Articles tagged with Type 2 Diabetes
Eating a healthy diet has been found to lower the risk of chronic kidney disease (CKD) and mortality among patients with type 2 diabetes. Moderate alcohol intake also reduced the risk of CKD, while high sodium intake was not associated with increased risk.
Four research projects, including insulin gene therapy and a revolutionary sensor platform, will receive funding from the Minnesota Partnership for Biotechnology and Medical Genomics to develop new therapies for diabetes management and prevention. The selected researchers were awarded $2 million in total.
A study by Professor Lesley Campbell and Dr Arthur Jenkins reveals that rare genetic defects are responsible for most of the problem with obesity and type 2 diabetes. The researchers found that many genes are involved, each contributing a unique genetic story, making it difficult to develop a single anti-obesity drug or treatment.
A study suggests that rapid economic growth between 1950 and 1980 may have contributed to the high prevalence of Type 2 diabetes in the American South. The 'thrifty phenotype' hypothesis proposes that children who grow up in poverty are unprepared biologically to manage the abundance of processed foods and sedentary lifestyle associate...
Researchers identified two genes, HKDC1 and BACE2, associated with glucose and insulin levels in pregnant women but not in the general population. This study suggests that genetic risk profiles could one day identify individuals at elevated risk for developing gestational diabetes.
A study by Boston Children's researchers found that the small intestine plays a crucial role in glucose regulation and resolves type 2 diabetes in rats after gastric bypass surgery. The intestine utilizes GLUT-1 to take glucose from circulation, swiftly stabilizing blood glucose levels.
A new systematic review and meta-analysis found that people with diabetes are at least 50% more likely to develop physical disability. The study also showed a significant association between diabetes and functional disability, including impaired mobility and ability to perform daily activities.
Researchers have discovered a protein, Neu1, that regulates insulin signaling in body cells, potentially helping to prevent type 2 diabetes. The study's findings, published in the journal Diabetes, suggest that restoring Neu1 levels and function could improve insulin absorption, reducing the need for insulin therapy.
A new study found that morbidly obese patients who underwent gastric bypass surgery experienced a decrease in the activity of genes tied to asthma, suggesting a potential link between obesity and asthma. The study also found higher concentrations of inflammatory compounds in obese individuals.
Researchers found that patients with pre-diabetes who lose 10% or more of their body weight have an 85% reduction in risk of developing diabetes within three years. Lifestyle changes can bring blood sugar levels back to normal, reducing the risk of progression to type 2 disease.
A new study found that DNA abnormalities, specifically clonal mosaic events, are more common in people with type 2 diabetes than the general population. This increase in CMEs may partly explain why individuals with type 2 diabetes have a higher risk of blood cancers like lymphoma and leukaemia.
Researchers found that excessive PKC beta in endothelial cells exacerbates atherosclerosis, a condition where blood vessel walls thicken due to fatty deposits. This inhibition leads to decreased nitric oxide production, increasing cardiovascular disease risk.
A study led by the University of Exeter found that 27% of over-70s with type 2 diabetes achieved better glycaemic control through individualized care alone. Researchers introduced a 'one-size-fits-all' approach for older patients, which proved ineffective due to multiple complications.
Joslin scientists found that salsalate effectively lowers blood glucose and improves glycemic control in type 2 diabetes. The study involved 286 participants with inadequately controlled diabetes, who showed significant reductions in hemoglobin A1c levels and fasting glucose concentration.
Salsalate shows promise as a type 2 diabetes treatment, reducing A1C and fasting blood glucose levels, but increases risk of hypoglycemia. Black men are less likely to have advanced colorectal neoplasia found at screening than white men, with disparities attributed to access and modifiable risk factors.
A new study published in Radiology found that moderate-intensity exercise significantly decreases fat volume in the abdomen, liver, and around the heart in patients with type 2 diabetes. The results suggest that exercise can reduce cardiovascular risk by targeting specific fat deposits.
A 11-year study found significant weight loss in the intervention group, but no reduction in cardiovascular disease risks. Participants who lost more weight experienced improved health benefits such as better blood sugar control and reduced risk factors.
A pilot study found that vitamin D supplementation significantly lowered blood pressure and improved moods in women with type 2 diabetes and symptoms of depression. Vitamin D also helped the women lose weight. The study suggests that vitamin D supplementation may be a valuable treatment option for these women.
Researchers developed a new risk assessment scoring system that better identifies high-risk adults, especially African Americans, for developing type 2 diabetes and heart disease. The scoring system considers sex and racial-ethnic differences, leading to earlier prevention and treatment.
A large-scale study published in JAMA Internal Medicine found that consuming more red meat over time increases the risk of developing Type 2 diabetes. The research followed over 149,000 participants and documented a 48% elevated risk for those who increased their red meat intake by more than 0.50 servings per day.
