Articles tagged with Type 2 Diabetes
A large cohort study found that universal strategies to prevent obesity, regardless of genetic risk, are more effective in reducing the risk of developing type 2 diabetes. The study highlights the importance of promoting healthy lifestyles to minimize excess weight, particularly among younger and leaner individuals.
A study of over 4,500 women with a history of gestational diabetes found that increased physical activity significantly reduces the risk of developing type 2 diabetes. Women who engaged in moderate-to-vigorous physical activity for at least 150 minutes per week had a 47% lower risk of progressing to type 2 diabetes.
A study published in Diabetologia found that eating two large meals (breakfast and lunch) is more effective than six small meals with the same calories in controlling weight and blood sugar levels in people with type 2 diabetes. The researchers also found that this approach improved insulin sensitivity and reduced liver fat content.
A recent study published in Diabetes Technology & Therapeutics reveals significant disparities in cardiovascular risk factors, such as blood pressure and cholesterol levels, between men and women with type 2 diabetes. The research highlights the importance of addressing gender differences in managing co-morbidities.
A landmark study shows that intensive insulin treatment significantly improves survival in patients with type 2 diabetes who have had a heart attack. The trial, which followed patients for up to 20 years, found that those who received intensified insulin treatment survived an average of 2.3 years longer than those on standard treatment.
A low-carbohydrate diet was found to significantly reduce inflammation in patients with type 2 diabetes, whereas a traditional low-fat diet showed no similar effect. After six months, the low-carb group exhibited reduced levels of inflammatory markers and improved glucose control.
Researchers at Wayne State University are investigating grape skin extract as a potential treatment for type 2 diabetes. The study aims to understand the novel inhibitory activity of GSE on postprandial hyperglycemia, with hopes of developing a safe and targeted nutritional intervention.
Researchers found significant increases in type 1 and 2 diabetes among US youth, with a 21% rise in type 1 diabetes and a 30.5% increase in type 2 diabetes between 2001 and 2009. The prevalence of both types increased across all racial/ethnic groups and age groups.
A study found that longer diabetes duration is associated with brain volume loss and grey matter shrinkage, contrary to previous assumptions about its impact on small vessel ischemic disease. The researchers suggest potential implications for cognitive decline in patients with diabetes.
Type 2 diabetes affects 24 million US citizens, with African Americans facing a 77% greater risk due to genetic, dietary and cultural factors. Culturally tailored healthcare is crucial for improving outcomes.
Researchers discovered that Mgat5 gene deficiency leads to improved glucose control and resistance to high calorie diets. The hexosamine biosynthesis pathway (HBP) enhances glucagon receptor sensitivity to increase liver glucose production.
A new study published in Diabetologia found that increasing daily coffee consumption by more than one cup per day can lower the risk of developing type 2 diabetes by 11%. Conversely, decreasing coffee consumption by more than a cup per day increases the risk of type 2 diabetes by 17%.
A four-year increase in coffee consumption was associated with a reduced risk of type 2 diabetes, while decreases in coffee intake were linked to a higher risk. Coffee's protective effect against type 2 diabetes appears to be independent of initial coffee consumption and other lifestyle factors.
A community-based structured weight loss program significantly improved blood sugar control and reduced medication use in overweight adults with type 2 diabetes. Participants who received personalized counseling and portion-controlled foods lost more weight and showed better diabetes management compared to a control group.
Researchers at the University of Adelaide found that a common diabetes treatment, GLP-1 in combination with insulin, can slow down stomach emptying after eating, leading to extended periods of hypoglycemia. This may result in increased health risks for people with type 2 diabetes.
A new study by Monash University has shown that gastric banding can lead to remission of diabetes in people who are overweight but not obese. The research, published in The Lancet Diabetes and Endocrinology, found that weight loss surgery significantly improved the condition in over half of participants.
A recent study published in The Lancet Diabetes & Endocrinology found that lifestyle interventions can significantly reduce the risk of death from cardiovascular disease and all-causes among individuals with impaired glucose tolerance. The 23-year follow-up of the Da Qing Diabetes Prevention Study showed a cumulative incidence of death...
Researchers found that blocking the effects of CMPF may help prevent and treat diabetes. A fat metabolite called CMPF was dramatically increased in both gestational and type 2 diabetic individuals, impairing insulin secretion from beta cells.
Bariatric surgery patients report better quality of life, reduced need for cardiovascular medications, and improved blood sugar control without insulin or most diabetic medications. The STAMPEDE trial shows gastric bypass surgery is more effective than medical therapy in treating type 2 diabetes in obese patients.
A recent study found that DKA rates among US youth with type 1 diabetes remained unchanged over the last 8 years, affecting nearly a third of all youth with the condition. The study also showed disproportionate rates among younger children, non-White racial/ethnic groups, and those without private health insurance.
