Articles tagged with Type 2 Diabetes
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A new study from Harvard T.H. Chan School of Public Health reveals a molecular mechanism connecting obesity-associated inflammation and endoplasmic reticulum dysfunction in the development of type 2 diabetes. The research suggests that targeting inflammatory pathways could aid in the treatment of metabolic disease.
A University of Queensland study has found that drinking alcohol around the time of conception increases the risk of type 2 diabetes and obesity in early middle age. Research using laboratory rat models showed that exposure to five standard drinks before implantation causes changes to the embryo, leading to increased risk.
Research demonstrates impaired activation of mitochondrial energy metabolism in patients with type 2 diabetes, leading to decreased insulin secretion. A novel fluorescence microscopic assay reveals a subtle disharmony between bioenergetic supply and demand pathways, suggesting a shift towards systems-level approaches to fight the disease.
Scientists at the University of Southampton have developed a molecule that acts as an exercise mimic, reducing fasting blood glucose levels and promoting weight loss in obese mice. The new compound 14 inhibits a cellular enzyme involved in metabolism, leading to improved glucose tolerance and reduced body weight.
A joint association between low birth weight and unhealthy lifestyle in adulthood increases the risk of type 2 diabetes. Research suggests that adopting a healthy lifestyle can prevent most cases of this condition.
A new study by Harvard T.H. Chan School of Public Health found that low birth weight combined with an unhealthy adult lifestyle can increase the risk of developing type 2 diabetes. The researchers analyzed data from over 149,000 healthy men and women and found that 18% of cases were attributable to the combined effect of low birth weig...
A recent study published in The BMJ found that regular consumption of sugary drinks is positively associated with type 2 diabetes, independent of obesity status. The study estimated that two million new-onset type 2 diabetes events in the US and 80,000 in the UK could be related to sugar sweetened beverage consumption over 10 years.
Researchers at the University of Missouri have identified a link between Type 2 diabetes and damaged lymphatic vessels, which can lead to impaired immune function. The study found that an amino acid commonly found in red meat and poultry may help improve lymphatic function in individuals with Type 2 diabetes.
The American College of Physicians recommends combined diet and physical activity promotion programs to prevent type 2 diabetes in at-risk patients. These interventions have been shown to be effective in reducing new onset diabetes and are also cost-effective.
Research published in Cell Metabolism reveals that ancestral undernutrition can lead to obesity and metabolic disorders, increasing the risk of type 2 diabetes. A study on rats found that descendants of undernourished ancestors were eight times more likely to develop diabetes when switched to a normal diet.
A review of 160 clinical trials found exercise improves health outcomes, but effects vary by age, gender, and health status. Intermediate biomarkers like insulin resistance and inflammation may mediate cardioprotective effects.
A study of 61 obese participants with type 2 diabetes mellitus found that bariatric surgery resulted in more disease remission than lifestyle intervention alone. At 3 years, 40% of those who underwent RYGB achieved complete remission, compared to 15% of those who received LAGB and no intensive lifestyle weight loss intervention.
Research suggests that medically complex patients with newly diagnosed Type 2 diabetes who receive early endocrinologist care have lower risk of cardiovascular events. The study, which analyzed Ontario health data, found that these patients had a 10-20% lower risk of heart attack, stroke, and death from coronary heart disease.
Researchers have discovered a potential target for the treatment of type 2 diabetes by inhibiting the S6K1 protein, which increases insulin sensitivity in mice. In animal models, S6K1 deficient mice displayed improved insulin response and reduced risk of developing diabetes.
A systematic review and meta-analysis of 36 observational studies found that nut consumption is associated with a decreased risk of colorectal cancer, endometrial cancer, and pancreatic cancer. However, it was not linked to type 2 diabetes.
A study published in the Journal of the American Pharmacists Association found that having pharmacists on primary care teams improved the treatment of blood pressure in patients with Type 2 diabetes. The addition of pharmacists led to substantial improvements in patient health, including a significant impact on blood pressure control.
The ELIXA study found no increased risk of cardiovascular death, heart attack, stroke, or heart failure in patients with type 2 diabetes taking lixisenatide. Lixisenatide also showed a modest benefit for weight control and no increase in hypoglycemia or pancreatic injury risk.
Researchers at Brigham and Women's Hospital found that lixisenatide did not increase risk of cardiovascular events in a large, double-blind trial involving over 6,000 type 2 diabetes patients. The study's results provide reassurance for healthcare providers about the cardiovascular safety of this widely prescribed glucose-lowering drug.
A team of scientists has identified an enzyme called Kit, which plays a key role in the development of obesity and metabolic disorders. In mice with functioning Kit, fed a high-fat diet, obesity and insulin resistance were prevented.
