Articles tagged with Transcriptional Regulators
Researchers at McGill University's Montreal Neurological Institute have discovered a key signaling pathway involved in brain connectivity. The study found that inhibiting the interaction between Calcineurin and NFAT resulted in more dendritic branches and synapses, suggesting a potent role for CaN in regulating neural connections.
Researchers using optical tweezers directly observed protein machines encountering nucleosomes, leading to halting and backsliding movements. This study provides a detailed insight into the regulation of gene expression through dynamic interactions between proteins and DNA.
Two new papers by University of Notre Dame biologist Michael Ferdig suggest that genomics and bioinformatics may hold the key to combating malaria. The research reveals previously unrecognized transcriptional complexity in Plasmodium falciparum, a key driver of drug resistance.
Researchers at UCLA and Rutgers University have solved the mystery of DNA transcription, revealing a new mechanism involving the 'scrunching' of DNA during transcription. The discovery could lead to breakthroughs in combating bacterial diseases that kill millions worldwide.
Dr. Hammarskjold's team reveals WT1(+KTS) promotes translation by facilitating mRNA transport and stability, highlighting links between transcription and post-transcriptional gene regulation. The study's findings suggest a crucial role for alternative splicing in regulating genes like WT1 during normal development and disease.
Researchers at UCSD found that E. coli exhibits only six distinct functional states regardless of the carbon source or electron acceptor used, suggesting a surprising level of simplicity in its metabolic processes. The study suggests that this principle may be generalizable to other species.
Researchers found that daily temperature cycles can reset zebrafish clocks, triggering changes in specific clock genes. This discovery sheds light on how temperature affects biological systems and may have implications for mammals.
Scientists developed a new bioinformatics technique to analyze key DNA regions controlling gene activity. The approach uses machine learning to predict binding site combinations and regulate genes, achieving success rates comparable to existing methods.
Researchers create synthetic transcription factors, mimicking natural regulators to probe gene regulation and explore new treatment approaches. The artificial activation domains developed in Mapp's lab were as effective as a natural activation domain at turning on genes.
Researchers identify source of random noise in gene expression, finding that promoter preparation and remodeling contribute to variability. This variation can affect protein levels and cell behavior, with implications for evolution and development.
A new two-step method for identifying transcription factors has been developed, reducing irrelevant regulators by 85%. The tool, ConSite, uses a combination of sequence scanning and conservation analysis to pinpoint regulatory elements.
Researchers propose that the APP tail participates in gene expression by binding to DNA, potentially activating transcription. This finding may shed light on mechanisms behind Alzheimer's disease and raise concerns about the effectiveness of drugs intended to prevent plaque formation.