Articles tagged with Allergic Reactions
A new Northwestern Medicine study shows that a pill taking proactively to prevent mild to life-threatening anaphylaxis could be a game-changer for those with food or drug allergies. The pill uses BTK inhibitors to block allergic reactions by inhibiting the Bruton's tyrosine kinase enzyme, which is found inside cells and mast cells.
Researchers at Massachusetts General Hospital have discovered a new marker for allergic diseases, sialic acid on IgE antibodies, which may improve diagnoses. The team also found that removing sialic acid from IgE enhances allergic reactions in animal models, paving the way for novel treatment strategies.
A study of 25 people found that Pavlovian conditioning to an allergen can lead to a placebo allergic reaction in the environment where the allergen was encountered. Sleep consolidation is thought to play a role in this response, according to the authors.
Current medical guidelines for diagnosing cow's milk allergy in babies and young children may lead to overdiagnosis due to common symptoms being mistaken for the condition. Studies have found that only around 1% of infants have cow's milk allergy, but up to 14% of families believe their child has it.
Researchers have developed a risk-stratification tool to identify patients with low-risk penicillin allergies in the MICU. Direct oral challenge with amoxicillin has been shown to remove up to 60% of all penicillin allergies without symptoms of an allergic reaction.
Researchers found no significant difference in Parkinson's disease progression between those taking isradipine and placebo. Despite its neuroprotective properties in animal models, the study didn't support the hypothesis that isradipine slows early-stage Parkinson's progression.
Scientists at NTU Singapore have developed a way to turn pollen into soft and flexible microgel particles, which could serve as building blocks for new eco-friendly materials. The resulting pollen-based particles show promise for applications such as wound dressing, prosthetics, and implantable electronics.
Researchers have described the overall structure of IgE antibodies, a key molecule in allergic diseases. The study provides insights into basic mechanisms of allergic reactions and may lead to more effective treatments.
A new study found that chemicals in common skincare products can trigger allergic contact dermatitis by displacing natural lipids on skin cells. Researchers identified CD1a molecules as a key player in this process and discovered competing lipids that can displace triggering chemicals, potentially treating the condition.
Researchers identify CD1a as a key player in triggering T cell responses to allergens in personal care products, shedding light on the 'molecular missing link' behind allergic contact dermatitis. The study highlights the importance of fragrance molecules like farnesol in initiating immune responses.
A new study published in Pediatrics found that eight in 10 children who reported being allergic to non-beta-lactam antibiotics were not truly allergic, highlighting the need for improved and timely access to formal allergy evaluations. This can prevent lifelong avoidance of certain antibiotic classes and help combat antibiotic resistance.
A study published in the Journal of Allergy and Clinical Immunology identified over 300 genes and 200 CpG sites associated with reaction severity. The research suggests that neutrophil-mediated immunity plays a prominent role in peanut allergy reactions, offering potential new targets for treatment.
Researchers have developed a novel vaccine that uses a virus-based platform to rewrite the body's natural response to peanut allergens, causing a non-allergic immune response. The vaccine has shown signs of success in mouse models and preliminary in vitro studies, paving the way for human trials.
Scientists are searching for the source of group E antibodies, which trigger most allergic reactions. They aim to deepen understanding of these molecules and develop effective treatments, as class E immunoglobulin is involved in one-third of all diseases.
Women are disproportionately affected by penicillin allergies, with a significantly higher rate of positive skin tests and reactions. Direct oral challenges without preliminary testing can safely rule out penicillin allergy in low-risk children, allowing them to have the allergy label removed from their medical records.
A study published in Pediatric Allergy and Immunology found that 17% of children with food allergies are also allergic to sesame. The researchers developed a mathematical model to predict sesame allergy in children with food allergies, which could help clinicians identify this common allergy.
Researchers at King's College London have found that immunotherapy for peanut allergy reduces sensitivity to peanuts, providing some protection against accidental reactions. However, the treatment does not cure allergies and can actually increase allergic reactions in some patients, highlighting the need for continued research.
Severe adverse reactions occurred within minutes of PICC insertion, especially among patients with cystic fibrosis. The study highlights the need for recognizing and evaluating adverse reactions following PICC insertion.
A large study of almost 200,000 patients found that premedicating with antihistamines and switching contrast media can reduce recurrent allergic reactions. Genetic predisposition may also play a role in reaction to CT contrast agents, according to the researchers.
Researchers have identified key immunological changes in people who develop a meat allergy triggered by tick bites, which can lead to mild hives or life-threatening anaphylaxis. The study provides important insights into why otherwise healthy individuals can suddenly become allergic to mammalian meat.
