Articles tagged with Type 2 Diabetes
A study of 61 obese participants with type 2 diabetes mellitus found that bariatric surgery resulted in more disease remission than lifestyle intervention alone. At 3 years, 40% of those who underwent RYGB achieved complete remission, compared to 15% of those who received LAGB and no intensive lifestyle weight loss intervention.
Research suggests that medically complex patients with newly diagnosed Type 2 diabetes who receive early endocrinologist care have lower risk of cardiovascular events. The study, which analyzed Ontario health data, found that these patients had a 10-20% lower risk of heart attack, stroke, and death from coronary heart disease.
Researchers have discovered a potential target for the treatment of type 2 diabetes by inhibiting the S6K1 protein, which increases insulin sensitivity in mice. In animal models, S6K1 deficient mice displayed improved insulin response and reduced risk of developing diabetes.
A systematic review and meta-analysis of 36 observational studies found that nut consumption is associated with a decreased risk of colorectal cancer, endometrial cancer, and pancreatic cancer. However, it was not linked to type 2 diabetes.
A study published in the Journal of the American Pharmacists Association found that having pharmacists on primary care teams improved the treatment of blood pressure in patients with Type 2 diabetes. The addition of pharmacists led to substantial improvements in patient health, including a significant impact on blood pressure control.
A team of scientists has identified an enzyme called Kit, which plays a key role in the development of obesity and metabolic disorders. In mice with functioning Kit, fed a high-fat diet, obesity and insulin resistance were prevented.
The ELIXA study found no increased risk of cardiovascular death, heart attack, stroke, or heart failure in patients with type 2 diabetes taking lixisenatide. Lixisenatide also showed a modest benefit for weight control and no increase in hypoglycemia or pancreatic injury risk.
Researchers at Brigham and Women's Hospital found that lixisenatide did not increase risk of cardiovascular events in a large, double-blind trial involving over 6,000 type 2 diabetes patients. The study's results provide reassurance for healthcare providers about the cardiovascular safety of this widely prescribed glucose-lowering drug.
A Danish study suggests that type 2 diabetes is associated with a reduced risk for amyotrophic lateral sclerosis (ALS). The study found that older age at diagnosis for either disease was associated with lower risk. The findings focus attention on the role of energy metabolism in ALS pathogenesis.
Researchers at the University of Iowa have found that prolonged exposure to Staphylococcus aureus bacteria causes insulin resistance and glucose intolerance in rabbits, mirroring the symptoms of type 2 diabetes. Anti-bacterial therapy or vaccines may hold promise for preventing or treating the disease.
Researchers have identified a genetic association between elevated triglyceride levels and decreased type 2 diabetes incidence. Triglyceride-increasing alleles were found to be associated with lower risk of developing type 2 diabetes, suggesting that these genetic variants may play a role in protecting against the disease.
A large European cohort study found that higher fibre intake was associated with a lower risk of type 2 diabetes. Cereal fibre had the strongest inverse association, suggesting it may help maintain a healthy weight and reduce the risk of developing diabetes.
Obesity alters splicing patterns of genes TCF7L2 and INSR, leading to impaired insulin action. Weight loss reverses these changes, suggesting a targeted treatment approach for metabolic disorders. Alternative splicing regulates obesity-related gene expression, offering new diagnostic and therapeutic avenues.
Women who were having sons were more likely to develop gestational diabetes than women who were pregnant with daughters. Women who developed gestational diabetes while pregnant with daughters were at higher risk of being diagnosed with Type 2 diabetes after pregnancy.
A new study suggests that early detection and treatment of type 2 diabetes can significantly reduce the risk of cardiovascular disease and death. The research found that screening followed by treatment led to a reduced risk of cardiovascular events within five years compared to patients with no screening.
The Lancet Diabetes & Endocrinology publishes a series on depression and diabetes, revealing a bi-directional association between the two conditions. The studies also suggest that depression-distress mediates the association between depression and glycaemic control.
Research found that patients with type 2 diabetes who are overweight but not obese live longer than those who are underweight or normal-weight. The 'obesity paradox' suggests that excess weight may be beneficial for survival in these patients, contrary to previous expectations. Meanwhile, daily low-molecular-weight heparin injections w...
Researchers found that quitting smoking is associated with a temporary deterioration in blood glucose control, which can last up to three years. The study suggests that smokers with type 2 diabetes should expect to take extra care to keep their blood glucose levels well-controlled after quitting smoking.
A clinical trial by Joslin Diabetes Center found that adjustable gastric band surgery and intensive group-based medical diabetes and weight management program achieved similar improvements in controlling blood sugar levels after one year. Participants experienced significant weight loss and better quality of life with both approaches.
