Articles tagged with Type 2 Diabetes
Researchers analyzed FDA and patent records to find that manufacturers extended market exclusivity by filing additional patents after FDA approval and obtaining patents on delivery devices. This resulted in a median of 16 years of protection, surpassing other top-selling small-molecule drugs.
A new USC study identifies two metabolites that may predict which young Latino people are most likely to develop prediabetes. The research found that allylphenol sulfate and caprylic acid were the most predictive of prediabetes when combined with other risk factors.
Researchers are developing a bioengineered pancreas-like tissue using innovative biomaterials and engineered cells. The goal is to implant these cell-laden scaffolds into patients who need help managing their glucose levels.
A study of 54,000 participants found that diabetes was associated with an elevated risk of colorectal cancer. The association was attenuated for those who completed colonoscopies, highlighting the potential benefits of preventative screening.
A new study found that curtailing sleep by 90 minutes for six weeks increased insulin resistance in women, particularly postmenopausal women. Insulin resistance was also linked to an increased risk of developing type 2 diabetes.
Researchers found that people with overweight or obesity who took semaglutide for over 3 years had a 20% lower risk of heart attack, stroke, or death from cardiovascular disease. The study showed significant weight loss and improved cardiovascular outcomes in adults without diabetes.
Researchers from Helmholtz Munich discovered that GIP decreases body weight by interacting with specific inhibitory neurons in the brain, offering a revolutionary approach to patients worldwide. The study reveals the underlying molecular mechanisms of GIPR:GLP-1R co-agonists and their potential as next-generation anti-obesity drugs.
A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a new mechanism for insulin regulation in type 2 diabetes. The preclinical discovery provides a new chemical tool for probing the biology of diabetes and could lead to better treatments.
A preclinical study by Weill Cornell Medicine researchers reveals that activating a pathway to promote cell division can expand insulin-producing cells without impairing their function. The study's findings support the concept that beta cell mass can be expanded without compromising function.
A large US study found that persistent tobacco use and prediabetes significantly increase the risk of stroke in young adults without other cardiovascular risk factors. Quitting smoking is crucial for preventing stroke and heart disease, especially among those with prediabetes.
Two preliminary studies presented at American Heart Association’s Scientific Sessions 2023 found a potential association between regular marijuana use and an increased risk of heart failure, heart attack, and stroke. Daily marijuana use was associated with incident heart failure in a study involving over 150,000 adults in the US.
Research highlights significantly higher heart attack death rates among American Indian and Alaska Native adults, particularly at younger ages. The study suggests that factors like limited healthcare access, socioeconomic conditions, and restricted health insurance coverage may contribute to these disparities.
A six-month produce prescription program improved hemoglobin A1c levels, indicating better blood sugar control. Participants also showed improved food security and nutrition security.
A new Cochrane review has found that human insulin can be stored at room temperature for up to six months without losing potency. This breakthrough research offers hope to millions of people living with diabetes in low- and middle-income countries, particularly those with limited access to refrigeration or healthcare.
A new study from Tulane University found that frequent salt consumption is associated with a higher risk of developing Type 2 diabetes. The study surveyed over 400,000 adults and found participants who regularly added salt had a 13% to 39% increased risk of developing the disease compared to those who never or rarely used salt.
Researchers at University of British Columbia find a direct link between high insulin levels and pancreatic cancer, highlighting the importance of keeping insulin levels within a healthy range. The study suggests that excessive insulin overstimulates pancreatic acinar cells, leading to inflammation and precancerous cell development.
A new study published in JAMA Network Open found time-restricted eating to be safe and effective for people with Type 2 diabetes, helping them lose weight and control blood sugar levels. Participants who followed the time-restricted eating plan had an easier time sticking to it than those on a calorie-reduced diet.
A six-month randomized clinical trial involving 75 adults with type 2 diabetes found that time-restricted eating was effective for weight loss. This novel dietary approach lowered hemoglobin A1c levels without calorie counting, offering potential for improved blood sugar management and overall health.
A new study published in The American Journal of Clinical Nutrition found that consuming more red meat is associated with a higher risk of developing type 2 diabetes. Replacing red meat with plant-based protein sources like nuts and legumes may reduce this risk.
A large Danish study finds that migrants typically receive inferior care for type 2 diabetes, particularly in monitoring and controlling biomarkers. Migrants from Somalia face the worst care, with elevated risks across all indicators.
A new study by Klick Labs reveals that AI technology can screen for Type 2 diabetes using six to 10 seconds of a person's voice, with high accuracy rates. The research used acoustic features to analyze recordings from over 18,000 participants and identified significant vocal variations between individuals with and without the condition.
