Articles tagged with Type 2 Diabetes
Researchers discovered that the intestinal immune system controls energy metabolism and can modify intestinal bacteria to prevent obesity and diabetes. By disabling a protein called MyD88, the team showed that mice can lose weight and reduce inflammation.
A systematic review of 12 studies found that lifestyle interventions, such as diet and exercise, reduced the risk of type 2 diabetes by 40% in both men and women. Men and women also experienced greater weight reductions with lifestyle interventions.
A high intake of yogurt has been found to be associated with a lower risk of developing type 2 diabetes. The researchers found that high consumption of yogurt was associated with a reduced risk, while other dairy foods did not show this association.
Researchers have discovered that brown fat, which burns calories and absorbs excess sugar, could be used to control blood glucose levels in people with type 2 diabetes. The study found that activating brown fat cells could lead to a new way of managing the disease without daily insulin injections.
A new study reveals a 48% increase in direct and indirect costs associated with diabetes over five years, with prediabetes costs rising 74% and undiagnosed diabetes costs increasing 82%. The growing burden of prediabetes highlights the need for prevention and early intervention.
A new review finds that genetic variation may prevent some individuals with type 2 diabetes from benefiting from supervised exercise regimens. The study suggests that targeted interventions and treatments could help those who do not respond to exercise, offering a potential new approach for managing the condition.
A study published in Nature found that thiazolidinediones, a class of diabetes drugs, work by targeting the CDK5 pathway, but unexpectedly led researchers to discover the ERK kinase instead. MEK inhibitors, initially developed for cancer treatment, have been shown to improve insulin resistance in mouse models of diabetes
Researchers at Indiana University School of Medicine have identified Sestrin 3 as a critical regulator of glucose homeostasis and insulin sensitivity in the liver. Mice with the protein showed improved glucose tolerance, while those without it exhibited impaired glucose metabolism.
A new study published in The Lancet Diabetes & Endocrinology found that bariatric surgery can reduce the risk of developing type 2 diabetes by around 80% in obese people compared to standard care. This significant reduction was observed even after controlling for other important factors such as smoking and high blood pressure.
Researchers found that patients who received more accessible primary care had better health-related quality of life and improvements comparable to eliminating early complications of diabetes. Women particularly benefited from doctors being more available, leading to stronger health improvements.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that diabetic men with low testosterone levels are more likely to develop severe atherosclerotic plaques and other cardiovascular markers. The research suggests a strong association between low testosterone concentration and the severi...
A team of scientists has successfully created a light-sensitive sulfonylurea compound that stimulates insulin release only in response to blue light. This breakthrough could lead to more precise control over blood sugar levels and reduce side effects associated with traditional diabetes treatments.
Researchers at Lund University have developed a personalized treatment for type 2 diabetes that targets the disease mechanism itself, rather than just its symptoms. The treatment, which uses a drug called Yohimbin, has shown promising results in improving insulin secretion in patients with the genetic risk variant.
Scientists at Imperial College London have created a light-activated drug that stimulates insulin release from pancreatic cells in response to blue light, potentially reducing side effects and improving blood sugar control. The drug, JB253, is reversible and can be switched on for short periods after meals.
Researchers from Lund University found epigenetic changes in DNA methylation and genetic code alterations that contribute to type 2 diabetes. Identical twins showed strong heredity similarities, suggesting a strong link between genetics and lifestyle.
A modified form of a medication called niclosamide may hold the key to battling type 2 diabetes by reducing liver fat and improving insulin function. The research aims to find a safe and practical way to diminish fat content in the liver, which could safely treat patients of all weights.
A large UK study has found a significant link between gout and diabetes in the general population, particularly among women. Women with gout were 71% more likely to develop diabetes than those without, highlighting the importance of prompt treatment of shared risk factors.
A large genetic study has found no evidence of a causal link between vitamin D levels and the development of type 2 diabetes. The study, conducted by scientists at the University of Cambridge, examined the genes that control blood levels of vitamin D and found no association with the risk of developing type 2 diabetes.
Research suggests physical activity reduces type 2 diabetes risk, but its effect may vary by genetic factors. Women at high genetic risk show weaker protective effect of physical activity compared to men.
A systematic review and meta-analysis found that people working more than 55 hours a week, especially those in low socioeconomic status jobs, have a 30% greater risk of developing type 2 diabetes. The study suggests that work factors affecting health behaviors and stress may need to be addressed for prevention.
