Articles tagged with Allergic Reactions
Researchers at Aarhus University have found a new mechanism by which an antibody can prevent allergic reactions, including those caused by birch pollen and insect venom. The antibody interferes with the binding of IgE molecules to immune cells, thereby eliminating allergic symptoms.
A new study published in Pediatric Allergy and Immunology reveals that food-induced anaphylaxis reactions occur frequently under adult supervision, with adults other than parents often present. The research highlights the importance of increasing education and awareness among all caregivers of food-allergic children.
Researchers at NIAID found that some patients' seemingly inexplicable anaphylaxis was caused by an uncommon allergy to a molecule found naturally in red meat. Six study participants tested positive for an allergy to galactose-a-1,3-galactose, or alpha-gal, and experienced no anaphylaxis after implementing diets free of red meat.
The number of laboratory services associated with diagnoses of anaphylactic food reaction increased by 871 percent from 2007 to 2016, and billed charges for those services rose even more. Milk product allergy was the most expensive food allergy in terms of average costs and services per patient.
Researchers at the University of Bonn have developed an RNA aptamer that specifically targets CCL17, blocking its interaction with T cells and dendritic cells. This approach shows promise for treating contact allergies by reducing inflammatory responses in mice.
A study published in Nature Communications has identified five genetic risk loci associated with food allergies in children, highlighting the importance of skin and mucous membrane barriers. The research, involving over 1,500 participants, also found that four of the five risk loci are linked to other chronic inflammatory diseases.
A recent study found that nearly one-quarter of school nurses reported administering epinephrine shots, often by nonmedical staff or students without known allergies. The survey also revealed that 10.8% of students with severe allergic reactions required more than one dose before emergency responders arrived.
Researchers developed a $40 portable allergen-detection system called iEAT, which can detect five common allergens in under 10 minutes. The device extracts allergens from food and uses an electronic keychain reader to sense and transmit results wirelessly.
A recent position paper reveals that animals and humans exhibit similar symptoms after consuming certain foods, highlighting the need for research on molecular allergy diagnostics. An elimination diet is recommended to diagnose food intolerance in both species, which may lead to improved prevention and treatment strategies.
Researchers from Hokkaido University successfully treated mice with atopic dermatitis using HLA-G1, a protein that inhibits immune responses. The treatment showed marked improvement in skin lesions and reduced immune response compared to untreated mice.
Researchers have pinpointed a specific subset of immune cells, known as TH2 subset or type 2 "helper" T cells, which are central to allergies. The identified cells, dubbed TH2A, were found to produce multiple inflammatory signaling molecules and unique gene expression patterns that drive allergic responses.
Researchers at the University of Notre Dame have developed a novel platform using nanoparticles to detect peanut allergies. The technology mimics natural allergens and evaluates the potency of allergic responses using antibodies from patient blood samples.
The new guideline provides practical advice on key areas, including diagnostic algorithms, treatment advice, and risk assessment. Patients will benefit from receiving evidence-based advice to reduce accidental reactions and manage reactions more effectively.
A new study published in the Journal of Allergy and Clinical Immunology found that 3.6 percent of the population studied had a documented food allergy or intolerance. Shellfish was the most commonly reported food allergy, with the highest rates among females and Asians.
A recent study found that a cancer drug called ibrutinib can reduce allergic skin test reactivity by 80-90% in patients with certain types of leukemia and lymphoma. The treatment also showed promise in preventing reactions to common airborne allergens, such as cat dander and ragweed.
Researchers created a potentially safer alternative to common hair dye ingredient PPD by mimicking melanin using polydopamine. The new dye lasts through multiple wash cycles without causing noticeable side effects.
Scientists have identified interleukin-1α as the key event triggering allergic reactions to air pollution. The release of IL-1α leads to inflammation in the lungs and intensifies the immune response, suggesting a promising therapeutic target for respiratory illnesses associated with air pollution.
Research shows that pre-sensitization to lipopolysaccharide (LPS) enhances nickel allergy in mice, shifting the immune balance towards a Th1 response. This finding suggests that an anamnestic history of oral infectious disease may contribute to nickel hypersensitivity.
Researchers genetically modified goats to lack the allergen BLG in their milk, resulting in less severe allergic reactions in susceptible mice. This breakthrough technology could lead to improved nutrition and reduced allergy risk for humans consuming goat's milk.
Researchers developed a method to stop allergic reactions by removing a key receptor from mast cells and basophils, targeting the immune system's response. The approach has implications for treating skin allergies and asthma, with potential benefits over current therapies.
