Articles tagged with Allergic Reactions
Use of ACE inhibitors can cause a life-threatening allergic reaction in oral allergy syndrome sufferers, characterized by extreme facial swelling and difficulty breathing. Hay fever sufferers often mistake oral allergy symptoms for food allergies, but it's not a food allergy and can be treated with cooked foods.
Researchers show that mice injected with small dose of bee venom developed immunity to lethal dose, surviving three times longer than control mice. Protection depends on IgE signaling and mast cell activation, suggesting a positive evolutionary pressure for this type of defense.
New studies suggest that immune response to bee venom and other allergens evolved as a defense mechanism, triggering reactions like sneezing and itching. Researchers found that mice developed resistance to deadly doses of venom after exposure to PLA2, an enzyme in bee venom.
Researchers at the University of Notre Dame have made progress toward a treatment for dangerous allergies by designing a special molecule that can out-compete allergens in their race to attach to mast cell receptors. The team has demonstrated the effectiveness of their inhibitor molecule on allergic reactions using animal models.
The University of Minnesota College of Veterinary Medicine has uncovered the role of ORMDL3 in asthma, linking it to inflammatory cell recruitment and airway inflammation. The study found that silencing or over-expressing ORMDL3 in eosinophils reduces inflammation by decreasing integrin expression.
Researchers found that toll-like receptor 4 is activated by fibrinogen cleavage products, which are generated by proteinase enzymes. This activation leads to the production of pro-inflammatory cytokines and the recruitment of immune cells to the airways, resulting in asthma-like symptoms.
Researchers have discovered that two receptors of leukotriene B4 play opposing roles in inflammation, with BLT1 promoting and BLT2 weakening inflammation during an allergic reaction. This finding suggests new approaches to developing anti-asthma and anti-COPD drugs.
Researchers at National Jewish Health have identified Cyp11a1 as a potential target for treatment of food allergies. Blocking the enzyme's activity in sensitized mice prevented diarrhea and inflammation, reducing levels of proteins associated with allergies.
A new international study identified eight behaviors that can reduce anxiety and chances of allergic reactions in passengers with peanut/tree nut allergies on airplane flights. These behaviors include requesting accommodations, wiping tray tables, and avoiding airline pillows and blankets.
Researchers found a once-a-month injection of omalizumab highly effective in treating teens and adults with chronic idiopathic urticaria. The treatment reduced symptoms by 53% after three months, offering a fast and safe alternative to antihistamines.
A new study published in The Journal of Allergy & Clinical Immunology shows that immunotherapy using peanut protein drops can desensitize patients to peanuts by up to 10 times. After 44 weeks, 70% of participants increased their safe consumption level from 3.5mg to 496mg.
A new study funded by NIH suggests that sublingual immunotherapy (SLIT) can reduce the allergic response to peanut in adolescents and adults, increasing their tolerance to peanut. The treatment approach involves placing a small amount of allergen under the tongue under medical supervision.
A recent study published by the American College of Allergy, Asthma and Immunology suggests that pesticides used for water purification can lead to food allergies. The research found a correlation between high levels of dichlorophenol-containing pesticides and weakened food tolerance in individuals.
A study by the American College of Allergy, Asthma, and Immunology found a higher incidence of alpha-gal sensitization in regions with lone star ticks. This allergy causes delayed reactions after consuming red meats, such as beef, pork, and lamb, posing a life-threatening risk.
A new study at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting found that only 15% of patients with anaphylaxis received epinephrine from paramedics. The authors recommend improving paramedic education on epinephrine use for allergic reactions and anaphylaxis.
A study by the American College of Allergy, Asthma, and Immunology found that individuals with severe anaphylaxis are less likely to have seen an allergist in the previous year. Regular care from an allergist can prevent severe allergic reactions and reduce hospitalization rates.
Scientists at National Jewish Health identified a novel target for treating peanut allergies by inhibiting Pim 1 kinase, which increases in the intestines of allergic mice. Treatment with a small molecule inhibitor reduced allergic symptoms, including diarrhea and histamine levels.
A team of scientists at Stanford University and the University of Bern have discovered a mechanism for destroying key allergy-inducing complexes using a new inhibitor called DARPin E2-79. This discovery could lead to rapid and potent interventions for acute allergic reactions, including anaphylactic shock.
A NIH study found a bacterial protein in common house dust may worsen allergic responses to indoor allergens, leading to asthma. Researchers discovered flagellin boosts allergic reactions in mice with asthma, suggesting cleaning could reduce symptoms by removing bacteria.
