Articles tagged with Type 2 Diabetes
A systematic review by the University of Southampton found that people taking antidepressants are at a higher risk of developing type 2 diabetes, although the exact cause is still unknown. Different types of antidepressants may carry varying risks, and further research is needed to determine their individual effects.
A new study by Cleveland Clinic found that bariatric surgery significantly improves and reverses Type 2 diabetes in obese patients. Long-term weight loss and gastric bypass surgery are key predictors of sustained remission, with nearly one-third of patients achieving normal blood glucose levels off medication.
A study published in Clinical Chemistry found that SHBG levels are significantly associated with type 2 diabetes risk in women, with age, estrogen therapy, and coffee consumption being key predictors. The research also suggests that adjusting these factors may impact SHBG levels and ultimately diabetes risk.
A new UMass Medical School study reveals that all postmenopausal women with diabetes, irrespective of their racial or ethnic background, are at a significantly higher risk of dying from cardiovascular disease and cancer. The research underscores the importance of prevention strategies to reduce disparities in diabetes-related mortality...
A novel biomarker, 2-aminoadipic acid (2-AAA), has been identified that can predict diabetes risk up to 12 years in advance. Individuals with high levels of 2-AAA concentrations had a fourfold risk of developing diabetes compared to those with lower levels.
Researchers have identified a metabolite as a biomarker of diabetes risk, revealing that individuals with increased levels are more likely to develop type 2 diabetes. Additionally, the study found that a specific genetic mutation affects muscle performance in elite endurance athletes by altering calcineurin signaling.
A study of 1,256 Argentine women found plaque buildup was more common among those with type 2 diabetes. Researchers recommend screening for heart disease in younger women with type 2 diabetes to reduce the risk of heart attacks.
A new study by UC San Diego researchers reveals that the pancreatic protein Nkx6.1 is crucial for regulating insulin biosynthesis and secretion in beta cells. The study found that impaired Nkx6.1 levels contribute to the pathogenesis of type 2 diabetes, leading to rapid onset of diabetes in mice.
Researchers link brain atrophy to cognitive decline in Type 2 diabetes, challenging previous assumptions. Brain atrophy is found to be the primary cause of cognitive impairment associated with T2DM, exceeding cerebrovascular lesions.
A variant of FGF21, LY2405319, has been shown to improve metabolism in obese humans with type 2 diabetes by reducing LDL cholesterol and triglycerides while increasing HDL cholesterol levels. The hormone also reduced body weight and fasting insulin, and increased adiponectin.
A team led by Dr. Aleksandar Jeremic will investigate the molecular and biochemical events leading to amylin aggregation, a key factor in type 2 diabetes. Their research may lead to new treatments for the disease by preventing amylin toxicity.
A new study found that consuming at least two servings of whole fruits, particularly blueberries, grapes, and apples, lowers the risk of type 2 diabetes. In contrast, drinking one or more servings of fruit juice daily increases diabetes risk.
A study led by Harvard School of Public Health identified a novel genetic variant associated with an increased risk of coronary heart disease in people with type 2 diabetes. The finding suggests that the genetic risk factors for cardiovascular disease may be different among those with and without diabetes.
A genetic locus on chromosome 1q25 has been identified as associated with an increased risk of coronary heart disease in individuals with type 2 diabetes. The variant affects glutamic acid metabolism and was specifically linked to CHD risk in diabetic patients, suggesting a mechanistic link.
A Vanderbilt University Medical Center study reveals that prescribing atypical antipsychotic medications to children with behavioral problems or mood disorders triples their risk of developing type 2 diabetes within a year. The risk persists even after medication discontinuation.
A new scoring system developed by researchers allows clinicians to predict the risk of dementia in older people with type 2 diabetes. The scores are based on six health complications, education, and age, accurately predicting patients' risk of developing dementia.
Researchers created the first risk score predicting 10-year dementia risk for type 2 diabetes patients based on medical history and electronic health records. The Diabetes-Specific Dementia Risk Score assigns a value to eight predictive factors, including microvascular disease and diabetic foot.
A Mediterranean-style diet and diets low in available carbohydrates can reduce the risk of type 2 diabetes. Patients with a high Mediterranean diet score (MDS) were 12% less likely to develop diabetes than those with the lowest MDS, while those with the highest available carbohydrate intake were 21% more likely.
Eating a healthy diet has been found to lower the risk of chronic kidney disease (CKD) and mortality among patients with type 2 diabetes. Moderate alcohol intake also reduced the risk of CKD, while high sodium intake was not associated with increased risk.
Four research projects, including insulin gene therapy and a revolutionary sensor platform, will receive funding from the Minnesota Partnership for Biotechnology and Medical Genomics to develop new therapies for diabetes management and prevention. The selected researchers were awarded $2 million in total.