New research reveals that disrupted energy production in the kidneys contributes to progressive kidney disease in diabetes. Monitoring urinary lactate levels may help predict prognosis and guide management for diabetic kidney disease.
A new study identifies children at high risk of developing type 2 diabetes and strategies for prevention, including anti-obesity medication and lifestyle changes. Higher levels on certain diabetes screening tests and worsening obesity may better predict diabetes risk in children.
Researchers from the University of Virginia Health System have made significant discoveries about the genetic influences on fatty acid metabolism in diverse populations. The study found broad similarities among groups but also notable differences, highlighting the need for genetic studies in diverse groups.
A new American Heart Association advisory introduces the concept of cardiovascular-kidney-metabolic (CKM) syndrome, which affects nearly every major organ. The approach highlights the importance of screening for CKM-related conditions and addressing social factors to prevent progression.
Research reveals that low muscle mass is associated with a two-fold risk of death from cardiovascular disease in individuals with diabetes. The study found that body composition, not just weight loss, plays a crucial role in managing weight in people with diabetes.
A recent study demonstrated that lasting remission of type 2 diabetes is feasible in the real-world setting through a low-calorie diet and weight loss maintenance. The DiRECT trial showed significant weight loss and remission rates, even after five years, with participants who maintained their weight losing type 2 diabetes permanently.
Researchers analyzed UK data to identify patterns of illnesses in individuals leading up to a type 2 diabetes diagnosis. High blood pressure, respiratory tract infections, heart conditions, and asthma were commonly observed, suggesting earlier diagnosis may be possible.
Researchers found tirzepatide equally effective in treating young-onset and late-onset type 2 diabetes, improving HbA1c levels and weight. The drug also showed similar benefits in cardiometabolic markers such as waist circumference and blood pressure.
A new study has identified commonly prescribed antibiotic, antipsychotic and prokinetic drugs as being associated with a higher risk of sudden cardiac arrest (SCA) in individuals with type 2 diabetes. Low fasting blood sugar levels are also linked to SCA, a leading cause of death.
The Second International Consensus Report on Precision Diabetes Medicine addresses the need for personalized approaches in diabetes care. The report highlights the potential of precision medicine to improve prevention and treatment outcomes by accounting for disease heterogeneity.
New research finds that cigarette smoking increases the risk of developing type 2 diabetes by affecting various metabolites in the bloodstream. A unique metabolic signature, identified through analysis of over 93,000 UK Biobank participants, can predict which smokers are more likely to develop the condition.
A UK study found that emergency department screening for type 2 diabetes could identify tens of thousands of previously undiagnosed cases every year. The study used the glycated haemoglobin test to screen 1,388 patients, yielding an additional 9% of type 2 diabetes cases and 30% of prediabetes cases.
Diagnosed with type 2 diabetes at age 30 can lead to a reduced life expectancy of up to 14 years due to complications such as heart attack, stroke, and cancer. The analysis found that every decade of earlier diagnosis was associated with about four years of reduced life expectancy.
Studies show that people with metabolically healthy obesity (MHO) have a 50% increased risk of coronary heart disease, despite not exhibiting metabolic complications. This raises questions about the validity of the MHO concept.
In a randomized clinical trial, weekly tirzepatide showed greater reductions in HbA1c levels and body weight compared to prandial insulin as an additional treatment in people with inadequately controlled type 2 diabetes. The study also found less hypoglycemia with tirzepatide.
Nick Burton's research aims to identify bacteria that influence insulin production and signaling, with the goal of finding new therapeutic strategies for Type 2 diabetes. Preliminary results from a small-scale pilot study are promising, suggesting that certain bacteria may play a role in regulating insulin levels.
A worldwide audit of testosterone deficiency in men with type 2 diabetes found that testosterone replacement therapy improves glycaemic control for up to 2 years. The study suggests that the ongoing effect of testosterone on insulin resistance and fat reduction contributes to the improvement in blood sugar levels.
A real-world study of over 23,000 adults with type 2 diabetes found that semaglutide significantly improved blood sugar control and weight loss for up to 3 years. The study showed that patients who had never taken a GLP-1 RA or those with higher adherence achieved more pronounced reductions in blood sugar levels and weight loss.
A study published in Diabetologia found that daily dark tea drinkers had a 53% lower risk of prediabetes and a 47% reduced risk of type 2 diabetes compared to non-drinkers. Drinking dark tea may help improve blood sugar control by increasing glucose excretion in urine and reducing insulin resistance.
A recent US study has found that food insecurity significantly increases the risk of severe hypoglycaemia in adults with diabetes. The study, which analyzed data from over 1,000 participants, revealed that those experiencing food insecurity were nearly twice as likely to experience severe hypoglycaemic events.
