Articles tagged with Type 2 Diabetes
A new study published today reveals the extent of type 2 diabetes problems in black and minority ethnic populations in the UK. By age 80, approximately half of all South Asians, Africans, and African Caribbean individuals will develop diabetes, with twice as many British South Asian, African, and African Caribbean men and women diagnos...
Researchers at Lund University have developed a new approach that links gene variants to their effect on insulin production in human beta cells. The study explains 25% of variations in blood sugar levels, providing greater insight into the causes of type 2 diabetes.
Researchers have discovered that Grb10 protein plays a crucial role in increasing muscle mass during development, which could lead to new strategies for treating muscle wasting conditions and metabolic disorders. The study found that blocking Grb10 function while mice were in the womb resulted in increased muscle strength and mass.
A study found that even in the normal range, urinary protein excretion increases diabetics' heart risks. Patients may benefit from cardioprotective medications to mitigate this risk.
Cytomegalovirus (CMV) infection is a significant risk factor for type 2 diabetes in the elderly, according to new research. CMV infection can cause inflammation and damage pancreatic cells, leading to insulin resistance and increased glucose levels.
Researchers found that mice exposed to methyl-glyoxal, a heat-processed food compound, developed abdominal weight gain, insulin resistance, and type 2 diabetes. A diet high in MG reduced SIRT1 and AGER1 levels, impairing glucose metabolism.
Researchers have identified 10 new gene regions associated with type 2 diabetes, providing a fuller picture of the disease's genetic underpinnings. The study reveals patterns in genes involved in cell growth, insulin production, and fat cell communication.
A new study published in Archives of Internal Medicine found that men who engage in weight training regularly may reduce their risk of type 2 diabetes by up to 34%, compared to those who do not. The study also showed that combining weight training with aerobic exercise can further lower the risk, even as high as 59%.
A study of 32,002 men found that weight training was associated with a lower risk of type 2 diabetes. Men who engaged in both weight training and aerobic exercise for at least 150 minutes per week had the greatest reduction in risk.
Researchers found that activation of A2b-type adenosine receptor reduces insulin and glucose levels and improves symptoms of high-fat diet-induced type 2 diabetes. The study identified a novel link between A2bAR and insulin signaling, providing new insights into the regulation of glucose and insulin homeostasis.
A new study found South Asians have higher levels of blood sugar than white Europeans, independent of risk factors. This suggests that South Asians should be monitored more closely for type 2 diabetes, as the diagnosis is already higher in this ethnic group.
A 32-country study found that linagliptin, a DPP-4 inhibitor, is effective in improving glycaemic control without weight gain or increased risk of hypoglycemia. The extended trial demonstrated sustained glucose control for up to 102 weeks treatment duration.
A study published in Diabetes found that exercise benefits diabetic hearts by improving energy exchange and resisting oxidative stress. Fatty acids, previously thought to be detrimental, were shown to improve heart function when the heart needs to beat faster.
A new study published in the Canadian Medical Association Journal found a potential link between the use of pioglitazone, a type of thiazolidinedione diabetes medication, and an increased risk of bladder cancer. Researchers analyzed data from over 2.6 million patients to quantify this association.
A UT Southwestern study found that early intensive treatment of type 2 diabetes slows down the progression of the disease by preserving the body's insulin-producing capacity. The intensive treatment regimen was shown to be effective in maintaining steady insulin-producing beta-cell function for three and a half years after diagnosis.
A new study found that modified bariatric surgery can resolve or improve Type 2 diabetes in obese and diabetic patients, regardless of body mass index (BMI). The procedure showed high success rates in reducing blood sugar levels and eliminating insulin needs.
A new study found an inverse relationship between vitamin D levels and the presence of metabolic syndrome, a group of risk factors that increases the risk of heart disease and Type 2 diabetes. People with high vitamin D levels had a 48% lower risk of having the metabolic syndrome.
A systematic review of seven studies involving over 32,400 patients found that metformin reduced the risk of any type of cancer by 38% compared to those not taking the medication. The benefits were seen in colon and breast cancer, but not pancreatic cancer.
A new study reveals that gastric bypass surgery successfully cures Type 2 diabetes in 92% of obese patients, but the disease recovers in approximately 21% of them within three to five years after surgery.
Adults exposed to secondhand smoke have higher rates of Type 2 diabetes and obesity compared to nonsmokers. They also experienced insulin resistance, higher fasting blood glucose, and a higher body mass index.
A new study has identified a genetic factor associated with lean type 2 diabetes patients, indicating that genetic predisposition may vary depending on body type. The 'Jack Spratt' gene is linked to an increased risk of the disease in lean individuals, contrasting with obese patients where other factors are more influential.
