Articles tagged with Type 2 Diabetes
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a potential target for preventing type 2 diabetes by blocking the cellular glucose sensor MondoA in muscle, improving insulin responsiveness. This study suggests that MondoA regulates genes involved in fat synthesis and inhibits insulin signaling.
Patients with non-functional adrenal tumors are at increased risk of developing type 2 diabetes, a new study reveals. According to the research, even benign tumors that don't secrete hormones can increase the risk of metabolic diseases.
A recent study found that the overall incidence of type 2 diabetes has stabilised over recent years, while mortality rates have declined, suggesting that increased prevalence may be attributed to longer survival. The findings suggest significant differences based on gender, age, and socioeconomic status.
A study published in Menopause found that women who began menopause before age 46 or after 55 were at higher risk of developing type 2 diabetes. The study also revealed that the length of a woman's lifetime reproductive cycle was associated with an increased risk of diabetes.
A study of 124,379 postmenopausal women found that shorter and longer reproductive spans increase the risk of type 2 diabetes. Women with optimal reproductive durations had lower BMI and waist circumferences compared to those with shorter or longer periods.
A new study found that flu vaccination in people with type 2 diabetes is associated with reduced rates of hospital admission for cardiovascular and respiratory diseases. The vaccine was linked to a 19% reduction in heart attacks, 30% lower risk of stroke, and 22% decrease in heart failure hospitalizations.
A new study from Imperial College London found that the flu vaccine may significantly reduce the likelihood of hospitalization with stroke and heart failure in people with type 2 diabetes. Patients who received the influenza vaccination had a 24% lower death rate compared to those who weren't vaccinated.
A recent study found that breastfeeding for over three months postpartum alters maternal metabolism, producing lower concentrations of branched-chain amino acids and phospholipids. This change in metabolites is linked to reduced insulin resistance and a lower risk of developing type 2 diabetes.
A systematic review with network meta-analysis found no significant differences in the associations between glucose-lowering drugs and cardiovascular or all-cause mortality. The study included nearly 120,000 adults with type 2 diabetes and estimated that diabetes accounted for approximately 1.5 million deaths in 2012.
A new systematic review found that gliclazide confers the lowest risk of hypoglycemia when added to metformin. This suggests prescribing a medication with a lower risk of low blood sugar may be a rational and affordable alternative for patients with type 2 diabetes.
A new meta-analysis of 102 randomized controlled trials found that consuming unsaturated fats in place of either carbohydrates or saturated fats improves insulin resistance and secretion. This could aid in the prevention and management of type 2 diabetes.
Higher levels of certain omega-6 fatty acids, like linoleic acid, were associated with lower type 2 diabetes risk. In contrast, higher levels of other minor omega-6 fatty acids and no association was found for omega-3 fatty acids.
Children born with heart disease have an increased risk of developing type 2 diabetes after age 30, according to a new study. Those with cyanotic congenital heart disease face the highest risk. The incidence of diabetes by age 45 was significantly higher in CHD subjects compared to the general population.
A cohort study of 24,623 men and 27,890 women found that habitual cycling was associated with a lower risk of developing type 2 diabetes. Participants who took up habitual cycling during the follow-up period were at 20% lower risk for T2D than non-cyclists.
A new education program has been shown to reduce the risk of type 2 diabetes in people at high risk by over 80%. The program, which includes a main session and follow-up sessions, resulted in an 88% risk reduction for those who attended fully.
A large international research team identified common genetic variants as the biggest culprits behind type 2 diabetes, with novel East Asian-specific variant PAX4 also found. The study's findings provide a more complete picture of the disease's genetics and hold promise for precision medicine.
A comprehensive study has mapped the genetic underpinnings of type 2 diabetes, revealing over a dozen risk genes and pinpointing specific protein sequences that contribute to disease development. The findings highlight the complexity of the condition and emphasize the need for personalized treatment approaches.
A comprehensive study of the genetics of type 2 diabetes has unveiled significant details about the disease's underlying mechanisms. The research identified common genetic variants that contribute to an individual's risk of developing the disease, as well as genes and proteins directly involved in its development.
A study of over 2.1 million people found that those who cooked at home more frequently had a lower risk of developing type 2 diabetes. The research suggests that preparing meals at home can contribute to diabetes prevention efforts through improved nutritional and lifestyle habits.
Researchers found CART hormone increases insulin secretion and decreases glucagon production, a potential target for new type 2 diabetes drugs. CART is overexpressed in human type 2 diabetic islets, suggesting a link between glucose levels and hormone production.