A study found that 87% of school staff knew what to do in an emergency, but only 18% felt confident. The majority of non-nurse staff can identify the correct sequence of actions to take in case of anaphylaxis.
Scientists have discovered a new target to combat severe and fatal allergic reactions by identifying a molecular motor that controls the release of inflammatory factors. Researchers found that depleting this motor reduces mast cell granule transport and release, potentially leading to new treatment options for anaphylaxis.
Researchers found that a protein called NOD2 plays a critical role in determining the strength of anaphylactic reactions to food allergens. A changed immune reaction leads to more Th2 helper cells and increased antibody immunoglobulin E production, triggering allergic reactions.
The National Institute of Allergy and Infectious Diseases has awarded BRI a five-year, $8 million grant to collaborate with UW Medicine and SCRI on immune system responses to allergens in the lungs. This study aims to inform new treatments for allergies and asthma.
A clinical trial found that oral immunotherapy is safe and effective for peanut-allergic preschool children, with over 80% successfully introducing peanut into their diets. The treatment involved gradually increasing amounts of peanut protein daily and was comparable in effectiveness between low-dose and high-dose regimens.
Research published in Frontiers in Cellular Neuroscience found that seasonal allergies can lead to increased neuron production in the hippocampus, a region responsible for forming new memories. This discovery raises questions about the long-term consequences of allergies on brain development and function.
A study published in Cell Reports found that mice fed a high-fiber diet had fewer severe peanut allergies than those with an average fiber intake. The researchers discovered that gut bacteria release specific fatty acids in response to fiber intake, which impact allergic responses via changes to the immune system.
Researchers at Aarhus University have developed individual profiles of allergy reactivity in patients who are not protected after immunotherapy. They created artificial allergens that perfectly mimic the allergens in insect venom, which can be used to improve medical treatment for people allergic to insect stings.
A new study by Northwestern Medicine reveals that low-income families spend 2.5 times more on emergency department and hospitalization costs for children with food allergies, highlighting a significant gap in preventive care and access to special foods and epinephrine auto-injectors.
A Massachusetts General Hospital study confirms the safety of allergy immunotherapy with no evidence of infections related to administration. The study analyzed 10 years of data from over 135,000 patients and found no soft-tissue or systemic infections attributed to AIT.
A new study by McGill University Health Centre researchers found that oral provocation tests are a more efficient and safer method for diagnosing non-life-threatening reactions to antibiotics in children. The study also showed that up to 10% of children may develop mild skin eruptions upon subsequent exposure.
A new study has shown that introducing probiotic Bifidobacterium longum KACC 91563 can reduce the effects of food allergies in mice. The probiotic works by releasing extracellular vesicles containing a protein called ESBP, which neutralizes mast cells responsible for allergic responses.
A recent study found that children aged 6-11 with seasonal allergic rhinitis reported significant symptom improvement after using MP-AzeFlu, while caregivers struggled to accurately assess symptoms. The study highlights the importance of pediatric symptom assessment in determining treatment efficacy.
A study of 1140 pregnant women and their children found that eczema, rhinitis, pet ownership, and age at introducing solid food are associated with different types of food hypersensitivity. A healthy diet was also found to be protective against both IgE-mediated and non-IgE mediated reactions.
Scientists have developed a method to purify cashew proteins, shedding light on their effects and potential treatments for allergies. The study found differences in how allergens bind to antibodies in children and adults, highlighting the importance of geography and age in allergies.
A study from Northwestern University found that many parents are unaware of how to use an epinephrine auto-injector and have a written emergency food allergy action plan. The guidelines for treatment are not being followed, highlighting the need for improved communication between doctors and parents.
Researchers found peanut proteins can persist in homes with no peanuts, despite avoidance efforts. Children with food allergies do not show increased anxiety compared to their peers, contrary to mother reports of panic disorder symptoms.
A recent study by the American College of Allergy, Asthma, and Immunology found that 34% of patients with cardiovascular disease were incorrectly labeled as having an aspirin allergy due to gastrointestinal symptoms. In reality, only 2.5% of patients had a true aspirin hypersensitivity.
Two case studies illustrate how allergists can solve unexpected allergic responses, such as a woman with dry, chapped lips caused by kissing a corpse and another with chronic contact dermatitis from hair dye.
A study by American College of Allergy, Asthma, and Immunology (ACAAI) found that patients who were told they had a penicillin allergy but tested negative could safely take the drug. Researchers examined records of 15 patients who received intravenous penicillin without adverse reactions.