Researchers at the University of Exeter Medical School have diagnosed a rare condition, MDP Syndrome, in Paralympic hopeful Tom Staniford through genetic sequencing. The discovery may help Tom's bid to participate in the Rio 2016 Paralympic Games and improve understanding of type 2 diabetes.
Researchers found that short post-meal walks were as effective at reducing blood sugar over 24 hours as a 45-minute sustained walk. The most effective time for walking was after the evening meal, which helped curb high blood sugar levels that often last into the night and early morning.
Adding gastric bypass surgery to lifestyle and medical management improved metabolic risk factors in type 2 diabetes patients, particularly those who experienced significant weight loss. The study found that 43% of the gastric bypass group achieved an HbA1c level of less than 7%, compared to 32% in the lifestyle-medical management group.
A new study from Wake Forest Baptist Medical Center suggests that cardiovascular disease (CVD) plays a role in cognitive decline before it is clinically apparent in patients with type 2 diabetes. The research found that CVD risk factors, such as calcified plaque and vascular status, contribute to type 2 diabetes-related cognitive decline.
A recent study found that night work can significantly impair glucose tolerance, increasing the risk of Type 2 diabetes among shift workers. The research showed peak glucose levels were 16% higher during night shifts compared to day shifts.
A new study finds that soccer training significantly improves the flexibility of the heart, reducing blood pressure and increasing exercise capacity in patients with type 2 diabetes. The study also shows reduced need for medication and improved physical condition.
Leading diabetes expert argues that 'Type 2 diabetes' is a category error, implying an entity that doesn't exist. This mislabeling has led to sub-optimal treatment for patients. Professor Edwin Gale proposes replacing the term with 'idiopathic hyperglycaemia', emphasizing individualized treatments based on varied causes.
Children who develop Type 2 diabetes are at high risk for early complications, including heart and kidney problems. The study found that young patients were more likely to develop hypertension and fatty liver due to obesity.
A meta-analysis of randomized clinical trials found that fish oil supplementation modestly increases adiponectin levels in the bloodstream. This hormone is associated with lower risk of diabetes and heart disease. The study suggests potential benefits of fish oil consumption on glucose control and fat cell metabolism.
Researchers at the University of North Carolina will assess three types of blood sugar home testing approaches on patient outcomes in a community-based clinic setting. The study aims to inform better, evidence-based decisions about glucose monitoring for patients with type 2 diabetes not treated with insulin.
Harvard researchers have discovered a novel hormone that regulates glucose production in the liver, offering new avenues for treating type 2 diabetes. The study found that switching off this hormone improves glucose metabolism, providing a potential therapeutic target.
Researchers created a new mouse model to study the development of type 2 diabetes, using middle-aged mice fed fatty food until old age. The study confirmed that inflammation in pancreatic islets leads to the disease, while DPP-4 inhibitors maintain good insulin production and prevent inflammation.
A recent study at Lund University has discovered a key factor behind gastric bypass surgery's ability to rapidly send type 2 diabetes into remission. The researchers found that insulin levels and intestinal hormones increase significantly after the procedure, suggesting a new potential treatment avenue for diabetes patients.
Researchers found that gastric bypass surgery increases insulin and GLP-1 levels after meals, helping patients manage type 2 diabetes. The study used catheters to mimic pre-operative digestion and compared hormonal activity post-surgery.
Green tea extract was shown to reduce body weight gain and insulin resistance in mice, especially when combined with polyethylene glycol. This compound prolonged gallated catechin absorption, limiting glucose uptake and improving glucose tolerance.
Researchers at Harvard University have discovered a hormone called betatrophin that increases insulin-secreting pancreatic beta cells by up to 30 times the normal rate. This could lead to a more natural regulation of insulin and reduced complications associated with diabetes.
A new study published in Diabetologia suggests that consuming one 12oz serving of sugar-sweetened soft drinks daily can increase the risk of developing type 2 diabetes by 22% in European populations. The research found a statistically significant association between artificially sweetened soft drink consumption and an increased risk of...
Researchers at Johns Hopkins Children's Center found that a previously minor protein called EPAC2 plays a central role in regulating insulin production. The study suggests that targeting EPAC2 with drugs could potentially restore pancreatic cell function and reverse Type 2 diabetes.
A study published in the BMJ found that a 5kg population-wide weight loss resulted in a significant reduction in Type 2 diabetes and cardiovascular disease mortality. The Cuban experience of rapid weight loss during economic crisis demonstrates the potential health benefits of reversing the global obesity epidemic.
A new study found that higher levels of mercury exposure in young adults increase their risk for type 2 diabetes later in life. The study, led by Indiana University School of Public Health-Bloomington epidemiologist Ka He, established the link between mercury and diabetes in humans.