A Swedish national register study found that individuals with type 2 diabetes from low socioeconomic status have a higher risk of death from all causes and cardiovascular disease. The study also revealed a less pronounced increased risk of cancer death among this group.
A new technique called targeted metabolomics predicts the development of type 2 diabetes in women with recent gestational diabetes with 83% accuracy, significantly better than conventional methods.
Research in Diabetologia found a link between genetically lowered birthweight and increased susceptibility to type 2 diabetes. The study suggests that restricted early life development can have long-term effects on metabolic disease risk.
The updated DIfE German Diabetes Risk Score takes into account familial predisposition and provides personalized recommendations to reduce risk. The test is now available online and on mobile devices, offering a quick and precise assessment of type 2 diabetes risk.
A randomized study found that highly structured nutrition plans lead to the most significant impact on A1C, body weight, and lipid profiles. Participants reduced A1C by an average of 0.67% and lost 3.5Kg over 16 weeks without changing medications or exercise.
A BU researcher has received a $2.95 million grant to investigate the relationship between immune cells and type 2 diabetes, with the goal of developing new treatments for both conditions.
Researchers found that several commercially available tests for hepatitis C virus core antigen are highly sensitive and specific, potentially replacing the current two-test screening process with a single test. This could streamline care in low- and middle-income countries where HCV is prevalent, but patients are often lost to follow-up.
Researchers at Cincinnati Children's Hospital Medical Center found significant changes in total brain gray matter volume and specific brain regions in teenagers with type 2 diabetes. These changes are associated with reduced cognitive abilities, particularly in pronunciation and language skills.
A plant-based diet rich in whole grains, fruits, vegetables, and legumes is associated with a 20% reduced risk of type 2 diabetes. The study found that even modestly lowering animal food consumption can lower diabetes incidence.
A plant-rich diet with high fruit and vegetable intake can reduce type 2 diabetes risk by 20%, according to a new study. A healthier version of this diet further reduces the risk by 34%, while an unhealthy version increases it.
A large clinical trial showed liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death for people with type 2 diabetes. The study also found a reduction in kidney disease and death from all causes.
Researchers have discovered that adults born in the 1940s with diabetes are living longer and with less disability, performing day-to-day tasks, compared to those born a decade earlier. This trend is attributed to improvements in diabetes management and healthy lifestyle choices.
A follow-up analysis of the ACCORD Trial found that people with type 2 diabetes who intensively controlled their blood sugar level had cut their risk of diabetic retinopathy in half. The study, supported by the National Eye Institute, suggests that well-controlled glycemia has a positive and lasting effect on eye health.
A new study shows that the innovative OnTouch Via patch enabled over 50% of diabetes patients to report improved insulin dose compliance. The wearable patch allows for discreet delivery of rapid-acting insulin at mealtimes, reducing stress and anxiety associated with dosing.
A global study found that patients with type 2 diabetes admitted to the hospital for congestive heart failure face a high risk of mortality, highlighting the need for increased attention to this critical condition. The study suggests that heart failure outcomes should receive equal scrutiny as other cardiovascular events in future rese...
A new study published in JAMA Internal Medicine found that over 25% of adults with type 2 diabetes received intensive glucose-lowering therapy, which increased the risk of severe hypoglycemia. Patients with advanced age and co-existing illnesses were at higher risk.
A new study found that intensive glucose treatment can nearly double the risk of severe hypoglycemia in older patients and those with serious chronic conditions. Patients taking multiple medications to lower HbA1C levels were at higher risk of experiencing severe low blood sugar episodes.
Researchers identify epigenomic changes that contribute to the development of type 2 diabetes in obese individuals. These changes are associated with inflammation and trigger insulin resistance, highlighting the importance of epigenetic regulation in metabolic diseases.
Researchers have identified a protein called TST that helps detoxify waste products in fat cells, leading to improved insulin sensitivity and reduced weight gain in obese mice. The study's findings suggest a potential new approach to treating type 2 diabetes associated with obesity.
Several commercial weight loss programs demonstrate potential benefits for improving blood sugar control in patients with type 2 diabetes and those at risk for the disease. However, a lack of rigorous studies hinders full endorsement by doctors.
A small study suggests that obese UK diabetics who undergo bariatric surgery can save the NHS around £95,000 over their lifetime due to reduced medication costs. The study found that 44 patients with type 2 diabetes who no longer required treatment after surgery resulted in significant outpatient and inpatient savings.