A Danish study suggests that type 2 diabetes is associated with a reduced risk for amyotrophic lateral sclerosis (ALS). The study found that older age at diagnosis for either disease was associated with lower risk. The findings focus attention on the role of energy metabolism in ALS pathogenesis.
Researchers at the University of Iowa have found that prolonged exposure to Staphylococcus aureus bacteria causes insulin resistance and glucose intolerance in rabbits, mirroring the symptoms of type 2 diabetes. Anti-bacterial therapy or vaccines may hold promise for preventing or treating the disease.
Researchers have identified a genetic association between elevated triglyceride levels and decreased type 2 diabetes incidence. Triglyceride-increasing alleles were found to be associated with lower risk of developing type 2 diabetes, suggesting that these genetic variants may play a role in protecting against the disease.
A large European cohort study found that higher fibre intake was associated with a lower risk of type 2 diabetes. Cereal fibre had the strongest inverse association, suggesting it may help maintain a healthy weight and reduce the risk of developing diabetes.
Obesity alters splicing patterns of genes TCF7L2 and INSR, leading to impaired insulin action. Weight loss reverses these changes, suggesting a targeted treatment approach for metabolic disorders. Alternative splicing regulates obesity-related gene expression, offering new diagnostic and therapeutic avenues.
Women who were having sons were more likely to develop gestational diabetes than women who were pregnant with daughters. Women who developed gestational diabetes while pregnant with daughters were at higher risk of being diagnosed with Type 2 diabetes after pregnancy.
A new study suggests that early detection and treatment of type 2 diabetes can significantly reduce the risk of cardiovascular disease and death. The research found that screening followed by treatment led to a reduced risk of cardiovascular events within five years compared to patients with no screening.
The Lancet Diabetes & Endocrinology publishes a series on depression and diabetes, revealing a bi-directional association between the two conditions. The studies also suggest that depression-distress mediates the association between depression and glycaemic control.
Research found that patients with type 2 diabetes who are overweight but not obese live longer than those who are underweight or normal-weight. The 'obesity paradox' suggests that excess weight may be beneficial for survival in these patients, contrary to previous expectations. Meanwhile, daily low-molecular-weight heparin injections w...
Researchers found that quitting smoking is associated with a temporary deterioration in blood glucose control, which can last up to three years. The study suggests that smokers with type 2 diabetes should expect to take extra care to keep their blood glucose levels well-controlled after quitting smoking.
A clinical trial by Joslin Diabetes Center found that adjustable gastric band surgery and intensive group-based medical diabetes and weight management program achieved similar improvements in controlling blood sugar levels after one year. Participants experienced significant weight loss and better quality of life with both approaches.
A new genetic mutation in the GLP1R gene has been found to decrease the risk of developing Type 2 diabetes by 14 percent. The discovery could lead to personalized treatment and prevention strategies for millions of diabetics worldwide.
Remogliflozin etabonate improves insulin sensitivity and beta cell function, reducing ALT levels and weight in patients with NASH. The investigational drug also exhibits intrinsic anti-oxidant activity, reversing steatohepatitis and oxidative stress.
Researchers have identified a new mechanism that controls glucagon secretion in humans, which could lead to more effective treatment of type 2 diabetes. By understanding this phenomenon, it is possible to elucidate the paradoxical effect of a new class of diabetes drugs and suggest modifications to this new type of treatment.
A study of over 2.4 million Danish citizens found that depression, type 2 diabetes, or both are associated with a higher risk of dementia. Individuals diagnosed with depression or type 2 diabetes alone have an increased risk, while those with both conditions experience the greatest increase in risk.
A large study found a significant association between intrauterine exposure to gestational diabetes and an increased risk of autism spectrum disorders in offspring. Maternal pre-existing type 2 diabetes was not significantly associated with this risk.
The USPSTF completed a systematic evidence review to inform an upcoming update of Task Force recommendations on screening asymptomatic adults for type 2 diabetes. Screening was found to help delay progression to diabetes by identifying those who could benefit from treatment, but did not improve mortality rates.
A study published in American Journal of Clinical Nutrition found that egg consumption was associated with a lower risk of type 2 diabetes. Men who ate four eggs per week had a 37% lower risk compared to those who ate one egg per week.
A new study published in the American Journal of Clinical Nutrition found that high-fat dairy products are associated with a reduced risk of type 2 diabetes. Researchers analyzed data from 27,000 individuals and found those who consumed more high-fat dairy had a 23% lower risk
Researchers have discovered a new class of potentially therapeutic lipids, FAHFAs, which are found at lower levels in people with insulin resistance. Administering FAHFAs to diabetic mice improved glucose metabolism and insulin secretion, suggesting a potential avenue for developing novel medications.
States expanding Medicaid under ACA see 23% increase in newly diagnosed diabetes patients compared to non-expansion states. Early detection can prevent complications and improve quality of life for those with diabetes.