A new study found that 70% of reported cases receive a physician's diagnosis for their child's food allergy, but only 1 in 5 receives an oral food challenge test. Lower-income and minority households are more likely to have undiagnosed food allergies, with 32% not receiving diagnostic testing.
Researchers at Tel Aviv University have identified a protein group, known as the Rab family, that regulates protein distribution and is involved in triggering allergic reactions. This discovery could lead to the development of targeted drugs that prevent allergic reactions before they start.
Researchers discover tick bites trigger alpha-gal antibodies in patients, leading to delayed anaphylaxis after eating red meat. The study highlights a previously unknown food-induced severe allergic reaction due to a carbohydrate, not protein.
A new study funded by the NIH suggests that oral immunotherapy can help children with egg allergies overcome their condition. The trial found that 55% of participants who received daily egg white powder doses were able to pass an oral food challenge after 10 months, and 75% were able to do so after 22 months.
Researchers at UNC School of Medicine found that eating small amounts of egg every day for months lowered the threshold for allergic reactions in 75% of children with egg allergies. After two years on treatment, 28% were able to incorporate egg into their regular diets.
A federally funded study found that oral immunotherapy can retrain the immune system to tolerate eggs in children with egg allergies. In a 10-month study, 35 of 40 children treated with escalating doses of egg powder experienced improvement, with 11 achieving complete long-term elimination of egg-related allergic reactions.
A recent study by the Consortium of Food Allergy Research (CoFAR) found that young children with milk and egg allergies experience severe reactions at a higher rate than previously believed. The study also revealed that some caregivers are hesitant to give epinephrine, a medication that reverses the symptoms of such reactions. Nearly 1...
A recent study found that young children with food allergies experience almost one allergic reaction per year, despite parental instructions on food avoidance. The study highlights the importance of educating parents and caregivers about avoiding allergenic foods and using epinephrine to treat severe reactions.
A study found that over 70% of preschool children with food allergies experienced significant reactions, while caregivers administered epinephrine only 30% of the time. The researchers highlight the need for increased vigilance and education on treating food allergies.
A case study reported a severe anaphylactic reaction to bee pollen in a woman with seasonal allergies. The authors warn healthcare providers and patients about the potential risk of allergic reactions to bee pollen supplements, particularly among individuals with no known allergy history.
Blood testing for food sensitivity is increasingly common, but its limitations and potential misuse have been emphasized by European and American allergy and immunology societies. Physicians should caution patients about the controversy surrounding IgG4 testing and advise them on alternative diagnostic approaches.
Scientists at The University of Nottingham have identified a new molecule DC-SIGN that plays a role in damping down the body's allergic response to house dust mites. This discovery could pave the way for developing new therapies or treatments for preventing allergies.
Scientists at La Jolla Institute identify histamine releasing factor molecule as a promising target for developing new treatments for asthma and allergies. The discovery provides new insights on the role of HRF in promoting asthma and some allergies, including its receptor.
A study by researchers at the Medical College of Wisconsin suggests a possible link between norovirus and food allergies. The team found an immunoglobulin E response to egg protein in mice infected with norovirus, indicating a potential connection between gastrointestinal viruses and allergic diseases like asthma.
Researchers at University of Notre Dame engineer a new way to inhibit allergic reactions by introducing a special molecule that outcompetes allergens for mast cells. This approach prevents allergic reactions from occurring in the first place without suppressing the entire immune system.
Researchers have developed a method to create tolerance in the immune system by attaching peanut proteins onto blood cells and reintroducing them. This approach has shown promise in preventing life-threatening allergic reactions. By tricking the immune system, researchers hope to target multiple food allergies at once.
Researchers developed a cell-based test that can classify chemicals as sensitizing or non-sensitizing, predicting the strength of allergic responses. This alternative to animal testing aims to reduce suffering from skin conditions such as eczema.
Misdiagnosis of spider bites is delaying appropriate treatment for common conditions, such as methicillin-resistant Staphylococcus aureus and Lyme disease. The use of antivenom is also putting patients at risk due to a lack of well-conducted research and conflicting animal study results.
A study investigated the role of uncertainty in human associative learning, finding that people pay more attention to unfamiliar cues. The researchers discovered that when a cue's reliability is uncertain, it becomes more predictive and leads to faster learning.
A new study reveals apparent gaps in restaurant staff's knowledge of food allergy, with common allergens not separated from other foods in one out of three kitchens. Despite lacking formal training, 80% of respondents reported confidence in providing safe meals for food-allergic customers.
