Articles tagged with Type 2 Diabetes
Researchers found that exercise significantly improved glucose tolerance and weight loss in people with increased risk of type 2 diabetes due to family history, but the effect was similar among healthy individuals who also exercised regularly.
For patients with low pre-test probability of PE, applying PERC rule should guide diagnostic strategy. Imaging and testing can be reserved for those with high pre-test probability or contraindications to CT pulmonary angiography.
A new study found that a Mediterranean-type diet high in monounsaturated fats and low in saturated fats decreased the inflammatory response, compared to diets high or low in palmitic acid. The research suggests that dietary fats may play a key role in obesity-related diseases.
A new study published in Diabetologia shows that taking blood pressure medications at bedtime halves the risk of developing type 2 diabetes in hypertensive patients. The research found a 57% decrease in risk with nighttime treatment compared to morning treatment.
A study by University of Alberta researchers discovered a new molecular pathway that manages insulin production, offering hope for restoring the 'dimmer switch' in Type 2 diabetes. The findings suggest that this pathway can be revived to control insulin secretion from islet cells.
A new study suggests that obese patients with type 2 diabetes may benefit from priority access to obesity surgery, as they often experience remission of diabetes and reduced complications. This can lead to lower accumulated drug costs and overall healthcare expenses.
A new meta-analysis has found that smoking significantly increases the risk of type 2 diabetes, with current smokers at a 37% higher risk than never smokers. The risk decreases after quitting, but former smokers are still at an 18% increased risk after 5 years and 11% more than 10 years ago.
Research suggests that excessive daytime sleepiness and taking long naps during the day are associated with a higher risk of developing type 2 diabetes. A meta-analysis of 261,365 subjects found that excessive daytime sleepiness increased the risk by 56%, while longer naps of 60 minutes or more increased the risk by 46%.
A new study published in Diabetologia shows that high protein diets from both animal and plant sources improve blood sugar control and reduce liver fat in patients with type 2 diabetes. Insulin sensitivity improved only in the animal protein group, while the plant protein group showed significant reductions in kidney function parameters.
Research shows high consumption of sugar-sweetened beverages is associated with lower intakes of healthy foods like fruits, vegetables, and yoghurt. In contrast, tea and juice consumption is linked to higher intakes of these nutritious foods.
New research suggests that obese patients with type 2 diabetes should be prioritized for obesity surgery, as they often experience remission of diabetes and reduced healthcare costs. The study, based on the Swedish Obese Subjects (SOS) study, found that total healthcare costs were lower in surgery patients who had prediabetes or diabetes.
A 3-year-old girl with obesity and symptoms of excessive urination and thirst was diagnosed with type 2 diabetes, reversing the disease through lifestyle modification and medication, highlighting early screening and diagnosis as key factors in disease management.
A study of 350,000 patients with type 2 diabetes found those with poor blood sugar control have a 50% higher risk of being admitted to hospital for dementia compared to those with good control. Improved blood sugar control may prevent many cases of dementia in these patients.
Researchers found that current and former marijuana users are more likely to have prediabetes, but not type 2 diabetes, compared to never users. Marijuana use was associated with a higher risk of developing prediabetes in middle adulthood, particularly among those who used the drug excessively.
A new study reveals that high-intensity intermittent exercise training improves heart structure and benefits diabetes control in patients with type 2 diabetes. The study showed significant improvements in cardiac structure and function, particularly in the left ventricle, and a modest improvement in diabetes control.
Researchers found that nearly 50% of Asian Americans with diabetes remain undiagnosed, with the highest prevalence in Hispanic Americans at nearly 23%. The study highlights the need for increased education and testing efforts among this population.
A new study published in the Lancet found that metabolic or bariatric surgery was more effective than standard medical treatment for the long-term control of type 2 diabetes in obese patients. Surgery resulted in better glycemic control, lower levels of blood glucose, and reduced need for anti-diabetic medication.
Researchers found a strong link between prenatal exposure to the Ukrainian Famine of 1932-33 and an increased risk of type 2 diabetes in adulthood. The study, which included over 43,000 cases of type 2 diabetes, suggests that early gestation is a critical period for the development of long-term health outcomes.
A new study found that people with Type 2 diabetes took more antibiotics in the years leading up to their diagnosis compared to healthy controls. Narrow-spectrum antibiotics like penicillin V were particularly associated with a higher risk of diabetes.
A study found that daily liraglutide injections, combined with diet and exercise, resulted in greater weight loss over 56 weeks compared to placebo. Average weight loss was 6.0% with liraglutide (3.0-mg dose), significantly better than the 2.0% with placebo.
