Articles tagged with Telomeres
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Researchers from Charité - Universitätsmedizin Berlin studied genetic factors behind different tumor subtypes and their prognoses. They found that telomere maintenance mechanisms play a crucial role in the development of malignant tumors, enabling precise predictions of disease prognosis.
A recent study published by the European Society of Cardiology found that endurance training but not resistance training slows or reverses cellular aging. Telomerase activity and telomere length increased in volunteers who underwent endurance and high-intensity training, suggesting a potential mechanism for healthy aging.
Researchers at Stanford University have developed a new technique called CRISPR-GO, which allows them to manipulate the genome in three-dimensional space. By reorganizing genetic elements in different locations within the nucleus, scientists can alter their function and study the impact on cell behavior.
A new study found that exercising at least three times a week for six months reduced stress in family caregivers and even lengthened their chromosomes, slowing down cellular aging. The researchers also observed improved cardiorespiratory fitness, weight loss, and lower levels of perceived stress among the participants.
Research suggests that women's reproductive health, hormones, and mental health play a crucial role in maintaining telomere length and slowing the aging process. Dr. Elissa Epel's presentation highlights the importance of estrogen's protective effects on telomeres and heart disease.
Researchers at Indiana University have identified two enzymes that combine to speed up telomere growth, potentially leading to new ways to treat cancer and premature aging disorders. The study sheds light on the role of helicases in telomere maintenance and may lead to the development of new therapies.
Researchers discovered that regulatory T-cells can inhibit the activity of telomerase in effector lymphocytes, causing telomere loss and cell death. This mechanism, based on physiological ageing of immune cells, has potential for treating autoimmune diseases and preventing implant rejection.
A new study published in Frontiers finds that short chromosome tips (telomeres) are an independent risk factor for age-related functional decline. Participants with the shortest telomeres were more likely to have reduced physical function, regardless of geographical location, age, sex, or weight.
Researchers found that dominant meerkat breeders exhibit accelerated aging due to the physical and social stresses of leadership, yet they consistently outlive their subordinate counterparts. This study suggests that being a dominant breeder is key to longevity in meerkats.
Researchers at Stanford University School of Medicine discovered that people with cardiomyopathy have abnormally short telomeres in their heart muscle cells. This finding opens the door to new research and drug discovery, potentially allowing for the identification of individuals at risk for heart failure due to genetic defects.
A study published in Frontiers in Zoology found that traffic noise may contribute to aging in Zebra finches, with birds exposed after fledging having shorter telomeres. The researchers suggest that this period is critical for song learning and development, making birds more sensitive to noise.
A study published in the American Journal of Epidemiology found that a healthy diet high in fruits, vegetables, and whole grains can promote healthy cellular aging in women. The researchers used telomere length as a measure of cellular aging and found that higher diet quality indices were associated with longer telomeres.
The team found that telomeres are regulated by proteins, including Taz1, which tether internal regions to the telomeres. This process ensures faithful duplication of genetic material. Better understanding of this mechanism may inform research into maintaining genetic information and preventing diseases.
A new study found that measuring blood telomeres can predict future risk of worsening COPD or death. Azithromycin treatment was shown to help patients with short telomeres stave off negative clinical outcomes, suggesting its potential as a biomarker for patient risk-stratification.
Researchers used precision genomics to identify new genetic abnormalities associated with short telomeres, which can cause premature aging. The study aimed to find better ways to screen, diagnose, and treat patients with these rare conditions.
Hollings Cancer Center researchers discovered that cancer cells protect their telomeres from damage to prevent cell death, contributing to their long lifespan. By inhibiting this mechanism, the researchers hope to develop a new treatment for cancer and potentially delay aging.
Scientists have discovered two antioxidant enzymes that work together to prevent telomeric DNA oxidation, leading to telomere shortening and eventual cell death. Disrupting these enzymes in cancer cells has shown promising results in preventing the enzyme telomerase from extending telomeres.
Research by Maria A. Blasco and colleagues reveals TERRAs interact with the Polycomb complex to assemble telomeric heterochromatin. In cells deficient for TERRA, telomeres show decreased heterochromatic marks, indicating a crucial role in telomere protection and maintenance.
A recent study by George Mason University researchers found that women who have given birth have shorter telomeres compared to childless women. The study suggests a link between having children and increased telomere shortening, which may be associated with higher morbidity and mortality rates.
