Articles tagged with Type 2 Diabetes
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Scientists have observed the creation of temporary intermediate structures during amylin aggregation, which may explain why proteins aggregate into toxic plaques. The new technology using 2D IR spectroscopy helps elucidate the physics and chemistry behind amyloid diseases.
A recent study published in Cell Press found that high levels of a molecule called heme oxygenase-1 (HO-1) are linked to poor metabolic health and an increased risk of type 2 diabetes in obese humans.
The OpT2mise trial found that insulin pumps result in better blood sugar control than multiple daily injections in people with type 2 diabetes. The study showed that patients using the pumps achieved a significantly greater reduction in average blood sugar levels and spent less time in hyperglycaemia.
A systematic review and meta-analysis suggest that combined aerobic and resistance training is most effective for controlling blood sugar and blood fat profiles in people with type 2 diabetes. However, more high-quality trials are needed to confirm these findings.
A new study finds that for many patients with type 2 diabetes, the benefits of treatment are outweighed by the negative impact of side effects like weight gain and frequent insulin shots. The study suggests that individualized treatment recommendations based on patient risk factors and preferences may be a better approach than focusing...
A new clinical trial shows that Roux-en-Y gastric bypass surgery can help obese patients with Type 2 diabetes reduce their risk of heart disease. The study found significant weight loss and improved blood sugar control, blood pressure, and cholesterol levels in the surgical group compared to the lifestyle modification group.
A large-scale study found that young women with Polycystic Ovary Syndrome (PCOS) have a higher incidence and prevalence of type 2 diabetes, even if not overweight. Obesity is not a significant trigger for type 2 diabetes in PCOS patients.
Researchers found that incorporating two ounces of tree nuts into the diet reduced CHD risk factors and 10-year CHD risk. The study's findings suggest that tree nuts can modify the fatty acid profile of adults with type 2 diabetes, contributing to a reduction in CHD risk.
A study published in Cell Metabolism reveals that free radical molecules contribute to the development of type 2 diabetes, obesity, and fatty liver disease by inactivating protein tyrosine phosphatases. This inactivation leads to a cascade of events promoting disease progression.
A new study presented at ICE/ENDO 2014 found that adults with Type 2 diabetes who improve their physical fitness have a lower chance of getting chronic kidney disease. The study also showed that exercise can improve kidney function in people with existing kidney damage, providing hope for patients with progressive kidney disease.
Adults with Type 2 diabetes who undergo sleeve gastrectomy surgery achieve better blood glucose control two years post-surgery compared to those receiving standard medical care. This study highlights the benefits of a surgical approach in improving diabetes outcomes.
Researchers found changes in gut microbiota composition among people with Type 2 diabetes or obesity compared to healthy individuals. The study identified associations between specific bacterial species and metabolic variables such as BMI, hemoglobin A1c, and waist circumference.
Recent research from BUSM sheds light on the regulatory strategies controlling PPARgamma activity in cells, offering potential avenues for developing effective treatments. By targeting specific subsets of PPARgamma target genes, researchers aim to improve insulin sensitivity and combat type 2 diabetes.
A new study found that soy protein supplements containing phytoestrogens do not reduce testosterone levels in men with Type 2 diabetes. Instead, they improve diabetes control and cardiovascular risk factors. The supplements also show promise in reducing the risk of heart disease.
A new study found that empagliflozin lowers blood pressure in patients with Type 2 diabetes and hypertension. The drug also reduced blood glucose levels by 0.62-0.65 percentage points, suggesting a potential to reduce cardiovascular events.
A study found that older adults have fewer taste buds, leading to higher fasting blood sugar levels and lower adiponectin levels. The researchers suggest a link between the number of taste buds and glucose metabolism during aging.
A new study finds that diabetes drug liraglutide, when combined with diet and exercise, leads to significant weight loss of up to 18.7 pounds and reversal of prediabetes in nearly 70% of participants. The medication also delays the development of type 2 diabetes by three times.
A new study finds that women with polycystic ovary syndrome (PCOS) are at a high risk of developing type 2 diabetes, regardless of their body mass index (BMI). The study analyzed data from over 6,000 women and found that PCOS was associated with a five-fold increased risk of T2DM.
A long-term follow-up study found that bariatric surgery resulted in more frequent diabetes remission and fewer complications compared to usual care. The study showed a significant decrease in microvascular and macrovascular complications.
Researchers mapped a gene variant among Greenlanders that markedly increases the risk of developing type 2 diabetes. The gene variant is primarily found in Greenlanders and explains 15% of cases in the country.
Researchers found that interventions for diabetes distress significantly reduced symptoms of depression in people with type 2 diabetes. In contrast, patients with type 1 diabetes who reported high levels of depressive symptoms had a higher mortality risk. These findings suggest that 'diabetes distress' may not be a co-morbid psychiatri...