A new genetic mutation in the GLP1R gene has been found to decrease the risk of developing Type 2 diabetes by 14 percent. The discovery could lead to personalized treatment and prevention strategies for millions of diabetics worldwide.
Remogliflozin etabonate improves insulin sensitivity and beta cell function, reducing ALT levels and weight in patients with NASH. The investigational drug also exhibits intrinsic anti-oxidant activity, reversing steatohepatitis and oxidative stress.
Researchers have identified a new mechanism that controls glucagon secretion in humans, which could lead to more effective treatment of type 2 diabetes. By understanding this phenomenon, it is possible to elucidate the paradoxical effect of a new class of diabetes drugs and suggest modifications to this new type of treatment.
A study of over 2.4 million Danish citizens found that depression, type 2 diabetes, or both are associated with a higher risk of dementia. Individuals diagnosed with depression or type 2 diabetes alone have an increased risk, while those with both conditions experience the greatest increase in risk.
A large study found a significant association between intrauterine exposure to gestational diabetes and an increased risk of autism spectrum disorders in offspring. Maternal pre-existing type 2 diabetes was not significantly associated with this risk.
The USPSTF completed a systematic evidence review to inform an upcoming update of Task Force recommendations on screening asymptomatic adults for type 2 diabetes. Screening was found to help delay progression to diabetes by identifying those who could benefit from treatment, but did not improve mortality rates.
A study published in American Journal of Clinical Nutrition found that egg consumption was associated with a lower risk of type 2 diabetes. Men who ate four eggs per week had a 37% lower risk compared to those who ate one egg per week.
A new study published in the American Journal of Clinical Nutrition found that high-fat dairy products are associated with a reduced risk of type 2 diabetes. Researchers analyzed data from 27,000 individuals and found those who consumed more high-fat dairy had a 23% lower risk
Researchers have discovered a new class of potentially therapeutic lipids, FAHFAs, which are found at lower levels in people with insulin resistance. Administering FAHFAs to diabetic mice improved glucose metabolism and insulin secretion, suggesting a potential avenue for developing novel medications.
States expanding Medicaid under ACA see 23% increase in newly diagnosed diabetes patients compared to non-expansion states. Early detection can prevent complications and improve quality of life for those with diabetes.
Researchers found that vitamin D helps regulate glucose metabolism, reducing the risk of type 2 diabetes. In mice without adequate vitamin D, immune cells became fat transporters, leading to artery clogging and inflammation.
Researchers at University of British Columbia found a new approach to treating Type 2 diabetes using stem cell transplants and conventional drugs. The study showed mice became glucose tolerant after receiving the transplants, while those without received only drugs, resulting in unexpected weight loss.
A stem cell-based approach using human embryonic stem cells proved effective in improving insulin sensitivity and glucose metabolism in mice. The combination of stem cell transplantation and antidiabetic drugs resulted in rapid weight loss and significant improvements in glucose control compared to individual treatments.
A new study found that obese women who develop gestational diabetes are 43 times more likely to develop type 2 diabetes if they gain 5 kg or more after pregnancy. The research emphasizes the importance of maintaining a healthy body weight before and after pregnancy to prevent type 2 diabetes.
Researchers at McMaster University found that women's muscle appears more efficient in neutralizing the protein PTEN, which reduces insulin resistance and increases protection against type 2 diabetes. This discovery provides a potential therapeutic target for improving muscle responses to insulin and treating the disease.
A study of 25,000 patients with familial hypercholesterolemia found a significant lower prevalence of type 2 diabetes compared to unaffected relatives, varying by the type of gene mutation. The findings suggest decreased pancreatic LDL transport may reduce cell death and lower diabetes rates.
A new study by the Endocrine Society finds that accumulating just 30 minutes of sleep debt on weekdays can lead to significant effects on obesity and insulin resistance at follow-up. The research suggests that avoiding sleep debt could have positive benefits for waistlines and metabolism.
A new study reveals that changes in the gut microbiota occur early in diabetes development, with beneficial bacteria more prevalent in those maintaining stable blood sugar control. The research suggests a link between gut bacteria and metabolic health, potentially informing strategies to prevent or manage Type 2 diabetes.
Research suggests that African American men with pre-diabetic blood sugar levels have fewer beneficial and more harmful intestinal bacteria. The study found that a specific microbiota is associated with stable, normal blood glucose levels, while a different profile is linked to pre-diabetes.
Research found that GLP-1 secretion is lower among people with pre-diabetes and obesity compared to normal weight individuals. The study suggests that early intervention with GLP-1 analogues may postpone the onset of type 2 diabetes.