Researchers identified protective structures at the end of chromosomes called telomeres that don't shorten with age in longest-lived bat species. The study found two genes ATM and SETX drive this process, potentially leading to new solutions to slow down aging and extend human lifespan.
Researchers analyzed blood samples from nearly 10,000 people and found gene variants associated with intrinsic and extrinsic epigenetic age acceleration. Variants in the TERT gene were linked to older epigenetic aging rates and longer telomeres, highlighting its critical role in regulating the epigenetic clock.
Researchers found that babies exposed to high levels of air pollution in the womb had shorter telomeres, linked to higher risk of cancer, heart disease, and premature death. The study suggests that reducing air pollution exposure can have long-term benefits for children's health.
Researchers created a 3D model of telomerase, an enzyme that lengthens chromosome ends, in baker's yeast. The study provides new insights into how telomerase recruits itself to chromosome tips and sheds light on its role in cancer cell survival.
Researchers from Instituto de Medicina Molecular found that TERRA, a functional component of telomeres, must be constantly regulated to prevent telomeric and chromosomal instability. This study sheds light on the molecular basis of genome stability and may pave the way for new therapeutic approaches.
A null mutation in SERPINE1 is associated with a longer life span and improved metabolism among the Amish population. The study found that carriers of this mutation lived 10 years longer than non-carriers, with lower rates of diabetes.
Researchers compared 11 measures of aging, including blood and chromosome tests, and found that none consistently predicted physical or cognitive changes. Telomere length and epigenetic clocks showed some promise but were less clearly linked to physiological outcomes.
Researchers have identified a connection between the PI3K pathway and telomere protection, revealing a potential target for cancer treatment. Inhibition of PI3K reduces TRF1 levels, leading to chromosome destabilization and cancer cell death.
Researchers found that pregnant women with low socioeconomic status during childhood and poor family social support had shorter telomeres, indicating a faster biological age. This rapid aging may increase the risk of premature delivery, gestational hypertension, and other pregnancy complications.
Researchers found that birds with related or familiar neighbors had better body condition and telomere length, indicating improved health and aging. The study suggests that keeping good neighbors is crucial for wild animals' well-being, particularly in densely populated areas.
A team of Penn researchers found a correlation between shorter telomeres and heart failure in human patients. Telomere length was directly related to cardiac function, with severely shortened telomeres indicating decreased cardiac performance.
The Harvard-Osher Center for Integrative Medicine has partnered with The Journal of Alternative and Complementary Medicine (JACM) to showcase cutting-edge mind-body research. Recent studies explored the impact on telomere length, group-based clinical interventions, and electronic apps for veterans' mental health.
New research reveals a two-step process for cell immortalization and cancer development, with telomerase playing a complex role. Telomerase levels are insufficient to lengthen all telomeres, leading to genomic instability and tumor formation.
Scientists at Houston Methodist have developed a technology that can rejuvenate human cells by lengthening telomeres, the timekeepers of chromosomes. This breakthrough has the potential to improve cell function and extend lifespan in individuals with progeria, a rare condition marked by rapid aging.
Researchers used CRISPR to study dyskeratosis congenita, a rare condition that causes progressive DNA damage leading to blood cell failure. The study reveals new ways to potentially treat the disease by blocking signaling pathways involved in blood cell formation.
Research suggests that individuals with a family history of bipolar disorder may experience faster biological aging. The study found that patients treated with lithium had longer telomeres, which could help reverse age-related changes. This association may explain the higher rates of aging-related diseases among bipolar disorder patients.
A study found that children who lost their fathers had significantly shorter telomeres at age 9, indicating increased cell aging and stress. The effect was greatest for boys and those whose fathers died.
A recent study by University of Kent researchers has found that premature babies have longer telomeres than their term-born counterparts, contradicting the expectation. This finding suggests other factors may influence telomere length in premature infants and raises the possibility that prematurity affects aging rate.
Researchers discovered the role of TERRA in repairing critically short telomeres, which play a key role in determining cellular senescence. The study provides new insights into the regulation of cell senescence and survival in ageing and cancer.
Researchers discovered ZBTB48 regulates both telomeres and mitochondria, contributing to a better understanding of the human ageing process. The protein limits abnormal telomere lengthening in cells, while activating genes involved in mitochondrial function.
Researchers from Brigham Young University discovered a significant link between high physical activity and longer telomeres, which can slow down cellular aging. Adults with highly active lifestyles have telomeres that are nine years younger than those who are sedentary or moderately active.