A study by Professor Lesley Campbell and Dr Arthur Jenkins reveals that rare genetic defects are responsible for most of the problem with obesity and type 2 diabetes. The researchers found that many genes are involved, each contributing a unique genetic story, making it difficult to develop a single anti-obesity drug or treatment.
A study suggests that rapid economic growth between 1950 and 1980 may have contributed to the high prevalence of Type 2 diabetes in the American South. The 'thrifty phenotype' hypothesis proposes that children who grow up in poverty are unprepared biologically to manage the abundance of processed foods and sedentary lifestyle associate...
Researchers identified two genes, HKDC1 and BACE2, associated with glucose and insulin levels in pregnant women but not in the general population. This study suggests that genetic risk profiles could one day identify individuals at elevated risk for developing gestational diabetes.
A study by Boston Children's researchers found that the small intestine plays a crucial role in glucose regulation and resolves type 2 diabetes in rats after gastric bypass surgery. The intestine utilizes GLUT-1 to take glucose from circulation, swiftly stabilizing blood glucose levels.
A new systematic review and meta-analysis found that people with diabetes are at least 50% more likely to develop physical disability. The study also showed a significant association between diabetes and functional disability, including impaired mobility and ability to perform daily activities.
Researchers have discovered a protein, Neu1, that regulates insulin signaling in body cells, potentially helping to prevent type 2 diabetes. The study's findings, published in the journal Diabetes, suggest that restoring Neu1 levels and function could improve insulin absorption, reducing the need for insulin therapy.
A new study found that morbidly obese patients who underwent gastric bypass surgery experienced a decrease in the activity of genes tied to asthma, suggesting a potential link between obesity and asthma. The study also found higher concentrations of inflammatory compounds in obese individuals.
Researchers found that patients with pre-diabetes who lose 10% or more of their body weight have an 85% reduction in risk of developing diabetes within three years. Lifestyle changes can bring blood sugar levels back to normal, reducing the risk of progression to type 2 disease.
A new study found that DNA abnormalities, specifically clonal mosaic events, are more common in people with type 2 diabetes than the general population. This increase in CMEs may partly explain why individuals with type 2 diabetes have a higher risk of blood cancers like lymphoma and leukaemia.
Researchers found that excessive PKC beta in endothelial cells exacerbates atherosclerosis, a condition where blood vessel walls thicken due to fatty deposits. This inhibition leads to decreased nitric oxide production, increasing cardiovascular disease risk.
A study led by the University of Exeter found that 27% of over-70s with type 2 diabetes achieved better glycaemic control through individualized care alone. Researchers introduced a 'one-size-fits-all' approach for older patients, which proved ineffective due to multiple complications.
Joslin scientists found that salsalate effectively lowers blood glucose and improves glycemic control in type 2 diabetes. The study involved 286 participants with inadequately controlled diabetes, who showed significant reductions in hemoglobin A1c levels and fasting glucose concentration.
Salsalate shows promise as a type 2 diabetes treatment, reducing A1C and fasting blood glucose levels, but increases risk of hypoglycemia. Black men are less likely to have advanced colorectal neoplasia found at screening than white men, with disparities attributed to access and modifiable risk factors.
A new study published in Radiology found that moderate-intensity exercise significantly decreases fat volume in the abdomen, liver, and around the heart in patients with type 2 diabetes. The results suggest that exercise can reduce cardiovascular risk by targeting specific fat deposits.
A pilot study found that vitamin D supplementation significantly lowered blood pressure and improved moods in women with type 2 diabetes and symptoms of depression. Vitamin D also helped the women lose weight. The study suggests that vitamin D supplementation may be a valuable treatment option for these women.
A 11-year study found significant weight loss in the intervention group, but no reduction in cardiovascular disease risks. Participants who lost more weight experienced improved health benefits such as better blood sugar control and reduced risk factors.
Researchers developed a new risk assessment scoring system that better identifies high-risk adults, especially African Americans, for developing type 2 diabetes and heart disease. The scoring system considers sex and racial-ethnic differences, leading to earlier prevention and treatment.
A large-scale study published in JAMA Internal Medicine found that consuming more red meat over time increases the risk of developing Type 2 diabetes. The research followed over 149,000 participants and documented a 48% elevated risk for those who increased their red meat intake by more than 0.50 servings per day.
Researchers at the University of Exeter Medical School have diagnosed a rare condition, MDP Syndrome, in Paralympic hopeful Tom Staniford through genetic sequencing. The discovery may help Tom's bid to participate in the Rio 2016 Paralympic Games and improve understanding of type 2 diabetes.
Researchers found that short post-meal walks were as effective at reducing blood sugar over 24 hours as a 45-minute sustained walk. The most effective time for walking was after the evening meal, which helped curb high blood sugar levels that often last into the night and early morning.
