Articles tagged with Allergic Reactions
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A study comparing results of allergy patch tests between children and adults found that both groups reacted to various allergens at approximately the same rate. However, children were more likely to react to nickel, cobalt, thimerosal, and lanolin, while adults were more likely to react to neomycin, fragrance mix, M. pereirae, and quat...
A team of vaccine safety experts has developed a step-by-step tool to identify children with allergic reactions to vaccines and provide safe immunization plans. Most children with known or suspected vaccine allergies can be safely vaccinated with proper monitoring and precautions, according to the study.
A new study reveals that even slight stress and anxiety can substantially worsen allergic reactions to routine allergens, leading to longer-lasting symptoms. The researchers found that the next day's reaction was often stronger and more severe, suggesting an ongoing response to the allergens.
A recent study published in Clinical Infectious Diseases reveals that adverse reactions to antibiotics cause an estimated 142,000 emergency department visits per year in the United States. The majority of these reactions are allergic, with over 80% being related to penicillins and other antibiotics.
Researchers at the Salk Institute have discovered that a protein called IKK2 plays a crucial role in regulating de-granulation, a process involved in allergic reactions. By targeting IKK2, scientists hope to develop acute inhibitors for treating allergies and potentially other diseases.
Despite having food allergies, many college students are not taking necessary precautions, such as carrying emergency medication and having a plan in place. Researchers found that only 50% of students with food allergies always avoid their allergenic foods, and 43% do not have an EpiPen on hand.
Researchers at the University of Michigan Hospitals found that 545 patients (0.6%) experienced allergic-like reactions after receiving nonionic iodinated contrast media, but 99% resolved completely within 24 hours with commonly used medications like diphenhydramine and corticosteroids.
Researchers at NYU Langone Health identified a class of custom-made immune cells called regulatory T cells that prevent allergic reactions by recognizing potential allergens. These cells are produced in response to a gene called Foxp3 and help control damage from long-term inflammation.
Twelve investigators receive $5 million in grants to study food allergy causes, treatment, and prevention. The initiative aims to improve understanding of the condition and ultimately end its limitations on lives.
Researchers found that a chicken antibody behaves differently from its human counterpart, which sheds light on the origin of allergic reactions. The discovery could lead to designing drugs that alter the interaction between antibodies and white blood cells.
Researchers believe immunotherapy could curb the immune response and induce tolerance to peanut allergens, potentially reducing severe reactions. In the next five years, some form of immunotherapy is expected to be available for individuals with peanut allergy.
A new trial aims to develop a preventive treatment for food allergies using immunotherapy. Researchers will administer increasing doses of peanut or egg protein to desensitize participants' immune systems. The goal is to achieve long-term results and offer relief from the daily fear of food.
A new study has discovered that specific pre-existing IgE antibodies are the primary cause of severe allergic reactions to cancer drug cetuximab. The research found these antibodies were more prevalent in certain regions of the US, including Tennessee, Arkansas, and North Carolina, which have higher rates of anaphylactic reactions.
Researchers at Penn State University have discovered that lipid molecules in cell membranes play a key role in triggering allergic reactions. The team used advanced imaging techniques to show how cholesterol-rich lipid domains associate with IgE antibodies and their receptors, leading to histamine release and allergic symptoms.
Scientists have identified a key component of the body's response to allergens that can be targeted to reduce allergic reactions in mice. The research confirms that p110delta is a crucial player in allergic reactions and offers hope for therapies that target the real causes, not just symptoms.
A recent study found that gadolinium-containing contrast agents can cause allergic-like reactions in premedicated patients, including children and adults. Pre-medication with corticosteroids and antihistamines may not completely eliminate the risk of breakthrough reactions.
A Johns Hopkins study finds activating a specific protein on immune cells can reduce allergic reactions and asthma attacks. By targeting this protein, researchers hope to develop new treatments for allergies.
A recent study found that acute allergic-like reactions to gadolinium-containing contrast injections are rare, with 74% of cases being mild. The study included over 78,000 administrations and reported no fatal reactions, supporting the safe use of these agents in patients with normal or mildly impaired renal function.
A study published in Pediatrics found that children with peanut allergies are being exposed to peanuts at younger ages than recommended. The median age of first exposure and reaction dropped from 22-24 months to 14-18 months over the last decade, suggesting a potential conflict between guidelines and real-world practices.
