Articles tagged with Type 2 Diabetes
An ongoing clinical trial found that older overweight and obese adults with Type 2 diabetes can improve glucose control, body composition, and physical function through healthier diets and regular exercise. The study's results suggest that lifestyle changes may be a viable treatment option for this age group.
Researchers at Lund University developed a new method to predict type 2 diabetes risk by detecting epigenetic changes in specific genes through a simple blood test. The study found that higher DNA methylation levels were associated with increased insulin secretion and lower disease risk.
A recent study by University of Montreal researchers has discovered a common genetic defect in beta cells that may lead to the loss of insulin production in both type 1 and type 2 diabetics. The findings suggest that genetics play a critical role in beta cell survival, with fragile cells being more prone to damage and disease.
A new study found a significant association between high serum omega-6 polyunsaturated fatty acid concentrations and a lower risk of developing type 2 diabetes. Linoleic and arachidonic acids showed similar protective effects, while gamma-linolenic and dihomo-γ-linolenic acids were linked to a higher risk.
A new study from Newcastle University found that people who reverse their Type 2 diabetes and keep their weight down remain free of the condition. The research shows that even patients with diabetes for up to 10 years can reverse their condition by removing fat from their pancreas.
A new study discovered that a common genetic defect in beta cells may underlie both form of diabetes. The research found that genetics is critical for the survival of beta cells, and a genetic predisposition for fragile beta cells may lead to diabetes development.
Researchers found that replacing saturated fat with polyunsaturated fat slows diabetes progression in people with prediabetes whose muscles do not take up glucose properly. In contrast, reducing saturated fat had no effect on progress for those with liver-produced excess glucose.
Patients with maturity-onset diabetes of the young (MODY1) benefit from therapies targeting a specific pathway regulating insulin secretion, not oral medications linked to beta-cell destruction. Research suggests MODY1 patients may become dependent on insulin injections sooner due to cellular stress levels.
A study published in Diabetologia found that bariatric surgery significantly improved type 2 diabetes remission rates compared to an intensive lifestyle and medical intervention. Patients with mild-to-moderate obesity experienced greater weight loss, improved glucose control, and reduced need for diabetes medications after RYGB.
A new article explores the effect of frailty on diabetes in older people, suggesting a regressive course with increased risk of hypoglycemia. The review highlights the importance of regular medication reviews and gradual reduction or withdrawal of hypoglycemic medications.
A randomized controlled trial found that CPAP did not significantly improve glycemic control in patients with type 2 diabetes and obstructive sleep apnea. Researchers suggest that OSA may play a bigger role in the development of diabetes than its control, and that adherence to CPAP treatment may be a challenge.
Researchers at Lund University discovered a link between nicotine and type 2 diabetes, finding that nicotinic acetylcholine receptors influence insulin release. A genetic alteration affecting these receptors increases the risk of developing type 2 diabetes.
Research suggests CPAP improves insulin sensitivity and decreases inflammatory proteins, lowering HbA1c levels and cardiovascular disease risk. Patients with OSA and type 2 diabetes who used CPAP showed significant improvements in glycemic control, inflammation and cardiovascular risk factors.
A UC Riverside-led study links thirdhand smoke exposure to insulin resistance and hyperglycemia in mice, a precursor to type 2 diabetes. Exposure to toxins from second-hand smoke causes oxidative stress, damaging proteins and DNA, leading to insulin resistance.
A study found that degludec/liraglutide was associated with greater HbA1c level reduction, weight loss, and lower hypoglycemia rates compared to glargine. The medication also had more nonserious gastrointestinal adverse events.
Researchers found that mitochondria in brain cells rapidly change shape and function in response to high blood sugar levels, affecting peripheral tissue functions. The study suggests that alterations in this mechanism may be crucial for type 2 diabetes development.
A new randomized controlled study found that adults with prediabetes who followed a nationally-available weight management program with a prediabetes-specific component, Weight Watchers, lost significantly more weight and experienced better blood glucose control than those following a self-initiated program. The study suggests that nat...
A new study found an important relationship between proteins secreted by the heart and obesity, glucose intolerance and insulin resistance. Higher levels of cardiac natriuretic peptides and lower clearance receptor in adipose tissue suggest a potential new approach to treating metabolic disorders.
Researchers developed a screening algorithm using electronic health records to identify people with undiagnosed Type 2 diabetes, uncovering previously unknown risk factors such as sexual and gender identity disorders and intestinal infections. The tool showed promise in detecting 400,000 potential cases nationally.
Researchers have found an epigenetic mechanism implicated in the regulation of blood sugar, with the TXNIP gene associated with diabetes mellitus type 2 and poor glucose control. The study's results could help identify patients at risk of developing diabetes and develop new therapies.