Adding gastric bypass surgery to lifestyle and medical management improved metabolic risk factors in type 2 diabetes patients, particularly those who experienced significant weight loss. The study found that 43% of the gastric bypass group achieved an HbA1c level of less than 7%, compared to 32% in the lifestyle-medical management group.
A new study from Wake Forest Baptist Medical Center suggests that cardiovascular disease (CVD) plays a role in cognitive decline before it is clinically apparent in patients with type 2 diabetes. The research found that CVD risk factors, such as calcified plaque and vascular status, contribute to type 2 diabetes-related cognitive decline.
A recent study found that night work can significantly impair glucose tolerance, increasing the risk of Type 2 diabetes among shift workers. The research showed peak glucose levels were 16% higher during night shifts compared to day shifts.
A new study finds that soccer training significantly improves the flexibility of the heart, reducing blood pressure and increasing exercise capacity in patients with type 2 diabetes. The study also shows reduced need for medication and improved physical condition.
Leading diabetes expert argues that 'Type 2 diabetes' is a category error, implying an entity that doesn't exist. This mislabeling has led to sub-optimal treatment for patients. Professor Edwin Gale proposes replacing the term with 'idiopathic hyperglycaemia', emphasizing individualized treatments based on varied causes.
Children who develop Type 2 diabetes are at high risk for early complications, including heart and kidney problems. The study found that young patients were more likely to develop hypertension and fatty liver due to obesity.
A meta-analysis of randomized clinical trials found that fish oil supplementation modestly increases adiponectin levels in the bloodstream. This hormone is associated with lower risk of diabetes and heart disease. The study suggests potential benefits of fish oil consumption on glucose control and fat cell metabolism.
Researchers at the University of North Carolina will assess three types of blood sugar home testing approaches on patient outcomes in a community-based clinic setting. The study aims to inform better, evidence-based decisions about glucose monitoring for patients with type 2 diabetes not treated with insulin.
Harvard researchers have discovered a novel hormone that regulates glucose production in the liver, offering new avenues for treating type 2 diabetes. The study found that switching off this hormone improves glucose metabolism, providing a potential therapeutic target.
Researchers created a new mouse model to study the development of type 2 diabetes, using middle-aged mice fed fatty food until old age. The study confirmed that inflammation in pancreatic islets leads to the disease, while DPP-4 inhibitors maintain good insulin production and prevent inflammation.
A recent study at Lund University has discovered a key factor behind gastric bypass surgery's ability to rapidly send type 2 diabetes into remission. The researchers found that insulin levels and intestinal hormones increase significantly after the procedure, suggesting a new potential treatment avenue for diabetes patients.
Researchers found that gastric bypass surgery increases insulin and GLP-1 levels after meals, helping patients manage type 2 diabetes. The study used catheters to mimic pre-operative digestion and compared hormonal activity post-surgery.
Green tea extract was shown to reduce body weight gain and insulin resistance in mice, especially when combined with polyethylene glycol. This compound prolonged gallated catechin absorption, limiting glucose uptake and improving glucose tolerance.
Researchers at Harvard University have discovered a hormone called betatrophin that increases insulin-secreting pancreatic beta cells by up to 30 times the normal rate. This could lead to a more natural regulation of insulin and reduced complications associated with diabetes.
A new study published in Diabetologia suggests that consuming one 12oz serving of sugar-sweetened soft drinks daily can increase the risk of developing type 2 diabetes by 22% in European populations. The research found a statistically significant association between artificially sweetened soft drink consumption and an increased risk of...
Researchers at Johns Hopkins Children's Center found that a previously minor protein called EPAC2 plays a central role in regulating insulin production. The study suggests that targeting EPAC2 with drugs could potentially restore pancreatic cell function and reverse Type 2 diabetes.
A study published in the BMJ found that a 5kg population-wide weight loss resulted in a significant reduction in Type 2 diabetes and cardiovascular disease mortality. The Cuban experience of rapid weight loss during economic crisis demonstrates the potential health benefits of reversing the global obesity epidemic.
A Danish study found that patients who tailor their own treatment in cooperation with their doctor can reduce their risk of complications, including heart attacks, with up to 20%. The study also shows that taking individual needs into consideration is crucial when treating patients with multiple diseases.
A new study found that higher levels of mercury exposure in young adults increase their risk for type 2 diabetes later in life. The study, led by Indiana University School of Public Health-Bloomington epidemiologist Ka He, established the link between mercury and diabetes in humans.
A new study from Brigham and Women's Hospital found that low nocturnal melatonin secretion levels are associated with an increased risk of developing type 2 diabetes. The study, which accounted for other established risk factors, suggests that melatonin plays a role in regulating glucose metabolism and risk of diabetes.