Research finds one-off advice sessions are insufficient for long-term management; ongoing support is crucial for improved lifestyle and biomedical outcomes.
Researchers found a high prevalence of sleep apnea (82%) and associated carbohydrate cravings in diabetic patients. The study suggests that sleep apnea is an independent risk factor for self-reported carbohydrate cravings among Type 2 diabetes patients.
A systematic review found that aggressive blood sugar control can prevent diabetic neuropathy, a disabling condition affecting nerves in the feet and legs. However, the review suggests that optimal target levels for glucose control need to be established to balance benefits and side effects.
Researchers found that normalizing blood glucose levels in pre-diabetes patients can significantly reduce the risk of developing Type 2 diabetes. A study published in The Lancet revealed a 56% reduction in progression to diabetes among participants who achieved normal glucose regulation, regardless of its duration.
A large retrospective cohort study found that thiazolidinedione use may increase the risk of diabetic macular edema (DME) at 1-year and 10-year follow-up evaluations. The association was strongest among patients taking thiazolidinediones in combination with insulin.
In a pilot study, patients with type 2 diabetes who used Almased, a protein-rich meal replacement, lost weight and gained better blood sugar control. After 12 weeks, average insulin doses decreased from 147 to 65 units per day and HbA1c levels dropped by 7.7%.
A new study found that early and aggressive glucose-lowering treatment can significantly reduce the risk of progression to diabetes in people with prediabetes. The research analyzed data from over 3,000 patients who experienced periods of normal glucose regulation, revealing a 56% reduction in diabetes risk.
Fruit flies developed insulin resistance by overloading on carbs and protein, mimicking Type 2 diabetes. The flies' lifespan shortened and fertility decreased with both diets, offering a new model for studying human disease.
A new study from the University of Exeter has identified a genetic predisposition to Type 2 diabetes in lean patients, contradicting the long-held assumption that obesity is the primary cause. The study found that genetic variants near the LAMA1 gene are linked to type 2 diabetes risk only in lean patients.
Researchers at Yale University found that intensively controlling glucose levels did not definitively reduce the risk of impaired kidney function, dialysis, or death from kidney disease. The study suggests that patients may not be better off with this approach and questions the benefits of aggressive glycemic control in Type 2 diabetes
A new study published in Population Health Management projects that 53.1 million Americans will have diabetes by 2025, a 64% increase from 2010. The Diabetes 2025 Model can estimate the impact of lifestyle changes and interventions on reducing diabetes burden.
A study in mice found a connection between obesity and elevated blood sugar levels, potentially leading to new treatments for Type 2 diabetes. The research suggests that targeting glucagon, a pancreas-produced hormone, may be an effective pathway to lowering sugar levels.
A two-year study found that a high-fat diet improved glycaemic control and increased 'good' cholesterol in patients with Type 2 diabetes. The low-carbohydrate group experienced significant weight loss and reduced blood sugar levels, while the low-fat group showed minimal improvements despite similar weight loss.
Researchers have identified significant differences in how diabetes affects Asian populations, including unique markers for type 1 diabetes diagnosis. The study highlights the need for culturally sensitive care, tailored treatment guidelines, and expanded education programs.
The 'From Clinic to Community' project aims to improve health outcomes for at-risk populations in Southeastern US counties. It combines modern technology with community-based healthcare professionals to address the triple aim of better outcomes, better care, and lower cost.
Researchers have found that levels of certain proteins in the blood are associated with a greatly reduced risk for developing Type 2 diabetes. High levels of IGFBP-1 and IGFBP-2 were linked to a significant reduction in diabetes risk, suggesting these proteins may help stratify people at risk for diabetes.
A combination of two diabetes drugs, metformin and rosiglitazone, was more effective in treating youth with recent-onset type 2 diabetes than metformin alone. The study found that adding intensive lifestyle intervention to metformin provided no additional benefit.
A joint study by Group Health Research Institute and Bastyr University found that type 2 diabetes patients receiving naturopathic care had lower blood-sugar levels and improved moods. Naturopathic physicians provided counseling on diet, exercise, and stress management to add to conventional care.
A study comparing sleeve gastrectomy with medical treatment found that bariatric surgery was effective in achieving diabetes remission, particularly for those with short-term type 2 diabetes. In contrast, conventional medical therapy did not lead to significant improvements in diabetes-related outcomes.
A study by BUSM researchers has identified a gene called GPS2 that plays a critical role in regulating inflammatory response and homeostasis. Increasing GPS2 levels was found to impair the response to TNF-alpha, resulting in a decreased inflammatory response.