A new delayed-release metformin treatment has been developed to target the lower bowel and limit absorption into the blood. The treatment may help 40% of type 2 diabetes patients who currently can't take metformin due to impaired kidney function.
Research published in Diabetologia found that insulin resistance is associated with poorer verbal fluency in women, a sign of cognitive decline. The study also discovered that higher insulin resistance is linked to slower reaction times and increased risk for Alzheimer's disease in this demographic.
A study published in The BMJ found that trans fats are associated with a greater risk of death and coronary heart disease, but saturated fats are not. The study suggests that industrial trans fats may increase the risk of coronary heart disease and calls for a review of dietary guidelines.
A study published in the British Medical Journal found that trans fats are associated with a 34% increase in death for any reason, while saturated fats showed no clear association with an increased risk of death or heart disease. However, researchers recommend replacing high-fat foods with vegetable oils, nuts, and whole grains.
A study found that physical activity reduces insulin resistance in early-teens, but not at age 16. The findings suggest targeting the early-teens for more effective interventions to prevent type 2 diabetes.
A University of Queensland study has found that drinking alcohol around the time of conception increases the risk of type 2 diabetes and obesity in early middle age. Research using laboratory rat models showed that exposure to five standard drinks before implantation causes changes to the embryo, leading to increased risk.
A new study from Harvard T.H. Chan School of Public Health reveals a molecular mechanism connecting obesity-associated inflammation and endoplasmic reticulum dysfunction in the development of type 2 diabetes. The research suggests that targeting inflammatory pathways could aid in the treatment of metabolic disease.
Research demonstrates impaired activation of mitochondrial energy metabolism in patients with type 2 diabetes, leading to decreased insulin secretion. A novel fluorescence microscopic assay reveals a subtle disharmony between bioenergetic supply and demand pathways, suggesting a shift towards systems-level approaches to fight the disease.
Scientists at the University of Southampton have developed a molecule that acts as an exercise mimic, reducing fasting blood glucose levels and promoting weight loss in obese mice. The new compound 14 inhibits a cellular enzyme involved in metabolism, leading to improved glucose tolerance and reduced body weight.
A new study by Harvard T.H. Chan School of Public Health found that low birth weight combined with an unhealthy adult lifestyle can increase the risk of developing type 2 diabetes. The researchers analyzed data from over 149,000 healthy men and women and found that 18% of cases were attributable to the combined effect of low birth weig...
A recent study published in The BMJ found that regular consumption of sugary drinks is positively associated with type 2 diabetes, independent of obesity status. The study estimated that two million new-onset type 2 diabetes events in the US and 80,000 in the UK could be related to sugar sweetened beverage consumption over 10 years.
A joint association between low birth weight and unhealthy lifestyle in adulthood increases the risk of type 2 diabetes. Research suggests that adopting a healthy lifestyle can prevent most cases of this condition.
Researchers at the University of Missouri have identified a link between Type 2 diabetes and damaged lymphatic vessels, which can lead to impaired immune function. The study found that an amino acid commonly found in red meat and poultry may help improve lymphatic function in individuals with Type 2 diabetes.
The American College of Physicians recommends combined diet and physical activity promotion programs to prevent type 2 diabetes in at-risk patients. These interventions have been shown to be effective in reducing new onset diabetes and are also cost-effective.
Research published in Cell Metabolism reveals that ancestral undernutrition can lead to obesity and metabolic disorders, increasing the risk of type 2 diabetes. A study on rats found that descendants of undernourished ancestors were eight times more likely to develop diabetes when switched to a normal diet.
A review of 160 clinical trials found exercise improves health outcomes, but effects vary by age, gender, and health status. Intermediate biomarkers like insulin resistance and inflammation may mediate cardioprotective effects.
A study of 61 obese participants with type 2 diabetes mellitus found that bariatric surgery resulted in more disease remission than lifestyle intervention alone. At 3 years, 40% of those who underwent RYGB achieved complete remission, compared to 15% of those who received LAGB and no intensive lifestyle weight loss intervention.
Research suggests that medically complex patients with newly diagnosed Type 2 diabetes who receive early endocrinologist care have lower risk of cardiovascular events. The study, which analyzed Ontario health data, found that these patients had a 10-20% lower risk of heart attack, stroke, and death from coronary heart disease.
Researchers have discovered a potential target for the treatment of type 2 diabetes by inhibiting the S6K1 protein, which increases insulin sensitivity in mice. In animal models, S6K1 deficient mice displayed improved insulin response and reduced risk of developing diabetes.
A systematic review and meta-analysis of 36 observational studies found that nut consumption is associated with a decreased risk of colorectal cancer, endometrial cancer, and pancreatic cancer. However, it was not linked to type 2 diabetes.