A new study published in Neuropsychopharmacology found that maternal stress during pregnancy may influence the biological clock for ageing in children. Telomere length in newborns was found to be shorter in mothers who experienced increased psychosocial stress, suggesting a potential link between maternal stress and premature ageing.
The Salk Institute has received a $3 million gift from the Glenn Foundation, enabling continued investigation into aging and age-related diseases. The center aims to advance understanding of biological aging and its effects on various diseases, with a focus on developing interventions to delay or cure age-related conditions.
A study of red-sided garter snakes reveals that males who prioritize mating over self-preservation age faster and die earlier than females. Females, on the other hand, maintain their body condition with age, allowing them to live longer lives and reproduce more effectively.
Researchers found shorter telomeres in mice with a human genetic mutation linked to heart disease leads to deadly buildup of calcium in heart valves and vessels. The study provides a potential solution to studying other human disorders of aging in mice.
A recent study found that longer telomeres in mice may shield them from age-related human diseases. Researchers used mice with shortened telomeres to examine a genetic defect causing an age-associated congenital heart disease in humans. The findings suggest that decreasing telomere length contributes to the onset of age-related diseases.
Telomeres are protective caps on chromosomes that protect DNA ends from damage. Brian Luke's research focuses on the non-coding RNA TERRA, which plays a crucial role in telomere function. His lab will also investigate telomere looping, a mechanism that protects chromosome ends from degradation.
In vivo reprogramming induces signs of telomere rejuvenation, reversing aging's hallmark: short telomeres. The process involves telomerase activation and elongation, similar to early stages of tumor development.
Researchers at Jackson Laboratory have identified a newly discovered telomere maintenance mechanism that enables cancer cells to survive and thrive. The study found that most cancer cells reactivate telomerase through TERT transcription, but the exact mechanisms behind this process remained unclear until now.
Research found that babies with more diarrhea as infants had shorter telomeres in adulthood, associated with a higher burden of disease. Telomere length may be an important determinant of susceptibility to diarrheal infections and overall health outcomes.
A study found that sedentary elderly women have shorter telomeres, indicating accelerated biological aging. Regular exercise can slow down this process.
Researchers at TSRI have discovered a protein called TZAP that regulates telomere length, which is crucial for determining cell lifespan and preventing cancer. Understanding this process opens up new avenues for studying aging and developing treatments.
A protein called Peroxiredoxin 1 (PRDX1) has been identified as a key player in protecting telomeres from oxidative damage. By analyzing the protein composition of telomeres across the cell cycle, researchers found that PRDX1 functions as an antioxidant enzyme, preserving telomeric DNA for extension by telomerase.
Scientists found that a balance of telomere elongation and trimming in stem cells is necessary for optimal telomere length. Over-elongated telomeres accumulate DNA damage and can lead to cancer. The study deepens understanding of stem cell biology and has implications for regenerative medicine and aging research.
Researchers discovered a correlation between starvation and shortened telomere lengths in men born after the mass famine of the early 1920s. The team found that these shorter telomeres were stable in ensuing generations, suggesting a potential impact on male lifespan.
In a study published in Scientific Reports, researchers discovered that edible dormice experience increased telomere length with age, contrary to human aging. The unique life history of the species and its remarkable longevity may hold the key to understanding cellular rejuvenation.
A small study of black children in New Orleans found that neighborhood stressors such as violence and crime were associated with shortened telomere length and cortisol functioning, indicating biological stress. The study highlights the importance of addressing social environmental conditions to reduce health disparities.
Researchers are studying the impact of vitamin D and omega-3 supplements on telomere length and cardiovascular risk. The study aims to determine if these supplements can help maintain youthful telomeres and reduce disease risk.
Researchers found that shorter leukocyte telomere length is associated with poorer cardiovascular health and reflects cardiovascular health more accurately in women and white people. The study used data from the National Health and Nutrition Examination Survey to measure telomere length and overall cardiovascular health in 5,194 subjects.
Researchers at the University of Pittsburgh Cancer Institute discovered that cancer cells exploit a previously unknown mechanism called alternative lengthening of telomeres (ALT) to reset their telomere clocks. This allows them to continue dividing and growing, making them more aggressive and resistant to treatment.
Pitt researchers discovered how oxidative stress accelerates telomere shortening by damaging DNA precursor molecules. This finding offers a new way to inhibit telomerase activity, potentially treating cancer. The study also reveals that oxidative stress can promote telomere lengthening.