Articles tagged with Type 2 Diabetes
Researchers have successfully reactivated oscillations in insulin-producing pancreatic beta cells using mathematical models and microfluidic devices. By delivering controlled glucose levels to dormant cells, scientists can test how insulin-producing cells get turned off and whether they can be reactivated.
The study confirms that cardiorespiratory fitness is a stronger predictor of mortality than established risk factors such as smoking and hypertension. Higher levels of CRF are associated with improved outcomes for certain forms of cancer, surgical risk, dementia, Alzheimer's disease, depression and Type 2 diabetes.
A study published in the Journal of General Internal Medicine found that Asian Americans have a high prevalence of undiagnosed type 2 diabetes and are less likely to undergo recommended screening. Only 47.1% of Asian Americans received appropriate screening, compared to 60.2% of non-Hispanic blacks.
A recent survey found that Asian Americans are the least likely racial or ethnic group in the US to receive type 2 diabetes screening, despite having a high risk of developing the disease. Only 47.1% of eligible Asian Americans received screening tests between 2012 and 2014.
Researchers found that patients with high cholesterol who take statins have a 20% increased risk of developing Type 2 diabetes. However, those in the fit and highly fit categories had significantly lower diabetes risk, with reductions of 22% and 42%, respectively.
A new wearable medical device has been found to reduce visceral fat and improve blood glucose levels in patients with type 2 diabetes. The device, which uses mild electrical stimulation and heat shock, has shown significant improvements in glycated hemoglobin values and insulin resistance.
Regular aerobic exercise has been shown to improve artery health and reduce stiffness in individuals with type 2 diabetes. The study found that aerobic exercise significantly benefits vascular function and smooth muscle function in the arteries.
A 14-year study of 1,685 adult Americans found that regular sugar-sweetened beverage consumption is associated with increased risk of prediabetes and insulin resistance. Higher intake was linked to a 46% higher risk of developing prediabetes compared to low- or non-consumers.
A recent study published in Cell Metabolism suggests that accumulation of ceramides may make people more prone to type 2 diabetes. Researchers found that patients with higher ceramide levels were more likely to develop the condition, even if they were obese.
A recent study published in the Obesity Journal found that participants who used Weight Watchers for one year showed significant improvements in blood sugar control and weight loss compared to those receiving standard care. The program helped participants reduce their medication needs and improve long-term diabetes management.
A systematic review of 14 studies found that mobile app users with type 2 diabetes experienced a reduction in average blood glucose levels, with an approximate 0.5% decrease in HbA1c. Younger patients reported more benefits from using apps.
Two new papers published in Diabetologia found a 26% reduction in T2D risk among participants who achieved 11.25 MET hours/week, more than twice the recommended minimum. The studies also suggest that exercising after meals can deliver significant additional health benefits.
Researchers at Buck Institute have found a sensor for reactive molecules linked to diabetic complications, providing a pathway to study many of the ravages of diabetes. Two natural compounds, including alpha-lipoic acid, prevented nerve damage in worms experiencing similar hypersensitivity to touch as humans with diabetic neuropathy.
New research from the University of Otago suggests that walking after meals can significantly lower blood sugar levels in people with type 2 diabetes. The study found that post-meal physical activity can reduce blood sugar levels by up to 22% compared to taking a single 30-minute walk at any time of the day.
Two new papers published in Diabetologia found a 26% reduction in T2D risk among participants who achieved moderate activity levels, with benefits increasing at higher activity levels. Timing of physical activity also played a role, with exercising after meals delivering greater health benefits.
By 2025, up to 12 million children may develop impaired glucose tolerance, while 4 million will be diagnosed with type 2 diabetes. The study forecasts a sharp increase in obesity-related conditions among children, sparking calls for governments to reduce childhood obesity.
Clemson University scientists are using high-tech computer modeling and experimental validation techniques to understand the molecular causes of adult-onset diabetes. They aim to develop new therapeutic approaches by studying peptide protein co-secreted with insulin in the pancreas.
A review of the current knowledge on the causes of type 2 diabetes and obesity reveals a complex interplay between genetic and environmental factors. The study highlights the importance of epigenomic changes, such as DNA methylation and histone modifications, in modulating gene expression and disease risk.
A recent expert review from the International Osteoporosis Foundation confirms that both type 1 and type 2 diabetes increase the risk of bone fragility. The mechanisms behind this include hyperglycemia, oxidative stress, and microvascular complications, which alter bone turnover and material properties.
