Articles tagged with Telomeres
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The International Society for Advancement of Cytometry presented its 2012 awards to Dr. Leon Terstappen and Dr. Robert Leif, recognizing their innovative work in cytometry technology. The awards also honored Drs. Jan Visser and Peter Lansdorp for their significant contributions to the field and society.
Modified human stem cells helped enhance the activity of an enzyme called telomerase, which elongates telomere length. This technique increased telomere length and activity, as well as increasing cardiac stem cell proliferation, vital steps in combating heart failure.
A study by researchers at Brigham and Women's Hospital found that phobic anxiety is associated with shortened telomeres, a marker of biological aging. This association suggests that phobic anxiety may be a risk factor for accelerated aging, linked to increased risks of cancers, heart disease, dementia, and mortality.
Scientists at Max Planck Institute have discovered a molecular link between telomerase and the Wnt/β-signalling pathway, which regulates telomere length in stem cells and cancer cells. This regulation mechanism could lead to the development of new treatments for human tumours.
A new Northwestern University study suggests that children of older fathers inherit longer telomeres, which may promote slower aging and facilitate extension of lifespan. The association is cumulative across multiple generations, offering insights into the evolution of aging.
Researchers from Brazil and Korea used human immature dental pulp stem cells to create induced pluripotent stem cells, showing promising characteristics for therapeutic applications. The studies suggest that dental stem cells may be a valuable alternative source for regenerative medicine, including tooth regeneration and repair.
Researchers identified new functions of cohesin SA1 relevant to human disease, including efficient chromosome duplication and regulation of gene expression during embryonic development. This work offers new clues to understand the pathologies observed in CdLS patients and may lead to a better understanding of cancer.
A new study found that children who experienced violence in their young lives have shorter telomeres, a sign of accelerated aging. This can increase the risk of chronic diseases and poor survival rates. The research suggests a link between cumulative childhood stress and telomere maintenance.
A new biomarker has been identified to detect hepatitis B-infected patients at risk of developing liver cancer. Telomere length analysis revealed a significant association between longer telomeres and increased risk of liver cancer in patients with hepatitis B.
Researchers have identified a unique population of individuals who experienced intrauterine growth restriction (IUGR) and childhood starvation, which may be at greatest risk of developing long-term heart complications. Cellular changes associated with IUGR and starvation could be targeted to prevent or reverse structural heart changes.
A new study from Brigham and Women's Hospital suggests a strong link between telomere shortening and poor cardiovascular outcomes in patients with acute coronary syndrome. Telomeres are DNA-protein complexes that protect chromosomes from deteriorating, and their length is associated with increased risk of heart attack and death.
Scientists at Salk Institute create worm model that relies on alternative lengthening of telomeres (ALT) pathway to maintain telomeres, a key strategy used by cancer cells. The study provides valuable tool to block ALT and induce senescence in tumor cells, with potential for developing new anti-cancer drugs.
Researchers analyzed 100,000 molecular components from a patient's genome, revealing genetic risks and biomarkers for diseases. The study provides insights into the correlation between individual genetic profiles and environmental interactions in disease development.
Researchers found that telomeres send out a molecular SOS signal when cells take too long to divide, leading to the activation of DNA damage pathways and cell death. This discovery has implications for cancer chemotherapy, suggesting ways to make therapy more potent by combining mitotic inhibitors with other drugs.
Planarian worms, a species of flatworm, have been found to maintain telomere length indefinitely, allowing them to regenerate tissues and cells without aging. This discovery sheds light on the mechanisms underlying their immortality and may shed new insights into alleviating aging in human cells.
A recent study published in Biological Psychiatry found that depression is associated with shorter telomeres and a low cortisol state, suggesting that stress plays an important role in depression. The study's findings have implications for understanding the aging process and developing treatment strategies.
A study by UCSF researchers found that anticipating stressful situations accelerates cellular aging, leading to shorter telomeres and increased risk for chronic diseases. Caregivers who anticipated more threat showed signs of accelerated cellular aging.
Researchers found that inhibiting telomerase triggers alternative lengthening of telomeres (ALT) in cancer cells, leading to increased expression of PGC-1ß gene. Targeting PGC-1ß weakens mitochondria function and enhances anti-telomerase therapy.
Two proteins, Rif1 and Rif2, discovered to deactivate DNA repair surveillance system, preventing cell 'anti-enzyme shield' from malfunctioning. Telomeres provide molecular 'caps' protecting chromosome ends from accidental breaks.