The study found that participants who received lifestyle intervention or metformin had lower rates of type 2 diabetes development, with reductions of 27% and 17%, respectively. However, the interventions did not reduce microvascular complications such as eye, nerve, and kidney disease.
A study found that improving diet quality by 10% over four years reduced the risk of type 2 diabetes by about 20%. This benefit was independent of other lifestyle changes such as weight loss or increased physical activity. Improving diet quality alone has significant health benefits.
The Affordable Care Act (ACA) offers significant benefits for diabetes patients, including non-exclusion of pre-existing conditions and access to preventive services. The law also authorizes the creation of the National Diabetes Prevention Program, delivering evidence-based lifestyle change programs to prevent type 2 diabetes.
Men with type 2 diabetes lost 12% of abdominal fat and reduced blood sugar levels by 20%, while those with high blood pressure showed improved heart rate and fitness, reducing the risk of heart disease. Football training also provided social benefits and increased motivation for further exercise.
Use of insulin analogs among privately insured patients with type 2 diabetes increased significantly between 2000 and 2010. Out-of-pocket expenditures for insulin prescriptions also rose substantially during this period.
Researchers discovered altered salivary biomarker levels in obese children, indicating a potential non-invasive method for identifying early Type 2 diabetes risk. The study's findings provide valuable insights into childhood obesity and metabolic syndrome, paving the way for development of prevention strategies.
A genetic analysis of 3,700 Mexican and U.S. Latino individuals identified a gene variant associated with a 5-fold increase in type 2 diabetes prevalence. The HNF1A gene variant was found to be more common in participants with type 2 diabetes, particularly in Latino patients.
A long-term follow-up of obese patients with type 2 diabetes shows that bariatric surgery leads to more frequent diabetes remission. The study found that bariatric surgery results in a lower incidence of microvascular and macrovascular complications compared to usual care.
Researchers identified a strong genetic risk factor for type 2 diabetes that primarily affects Latin American patients, with potential implications for tailored treatments. The study's findings suggest that patients carrying this variant may benefit from drugs effective in treating MODY, a rare form of diabetes.
Two recent JAMA Surgery studies investigate bariatric surgery as a treatment option for type 2 diabetes in obese patients. The studies found that bariatric surgery can lead to significant weight loss and improvements in blood sugar control, suggesting it may be an effective adjunctive therapy for managing the condition.
A study published in Human Reproduction found that mothers of daughters with polycystic ovary syndrome (PCOS) have a significantly increased risk of death, especially when combined with type 2 diabetes. The research compared mortality rates between mothers and fathers of PCOS daughters with the general Dutch population.
Researchers at the University of Montreal have identified a novel enzyme, ABHD6, that breaks down a fat-like signal involved in insulin release. Inhibiting this enzyme may increase insulin levels in blood and improve sensitivity to insulin, providing a potential new target for type 2 diabetes treatment.
A new study found that online therapeutic communities can foster empathy and peer-to-peer mentoring among people living with chronic disease. Interactive social platforms build community engagement and markets for new technologies, supporting healthcare reform.
A study found a fat-storage gene mutation that interferes with key enzyme in lipid metabolism, increasing diabetes risk. The mutation affects 5.1% of the Old Order Amish study participants, with four individuals having two copies of the mutation.
A large cohort study found that universal strategies to prevent obesity, regardless of genetic risk, are more effective in reducing the risk of developing type 2 diabetes. The study highlights the importance of promoting healthy lifestyles to minimize excess weight, particularly among younger and leaner individuals.
A study of over 4,500 women with a history of gestational diabetes found that increased physical activity significantly reduces the risk of developing type 2 diabetes. Women who engaged in moderate-to-vigorous physical activity for at least 150 minutes per week had a 47% lower risk of progressing to type 2 diabetes.
A recent study published in Diabetes Technology & Therapeutics reveals significant disparities in cardiovascular risk factors, such as blood pressure and cholesterol levels, between men and women with type 2 diabetes. The research highlights the importance of addressing gender differences in managing co-morbidities.
A study published in Diabetologia found that eating two large meals (breakfast and lunch) is more effective than six small meals with the same calories in controlling weight and blood sugar levels in people with type 2 diabetes. The researchers also found that this approach improved insulin sensitivity and reduced liver fat content.
A landmark study shows that intensive insulin treatment significantly improves survival in patients with type 2 diabetes who have had a heart attack. The trial, which followed patients for up to 20 years, found that those who received intensified insulin treatment survived an average of 2.3 years longer than those on standard treatment.