A new oral, controlled-release form of DNP, known as CRMP, reversed fatty liver, insulin resistance, and hyperglycemia in rat models of NAFLD and type 2 diabetes, with no adverse effects. The therapy achieved plasma concentrations that were more than a 100-fold less than the toxic threshold.
Researchers found that habitual breakfast skippers had poorer glucose control after consuming a high-protein breakfast, while those who typically ate breakfast experienced improved glucose control. The study suggests that young women should gradually increase protein intake in the morning to improve glycemic control.
A new study published in Diabetologia shows that eating a high energy breakfast and a low energy dinner improves blood sugar control for individuals with type 2 diabetes. The study found significant reductions in post-meal glucose levels and insulin levels when participants followed the high-energy breakfast and low-energy dinner diet.
A new study found that intensive lifestyle intervention or medication can significantly reduce the risk of developing Type 2 diabetes in women who had gestational diabetes. Women with a history of gestational diabetes were less likely to develop diabetes when assigned to take metformin or undergo intensive lifestyle intervention.
Research suggests that exercising after a meal can lower blood sugar and fat levels, providing more benefits than exercising before dinner. The study found that resistance exercise performed after dinner had the most powerful effect on reducing glucose and fat levels.
A new study from the University of Waterloo found that type 2 diabetes is associated with worse performance on cognitive tests measuring executive functions. Researchers analyzed 60 studies involving over 80,000 individuals with type 2 diabetes and their counterparts without it.
A study published in JAMA found that blood pressure-lowering treatment among patients with type 2 diabetes is associated with a lower risk of cardiovascular disease, heart disease events, and improved mortality. By reducing systolic BP by 10 mmHg, patients experienced better clinical outcomes.
Recent studies suggest that added sugars, particularly fructose, are a principal driver of type 2 diabetes. Clinical experts recommend drastic reductions in added sugar and especially fructose consumption to combat the growing epidemic.
Researchers discovered that specialised immune cells called regulatory T cells played a key role in controlling inflammation in fat tissue and maintaining insulin sensitivity. Treating fat tissues with IL-33 restored normal Treg cell levels, reducing inflammation and decreasing blood glucose levels.
A healthy diet is associated with a lower risk of type 2 diabetes among women in all racial and ethnic groups, but has an even greater benefit for Asian, Hispanic, and black women. The study found that healthy diets can prevent 5.3 cases of diabetes per 1,000 white women per year, compared to 8.0 cases per 1,000 minority women per year.
A new study found that magnesium intake, genes, and ethnicity interact to determine type 2 diabetes risk in postmenopausal women. The study analyzed data from the Women's Health Initiative and found specific interactions between diet, genetics, and ethnicity.
A long-term study of civilian women found that those with more PTSD symptoms had a nearly two-fold increased risk of developing type 2 diabetes. The study suggests that antidepressant use and higher body mass index associated with PTSD may mediate this relationship.
A longitudinal cohort study of 49,739 women found a dose-response relationship between PTSD symptoms and increased risk of type 2 diabetes. The researchers also identified antidepressant use and elevated body mass index as significant contributors to the association.
A study by Penn Medicine found that many patients with type 2 diabetes are being discouraged from taking metformin due to an overly conservative FDA label. The authors recommend amending the label to reflect more modern guidelines, which could extend the drug's use to nearly 1 million additional patients.
A new study confirmed that people born weighing 6 pounds or less face an increased risk for type 2 diabetes as adults. The research identified specific biomarkers with relative predictive value, giving doctors potential new tools to understand individual risk among low birthweight women.
A systematic review of the literature suggests that metformin is safe for patients with mild to moderate kidney disease, contrary to FDA guidelines. The risk of lactic acidosis is extremely low and comparable to those who do not take metformin.
The American Diabetes Association has lowered its recommended BMI cut point for type 2 diabetes screening in Asian Americans from 25 kg/m2 to 23 kg/m2. This change is based on evidence that many Asian Americans develop the disease at lower BMI levels than other populations.
A new study found that only 18% of seniors with Type 2 diabetes use apps to manage their condition, despite interest in web and mobile applications. The study suggests that age-related confidence in technology use is a significant barrier to adoption.
A study of over 80,000 women found a significant association between specific ABO blood groups and an increased risk of type 2 diabetes. Those with blood groups A, B, and AB had a higher risk compared to individuals with group O blood.
A study of over 4,000 non-diabetic Mexican-Americans reveals shared and distinct genetic contributions to insulin signaling and glucose response. The findings identify potential novel genetic risk factors for type 2 diabetes, highlighting the complexity of the disease.
A study published in Diabetes Care found that hypoglycaemia significantly increases the risk of cardiovascular events and mortality in insulin-treated patients with diabetes. The research, led by University of Leicester, showed a ~60% higher risk of cardiovascular events following hypoglycaemia.