A French research team analyzed data from over 13,000 patients to investigate the long-term effects of metformin. The study found no significant impact on mortality or cardiovascular risk with metformin compared to other drugs.
A new study has found that consuming a vitamin D-fortified yogurt drink can improve inflammatory markers in patients with type 2 diabetes, reducing the risk of coronary heart disease and stroke. Additionally, extra calcium in the fortified drink may confer additional anti-inflammatory benefits.
The study found that weight loss and improved fitness nearly halved the risk of losing mobility in overweight or obese adults with type 2 diabetes. Weight loss was a stronger predictor of better mobility than improved fitness, contributing significantly to the observed reduction in risk.
A study published in NEJM shows that bariatric surgery dramatically improves type 2 diabetes remission rates, with 95% of patients undergoing BPD achieving remission and 75% of those receiving RYGB. The study's authors suggest that the mechanisms behind the surgery are key to improving diabetes control.
A study found bariatric surgery to be superior to intensive medical management in achieving glycemic control and weight loss for obese patients with uncontrolled type 2 diabetes. The surgery resulted in a significant reduction of medications and improved glycemic control after one year.
A new study by Brigham and Women's Hospital found that men with type 2 diabetes treated with insulin without a history of cardiovascular disease are at higher risk for major cardiovascular events. The study showed an accelerated rate of new cardiovascular events in these patients, with a 16% rate over four years.
A study published in PNAS reveals that a deficiency of Mitofusin 2 protein causes insulin resistance and glucose intolerance in mice, highlighting its potential as a target for treating type 2 diabetes. The researchers also note that the protein plays a crucial role in maintaining normal glucose homeostasis.
A new NIH study finds that programs to prevent or delay type 2 diabetes in high-risk adults can improve quality of life, reduce healthcare costs, and result in significant savings over time. Lifestyle interventions and metformin treatment were found to be cost-effective options for preventing type 2 diabetes.
Researchers found that lowering the HbA1c cutoff from 6.4% to 5.7% increases the health benefits of preventive interventions, while also being cost-effective with a higher threshold.
Cedars-Sinai researchers identified the mechanism that leads to interleukin-1beta production, a major contributor to inflammation in conditions like atherosclerotic heart disease and strokes. This discovery could lead to treatments that prevent its production, resulting in more effective medications for inflammatory diseases.
A University of Leicester study found that long periods of sitting increase the risk of type 2 diabetes in women, with higher levels of insulin and inflammatory chemicals detected in sedentary individuals. The research highlights the importance of reducing sitting time for women to prevent chronic disease.
A study published in Stroke found that long-term diabetics are at a higher risk of stroke, with the risk increasing by 3% each year and tripling for those with diabetes for 10 years or more. The study highlights the chronic nature of diabetes and its impact on blood vessels over time.
A new study published in The Lancet shows that TAK-875, a novel oral medication, significantly improves glycemic control in patients with type 2 diabetes without increasing the risk of hypoglycemia. The results suggest that targeting free fatty acid receptor 1 (FFAR1) may be a viable therapeutic target for treating type 2 diabetes.
TAK-875, a novel oral medication, enhances insulin secretion in a glucose-dependent manner, improving blood sugar control and lowering the risk of hypoglycemia. The study showed significant reductions in HbA1c levels across all TAK-875 doses, with higher efficacy rates compared to glimepiride.
A Mayo Clinic study found no link between prediabetes and diabetic polyneuropathy, suggesting alternative explanations for nerve damage. The five-year study tested nearly 550 people and concluded that impaired glucose does not cause polyneuropathy at high frequency.
A large-scale study found that young urban Sri Lankans have a high prevalence of risk factors for type 2 diabetes, including raised BMI and physical inactivity. The research highlights the need for early intervention and preventive strategies to address this growing public health concern.
Researchers identify FoxO1 as critical for diabetic cardiomyopathy development, suggesting a promising therapeutic target. Activation of FoxO1 in mice with type 2 diabetes models triggers cardiomyopathy, highlighting the need for new treatments to address this leading cause of death in diabetics.
A large-scale genetic screening of over 17,000 individuals with Type 2 diabetes and 70,000 control subjects identified nearly 40 gene variants associated with the disease. The study found that many gene variants overlap across multiple ethnic groups, providing new insights into the biological targets for developing more effective drugs.
A specific daily serving goal of low-glycemic-index foods significantly improved dietary habits among people with Type 2 diabetes. Participants who set a higher individualized goal and felt more committed showed better results in reaching the goal.