Gastric bypass and sleeve gastrectomy surgeries show significant improvement in glycemic control, weight loss, and cardiovascular risk factors compared to intensive medical therapy. Patients undergoing surgery also experience reduced reliance on medications and improved quality of life measures.
The study found that aleglitazar did not decrease the time to cardiovascular death, nonfatal heart attack, or nonfatal stroke among patients with type 2 diabetes. The drug was associated with increased risks of kidney abnormalities, bone fractures, gastrointestinal bleeding, and hypoglycemia.
A study published by Helmholtz Munich researchers found that patients with good diabetes self-management have a significantly lower mortality risk than those with poor self-management. The study, which analyzed data from 340 participants, showed that active participation in treatment and lifestyle modifications can lead to better healt...
Researchers at Vanderbilt University Medical Center have found evidence that the insulin-secreting beta cells of the pancreas can regenerate. This surprising discovery suggests that understanding how regeneration occurs may lead to new treatments for the rising tide of diabetes, affecting over 8% of the US population.
Researchers at the Children's Hospital of Eastern Ontario Research Institute found a new cellular pathway that helps keep blood sugar levels low in obese or pre-diabetic people, which may prevent the onset of Type 2 diabetes. The discovery could lead to new targets for improving beta cell functionality and treating type 2 diabetes.
A Kaiser Permanente study found that women who experienced gestational diabetes during pregnancy had a larger carotid artery wall thickness, indicating an increased risk of early atherosclerosis and heart disease. This finding suggests that reproductive complications can signal future disease risk.
The BRCA1 gene is expressed in skeletal muscle cells and plays a critical role in fat storage, insulin response, and mitochondrial function. Mutations in the BRCA1 gene may increase the risk of metabolic diseases like obesity and type 2 diabetes.
Researchers at Lund University found epigenetic changes in approximately 800 genes of people with type 2 diabetes, which could contribute to reduced insulin production. Epigenetic changes are reversible and can be influenced by factors like age, BMI, and lifestyle.
An international team has identified genetic mutations that reduce the risk of type 2 diabetes by 65% in people with risk factors. These mutations may lead to the development of a new therapeutic strategy for preventing and treating the disease.
Research finds that living in a socioeconomically deprived region increases the risk of diabetes and obesity, regardless of individual social status. The study analyzed data from over 33,000 people and found significant correlations between regional deprivation and type 2 diabetes and obesity rates.
James Watson suggests that type 2 diabetes is linked to a lack of biological oxidants, not an excess. Exercise promotes oxidation, which can help remedy this deficiency and benefit individuals with high blood sugar.
A new study published in Diabetologia found that diabetes in women is associated with a higher risk of stroke compared to men. The research showed a graded association between HbA1c levels and stroke risk in women, indicating that those with higher blood sugar levels are more likely to experience a stroke.
A study by Massachusetts General Hospital found that cognitive behavioral therapy addressing mood and treatment management skills improved blood sugar control and reduced depression symptoms in poorly-controlled type 2 diabetes patients. The integrated approach showed faster relief of depression symptoms compared to usual care.
A new study by the University of Michigan finds that pediatric providers are using less effective screening tests for type 2 diabetes in children, leading to potential missed diagnoses. The new American Diabetes Association guidelines have been criticized due to lower test performance and increased costs for non-fasting tests.
A recent study published in PLOS Medicine suggests that type 2 diabetes may not be directly linked to substantial weight gain over time. Instead, researchers identified distinct patterns of obesity development, including stable overweight individuals and those who experience continuous weight gain before diagnosis. The findings highlig...
A study of over 48,000 patients and 139,000 healthy controls from four ethnic groups revealed seven new genetic regions associated with type 2 diabetes. The research provides insights into the biological processes involved in the disease and may lead to novel therapies.
A large study published in Diabetologia found that higher yogurt consumption was associated with a reduced risk of developing type 2 diabetes. The researchers found that consuming low-fat fermented dairy products, such as yoghurt, reduced the relative risk of diabetes by 24% overall.
Research suggests that intensive blood pressure and cholesterol lowering treatment does not lower the risk of cognitive decline in older patients with long-standing type 2 diabetes mellitus. In contrast, a lower brain volume was observed in patients who received intensive blood pressure-lowering therapy.
Bariatric surgery is the most effective treatment for both obesity and type 2 diabetes, offering substantial benefits in terms of weight loss, metabolic status, and quality of life. In people with type 2 diabetes, bariatric surgery can reverse complications and improve end-organ health, including pancreatic, renal, retinal, peripheral ...