A small Dutch study found that exposure to natural light improved blood sugar control and nutrient use in individuals with type 2 diabetes. The study showed that participants experienced better blood sugar levels, increased fat as an energy source, and improved clock gene expression when exposed to natural light.
Researchers found that natural blood loss through menstruation may impact women's blood sugar control, leading to delayed diagnosis of type 2 diabetes. A lower HbA1c threshold for premenopausal women could help catch T2D earlier, improving health outcomes.
A pharmacist-led intervention has been shown to improve medication adherence among Latinos with type 2 diabetes, leading to significant reductions in blood sugar levels. The study found that patients who interacted with a pharmacist had an average 0.45% reduction in blood sugar, while systolic blood pressure remained unchanged.
A pharmacist-led diabetes control intervention was found to improve glycemic control and reduce the risk of complications among Hispanic adults with type 2 diabetes. The study, which included 931 participants, suggests that this type of intervention may be an effective strategy for improving health outcomes in this population.
A new quality improvement study shows a primary care intervention reduced the number of older adult patients at risk for hypoglycemia by almost 50%. The tool facilitated shared decision-making and improved patients' daily lives, leading to de-escalation of diabetes medications causing hypoglycemia in 20% of participants.
A study by the DZD found that losing abdominal fat can reverse prediabetes and reduce the risk of developing type 2 diabetes. Participants who achieved remission showed improved insulin sensitivity and reduced markers of kidney damage, while maintaining similar weight loss as non-responders.
A new study reveals that consanguinity may increase the risk of common diseases such as type 2 diabetes and post-traumatic stress disorder. The research analyzed genomic data from diverse groups to investigate the relationship between autozygosity, or genetic relatedness, and disease prevalence.
Researchers have identified a mechanistic link between zinc levels in humans and the risk of type 2 diabetes and fatty liver disease. Genetic analysis revealed that zinc plays a crucial role in insulin production and glucose metabolism, with circulating zinc levels associated with reduced diabetes risk.
A study of over 1 million Swedish men found that high blood pressure at age 18 was associated with a higher risk of major cardiovascular events, including heart failure, heart attacks, and strokes. Early intervention for hypertension may be critical to reducing later cardiovascular events.
A new meta-analysis of 22 clinical trials found that tirzepatide is more effective than semaglutide in controlling blood sugar levels and promoting weight loss. The study showed that higher doses of tirzepatide resulted in greater reductions in HbA1c levels and body weight compared to semaglutide.
The study found that type 1 diabetes incidence slightly increased overall, while type 2 diabetes significantly increased after the COVID-19 pandemic. Non-Hispanic Black and Hispanic youth were disproportionately affected.
A new study reveals that newer diabetes treatments such as SGLT2-Is and GLP1-RAs offer no cardiovascular or renal benefits for Black populations. The research emphasizes the need for targeted access to care and treatment for those most at risk, considering racial disparities in healthcare.
Research finds that hyperglycemia-induced hypoxia disrupts pancreatic beta-cell function, leading to impaired insulin secretion. Overexpression of BHLHE40 impairs insulin secretion by reducing MAFA expression.
A new model for producing human brown fat cells in vitro has been developed, providing a potential solution for treating obesity and type 2 diabetes. The researchers identified key cellular signaling cues that lead to brown adipocyte formation and successfully reproduced this process in human pluripotent stem cells.
Researchers at Helmholtz Munich discovered how exercise influences muscle function, immune cells, and metabolism in conditions like obesity and type 2 diabetes. They found that regulatory T cells play a critical role in controlling muscle function and regeneration.
A new study published in Diabetologia reveals that morning and afternoon physical activity are associated with a lower risk of developing type 2 diabetes. The researchers found that each 1-unit increase in MET-hour physical activity was linked to a 10% reduction in risk, with the association being most pronounced in the morning and aft...
Research shows a significant decline in death rates after a first heart attack for individuals without diabetes and those with type 2 diabetes. However, this trend is absent in people with type 1 diabetes. The study suggests that improved standard care following a heart attack may contribute to the observed differences.
The Louisiana Clinical & Translational Science Center has received a $1.3 million NIH grant to support the creation of a network of data warehouses for healthcare providers and researchers in Baton Rouge. The project aims to enhance research capacity, address health care disparities, and improve patient engagement.
A randomized controlled trial found that high-protein and normal-protein diets were both effective in improving glucose control, weight loss, and body composition in adults with Type 2 diabetes. The study suggests that individuals can choose a dietary pattern that suits their preferences while still achieving significant health benefits.