A novel type 2 diabetes risk model has been developed to better understand disease progression, revealing people on atypical trajectories face significantly increased or decreased risks of developing T2D. The new model has overcome challenges associated with estimating T2D onset based on comorbid conditions.
A new study found that vitamin nicotinamide riboside (NR) can protect mice from diabetes complications by lowering blood sugar levels, reducing fatty liver, and preventing peripheral nerve damage. NR is a precursor to NAD+, an important cellular metabolite required for energy conversion.
A recent study published in PLOS Genetics has identified a single gene, RCAN1, that may contribute to insulin secretion problems in both conditions. Overexpression of this gene leads to mitochondrial dysfunction and reduced insulin production in beta cells.
Researchers found that hormone PYY improves insulin and glucagon secretion in rats with type 2 diabetes. Gastric bypass surgery has been shown to improve diabetes symptoms, and this study suggests a potential link between the two.
A new experimental and clinical study from Lund University shows that the sleep hormone melatonin impairs insulin secretion in people with a specific gene variant. The researchers found that carriers of this gene have a higher risk of developing type 2 diabetes, with impaired insulin secretion and increased glucose levels in their blood.
A recent study found that junk food diets can cause significant damage to the kidneys, similar to type 2 diabetes. The research used animal models and found that certain glucose transporters were present in higher numbers in rats with type 2 diabetes, but also increased after consuming high-fat or junk food diets.
A new study by Cardiff University found that combining insulin with metformin reduces mortality and heart attacks in people with type 2 diabetes. The researchers tracked 12,020 patients for three and a half years on average, finding no difference in cancer risk between single-insulin therapy and combination treatment.
A unique study of 60,000 refugee immigrants in Sweden found that living in high-deprivation neighborhoods significantly increased the risk of developing type 2 diabetes over time. The study suggests a direct link between neighborhood deprivation and health, particularly for vulnerable populations.
A University of Leicester study found that people with Type 2 diabetes wait an average of 3.7 years for increased treatment, leading to a failure to achieve tight blood sugar control. Clinical inertia is being identified as the major contributor to this issue.
Researchers identified specific measures of low blood oxygenation associated with impaired kidney function and diabetic nephropathy. The study highlights the association between sleep apnea and microvascular disease linked to diabetes.
A clinical score called DiaRem can predict the likelihood of bariatric surgery curing type 2 diabetes in patients. The study found that patients with lower DiaRem scores were more likely to experience complete remission or prolonged partial remission after surgery.
Research shows people with type 2 diabetes are more susceptible to non-alcoholic fatty liver disease (NAFLD), a condition characterized by a build-up of fat in liver cells. The study found that hospital admissions and deaths caused by liver disease are likely to rise if cases of type 2 diabetes continue to increase.
A Finnish group found that vascular endothelial growth factor B (VEGFB) can increase the density of adipose tissue vasculature, reducing inflammation and improving insulin function. Blocking the VEGFR1 receptor enhances the treatment effect by stimulating catabolic processes in adipose tissue.
Researchers have created a light-activated tool to adapt drugs for type 2 diabetes. The study provides insight into cellular receptor signalling and could lead to more efficient anti-diabetic drugs. The new tool, PhotoETP, allows precise control over blood glucose levels with fewer side effects.
The number of adults with diabetes has quadrupled since 1980, with significant increases in low and middle income countries. The study's findings highlight the urgent need for effective action to reduce the health and economic impact of diabetes.
Glycemic control and weight loss achieved through bariatric surgery persist for up to five years, with significant advantages over a medical therapy-only approach. The study found that gastric bypass and sleeve gastrectomy patients maintained healthy blood glucose levels without insulin use, while also experiencing greater weight loss.
A three-year study found that liraglutide can help nondiabetic overweight and obese adults lose weight and reduce their risk of developing Type 2 diabetes. After three years, 66% of participants taking liraglutide no longer had prediabetes.
A study of nearly 8,500 people found that low thyroid function increases the risk of developing Type 2 diabetes by 13%, with a higher risk for those already with prediabetes. Screening for thyroid function may be beneficial in individuals at risk of developing diabetes.
Whey protein diet participants lost the most weight and experienced reduced hunger and glucose spikes compared to other diets. The study found that a high-protein breakfast containing whey protein induced greater satiety and reduction of glucose spikes after meals.