A study at Lund University Diabetes Centre found that gastric bypass surgery increases the number of beta cells and improves their function in pigs. The procedure raised blood sugar levels without weight loss or reduced food intake, contradicting previous assumptions.
Research from the University of East Anglia found that high intakes of flavonoids lower insulin resistance and inflammation, reducing the risk of diabetes. Flavone compounds also improved blood glucose regulation.
A recent study has made significant progress in understanding the role of DNA in predisposing individuals to diseases such as type 2 diabetes. The research integrated computational methodology with experimentation to identify genetic variants that promote disease by interfering with gene regulation and altering fat cell function.
A large-scale study refutes previous findings that suggested being overweight or obese could lead to lower mortality among people with type 2 diabetes. The study found no association between BMI and risk of death, with normal-weight individuals having the lowest risk.
A study discovered that PGC-1α, a protein regulating energy production in cells, may contribute to the development of type 2 diabetes. Chronically low levels of this protein in muscle tissue were linked to increased risk and detrimental effects on other tissues, including inflammation in the liver and adipose tissue.
A study published in the Journal of the American Medical Association found that maintaining higher blood glucose levels than recommended does not increase the risk of diabetes complications. People with MODY, a genetic change leading to elevated blood glucose from birth, had the same risk as their normal relatives.
A large study found that women who engaged in muscle-strengthening activities, such as weight training and yoga, had a reduced risk of developing type 2 diabetes. Women who met current physical activity guidelines, including both muscle-strengthening and aerobic exercise, experienced the greatest benefit.
Scientists have discovered that insulin-producing beta cells may fail due to oxygen deprivation, leading to type 2 diabetes. A second study reveals that acinar cells can be converted into functional beta cells, offering a promising new approach for treating the disease.
A recent study published in Diabetes Care found that high concentrations of serum long-chain omega-3 fatty acids from fish consumption significantly lower the risk of developing type 2 diabetes. The research involved over 2,200 Finnish men, with those in the highest omega-3 group showing a 33% reduced risk.
Researchers found that variations in non-coding DNA sequences influence insulin-producing cell behavior in people with type 2 diabetes. Genome sequences controlling gene activity were identified, and genetic variants associated with diabetes risk were also linked to these clusters.
A new study has found that genetic regions associated with increased risk of type 2 diabetes were unlikely to have been beneficial to people at stages through human evolution. The researchers tested this theory by examining 65 genetic regions and found no evidence to support the thrifty gene hypothesis.
A sugar-sweetened beverage tax could mitigate the rise in obesity and type 2 diabetes rates in India by averting millions of cases. The study estimates that a 20% SSB tax would save 11.2 million cases of overweight/obesity and 400,000 cases of type 2 diabetes between 2014 and 2023.
Researchers found that a single gene defect in MADD leads to fasting hyperglycemia and insufficient insulin secretion in mice. The study suggests that type 2 diabetes can be directly caused by the loss of a properly functioning MADD gene, highlighting potential therapeutic targets for treating people with this mutation.
Scientists have found that macrophages invade the diabetic pancreas, producing cytokines that contribute to insulin-producing beta cells' elimination. This discovery may lead to development of tailor-made anti-inflammatory therapies to reduce type 2 diabetes burden.
Researchers have identified a new genetic risk factor for type 2 diabetes, found to be more common in Latin Americans than other populations. The variant, SLC16A11, is associated with a 25% increased risk of diabetes and is linked to Neanderthal ancestry.
A texting service, txt4health, motivated people to change behavior and reduce their risk of type 2 diabetes, but less than half of enrollees stuck with the service. The program led to significant improvements in diet and physical activity habits among participants.
Researchers found that longer duration of diabetes and advancing age are associated with increased rates of diabetes complications, hypoglycemia, cardiovascular complications, and mortality. The study highlights the need for individualized care for older patients with type 2 diabetes.
A study found that nonsurgical periodontal treatment did not result in improved glycemic control in people with type 2 diabetes and chronic periodontitis. Despite improvements in clinical measures of chronic periodontitis, the treatment had no impact on HbAlc levels.
Research suggests a link between red meat and increased risk of gestational diabetes in pregnant women. Women are advised to consume more vegetable protein, nuts, and fish, while replacing some red meat with poultry.
A UK Biobank study has found a strong link between fathers' diabetes and their child's low birth weight, with genetic variations potentially explaining this effect. The research used data from 250,000 adults and suggests that treatments aimed at increasing birth weight may not be effective in preventing type 2 diabetes.
A recent study published in Diabetes Care found that Native Americans and African-Americans with type 2 diabetes have a significantly higher risk of developing dementia. The study analyzed data from over 22,000 patients aged 60 or older with type 2 diabetes and found that dementia rates were highest among these groups.