A new study by the American College of Allergy, Asthma and Immunology found that 53% of siblings of children with food allergies had a sensitivity to a food, while only 13% had an actual food allergy. The study suggests that food allergy testing should be limited in these cases.
A survey of over 6,000 schools found that nearly 22% of anaphylactic events occurred in individuals with no previously known allergies. The majority were treated with epinephrine auto-injectors, and the most common triggers included food and insect stings.
Researchers believe that tick spit proteins, such as alpha-gal, can cause severe allergic reactions in humans. A vaccine could be created to target these proteins, potentially providing protection against tick bite allergies.
Researchers discovered a new cell type that produces IL-9, amplifying anaphylactic shock in response to ingested food. The 'IL-9-producing mucosal mast cells' require the presence of specific immune cells and proteins to produce severe allergic reactions.
A new article from the American College of Allergy, Asthma and Immunology recommends using epinephrine for all severe allergic reactions, regardless of symptom certainty. Experts stress that delays can have severe consequences, making epinephrine the most effective tool in combatting anaphylaxis.
The study demonstrates how the microbiota acts on the balance of the immune system, specifically blocking type 2 immune responses that lead to allergic reactions. By stimulating type 3 cells, which coordinate phagocytosis and killing of microbes, the researchers provide an innovative therapeutic approach for allergy treatment.
A Northwestern University study finds that severe food allergies are impacting children of all races and income levels in Illinois, with a significant increase in emergency room visits for anaphylaxis. The study also reveals a notable rise in hospitalizations among Hispanic children, up 44% per year.
A recent study by Technical University of Munich found that ragweed pollen triggers a strong allergic response due to the presence of adenosine. The protein Amb a 1 alone did not induce such a reaction, but combining it with adenosine led to increased inflammation in lung tissue.
Researchers at the University of Gothenburg found that linalyl acetate, a common fragrance chemical, can react with oxygen to form allergenic hydroperoxides. Approximately 2% of tested individuals had allergic reactions to oxidized linalyl acetate, highlighting the need for broader testing and declaration on cosmetic products.
Children with peanut allergies are most at risk of exposure in their own homes, according to a new study. The research found that caregivers and physicians often fail to provide proper management for moderate and severe reactions, highlighting the need for education on strict allergen avoidance.
Researchers at the University of Edinburgh have discovered that Shetland ponies' immune response to insect bites can prevent allergic reactions, similar to what happens in people with allergies. The study found that two different responses occur in horses, one triggering allergy symptoms and the other preventing allergic reactions.
A rare case study published in CMAJ found that blood transfusions can transmit food allergies to children, causing severe symptoms. The condition typically resolves within a few months with careful reintroduction of the allergenic foods into their diet.
A novel anti-clotting therapy was compared to established anticoagulants in a Phase III trial, but showed similar efficacy and higher moderate to severe bleeding rates, leading to its early termination due to allergic reactions.
A small study found that UK trainee doctors still struggle to recognize and treat anaphylaxis, a potentially fatal allergic reaction. Despite updated guidelines and training, many doctors lack basic knowledge of treating the condition, which causes breathing and circulatory problems.
Researchers found that estrogen enhances an enzyme driving life-threatening allergic reactions in female mice, leading to more severe and longer-lasting reactions. Blocking estrogen or reducing eNOS activity eliminated the gender disparity, suggesting a potential role for estrogen in allergic reactions.
A new study by the American College of Allergy, Asthma and Immunology found that stocking emergency epinephrine in Chicago Public Schools saved the lives of 38 children and adults experiencing severe anaphylactic reactions. The majority of reactions occurred in elementary schools, primarily due to peanuts and fin fish triggers.
An allergic response to a medication for allergies can often go undiagnosed due to its initial purpose of reducing inflammation. Patients experiencing worsening symptoms or an unresponsive rash may be reacting to the medication itself or one of its components, such as antibiotics or antifungals.
A study published by Northwestern Medicine found that emergency epinephrine was administered to 38 Chicago Public School students and staff during the 2012-2013 school year. Most of those receiving epinephrine had no known history of allergic reaction, emphasizing the need for widespread access to this life-saving medication.
Researchers at Oxford University found that dry roasting peanuts causes chemical modifications that activate the immune system, leading to an allergic response. This discovery may explain the higher prevalence of peanut allergies in Western countries compared to East Asia.
A team of researchers at the University of Cincinnati is working on a potential cure for food allergies by using a laboratory-grown monoclonal antibody to rapidly desensitize patients. The therapy has shown promise in mice and aims to suppress multiple types of allergies, including skin allergies and asthma, quickly and safely.