Researchers at Wayne State University are investigating grape skin extract as a potential treatment for type 2 diabetes. The study aims to understand the novel inhibitory activity of GSE on postprandial hyperglycemia, with hopes of developing a safe and targeted nutritional intervention.
A low-carbohydrate diet was found to significantly reduce inflammation in patients with type 2 diabetes, whereas a traditional low-fat diet showed no similar effect. After six months, the low-carb group exhibited reduced levels of inflammatory markers and improved glucose control.
Researchers found significant increases in type 1 and 2 diabetes among US youth, with a 21% rise in type 1 diabetes and a 30.5% increase in type 2 diabetes between 2001 and 2009. The prevalence of both types increased across all racial/ethnic groups and age groups.
Researchers discovered that Mgat5 gene deficiency leads to improved glucose control and resistance to high calorie diets. The hexosamine biosynthesis pathway (HBP) enhances glucagon receptor sensitivity to increase liver glucose production.
A study found that longer diabetes duration is associated with brain volume loss and grey matter shrinkage, contrary to previous assumptions about its impact on small vessel ischemic disease. The researchers suggest potential implications for cognitive decline in patients with diabetes.
Type 2 diabetes affects 24 million US citizens, with African Americans facing a 77% greater risk due to genetic, dietary and cultural factors. Culturally tailored healthcare is crucial for improving outcomes.
A four-year increase in coffee consumption was associated with a reduced risk of type 2 diabetes, while decreases in coffee intake were linked to a higher risk. Coffee's protective effect against type 2 diabetes appears to be independent of initial coffee consumption and other lifestyle factors.
A new study published in Diabetologia found that increasing daily coffee consumption by more than one cup per day can lower the risk of developing type 2 diabetes by 11%. Conversely, decreasing coffee consumption by more than a cup per day increases the risk of type 2 diabetes by 17%.
A community-based structured weight loss program significantly improved blood sugar control and reduced medication use in overweight adults with type 2 diabetes. Participants who received personalized counseling and portion-controlled foods lost more weight and showed better diabetes management compared to a control group.
Researchers at the University of Adelaide found that a common diabetes treatment, GLP-1 in combination with insulin, can slow down stomach emptying after eating, leading to extended periods of hypoglycemia. This may result in increased health risks for people with type 2 diabetes.
A new study by Monash University has shown that gastric banding can lead to remission of diabetes in people who are overweight but not obese. The research, published in The Lancet Diabetes and Endocrinology, found that weight loss surgery significantly improved the condition in over half of participants.
A recent study published in The Lancet Diabetes & Endocrinology found that lifestyle interventions can significantly reduce the risk of death from cardiovascular disease and all-causes among individuals with impaired glucose tolerance. The 23-year follow-up of the Da Qing Diabetes Prevention Study showed a cumulative incidence of death...
Researchers found that blocking the effects of CMPF may help prevent and treat diabetes. A fat metabolite called CMPF was dramatically increased in both gestational and type 2 diabetic individuals, impairing insulin secretion from beta cells.
A recent study found that DKA rates among US youth with type 1 diabetes remained unchanged over the last 8 years, affecting nearly a third of all youth with the condition. The study also showed disproportionate rates among younger children, non-White racial/ethnic groups, and those without private health insurance.
Gastric bypass and sleeve gastrectomy surgeries show significant improvement in glycemic control, weight loss, and cardiovascular risk factors compared to intensive medical therapy. Patients undergoing surgery also experience reduced reliance on medications and improved quality of life measures.
Bariatric surgery patients report better quality of life, reduced need for cardiovascular medications, and improved blood sugar control without insulin or most diabetic medications. The STAMPEDE trial shows gastric bypass surgery is more effective than medical therapy in treating type 2 diabetes in obese patients.
The study found that aleglitazar did not decrease the time to cardiovascular death, nonfatal heart attack, or nonfatal stroke among patients with type 2 diabetes. The drug was associated with increased risks of kidney abnormalities, bone fractures, gastrointestinal bleeding, and hypoglycemia.
A study published by Helmholtz Munich researchers found that patients with good diabetes self-management have a significantly lower mortality risk than those with poor self-management. The study, which analyzed data from 340 participants, showed that active participation in treatment and lifestyle modifications can lead to better healt...
Researchers at the Children's Hospital of Eastern Ontario Research Institute found a new cellular pathway that helps keep blood sugar levels low in obese or pre-diabetic people, which may prevent the onset of Type 2 diabetes. The discovery could lead to new targets for improving beta cell functionality and treating type 2 diabetes.
Researchers at Vanderbilt University Medical Center have found evidence that the insulin-secreting beta cells of the pancreas can regenerate. This surprising discovery suggests that understanding how regeneration occurs may lead to new treatments for the rising tide of diabetes, affecting over 8% of the US population.