A new study by Northwestern University reveals sesame allergy is more common than previously known, affecting over 1.5 million individuals in the US. The study found that sesame is often a hidden ingredient in foods, increasing the risk of accidental ingestion.
A study of nearly 79,000 individuals found that approximately 0.8% of the US population has a sesame allergy. The survey responses indicated that sesame allergy is more common among children and individuals with other food allergies.
Researchers identified a specific type of T-cell that drives the production of high-affinity IgE antibodies associated with severe allergic reactions. This discovery suggests a potential target for new therapies to prevent or treat allergic diseases, including anaphylaxis.
The OUtMATCH study will test the ability of omalizumab to increase tolerance to peanut and other food allergens in children and adults. The trial aims to enroll 225 participants with a history of multiple food allergies, assessing whether biweekly or monthly injections of omalizumab can prevent allergic reactions.
A clinical trial at Flinders University and Royal Adelaide Hospital included 27 adults with a history of allergic reactions to European honeybee stings. The vaccine used an adjuvant developed in Australia to neutralize bee venom, showing promising results and confirming safety.
Research suggests that scratching the skin can lead to allergic reactions to foods, including anaphylaxis, in children with eczema. The study found that mechanical skin injury expands and activates intestinal mast cells, promoting anaphylactic reactions.
A systematic review of 12 studies with over 1,000 patients found that peanut oral immunotherapy increases the risk and frequency of anaphylaxis and allergic reactions. Despite inducing desensitisation in the clinic, the treatment does not lead to improved quality of life for patients.
A new study published in the Journal of Allergy and Clinical Immunology: In Practice suggests that oral immunotherapy is safe for preschool-aged children with peanut allergies. Researchers followed 270 children who received oral immunotherapy and found that 90% reached the maintenance stage successfully.
According to a study published in the Canadian Medical Association Journal, vaccine allergies are extremely uncommon, affecting only one in 760,000 vaccinations. Most side effects from vaccines are not allergic reactions, but rather minor responses that can be managed with over-the-counter medications.
Researchers identified two epitopes capable of eliciting strong allergic reactions in serum samples from all or nearly all patients, and engineered molecules to selectively bind to IgEs recognizing these epitopes. Treatment with the inhibitors inhibited over 80% of the allergic response to peanut extract in patients.
Researchers at the University of Notre Dame have developed a novel inhibitor that selectively targets IgE and prevents allergic reactions to peanuts. The breakthrough finding has significant implications for treating severe peanut allergies, with up to 90% success rate in inhibiting an allergic response.
Researchers discovered that allergic reactions trigger changes in brain behavior development in unborn males and females. This study, published in Scientific Reports, found that immune cells play a critical role in sexual differentiation and may contribute to natural variations in male and female sexual behavior.
A new research suggests that a single allergic reaction during pregnancy can prompt significant changes in the brains of offspring, leading to more male-like behavior and brain development. Female rats born to mothers exposed to an allergen during pregnancy exhibited higher levels of male-like behavior and brain changes.
Researchers debunked a common misconception that millions of people have an antibiotic allergy. Studies show that only 10% of reported allergies are true, and many lose their allergy over time.
A multi-year observational study found that eating small amounts of peanut after immunotherapy can extend allergy treatment benefits and improve quality of life. The majority of participants continued regularly eating peanuts daily for up to eight years without any reactions from accidental ingestions.
New research from UNC School of Medicine reveals that tick bites can cause an allergic immune response to alpha-gal, a sugar found in most mammal blood except humans, leading to red meat allergy syndrome (AGS). This challenges previous theories and suggests the risk of each tick bite may be higher than anticipated.
A multi-year observational study found that certain participants who completed up to four years of egg oral immunotherapy (eOIT) treatment were able to safely incorporate egg into their diet for five years. The results support the effectiveness of eOIT as a safe way to desensitize children and youth with egg allergy.
Researchers found that healthy infant gut microbes protect against cow's milk allergy when transplanted into mice, while those from allergic infants caused an allergic reaction. A specific bacterial species, Anaerostipes caccae, was identified as the protector against allergic responses.
A new PhD thesis from the University of Eastern Finland reveals a link between early life environmental exposures, such as farming and air pollution, and altered immune responses. The study found that farming exposure decreases the risk of allergic diseases, while air pollution increases asthma prevalence in children.
Researchers found that those who used an average of 15 strategies when eating out had fewer reactions, while non-reactors only used six. People can minimize risk by using multiple strategies such as ordering simple ingredients and checking food before eating.