A recent study published in Diabetologia found that intensified and multifaceted treatment of patients with type 2 diabetes and known vascular damage can extend their lifespan by approximately 8 years. The treatment involved a combination of behavioural education, medication, and lifestyle modifications.
Researchers investigate the link between diet, obesity-linked Type 2 diabetes, and intervertebral disc degeneration. They suspect that a diet high in processed fats and sugars causes inflammation and modification of disc tissue, leading to degeneration.
A recent study found that canagliflozin slows the progression of kidney function decline to a greater extent than glimepiride, while having similar blood sugar-lowering effects. The findings suggest that potential kidney protective effects of canagliflozin may be unrelated to glycemic control.
A large-scale study found that consuming at least 500mg of dietary omega-3 fatty acids daily was associated with a 48% reduced risk of developing sight-threatening diabetic retinopathy. The study, published in JAMA Ophthalmology, involved over 3,500 adults with type 2 diabetes and followed them for six years.
Researchers at Boston University School of Medicine discover a novel protein called PTRF linked to type 2 diabetes and insulin resistance. The study finds that most obese individuals develop insulin resistance despite having normal fat cells.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a potential target for preventing type 2 diabetes by blocking the cellular glucose sensor MondoA in muscle, improving insulin responsiveness. This study suggests that MondoA regulates genes involved in fat synthesis and inhibits insulin signaling.
Patients with non-functional adrenal tumors are at increased risk of developing type 2 diabetes, a new study reveals. According to the research, even benign tumors that don't secrete hormones can increase the risk of metabolic diseases.
A recent study found that the overall incidence of type 2 diabetes has stabilised over recent years, while mortality rates have declined, suggesting that increased prevalence may be attributed to longer survival. The findings suggest significant differences based on gender, age, and socioeconomic status.
A study of 124,379 postmenopausal women found that shorter and longer reproductive spans increase the risk of type 2 diabetes. Women with optimal reproductive durations had lower BMI and waist circumferences compared to those with shorter or longer periods.
A study published in Menopause found that women who began menopause before age 46 or after 55 were at higher risk of developing type 2 diabetes. The study also revealed that the length of a woman's lifetime reproductive cycle was associated with an increased risk of diabetes.
A new study from Imperial College London found that the flu vaccine may significantly reduce the likelihood of hospitalization with stroke and heart failure in people with type 2 diabetes. Patients who received the influenza vaccination had a 24% lower death rate compared to those who weren't vaccinated.
A new study found that flu vaccination in people with type 2 diabetes is associated with reduced rates of hospital admission for cardiovascular and respiratory diseases. The vaccine was linked to a 19% reduction in heart attacks, 30% lower risk of stroke, and 22% decrease in heart failure hospitalizations.
A recent study found that breastfeeding for over three months postpartum alters maternal metabolism, producing lower concentrations of branched-chain amino acids and phospholipids. This change in metabolites is linked to reduced insulin resistance and a lower risk of developing type 2 diabetes.
A new meta-analysis of 102 randomized controlled trials found that consuming unsaturated fats in place of either carbohydrates or saturated fats improves insulin resistance and secretion. This could aid in the prevention and management of type 2 diabetes.
Higher levels of certain omega-6 fatty acids, like linoleic acid, were associated with lower type 2 diabetes risk. In contrast, higher levels of other minor omega-6 fatty acids and no association was found for omega-3 fatty acids.
Children born with heart disease have an increased risk of developing type 2 diabetes after age 30, according to a new study. Those with cyanotic congenital heart disease face the highest risk. The incidence of diabetes by age 45 was significantly higher in CHD subjects compared to the general population.
A systematic review with network meta-analysis found no significant differences in the associations between glucose-lowering drugs and cardiovascular or all-cause mortality. The study included nearly 120,000 adults with type 2 diabetes and estimated that diabetes accounted for approximately 1.5 million deaths in 2012.
A new systematic review found that gliclazide confers the lowest risk of hypoglycemia when added to metformin. This suggests prescribing a medication with a lower risk of low blood sugar may be a rational and affordable alternative for patients with type 2 diabetes.
A cohort study of 24,623 men and 27,890 women found that habitual cycling was associated with a lower risk of developing type 2 diabetes. Participants who took up habitual cycling during the follow-up period were at 20% lower risk for T2D than non-cyclists.
A new education program has been shown to reduce the risk of type 2 diabetes in people at high risk by over 80%. The program, which includes a main session and follow-up sessions, resulted in an 88% risk reduction for those who attended fully.