Research shows that ultra short telomeres in osteoarthritic knees are associated with increased severity of OA and proximity to the most damaged section. Abnormally shortened telomeres may lead to senescence, failure of joint repair and progression of the disease.
Researchers found that shortening telomeres in cancer cells makes them more sensitive to radiation treatment, leading to faster cell death. The study's results may lead to safer and more effective combination therapies for pediatric brain cancers.
Researchers have identified a key target of DNA damage checkpoint enzymes that must be modified to enable stable telomere maintenance. This finding may hold crucial implications for preventing cancer and understanding human aging.
Researchers report the presence of alternative lengthening of telomeres (ALT) in various cancers, including bladder, cervix, and lung tumors. ALT allows cancer cells to grow indefinitely, making it a potential target for anti-cancer therapies.
A UCI-led study found that prenatal exposure to stress accelerates cell aging, affecting chromosome regions controlling aging processes. Telomere shortening is a key marker of accelerated aging.
Researchers found familial breast cancer patients have significantly shorter telomeres, suggesting a genetic mechanism contributing to disease progression. The study also demonstrated genetic anticipation in affected daughters, with decreased telomere length relative to their mothers.
Researchers found that short telomeres increase emphysema risk after cigarette smoke exposure, suggesting a biological clock mechanism. Telomere length may be an inherited factor contributing to emphysema development.
A new study by NIH researchers reveals the interaction between telomeres and a toxic protein called progerin that triggers both premature aging syndrome and normal cellular aging. Shortened telomeres lead to increased production of progerin, causing cell damage and activation of programmed aging.
Researchers at Stanford University School of Medicine used undifferentiated induced pluripotent stem cells to study dyskeratosis congenita, a rare genetic disease. They found that the activity of telomerase, an enzyme critical to aging and cell renewal, is correlated with the severity of symptoms.
A study in institutionalized Romanian children found that social deprivation and neglect correlates with lower IQ and behavioral problems. Prematurely shortened telomeres, a measure of cell aging, were also observed in these children.
Researchers at UT Southwestern Medical Center have discovered that the telomerase enzyme repairs chromosomes in two distinct ways, depending on cell division and stress. This finding could lead to new cancer-fighting therapies by inhibiting this enzyme.
Researchers found shorter telomere length in adults with PTSD and a history of childhood trauma, associated with increased risk of cancer, cardiovascular disease, and autoimmune diseases. The study suggests that childhood trauma may contribute to the development of PTSD and accelerated aging.
Researchers at the University of Pennsylvania School of Medicine have discovered how telomere caps, made up of G-quadruplexes, protect chromosomes from unraveling. This discovery has implications for studying human aging, Werner syndrome, and Bloom syndrome.
A new study found that long-term depression is associated with premature aging of immune cells, potentially leading to increased susceptibility to other illnesses. Researchers also discovered a link between telomere shortening and oxidative stress in depressed individuals.
Studies found that exercise prevents telomere stress and cell aging, suggesting a link between physical activity and healthier cells. Telomeres measure cell age and health, with shorter lengths linked to diseases like cancer and cardiovascular disease.
Researchers discovered a single genetic variation associated with a 19% decrease in bladder cancer risk and longer telomeres, which guard against chromosomal damage. The finding provides new clues for understanding the causes of bladder cancer and developing therapies to reduce cancer risk.
A genetic variant has been linked to both longer telomeres and a reduced risk of bladder cancer, according to researchers. The study found that the variant, rs398652, was associated with a 19% reduction in bladder cancer risk.
Researchers found that Duchenne muscular dystrophy symptoms emerge when skeletal muscle stem cells can no longer keep up with repairs, leading to progressive muscle weakening and respiratory failure. Successful treatments targeting muscle stem cells may alleviate symptoms and offer new hope for managing the disease.
Researchers at UCLA have created a three-dimensional structural model of the RNA core domain of the telomerase enzyme, which plays a critical role in cancer cell immortality. The new model provides insights into how telomerase functions and could lead to new approaches for treating diseases associated with telomerase activity.
Researchers found a link between long telomeres and an increased risk of colorectal cancer in young-onset patients. The study suggests two distinct groups of colorectal cancer: one with accelerated aging due to telomere shortening, and another with longer telomeres.