The prevalence of diagnosed diabetes in the US population has plateaued for adults between 2008 and 2012, with a slight decrease in incidence. However, certain subgroups continue to experience an increase in diabetes rates, exacerbating existing racial and socioeconomic disparities.
A large-scale analysis found statin use associated with a 12% increased risk of type 2 diabetes over four years, as well as an average weight gain of 240g. Genetic variants linked to statin efficacy also showed smaller effects on weight and diabetes risk.
Researchers at Karolinska Institutet found that age-dependent reduction of mitochondrial function in beta cells leads to reduced insulin release. Impaired calcium ion dynamics is the molecular mechanism underlying this process.
A new study by Joslin Diabetes Center shows that Asian Americans who followed a traditional high-fiber, low-fat diet for 16 weeks lowered their insulin resistance and improved their LDL cholesterol levels. In contrast, those on a typical western diet experienced greater increases in insulin resistance.
A new study reveals that individuals with high intake of high-fat dairy products have a 23% lower risk of developing type 2 diabetes compared to those with low consumption. High fat from dairy may explain the protective association between dairy intake and T2D.
Researchers have discovered a pathological process that affects both mice and humans with type 2 diabetes. By analyzing genome, phenome, proteome, and metabolome data, they identified a specific gene on chromosome 2 that plays a crucial role in the development of the disease.
Research published in Diabetologia finds that age at diagnosis is not linked to microvascular complications, while longer diabetes duration increases the risk in younger patients. Effective prevention requires vigilance across all age groups, with intensified surveillance for macrovascular complications in older populations.
A new series published in The Lancet Diabetes & Endocrinology finds that the growing global diabetes epidemic is hampering progress in controlling and eliminating tuberculosis. With over 1 million cases annually, diabetes-associated TB cases are expected to offset the present downward trend in global TB cases by 8% or more by 2035.
A new study published in PLOS ONE suggests that the current way of diagnosing type-2 diabetes using blood glucose levels needs to be revised. The researchers found changes in blood fat metabolites before glucose levels increased, indicating a potential alternative approach for diagnosis and treatment.
A new study published in The FASEB Journal found that identical twins who eat fast food have similar levels of metabolites, regardless of weight. This suggests that genetics and gut microbiota play a crucial role in the development of Type 2 diabetes.
A recent study analyzing bariatric surgery data in Michigan reveals a significant shift towards sleeve gastrectomy (SG) as the most commonly performed procedure. SG became the predominant bariatric surgery procedure for patients with type 2 diabetes and its use increased by 61% between 2008 and 2013.
A new study suggests that a maternal diet low in protein can predispose offspring to type 2 diabetes. Offspring of mothers fed a low protein diet had decreased insulin levels and fewer β cells, leading to defective insulin secretion by adulthood.
Researchers found that high insulin levels foster processes leading to obesity, even in mice given insulin to counter diabetes. Suppressing glucagon action may prevent hyperinsulinemia without causing diabetes.
A new study found that overweight individuals with type 2 diabetes who lose weight through dieting and physical activity can reduce their healthcare costs by an average of over $500 per year. Those in the intensive lifestyle intervention group had fewer hospitalizations, shorter hospital stays, and used fewer prescription medications.
Research found a strong association between low birth weight and type 2 diabetes in African American women, with those born very low weight facing a 40% increased risk. The study's findings shed light on the long-term health effects of low birth weight in this population.
A study found that hospital admission blood glucose levels can predict the risk of developing type 2 diabetes over three years. The risk increases linearly with increasing blood glucose level at admission, with a 1% risk for patients with low glucose and up to 15% for those with high glucose.
A new study published in Diabetologia found that fenofibrate is as effective in treating type 2 diabetes in women as it is in men. The research showed that fenofibrate reduced levels of adverse blood fats and cardiovascular events by 30% in women, compared to 13% in men.
A major study estimates that nearly half of the US adult population will develop type 2 diabetes by age 20, with Hispanic men and non-Hispanic black women facing the highest risk. The study found a significant increase in lifetime risk of diabetes over 26 years, driven by rising rates and longer life expectancy.
A study by Helmholtz Munich found that individuals with high workplace stress and low control have a 45% higher risk of developing type 2 diabetes. The researchers analyzed data from over 5,300 employed individuals and identified the link independently of classic risk factors.
A large-scale study of over 180,000 people found that patients treated with metformin for type 2 diabetes had a small but statistically significant improvement in survival compared to non-diabetics. Meanwhile, those on sulphonylureas experienced reduced survival, even without statistical manipulation.