Researchers at University of British Columbia found a new approach to treating Type 2 diabetes using stem cell transplants and conventional drugs. The study showed mice became glucose tolerant after receiving the transplants, while those without received only drugs, resulting in unexpected weight loss.
A stem cell-based approach using human embryonic stem cells proved effective in improving insulin sensitivity and glucose metabolism in mice. The combination of stem cell transplantation and antidiabetic drugs resulted in rapid weight loss and significant improvements in glucose control compared to individual treatments.
Researchers found that vitamin D helps regulate glucose metabolism, reducing the risk of type 2 diabetes. In mice without adequate vitamin D, immune cells became fat transporters, leading to artery clogging and inflammation.
A new study found that obese women who develop gestational diabetes are 43 times more likely to develop type 2 diabetes if they gain 5 kg or more after pregnancy. The research emphasizes the importance of maintaining a healthy body weight before and after pregnancy to prevent type 2 diabetes.
Researchers at McMaster University found that women's muscle appears more efficient in neutralizing the protein PTEN, which reduces insulin resistance and increases protection against type 2 diabetes. This discovery provides a potential therapeutic target for improving muscle responses to insulin and treating the disease.
A study of 25,000 patients with familial hypercholesterolemia found a significant lower prevalence of type 2 diabetes compared to unaffected relatives, varying by the type of gene mutation. The findings suggest decreased pancreatic LDL transport may reduce cell death and lower diabetes rates.
Research suggests that African American men with pre-diabetic blood sugar levels have fewer beneficial and more harmful intestinal bacteria. The study found that a specific microbiota is associated with stable, normal blood glucose levels, while a different profile is linked to pre-diabetes.
A new study reveals that changes in the gut microbiota occur early in diabetes development, with beneficial bacteria more prevalent in those maintaining stable blood sugar control. The research suggests a link between gut bacteria and metabolic health, potentially informing strategies to prevent or manage Type 2 diabetes.
A new study by the Endocrine Society finds that accumulating just 30 minutes of sleep debt on weekdays can lead to significant effects on obesity and insulin resistance at follow-up. The research suggests that avoiding sleep debt could have positive benefits for waistlines and metabolism.
Research found that GLP-1 secretion is lower among people with pre-diabetes and obesity compared to normal weight individuals. The study suggests that early intervention with GLP-1 analogues may postpone the onset of type 2 diabetes.
A new oral, controlled-release form of DNP, known as CRMP, reversed fatty liver, insulin resistance, and hyperglycemia in rat models of NAFLD and type 2 diabetes, with no adverse effects. The therapy achieved plasma concentrations that were more than a 100-fold less than the toxic threshold.
Researchers found that habitual breakfast skippers had poorer glucose control after consuming a high-protein breakfast, while those who typically ate breakfast experienced improved glucose control. The study suggests that young women should gradually increase protein intake in the morning to improve glycemic control.
A new study published in Diabetologia shows that eating a high energy breakfast and a low energy dinner improves blood sugar control for individuals with type 2 diabetes. The study found significant reductions in post-meal glucose levels and insulin levels when participants followed the high-energy breakfast and low-energy dinner diet.
A new study found that intensive lifestyle intervention or medication can significantly reduce the risk of developing Type 2 diabetes in women who had gestational diabetes. Women with a history of gestational diabetes were less likely to develop diabetes when assigned to take metformin or undergo intensive lifestyle intervention.
Research suggests that exercising after a meal can lower blood sugar and fat levels, providing more benefits than exercising before dinner. The study found that resistance exercise performed after dinner had the most powerful effect on reducing glucose and fat levels.
A new study from the University of Waterloo found that type 2 diabetes is associated with worse performance on cognitive tests measuring executive functions. Researchers analyzed 60 studies involving over 80,000 individuals with type 2 diabetes and their counterparts without it.
A study published in JAMA found that blood pressure-lowering treatment among patients with type 2 diabetes is associated with a lower risk of cardiovascular disease, heart disease events, and improved mortality. By reducing systolic BP by 10 mmHg, patients experienced better clinical outcomes.
Recent studies suggest that added sugars, particularly fructose, are a principal driver of type 2 diabetes. Clinical experts recommend drastic reductions in added sugar and especially fructose consumption to combat the growing epidemic.
Researchers discovered that specialised immune cells called regulatory T cells played a key role in controlling inflammation in fat tissue and maintaining insulin sensitivity. Treating fat tissues with IL-33 restored normal Treg cell levels, reducing inflammation and decreasing blood glucose levels.
A healthy diet is associated with a lower risk of type 2 diabetes among women in all racial and ethnic groups, but has an even greater benefit for Asian, Hispanic, and black women. The study found that healthy diets can prevent 5.3 cases of diabetes per 1,000 white women per year, compared to 8.0 cases per 1,000 minority women per year.