A study published in the Journal of the American Pharmacists Association found that having pharmacists on primary care teams improved the treatment of blood pressure in patients with Type 2 diabetes. The addition of pharmacists led to substantial improvements in patient health, including a significant impact on blood pressure control.
The ELIXA study found no increased risk of cardiovascular death, heart attack, stroke, or heart failure in patients with type 2 diabetes taking lixisenatide. Lixisenatide also showed a modest benefit for weight control and no increase in hypoglycemia or pancreatic injury risk.
Researchers at Brigham and Women's Hospital found that lixisenatide did not increase risk of cardiovascular events in a large, double-blind trial involving over 6,000 type 2 diabetes patients. The study's results provide reassurance for healthcare providers about the cardiovascular safety of this widely prescribed glucose-lowering drug.
A team of scientists has identified an enzyme called Kit, which plays a key role in the development of obesity and metabolic disorders. In mice with functioning Kit, fed a high-fat diet, obesity and insulin resistance were prevented.
A Danish study suggests that type 2 diabetes is associated with a reduced risk for amyotrophic lateral sclerosis (ALS). The study found that older age at diagnosis for either disease was associated with lower risk. The findings focus attention on the role of energy metabolism in ALS pathogenesis.
Researchers at the University of Iowa have found that prolonged exposure to Staphylococcus aureus bacteria causes insulin resistance and glucose intolerance in rabbits, mirroring the symptoms of type 2 diabetes. Anti-bacterial therapy or vaccines may hold promise for preventing or treating the disease.
Researchers have identified a genetic association between elevated triglyceride levels and decreased type 2 diabetes incidence. Triglyceride-increasing alleles were found to be associated with lower risk of developing type 2 diabetes, suggesting that these genetic variants may play a role in protecting against the disease.
A large European cohort study found that higher fibre intake was associated with a lower risk of type 2 diabetes. Cereal fibre had the strongest inverse association, suggesting it may help maintain a healthy weight and reduce the risk of developing diabetes.
Obesity alters splicing patterns of genes TCF7L2 and INSR, leading to impaired insulin action. Weight loss reverses these changes, suggesting a targeted treatment approach for metabolic disorders. Alternative splicing regulates obesity-related gene expression, offering new diagnostic and therapeutic avenues.
Women who were having sons were more likely to develop gestational diabetes than women who were pregnant with daughters. Women who developed gestational diabetes while pregnant with daughters were at higher risk of being diagnosed with Type 2 diabetes after pregnancy.
A new study suggests that early detection and treatment of type 2 diabetes can significantly reduce the risk of cardiovascular disease and death. The research found that screening followed by treatment led to a reduced risk of cardiovascular events within five years compared to patients with no screening.
The Lancet Diabetes & Endocrinology publishes a series on depression and diabetes, revealing a bi-directional association between the two conditions. The studies also suggest that depression-distress mediates the association between depression and glycaemic control.
Research found that patients with type 2 diabetes who are overweight but not obese live longer than those who are underweight or normal-weight. The 'obesity paradox' suggests that excess weight may be beneficial for survival in these patients, contrary to previous expectations. Meanwhile, daily low-molecular-weight heparin injections w...
Researchers found that quitting smoking is associated with a temporary deterioration in blood glucose control, which can last up to three years. The study suggests that smokers with type 2 diabetes should expect to take extra care to keep their blood glucose levels well-controlled after quitting smoking.
A new genetic mutation in the GLP1R gene has been found to decrease the risk of developing Type 2 diabetes by 14 percent. The discovery could lead to personalized treatment and prevention strategies for millions of diabetics worldwide.
A clinical trial by Joslin Diabetes Center found that adjustable gastric band surgery and intensive group-based medical diabetes and weight management program achieved similar improvements in controlling blood sugar levels after one year. Participants experienced significant weight loss and better quality of life with both approaches.
Remogliflozin etabonate improves insulin sensitivity and beta cell function, reducing ALT levels and weight in patients with NASH. The investigational drug also exhibits intrinsic anti-oxidant activity, reversing steatohepatitis and oxidative stress.
Researchers have identified a new mechanism that controls glucagon secretion in humans, which could lead to more effective treatment of type 2 diabetes. By understanding this phenomenon, it is possible to elucidate the paradoxical effect of a new class of diabetes drugs and suggest modifications to this new type of treatment.
A study of over 2.4 million Danish citizens found that depression, type 2 diabetes, or both are associated with a higher risk of dementia. Individuals diagnosed with depression or type 2 diabetes alone have an increased risk, while those with both conditions experience the greatest increase in risk.
A large study found a significant association between intrauterine exposure to gestational diabetes and an increased risk of autism spectrum disorders in offspring. Maternal pre-existing type 2 diabetes was not significantly associated with this risk.