As human cells age, their telomeres shorten, triggering massive changes in the way DNA is packaged, known as chromatin. This leads to epigenetic changes that affect gene expression and contribute to aging. Researchers have identified histone proteins as key players in this process.
A study found that shorter biological marker length, specifically telomere length, was associated with a higher rate of relapse and lower overall survival in patients with severe aplastic anemia receiving immunosuppressive therapy. The results suggest that telomere length may be a risk factor for disease progression.
Researchers at The Wistar Institute have discovered the dimeric nature of Cdc13, a protein crucial for maintaining telomere length. This discovery sheds light on how Cdc13 regulates telomerase activity, which can help prevent telomere shortening and support cancer treatment.
A team of Portuguese researchers has discovered that a specific Histone modification prevents DNA damage recognition machinery from arresting the cell cycle at telomere ends. This finding provides insights into the relationship between telomeres and cancer, as well as potential therapeutic interventions.
A new study reveals that shorter leukocyte telomere length is associated with a significantly increased risk of developing cancer and dying from cancer. Participants with the shortest telomere lengths had approximately three times the risk of cancer compared to those in the longest group.
A new study from UCSF reveals that vigorous physical activity can protect individuals from the effects of stress by reducing its impact on telomere length. The researchers found that even moderate amounts of exercise can provide critical protection for telomeres.
Researchers found liver transplant recipients develop premature immune senescence due to chronic immune stress. The study suggests that accelerated T-cell aging contributes to increased morbidity and mortality in established liver graft recipients.
Research found a strong correlation between heavy alcohol use and shortened telomeres, increasing cancer risk. Telomere length was nearly half as long in heavy drinkers compared to non-abusers.
Researchers at the NIA have discovered a key to ES cell rejuvenation in the gene Zscan4, which restores telomere length through recombination. This process enables infinite generations of functional ES cells, offering new insights into aging research and regenerative medicine.
Research finds childhood maltreatment can lead to shorter telomeres, a marker of biological aging, and increased risk of age-related diseases. The study suggests early developmental experiences may have profound effects on biology, influencing cellular mechanisms that accelerate aging.
Researchers have identified a genetic variant associated with biological aging in humans, which can affect telomere length and increase the risk of age-related diseases. The study found that individuals carrying this variant showed shorter telomeres, indicating faster biological aging.
A study published in JAMA found that higher omega-3 fatty acid blood levels were associated with a lower rate of telomere shortening, a marker of biological aging, in patients with coronary heart disease. Patients with the highest levels of omega-3 fatty acids experienced the slowest rate of telomere shortening over 5 years.
Research found that long-term physical activity activates telomerase and stabilizes telomeres, reducing telomere shortening in human leukocytes. This activation has an anti-aging effect on the cardiovascular system, potentially preventing age-related disease.
Researchers found a direct connection between childhood psychological trauma and accelerated reduction in telomere size, which promotes cellular stability. Telomeres typically shorten with age, but the study shows that childhood abuse can accelerate this process.
Researchers at Albert Einstein College of Medicine discovered a link between longevity and genes that maintain telomere length. The study found that individuals with long telomeres were more likely to have inherited genes that enabled effective telomerase production, potentially protecting against age-related diseases.
Researchers from Texas A&M University and the University of Cincinnati have discovered a new set of essential telomere proteins in Arabidopsis, a plant found worldwide. The team identified human counterparts to these proteins, which could help understand human cancers and cellular aging.
Researchers studied mice with a genetic deficiency that shortens their telomeres, similar to patients with dyskeratosis congenita. After 12-14 generations, the mice's telomeres regained normal lengths, suggesting an equilibration process that could protect against telomere erosion and disease symptoms.
Jack W. Szostak's Nobel Prize-winning discovery of telomerase has revealed a crucial link between chromosome maintenance and cellular senescence. His work also laid the foundation for understanding the molecular origins of life and aging processes in humans.
A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres. Manipulating this RNA's expression may be useful in treating cancer and other diseases.
A protein specialist opens genomic door for DNA repair and gene expression while also protecting chromosome tips. Depletion of Gcn5 leads to decreased activity by another protein that protects yet a third protein from destruction.
Researchers at Rockefeller University discovered that telomeres resemble fragile sites in DNA, where replication can stall. A protein called TRF1 helps prevent this by removing unusual structures from telomeric DNA, allowing smooth progression of DNA replication.