Scientists find that telomerase enzyme contributes to chromosome stability beyond telomere length, offering a new target for extending cell life span and combating cancer. The discovery suggests a novel approach to manipulating the enzyme for therapeutic purposes.
Mice lacking a gene for making telomeres displayed symptoms of aging, including graying hair and increased tumor incidence. However, the study reveals that telomere loss is not solely responsible for aging, suggesting other mechanisms at play.
This book brings together international specialists to discuss the genetic structure of telomeres, telomerase function, and their importance in aging and cancer. The chapters cover topics such as telomere length regulation, chromosome end replication, and telomerase repressor genes.