A Danish study found that patients who tailor their own treatment in cooperation with their doctor can reduce their risk of complications, including heart attacks, with up to 20%. The study also shows that taking individual needs into consideration is crucial when treating patients with multiple diseases.
Researchers found an independent association between decreased melatonin secretion and increased risk for the development of type 2 diabetes. Lower nocturnal melatonin secretion was associated with increased insulin resistance in women, doubling their estimated diabetes incidence rate compared to those with higher melatonin secretion.
A new study from Brigham and Women's Hospital found that low nocturnal melatonin secretion levels are associated with an increased risk of developing type 2 diabetes. The study, which accounted for other established risk factors, suggests that melatonin plays a role in regulating glucose metabolism and risk of diabetes.
Researchers found that a restrictive diet following bariatric surgery leads to rapid improvements in blood glucose levels. The study's findings suggest that controlling food intake is key to successful diabetes remission.
A new study by Lund University researchers has found that epigenetic changes, such as DNA methylation, can influence the function of insulin-producing cells and alter genetic risk variants for type 2 diabetes. The findings suggest that these modifications may play a key role in the development of the disease.
A study from Boston University School of Medicine reveals that B cells secrete pro-inflammatory cytokines promoting insulin resistance and directly regulating inflammatory T cells. This discovery supports the exploration of FDA-approved B cell depletion drugs as novel agents to prevent obesity-associated inflammation and type 2 diabetes.
Researchers found that ranolazine, an anti-anginal drug, significantly reduced weekly episodes of chest pain in patients with type 2 diabetes. The study also showed that the drug had a more pronounced effect on reducing angina frequency in patients with poorer glucose control.
A recent study found that women with gestational diabetes are at risk for developing Type 2 diabetes, with a significant defect in insulin secretion identified as a key factor. The study's findings indicate that up to half of Asian women who had gestational diabetes may develop Type 2 diabetes within eight years of giving birth.
New research suggests that reducing sedentary time by 90 minutes per day can lead to significant health benefits for individuals at high risk of developing type 2 diabetes. The study found that sedentary time was more strongly associated with cardiometabolic markers than total physical activity or vigorous exercise.
A two-year study found that gastric bypass surgery reverses diabetes by uniquely restoring pancreatic function, particularly in reducing belly fat. The study showed a remarkable 5.8-fold increase in overall pancreatic cell function in patients who underwent gastric bypass.
A randomized controlled trial found that community health workers led by a nurse case-manager improved blood sugar levels among Samoans with type 2 diabetes. The intervention, which included culturally tailored education and home visits, resulted in clinically significant improvements in HbA1c levels.
A USC study finds that progestin-releasing long-acting reversible contraception (LARC) devices may pose a slight negative impact on metabolic markers, raising the risk for type 2 diabetes in healthy, obese reproductive-age women. The research concludes that LARC appears safe but merits further investigation.
A large population-based cohort study of 7,500 men in Sweden found that permanent stress increases the risk of type 2 diabetes. The study showed that men who reported permanent stress had a significantly higher risk of developing diabetes compared to those with no or periodic stress.
A study published in Environmental Research found a direct relationship between pesticide exposure and type 2 diabetes prevalence. Pesticide concentrations were significantly higher in the adipose tissue of people with type 2 diabetes, suggesting that pesticides may be an underlying factor in its development.
Researchers at University of Bristol identify MC4R as critical regulator of brain's response to obesity, also linked to increased blood pressure and type 2 diabetes. The study reveals a mechanism by which MC4R balances sympathetic and parasympathetic nervous system activity.
A new study published in Science Translational Medicine has found a strong link between binge drinking and the development of insulin resistance, which can lead to Type 2 diabetes. The research suggests that alcohol disrupts insulin-receptor signaling, causing inflammation in the brain and increasing the risk of metabolic disorders.
Researchers discovered a paradoxical relationship between diminished mitochondrial function and increased insulin sensitivity in mice. The study found that mice with mitochondrial mutations lived longer and had reduced body fat due to increased fat utilization.
A study found that among individuals with diabetes, those with both diabetes and kidney disease have a mortality rate of 31.1%, compared to 11.5% for those with diabetes but without kidney disease. Preventing and treating kidney disease in diabetics may be crucial to reducing mortality risk.
Research at the University of Missouri found that certain exercises benefit obese men but not women with Type 2 diabetes. Obese women may require longer or higher-intensity exercise programs to see similar improvements in cardiovascular function.
A Wayne State University researcher is evaluating the effectiveness of a 14-week text message-based behavioral intervention targeting Type 2 diabetes and its risks. The program, txt4Health, delivers tailored messages to users based on their individual risk for developing Type 2 diabetes.