Research published in Diabetologia reveals that each extra hour of daily sedentary time is associated with a 22% increased risk of developing type 2 diabetes. Participants with type 2 diabetes spent more time sedentary, highlighting the importance of reducing sedentary behavior in diabetes prevention.
A recent study by DZD researchers found that height has a significant impact on the mortality from certain common diseases. Tall people have a lower risk of cardiovascular disease and type 2 diabetes, but a higher cancer risk. The study suggests that increased height may be related to overnutrition during growth stages.
A new report identifies several forms of testing to measure the risk of heart disease in patients with type 2 diabetes. These tests include exercise testing and coronary calcium scanning, which can detect silent ischemia and identify the highest-risk patients for more effective treatments. The study suggests that a significant proporti...
A community lifestyle intervention program reduced cardiovascular disease risk in diabetes patients by 9.6%, fasting glucose by 9%, body mass index by 3.7% and systolic blood pressure by 5.7%. Participants experienced significant reductions after completing 16 two-hour classes on healthy living basics.
Research published in Diabetologia found that women with one sleep disorder have a 47% increased risk of developing type 2 diabetes. The risk increases to four times for those with multiple sleep disorders. The study highlights the importance of good sleeping patterns for preventing diabetes.
A new study found that women who began their menstrual cycles at a younger age are at greater risk of developing gestational diabetes, with those starting at age 11 having a 39% higher risk. Early menarche may also be associated with obesity and hormone imbalances in adulthood.
A meta-analysis found a significant association between antipsychotic treatment in youth and an increased risk of type 2 diabetes. The study included 13 studies and analyzed the cumulative risk of diabetes and its incidence rate per patient year of antipsychotic exposure.
Researchers used high-resolution imaging to identify structural defects in bones of people with type 2 diabetes, which can weaken them and increase the risk of fractures. The study found that individuals with diabetes have greater porosity in their cortical bone component, a key factor in fracture risk.
A new study found that low stress resilience in late adolescence is associated with an increased risk of developing type 2 diabetes in adulthood. The study, published in Diabetologia, followed 1.5 million Swedish male conscripts and found that those with lower stress resistance were 51% more likely to develop diabetes.
Reducing sugar content in sugar-sweetened drinks by 40% over 5 years could prevent 1.5 million cases of overweight and obesity in the UK and 300,000 cases of diabetes. This reduction would lead to a significant decrease in energy intake and body weight, resulting in a substantial decrease in these health issues.
A longitudinal study of 3882 bariatric surgery patients found sustained weight loss for at least four years post-surgery. The study also revealed significant improvements in pre-existing type 2 diabetes and hypertension, as well as a reduced risk of obesity-related co-morbidities.
A new study found that bariatric surgery can significantly improve type 2 diabetes and reduce high blood pressure. The procedure also prevents 80,000 cases of hypertension, 40,000 cases of type 2 diabetes, and 5,000 heart attacks over a four-year period.
Researchers at Oxford University are exploring the link between metabolism and inflammation in metabolic diseases, including type 2 diabetes and cardiovascular disease. The projects aim to deliver effective treatments and prevention strategies, addressing a global health problem affecting over 400 million people worldwide.
A Kaiser Permanente study found that a lifestyle intervention program increased the likelihood of meeting postpartum weight goals by 45% for women with gestational diabetes. The program also boosted vigorous-intensity physical activity by an average of 15.4 minutes per week.
A large US study found that over half of patients with controlled type 2 diabetes receive more tests than recommended guidelines, leading to overtreatment and potential patient harm. The study also highlights fragmented care coordination as a possible reason for repeat tests.
Women with Type 2 diabetes face increased cardiovascular disease risk, including earlier heart attacks, higher mortality rates, and reduced access to treatments. Lifestyle changes like improved diet and exercise may help reduce this risk, but more research is needed to understand these differences and improve health equity.
Researchers have identified two coffee compounds, cafestol and caffeic acid, that contribute to the health benefit of drinking three to four cups of coffee per day in preventing type 2 diabetes. Cafestol increases insulin secretion and glucose uptake in muscle cells, matching the effects of a currently prescribed antidiabetic drug.
Researchers at Newcastle University found that Type 2 diabetes is caused by excess fat in the pancreas, which can be removed through weight loss. Losing just one gram of pancreatic fat can reverse the condition and restore normal insulin function, regardless of body weight or method of weight loss.
A recent study published in Annals of Internal Medicine found that breastfeeding significantly lowers the risk of developing type 2 diabetes after gestational diabetes. Women who exclusively or mostly breastfed for at least two months after giving birth were half as likely to develop type 2 diabetes within two years after delivery.
