Researchers at UBC have successfully transplanted an enzyme-converted kidney into a brain-dead recipient, showing promise for universal donor organs in transplantation. The breakthrough uses special enzymes to remove blood-type antigens, making it possible to use mismatched organs from deceased donors.
SourceUniversity of British Columbia·JournalNature Biomedical Engineering·TypeExperimental study·DateOct 3, 2025
Blum investigates how the immune system interprets what we eat, exploring mechanisms of oral tolerance and signaling that help our bodies tolerate most foods. Her research could enable new immunotherapy strategies for preventing or treating food allergies.
Researchers have engineered a monoclonal antibody that blocks allergic reactions against common pollen when applied inside the nose of mice, providing new hope for hay fever sufferers. The treatment, known as a 'molecular shield,' acts immediately and locally at the lining of the nose to prevent IgE antibodies from being activated.
SourceFrontiers·JournalFrontiers in Immunology·TypeExperimental study·DateJul 11, 2025
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Researchers at Tulane University developed a handheld TB test inspired by the bombardier beetle's natural defense mechanism. The ASTRA device requires only a drop of blood and delivers same-day diagnoses without need for laboratory or trained staff, outperforming traditional tests in detection of TB with HIV co-infection.
SourceTulane University·JournalNature Biomedical Engineering·DateJun 27, 2025
Scientists at the Institute for Systems Biology have discovered how T cells respond to infections like COVID-19, revealing a predictable pattern based on genetic interactions. This breakthrough could lead to improved treatments and vaccine strategies for diseases such as cancer and autoimmune disorders.
SourceInstitute for Systems Biology·JournalNature Communications·DateFeb 9, 2025
Researchers found that neoself-antigens, presented on MHC-II, induce an immune response and lead to autoimmunity in lupus patients. EBV reactivation increases the presentation of these antigens, triggering T cell activation and autoimmune disease development.
SourceImmunology Frontier Research Center (IFReC) - Osaka University·JournalCell·TypeExperimental study·DateSep 13, 2024
Researchers found that STAP-1 plays a crucial role in activating T cells, which are white blood cells critical to defending against infections and maintaining overall health. The study suggests that STAP-1 may be involved in the development of immune disorders such as multiple sclerosis and asthma.
SourceHokkaido University·JournalThe Journal of Immunology·TypeExperimental study·DateMar 11, 2024
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Researchers have discovered a previously unknown mechanism behind immune tolerance, where B cells teach T cells to ignore the body's own proteins. This failure can lead to autoimmune diseases such as Multiple Sclerosis-like Neuromyelitis optica.
SourceTechnical University of Munich (TUM)·JournalNature·TypeExperimental study·DateFeb 21, 2024
Researchers at Institute for Systems Biology have made a breakthrough discovery about T cells, finding that the genetically encoded T-cell receptor sequence determines a T cell's function. This fundamental discovery has huge potential for developing custom immune responses to specific antigens.
SourceInstitute for Systems Biology·JournalCell Reports·TypeRandomized controlled/clinical trial·DateOct 25, 2023
Researchers from Osaka University found that RNase treatments can either enhance or weaken immune activation in systemic autoimmune diseases. The study suggests that the composition of immune complexes plays a crucial role in determining the effectiveness of RNase treatment.
SourceOsaka University·JournalJCI Insight·TypeExperimental study·DateJul 18, 2023
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
SourceUniversity of Huddersfield·JournalAdvanced Healthcare Materials·TypeImaging analysis·DateJun 12, 2023
Researchers at the University of Zurich have developed a new immunotherapy strategy to eliminate fibroblasts in targeted manner, reducing lung and liver fibrosis in mice. The treatment triggers an immune response via cytotoxic T-cells, eliminating activated connective tissue cells while leaving resting cells undamaged.
SourceUniversity of Zurich·JournalCell Stem Cell·TypeExperimental study·DateSep 15, 2022
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