Researchers identified heparin as the underlying mechanism that initiates the production of bradykinin, contributing to swelling, anaphylactic, and inflammatory symptoms associated with aberrant mast cell activity. This discovery provides a new strategy for treating allergic diseases by blocking bradykinin or factor XII activity.
The NIH-sponsored expert panel issued comprehensive guidelines to diagnose and manage food allergy, providing standardized recommendations for clinicians. The guidelines aim to improve the diagnosis and treatment of food allergy, which affects millions of Americans.
Researchers at Johns Hopkins Medicine have discovered a method for desensitizing the immune system to certain food proteins, potentially alleviating symptoms for millions suffering from severe allergies. The discovery involves targeting a specific receptor on immune cells using sugar-modified protein.
Researchers found that vitamin D can reduce the production of a protein driving an allergic response in cystic fibrosis patients and increase production of proteins promoting tolerance. The findings support a potential clinical trial to prevent or treat Allergic Bronchopulmonary Aspergillosis (ABPA) in these patients.
Research at LSU Health Sciences Center found that vitamin D can reduce allergic responses to Aspergillus fumigatus, a common mold that causes severe allergic symptoms in asthmatics and Cystic Fibrosis patients. Vitamin D also increased production of proteins promoting tolerance.
The NIH has renewed its food allergy research program, the Consortium of Food Allergy Research (CoFAR), with a $29.9 million grant for five more years. The program will expand to include research on genetic causes underlying food allergy and studies of eosinophilic gastrointestinal diseases.
Pfizer's pre-clinical study on recombinant factor Xa therapy and engineered recombinant factor VIIa molecule shows promising results in restoring hemostasis. The company is committed to advancing hemophilia care through its pipeline and research initiatives.
A large international study found that a burger diet may boost children's risk of asthma and wheeze, particularly in developed nations. Conversely, a Mediterranean diet rich in fruits, vegetables, and fish appears to reduce this risk. The study, published in Thorax, analyzed data from over 50,000 children aged 8-12 from 20 countries.
A new technology developed by MIT chemical engineer Christopher Love can analyze individual immune cells taken from patients, allowing for precise measurement of the cells' response to allergens. This approach enables faster and more reliable food allergy diagnoses than current tests.
A systematic review of food allergies found limited evidence on diagnosis, management, and prevention due to lack of uniformity in diagnostic criteria. Current treatments only target symptoms, not the underlying allergies.
A new study by Stanford researchers highlights the need for standardized criteria in diagnosing food allergies due to differing definitions and inconsistent treatment approaches. This could lead to misdiagnosis and unnecessary anxiety for patients with food intolerance, while also potentially overdiagnosing food allergies.
Families with food-allergic children face a life of constant vigilance and fear. Dr. Mary Klinnert's research aims to understand coping strategies and develop tools to support families.
Researchers at Johns Hopkins Children's Center report encouraging results in children with egg allergies who consume increasingly higher doses of egg protein. The study found that more than half of the children could tolerate 5 grams of eggs without an allergic reaction, experiencing mild to moderate symptoms.
The Inner City Asthma Consortium, funded by the NIH, investigates novel treatments and causes of asthma in urban children. Key studies include evaluating environmental factors influencing immune system development and exploring anti-IgE therapy to decrease viral-induced seasonal asthma exacerbations.
A small study found that 18 children with severe milk allergies could safely consume milk and dairy products, with reactions decreasing over time. Regular exposure to milk was needed to maintain tolerance.
The US EPA has awarded a grant to investigate how food allergies are initiated, with potential breakthroughs in predicting allergic reactions to genetically engineered foods. The study aims to identify key immune factors leading to food allergies, affecting approximately 3 million children in the US.
A study from Northwestern University found that Cremophor-based paclitaxel caused life-threatening allergic reactions in 38% of patients, leading to 109 deaths. The solvent is believed to trigger severe reactions, even in patients with premedication.
A study of over 8,000 people found that higher blood levels of folic acid were associated with fewer reported allergies, less wheezing, and a lower likelihood of asthma. The researchers recommend further studies to confirm their results and establish safe doses.
Research found that tiny mites living on Madagascar hissing cockroaches decrease the presence of molds, reducing allergic responses. The mites eat saliva and debris, eliminating material that fosters mold growth on the insects' bodies.
A clinical study found that a combination of steroids and antihistamines can alleviate Plavix allergy symptoms in 88% of patients, enabling them to continue treatment. The study's findings have significant implications for cardiac patients with stents, who require long-term Plavix use.
Scientists have identified a new role for lung epithelial cells in detecting airborne antigens and triggering allergic responses. The discovery suggests that targeting Toll-like receptors may lead to novel treatments for asthma and other allergic diseases.