Researchers identified a role for OX40 in TSLP-induced allergic reactions, finding that blocking its interaction reduced allergic responses in mice and monkeys with asthma. The study suggests OX40-OX40L interactions as a promising therapeutic target for treating allergic diseases.
A protein called RGS13 has been found to suppress allergic responses in mice, including severe anaphylaxis. Researchers believe RGS13 may be a target for developing new drugs to treat certain allergic diseases.
Researchers found mast cells with mutated cell surface receptor in patients with idiopathic anaphylaxis, suggesting a genetic trigger. The mutation may predispose people to idiopathic anaphylaxis and respond to inhibitors targeting the mutated cell surface receptor.
Researchers found that severe respiratory viral infections induce an allergic-type immune response, leading to long-term changes in the airways of mice. Interfering with this process could potentially prevent childhood asthma.
Researchers identified an unusually high rate of severe allergic reactions to cetuximab among patients living in the middle South, with a 22% rate compared to 2% nationwide. The strongest predictor of a reaction was a history of other hypersensitivities.
Researchers have identified Interleukin-12 (IL-12) as a vital molecule for resistance to food allergy. By delivering an allergen in the presence of IL-12, allergic reactions could be brought under control, potentially providing a new treatment option.
Researchers found that even moderate exposure to cat allergen resulted in significantly greater responsiveness among individuals with any sensitization. The study suggests that reduced exposure to cats may be beneficial for allergic individuals, regardless of their specific allergies.
A research team at Virginia Commonwealth University has identified a new biological function for buckyballs, discovering they can block allergic responses in human cell culture experiments. The buckyballs inhibit a basic process in cells that leads to the release of an allergic mediator, preventing mast cells from releasing histamine.
A recent study found that acute allergic-like reactions to newer nonionic contrast agents are rare in children, occurring in only 20 out of 11,306 pediatric IV administrations. The study confirms the safety and better understands the risks of these agents in children.
A study of nearly 600 people with hay fever symptoms found that workers missed an average of one hour of work per week during peak seasons. Diagnostic testing followed by proper treatment may help reduce missed work days.
Research suggests that nitric oxide and nitrite released by pollen grains trigger allergic responses in the nose. The study, funded by the Wellcome Trust, aims to investigate the role of these compounds in human cell inflammation during hayfever.
Researchers found a decline in allergic reactions to insulin, largely attributed to improved purification methods. New continuous subcutaneous insulin infusion (CSII) systems may help reduce these reactions even further.
In a groundbreaking pilot study, researchers at Duke University Medical Center found that children with egg allergies can build up their bodies' resistance to eggs by gradually consuming increased quantities over time. The study's findings show promising results for the development of a meaningful therapy for food allergy sufferers.
A new study found that an investigational therapy reduced allergy symptoms in adults for at least a year after just six injections of the major ragweed allergen, Amb a 1, coupled to a unique DNA sequence. The therapy showed promise in reducing symptoms and improving quality-of-life scores compared to standard immunotherapy.
A recent UK study found that one third of food packaging tested contained latex, with transferable amounts causing severe reactions. The lack of labelling poses a significant risk to individuals with natural rubber latex allergies, who can be exposed to deadly levels of the allergen.
Researchers find that inhibition of eNOS or PI3K provides total protection against anaphylactic shock. The study reveals a new mechanism underlying the condition, with eNOS-derived NO playing a crucial role.
A study by researchers at Mount Sinai School of Medicine identified CD23, a protein in the intestinal tract, as a receptor for IgE associated with allergic reactions. CD23 levels were found to correlate strongly with food-specific IgE in stool samples from patients with allergies.
Researchers found that laboratory animal workers who handled more than 50 rats per day had a two-fold reduction in the risk of developing work-related chest symptoms. This suggests that exposure to laboratory animals can lead to natural immunity, as indicated by high IgG4-IgE antibody ratios.
A new desensitization protocol allows eight patients with clopidogrel hypersensitivity to safely take the medication, reducing risk of blood clots and heart attacks. The study's findings suggest that desensitization can be a viable option for managing allergy symptoms in patients treated with clopidogrel.
Researchers at Cornell University have developed nano-keys that interact with receptors on cell membranes, triggering larger-scale responses within cells. By understanding the role of cell membranes in activating responses, scientists may develop new drug therapies for allergies, high cholesterol, and viral infections.
Children with tree nut allergies can safely eat some nuts as they grow older, according to a new study. Researchers found that 9% of children passed an oral food challenge test, and those with low levels of tree nut antibodies were more likely to succeed.