Researchers found that consuming two servings of pistachios per day lowered vascular constriction during stress and improved neural control of the heart in adults with well-controlled Type 2 diabetes. The pistachio diet also showed improvements in sleep blood pressure, vascular response to stress, and vagal control of the heart.
A new study suggests that consuming whey protein before meals can reduce blood sugar spikes and improve the body's insulin response in individuals with type 2 diabetes. Glucagon-like peptide-1 production is increased, stimulating insulin secretion and reducing glucose rise after meals.
Research suggests that interval walking training increases insulin sensitivity and improves glucose metabolism, leading to better blood sugar control. The study found no significant benefits from continuous walking training, highlighting the potential of interval training as a more effective approach for managing type 2 diabetes.
A new study published in the Journal of Leukocyte Biology suggests that modulation of B cells may effectively treat and/or prevent periodontitis symptoms related to type 2 diabetes. Researchers used a mouse model to demonstrate the B cell-response's viability as a target for pharmacological intervention.
Research suggests that shift work is associated with a heightened risk of developing type 2 diabetes, particularly among men and those working rotating shift patterns. The study found a 37% increased risk for men and a 9% increased risk for all participants compared to working normal office hours.
A team of researchers from UCLA discovered that autophagy, a process that clears damaged proteins, is impaired in people with Type 2 diabetes, leading to the destruction of insulin-producing beta cells. This impairment contributes to the accumulation of toxic IAPP protein.
A high-salt diet doubles the risk of cardiovascular disease in people with diabetes, according to a new study published by The Endocrine Society. Researchers found that poor blood sugar control exacerbates this effect.
A new study by Sanford-Burnham researchers identifies the NBR1 protein as a critical regulator of obesity-induced inflammation, which leads to metabolic disease. The study suggests that blocking this signal may protect against the development of metabolic disease and type 2 diabetes.
A new study suggests that cholesterol-lowering statins may help people with Type 2 diabetes live longer, with a 50% increase in survival rate among those taking statins. The use of statins was the only modifiable risk factor identified to be protective against mortality.
Scientists have observed the creation of temporary intermediate structures during amylin aggregation, which may explain why proteins aggregate into toxic plaques. The new technology using 2D IR spectroscopy helps elucidate the physics and chemistry behind amyloid diseases.
A recent study published in Cell Press found that high levels of a molecule called heme oxygenase-1 (HO-1) are linked to poor metabolic health and an increased risk of type 2 diabetes in obese humans.
A systematic review and meta-analysis suggest that combined aerobic and resistance training is most effective for controlling blood sugar and blood fat profiles in people with type 2 diabetes. However, more high-quality trials are needed to confirm these findings.
The OpT2mise trial found that insulin pumps result in better blood sugar control than multiple daily injections in people with type 2 diabetes. The study showed that patients using the pumps achieved a significantly greater reduction in average blood sugar levels and spent less time in hyperglycaemia.
A new study finds that for many patients with type 2 diabetes, the benefits of treatment are outweighed by the negative impact of side effects like weight gain and frequent insulin shots. The study suggests that individualized treatment recommendations based on patient risk factors and preferences may be a better approach than focusing...
Researchers found that incorporating two ounces of tree nuts into the diet reduced CHD risk factors and 10-year CHD risk. The study's findings suggest that tree nuts can modify the fatty acid profile of adults with type 2 diabetes, contributing to a reduction in CHD risk.
A new clinical trial shows that Roux-en-Y gastric bypass surgery can help obese patients with Type 2 diabetes reduce their risk of heart disease. The study found significant weight loss and improved blood sugar control, blood pressure, and cholesterol levels in the surgical group compared to the lifestyle modification group.
A large-scale study found that young women with Polycystic Ovary Syndrome (PCOS) have a higher incidence and prevalence of type 2 diabetes, even if not overweight. Obesity is not a significant trigger for type 2 diabetes in PCOS patients.
Researchers found changes in gut microbiota composition among people with Type 2 diabetes or obesity compared to healthy individuals. The study identified associations between specific bacterial species and metabolic variables such as BMI, hemoglobin A1c, and waist circumference.
Recent research from BUSM sheds light on the regulatory strategies controlling PPARgamma activity in cells, offering potential avenues for developing effective treatments. By targeting specific subsets of PPARgamma target genes, researchers aim to improve insulin sensitivity and combat type 2 diabetes.
A study published in Cell Metabolism reveals that free radical molecules contribute to the development of type 2 diabetes, obesity, and fatty liver disease by inactivating protein tyrosine phosphatases. This inactivation leads to a cascade of events promoting disease progression.