A large international research team identified common genetic variants as the biggest culprits behind type 2 diabetes, with novel East Asian-specific variant PAX4 also found. The study's findings provide a more complete picture of the disease's genetics and hold promise for precision medicine.
A comprehensive study has mapped the genetic underpinnings of type 2 diabetes, revealing over a dozen risk genes and pinpointing specific protein sequences that contribute to disease development. The findings highlight the complexity of the condition and emphasize the need for personalized treatment approaches.
A comprehensive study of the genetics of type 2 diabetes has unveiled significant details about the disease's underlying mechanisms. The research identified common genetic variants that contribute to an individual's risk of developing the disease, as well as genes and proteins directly involved in its development.
A study of over 2.1 million people found that those who cooked at home more frequently had a lower risk of developing type 2 diabetes. The research suggests that preparing meals at home can contribute to diabetes prevention efforts through improved nutritional and lifestyle habits.
Researchers found CART hormone increases insulin secretion and decreases glucagon production, a potential target for new type 2 diabetes drugs. CART is overexpressed in human type 2 diabetic islets, suggesting a link between glucose levels and hormone production.
A Swedish national register study found that individuals with type 2 diabetes from low socioeconomic status have a higher risk of death from all causes and cardiovascular disease. The study also revealed a less pronounced increased risk of cancer death among this group.
A new technique called targeted metabolomics predicts the development of type 2 diabetes in women with recent gestational diabetes with 83% accuracy, significantly better than conventional methods.
Research in Diabetologia found a link between genetically lowered birthweight and increased susceptibility to type 2 diabetes. The study suggests that restricted early life development can have long-term effects on metabolic disease risk.
The updated DIfE German Diabetes Risk Score takes into account familial predisposition and provides personalized recommendations to reduce risk. The test is now available online and on mobile devices, offering a quick and precise assessment of type 2 diabetes risk.
A randomized study found that highly structured nutrition plans lead to the most significant impact on A1C, body weight, and lipid profiles. Participants reduced A1C by an average of 0.67% and lost 3.5Kg over 16 weeks without changing medications or exercise.
A BU researcher has received a $2.95 million grant to investigate the relationship between immune cells and type 2 diabetes, with the goal of developing new treatments for both conditions.
Researchers found that several commercially available tests for hepatitis C virus core antigen are highly sensitive and specific, potentially replacing the current two-test screening process with a single test. This could streamline care in low- and middle-income countries where HCV is prevalent, but patients are often lost to follow-up.
Researchers at Cincinnati Children's Hospital Medical Center found significant changes in total brain gray matter volume and specific brain regions in teenagers with type 2 diabetes. These changes are associated with reduced cognitive abilities, particularly in pronunciation and language skills.
A plant-based diet rich in whole grains, fruits, vegetables, and legumes is associated with a 20% reduced risk of type 2 diabetes. The study found that even modestly lowering animal food consumption can lower diabetes incidence.
A plant-rich diet with high fruit and vegetable intake can reduce type 2 diabetes risk by 20%, according to a new study. A healthier version of this diet further reduces the risk by 34%, while an unhealthy version increases it.
A large clinical trial showed liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death for people with type 2 diabetes. The study also found a reduction in kidney disease and death from all causes.
Researchers have discovered that adults born in the 1940s with diabetes are living longer and with less disability, performing day-to-day tasks, compared to those born a decade earlier. This trend is attributed to improvements in diabetes management and healthy lifestyle choices.
A follow-up analysis of the ACCORD Trial found that people with type 2 diabetes who intensively controlled their blood sugar level had cut their risk of diabetic retinopathy in half. The study, supported by the National Eye Institute, suggests that well-controlled glycemia has a positive and lasting effect on eye health.
A new study shows that the innovative OnTouch Via patch enabled over 50% of diabetes patients to report improved insulin dose compliance. The wearable patch allows for discreet delivery of rapid-acting insulin at mealtimes, reducing stress and anxiety associated with dosing.
A global study found that patients with type 2 diabetes admitted to the hospital for congestive heart failure face a high risk of mortality, highlighting the need for increased attention to this critical condition. The study suggests that heart failure outcomes should receive equal scrutiny as other cardiovascular events in future rese...
Researchers identify epigenomic changes that contribute to the development of type 2 diabetes in obese individuals. These changes are associated with inflammation and trigger insulin resistance, highlighting the importance of epigenetic regulation in metabolic diseases.