchers identify a new gene that is essential for nuclear reprogramming
CNIO researchers discovered a new gene called TRF1 that plays a vital role in nuclear reprogramming. This discovery is crucial for understanding the mechanisms of cell differentiation and regeneration, and may lead to breakthroughs in regenerative medicine.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalNature Communications·DateJun 5, 2013
Depression linked to telomere enzyme, aging, chronic disease
Researchers found that individuals with untreated major depression have increased telomerase activity in immune cells, which may help fight back against disease progression. The study also suggests a potential protective role for telomerase in the hippocampus and reducing depressive symptoms with treatment.
How healthy are you for your age?
Researchers have developed a method to measure human genetic material's health in relation to age, using telomere length as an indicator. This technique could lead to the development of a 'genetic thermometer' to assess patient health.
SourceThe Journal of Visualized Experiments·JournalJournal of Visualized Experiments·DateMay 22, 2013
UTSW researchers identify new potential target for cancer therapy
Researchers at UT Southwestern Medical Center have found that alternative splicing may be a new approach for inhibiting telomerase, an enzyme driving uncontrolled division of cancer cells. By shifting the splicing, they demonstrated a potential method for turning off telomerase activity, which could lead to new cancer therapies.
Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
Researchers from UCLA and UC Berkeley have solved the puzzle of the telomerase enzyme complex's three-dimensional structure, revealing its role in cancer and aging. The discovery opens up new approaches to fighting disease, particularly cancer, by allowing for targeted drug development.
Researchers successfully map fountain of youth
Researchers successfully mapped telomerase, an enzyme that contributes to cellular rejuvenation and has a role in cancer development. The study's findings have implications for understanding the genetic correlation between cancer and telomere length.
Link between faster 'biological' aging and risk of developing age-related diseases
A study led by the University of Leicester found a link between faster telomere shortening and increased risk of age-related diseases, including coronary artery disease and certain cancers. The research suggests that biological aging plays a key role in causing these diseases.
Fewer children mean longer life?
Research from the University of Gothenburg found that birds with few offspring and delayed reproduction have better-protected telomeres, leading to longer lives. This study sheds light on the correlation between reproduction and aging in animals, particularly species like barnacle geese and elephants.
Spanish researchers link cancer to failures in chromosome protection for the first time
Researchers have discovered a new mechanism contributing to tumour development, including Chronic Lymphocytic Leukaemia, by identifying mutations in the POT1 gene that affect chromosome protection. This is the first time an essential gene has appeared mutated in human cancer.
Intermountain study finds length of DNA strands can predict life expectancy
Researchers found longer telomeres correlate with longer lives and increased survival rates among patients with heart disease. The study analyzed DNA samples from over 3,500 heart attack and stroke patients, revealing a link between telomere length and life expectancy.
Association found between length of biological marker and development of respiratory infection
Researchers found that shorter telomere lengths in certain cells are associated with an increased risk of developing upper respiratory infections. The study, published in JAMA, suggests a link between telomere shortening and immune system dysfunction in younger, healthy populations.
CMU researchers identify biological marker that predicts susceptibility to the common cold
Researchers at Carnegie Mellon University identified a biological marker, telomere length, that predicts resistance to the common cold in young and midlife adults. Telomeres shorten as people age, but their length also becomes a predictor of disease susceptibility starting at around age 22.
Accelerated biological aging, seen in women with Alzheimer's risk factor, blocked by hormone therapy
A study found that healthy menopausal women with an Alzheimer's risk factor showed accelerated biological aging, but hormone therapy reversed this effect. The research used telomere length as a measure of biological aging and found that estrogen therapy protected against this aging process.
Scientists discover how chromosomes keep their loose ends loose
Researchers have discovered that TRF2 suppresses DNA damage response by blocking signaling pathways, preventing chromosomes from sticking together. This finding has implications for understanding cancer and the aging process, as telomere shortening can lead to chromosomal instability.
Caloric restriction has a protective effect on chromosomes
A study by CNIO researchers discovered that caloric restriction increases telomere length in adult mice, leading to a lower incidence of cancer and age-related illnesses. The study also found that mice on reduced diets lived up to 20% longer than those with normal diets.
Chromosome 'anchors' organize DNA during cell division
Researchers used advanced microscopy to track telomere movement in real-time throughout the cell cycle, finding they move to the outer edge of the nucleus after duplication. This reorganization may help maintain correct gene expression profiles and influence aging and cancer development.
Proteins that work at the ends of DNA could provide cancer insight
Researchers have discovered how two proteins regulate telomeres, the protective caps on chromosome ends. The POT-1/TTP-1 complex promotes telomerase activity, a key target for anti-cancer drugs.
It takes two to tangle: Wistar scientists further unravel telomere biology
Researchers defined the structure of Cdc13, a key telomere maintenance protein in yeast, revealing how its mutations can disrupt telomere function and potentially lead to cancer. The study's findings may pave the way for novel anticancer therapies by targeting the OB2 region of Cdc13.
University of East Anglia research shows telomere lengths predict life expectancy in the wild
Researchers at the University of East Anglia found that individuals with shorter telomeres have an increased risk of death, and that longer telomeres are associated with a longer lifespan. The study, published in Molecular Ecology, measured telomere lengths in a wild population of Seychelles Warblers over 20 years.
Wandering minds associated with aging cells
A UCSF study suggests an association between attentional state and length of telomeres, finding that those who report more mind wandering have shorter telomeres, while those who are more present in the moment have longer telomeres. Mindful meditation interventions may promote health by increasing activity of telomerase.
SourceUniversity of California - San Francisco·JournalClinical Psychological Science·DateNov 16, 2012