Research suggests fetal exposure to environmental toxins may contribute to the rising incidence of asthma and allergies. A more detailed two-generation screening is needed to understand the health risks associated with early life immunotoxicity.
A new study by researchers at NIEHS found that over half of the US population is sensitive to one or more allergens. The prevalence of positive skin test responses was significantly higher in NHANES III than in NHANES II, coinciding with an increase in asthma cases between 1980 and 1996.
A new study published in the Journal of Immunology reveals that allergic eye disease can significantly increase the risk of corneal transplant rejection. Researchers found that mice with ocular allergies experienced a dramatic increase in graft rejection, with all grafts rejected in affected mice.
Researchers at Imperial College London have discovered a way to decrease allergic reactions by boosting the levels of CD4+ regulatory T-cells. This breakthrough could lead to new treatments for allergies and autoimmune diseases such as type 1 diabetes and multiple sclerosis.
Researchers from Imperial College London identified a population of T cells that can suppress the proliferation of allergen-reactive T cells in vitro. This finding suggests a potential new approach to treating cat allergy, which has become more frequent in industrialized countries.
Researchers develop injectable treatment that blocks release of histamine, a key chemical causing allergy symptoms. The treatment, GFD, successfully prevents immune cells from reacting to cat allergen in both passively and actively allergic mice.
A study by Emory University researchers found that patients with hypersensitivity reactions to drug-eluting stents had a higher risk of cardiovascular complications, including heart attacks. The research suggests that careful monitoring and timely treatment are essential for patients at risk.
Scientists discovered that birch pollen extracts inhibit a protein that normally blocks allergic reactions, leading to increased sensitivity in allergy-prone individuals.
A study at University College London found that macrophage inflammatory protein-1a plays a crucial role in allergic responses. Drugs blocking MIP-1a's binding to its receptors could help treat ocular allergy and other diseases.
A study published in the Journal of Allergy and Clinical Immunology found that children who eat concentrated peanut products frequently have a lower chance of having their peanut allergy recur. The researchers recommend that these children maintain tolerance by consuming peanut products at least once a month.
A study by Dr. Bart Vanhaesebroeck and his team found that inactivating p110delta in mast cells significantly reduces the allergic response seen in mice. Current therapies targeting symptoms rather than mast cell activation are insufficient, highlighting the need for targeted treatments.
Researchers found that children who received venom allergy shots had significantly fewer life-threatening reactions when restung, even years later. Dr. Rebecca Gruchalla recommends the shots for kids with severe allergic reactions to insect stings, which are responsible for at least 40 fatal stings per year.
A study found that children who received venom immunotherapy for moderate to severe allergic reactions had a lower risk of future reactions, including those with no prior treatment. The therapy was shown to last for up to three and a half years, making it an effective long-term solution for managing bee sting allergies.
A nationwide survey found that approximately 11 million people in the US have food allergies, with shellfish being the most commonly reported severe allergy in adults. The study also revealed that seafood allergies often begin later in life, with a prevalence of at least 2.5% among adults and 0.8% among children.
Researchers recommend performing oral food challenges on children with at least a 50-50 chance of passing, based on IgE antibody levels less than 2.0 kilounits per liter of blood. This guideline aims to reduce unnecessary avoidance of common allergenic foods and improve the accuracy of food allergy diagnosis.
Anaphylactic and anaphylactoid reactions can occur in cancer patients receiving potentially life-prolonging agents, necessitating expert nursing care. Nurses play a critical role in monitoring patients, stabilizing reactions, and providing emotional support.
Researchers found a link between a family of antioxidant-related genes and the allergic response to diesel exhaust particles. The study suggests that people lacking these genes may have difficulty fighting air pollution's harmful effects, with potential treatments being explored.
Researchers developed a novel fluorosugar modifier that prevents leukocyte migration to inflamed skin. This finding offers new hope for treating inflammatory diseases.
Pediatric food allergies affect 6-8% of infants/children, primarily milk. Diagnosis involves a complete work-up, including history, physical, laboratory evaluation, and biopsy. Treatment includes elimination diets, oral challenge testing, and treatment for severe reactions.
Researchers at Johns Hopkins Children's Center and Arkansas Children's Hospital found that certain children with low levels of allergy antibodies may completely lose their peanut allergy. The study suggests that these 'outgrowers' should be retested on a regular basis to determine if they have maintained their tolerance level.