Researchers at Boston University School of Medicine have identified Th17 cells and Th1 as key players in obesity-associated type 2 diabetes. The study reveals a biomarker that can predict the development of Type 2 diabetes in 75% of people with obesity, offering new potential targets for prevention.
Aging mice with a new type of diabetes have high levels of immune cells called T regulatory cells in their fat tissue, leading to insulin resistance. Blocking these cells may hold the key to treating this age-related form of diabetes.
Researchers at the University of Exeter have created a genetic test to identify young adults at risk of type 1 diabetes. The new tool combines genetic variants to provide a single score, helping doctors diagnose and treat patients more effectively.
Researchers found obesity and Type 2 diabetes negatively impact bone health, while exercise prevents weight gain, diabetes, and increases bone strength. This study informs interventions to improve bone health in individuals with obesity and Type 2 diabetes.
Higher levels of urinary potassium excretion were linked with slower declines in kidney function and lower cardiovascular complications among patients with type 2 diabetes. A diet rich in potassium may help protect heart and kidney health, according to the study.
Virginia Tech researchers will investigate how people on the brink of developing Type 2 diabetes value the future, aiming to improve self-regulation and prevent medical complications. The study, funded by $2.4 million grant, applies approaches developed in addiction research to develop a behavioral treatment.
A new study found that short bursts of high-intensity exercise improved cholesterol, blood sugar, and weight among Type 2 diabetes patients. Researchers compared the effects of 30 minutes of lower-intensity exercise to three months of high-intensity exercise in 10-minute bursts, finding a significant difference in outcomes.
Researchers found that short bursts of light physical activity, such as walking breaks or desk exercises, reduced systolic blood pressure by 10 and 12 points respectively. This study provides evidence for the benefits of breaking sedentary behavior in people with type 2 diabetes.
A new class of type 2 diabetes drugs, SGLT2 inhibitors, have been shown to significantly reduce hospitalizations and deaths from heart failure. The EMPA-REG trial found that patients treated with the drug experienced significant reductions in blood sugar, blood pressure, weight loss, and major hospitalizations for heart failure.
Researchers have identified genetic markers associated with individual risk of type 2 diabetes, providing new insights into the biological processes underlying the disease. The study's findings suggest that specific DNA variants can influence gene expression in key organs, offering a promising avenue for translation into clinical utility.
Research presented at the American Heart Association's Scientific Sessions 2015 found that eating about two homemade lunches or dinners a week can lower Type 2 diabetes risk by 13%. The study analyzed data from nearly 58,000 women and 41,000 men over 36 years.
The study suggests specific criteria for adolescents that differ from those in adults to predict outcomes and guide treatment. An A1C greater than 6.3% within three months of starting metformin increases the risk of losing glucose control within 11 months.
Chronic short sleep duration of 6 hours or less increases the risk of developing type 2 diabetes in middle-aged and older women. Increasing sleep duration by 2 hours or more also associated with a modest increased risk of diabetes, even after adjusting for other factors such as diet and physical activity.
Researchers used data analysis to identify three distinct subtypes of patients with type 2 diabetes, each associated with different clinical characteristics and genetic variants. The study suggests a novel approach that can be applied to virtually any disease, potentially leading to more effective diagnosis and treatment.
A Wayne State University research team, led by Zhengping Yi, aims to discover the abnormality in protein phosphatase 1 contributing to insulin resistance and type 2 diabetes. The $2.58 million NIH grant will support clinical studies, in vitro cell studies, and proteomics research.
Researchers have discovered a biological sensor called NLRP1 that responds to excess energy intake and instructs cells to burn fat stores. The study, published in Cell Metabolism, suggests that activating this protein could help combat obesity and type 2 diabetes.
A pilot study found early insulin therapy to be as effective as 15 months of oral therapy, improving A1C levels from 10.1% to 6.7% in insulin-treated group and 9.9% to 6.8% in oral therapy group, with no severe hypoglycemia reported
A recent CU Anschutz study reveals that people with Type 2 diabetes perceive exercise as more difficult due to metabolic and cardiovascular challenges. The researchers found elevated lactate levels and increased rating of perceived exertion among individuals with the disease.
Patients with well-controlled type 2 diabetes who drank red wine daily for two years showed improved cardiac health and cholesterol management. The study suggests that moderate alcohol intake may have specific benefits for lipid variables, but the authors caution against potential risks.
A genetic variant near the KLF14 gene regulates fat storage in women, affecting their risk of developing Type 2 diabetes. The variant influences hip circumference, with women carrying one allele tending to have larger hips than those with the other allele.
A $3.5 million grant will fund a five-year study to evaluate the efficacy of virtual world and classroom groups in teaching diabetes self-management skills to minority women with type 2 diabetes. The study aims to increase physical activity levels and measure technological development milestones.