A recent study published at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting found that epinephrine auto injectors (EAIs) can still function properly even if they are unintentionally frozen. Researchers tested 104 devices and found no significant difference in weight changes before and after freezing.
A study published in The Pediatric Infectious Disease Journal found that repeat vaccinations are safe for most children with mild to moderate reactions after their initial immunization. Sixteen percent of patients experienced recurrent adverse events following immunization, but most were no more severe than the initial reaction.
Researchers at the University of Bonn have found that CCL17 influences signal transmission in the brain and may be linked to autism. The chemokine is mainly produced by neurons in the hippocampus, a structure involved in tasks such as orientation and memory formation.
A new study from Lund University and Skåne University Hospital found that children with allergies have a lower risk of developing complicated appendicitis. The study compared outcomes for 605 children with and without IgE-mediated allergy, finding a significant association between the two.
Researchers found that guanylate cyclase enzyme plays a crucial role in the allergic immune response, and its inhibition can lead to reduced symptoms. The study used knock-out mice lacking this enzyme to show that Th1 responses can suppress Th2 responses, resulting in weaker allergy symptoms.
Research found that strawberry and tomato allergy potential depends on the specific variety, with some varieties exhibiting lower allergenic proteins due to heat sensitivity. The study's results could lead to the development of hypoallergenic tomato and strawberry varieties.
Researchers found that IgG antibodies play a key role in the severity of anaphylactic shock by activating blood platelets. Platelet activation may be behind the process, leading to a drop in body temperature and reduced circulating platelet count.
Scientists developed a new laboratory test to diagnose peanut allergies with high accuracy and safety. The mast activation test (MAT) measures biomarkers associated with allergic reactions and can detect peanut allergy in children as young as six months old.
Researchers are working to identify biomarkers for food allergies, aiming to improve understanding of how children's immune systems react to certain foods. Current blood tests are only 30-55% specific, leaving room for further innovation in diagnostics and treatments.
Researchers have developed a vaccine that can redirect the immune response to prevent allergic symptoms, providing extended relief from peanut allergies. The study shows promise for potential therapy of allergies in humans and may lead to long-lasting suppression of food allergies.
Researchers developed a nasal spray vaccine that shifts the immune response toward peanut tolerance in mice with established allergies. The vaccine's nano-emulsion adjuvant promotes a strong infection-fighting response that suppresses allergic reactions.
A team of scientists has identified a human protein called interleukin-33 (IL-33) that reacts to various environmental allergens, including mold, pollen, and cockroaches. This discovery establishes a direct link between genetics and the environment, and offers new potential targets for treatment of allergic diseases.
A special receptor called dectin-1 recognizes a protein found in house dust mites, cockroaches, shellfish, and other invertebrates, suppressing immune reactions to these common allergy triggers. The discovery suggests new ways to treat or prevent allergies and asthma, which affect tens of millions in the US.
Research found that a protein interacts with blood vessels to intensify anaphylaxis symptoms, making it a potential target for drug therapies. Therapies targeting this protein could moderate reactions and make anaphylaxis less deadly.
Researchers at Duke University Medical Center have developed an innovative approach to treat peanut allergies by retraining the immune system using nanoparticles. The study found that delivering molecules to the lymph nodes quells allergic reactions, providing long-lasting tolerance without repeated exposures.
Early introduction of peanuts into the diet may prevent the development of peanut allergy in high-risk infants. Oral immunotherapy is a promising approach to allergen desensitization for children with known peanut allergies, increasing threshold amounts before experiencing reactions by at least 25 times.
A recent study suggests that vitamin A in cattle fodder can prevent a reaction to cow's milk proteins. The study found that retinoic acid pockets the beta-lactoglobulin protein, transforming it into a tolerogen and potentially preventing an allergic immune response.
Researchers at Aarhus University have found a new mechanism by which an antibody can prevent allergic reactions, including those caused by birch pollen and insect venom. The antibody interferes with the binding of IgE molecules to immune cells, thereby eliminating allergic symptoms.
A new study published in Pediatric Allergy and Immunology reveals that food-induced anaphylaxis reactions occur frequently under adult supervision, with adults other than parents often present. The research highlights the importance of increasing education and awareness among all caregivers of food-allergic children.
Researchers at NIAID found that some patients' seemingly inexplicable anaphylaxis was caused by an uncommon allergy to a molecule found naturally in red meat. Six study participants tested positive for an allergy to galactose-a-1,3-galactose, or alpha-gal, and experienced no anaphylaxis after implementing diets free of red meat.