Articles tagged with Type 2 Diabetes
Researchers found that a restrictive diet following bariatric surgery leads to rapid improvements in blood glucose levels. The study's findings suggest that controlling food intake is key to successful diabetes remission.
Researchers found an independent association between decreased melatonin secretion and increased risk for the development of type 2 diabetes. Lower nocturnal melatonin secretion was associated with increased insulin resistance in women, doubling their estimated diabetes incidence rate compared to those with higher melatonin secretion.
A new study by Lund University researchers has found that epigenetic changes, such as DNA methylation, can influence the function of insulin-producing cells and alter genetic risk variants for type 2 diabetes. The findings suggest that these modifications may play a key role in the development of the disease.
A study from Boston University School of Medicine reveals that B cells secrete pro-inflammatory cytokines promoting insulin resistance and directly regulating inflammatory T cells. This discovery supports the exploration of FDA-approved B cell depletion drugs as novel agents to prevent obesity-associated inflammation and type 2 diabetes.
Researchers found that ranolazine, an anti-anginal drug, significantly reduced weekly episodes of chest pain in patients with type 2 diabetes. The study also showed that the drug had a more pronounced effect on reducing angina frequency in patients with poorer glucose control.
A recent study found that women with gestational diabetes are at risk for developing Type 2 diabetes, with a significant defect in insulin secretion identified as a key factor. The study's findings indicate that up to half of Asian women who had gestational diabetes may develop Type 2 diabetes within eight years of giving birth.
New research suggests that reducing sedentary time by 90 minutes per day can lead to significant health benefits for individuals at high risk of developing type 2 diabetes. The study found that sedentary time was more strongly associated with cardiometabolic markers than total physical activity or vigorous exercise.
A two-year study found that gastric bypass surgery reverses diabetes by uniquely restoring pancreatic function, particularly in reducing belly fat. The study showed a remarkable 5.8-fold increase in overall pancreatic cell function in patients who underwent gastric bypass.
A randomized controlled trial found that community health workers led by a nurse case-manager improved blood sugar levels among Samoans with type 2 diabetes. The intervention, which included culturally tailored education and home visits, resulted in clinically significant improvements in HbA1c levels.
A large population-based cohort study of 7,500 men in Sweden found that permanent stress increases the risk of type 2 diabetes. The study showed that men who reported permanent stress had a significantly higher risk of developing diabetes compared to those with no or periodic stress.
A USC study finds that progestin-releasing long-acting reversible contraception (LARC) devices may pose a slight negative impact on metabolic markers, raising the risk for type 2 diabetes in healthy, obese reproductive-age women. The research concludes that LARC appears safe but merits further investigation.
A study published in Environmental Research found a direct relationship between pesticide exposure and type 2 diabetes prevalence. Pesticide concentrations were significantly higher in the adipose tissue of people with type 2 diabetes, suggesting that pesticides may be an underlying factor in its development.
Researchers at University of Bristol identify MC4R as critical regulator of brain's response to obesity, also linked to increased blood pressure and type 2 diabetes. The study reveals a mechanism by which MC4R balances sympathetic and parasympathetic nervous system activity.
A new study published in Science Translational Medicine has found a strong link between binge drinking and the development of insulin resistance, which can lead to Type 2 diabetes. The research suggests that alcohol disrupts insulin-receptor signaling, causing inflammation in the brain and increasing the risk of metabolic disorders.
Researchers discovered a paradoxical relationship between diminished mitochondrial function and increased insulin sensitivity in mice. The study found that mice with mitochondrial mutations lived longer and had reduced body fat due to increased fat utilization.
A study found that among individuals with diabetes, those with both diabetes and kidney disease have a mortality rate of 31.1%, compared to 11.5% for those with diabetes but without kidney disease. Preventing and treating kidney disease in diabetics may be crucial to reducing mortality risk.
Research at the University of Missouri found that certain exercises benefit obese men but not women with Type 2 diabetes. Obese women may require longer or higher-intensity exercise programs to see similar improvements in cardiovascular function.
A Wayne State University researcher is evaluating the effectiveness of a 14-week text message-based behavioral intervention targeting Type 2 diabetes and its risks. The program, txt4Health, delivers tailored messages to users based on their individual risk for developing Type 2 diabetes.
A team of UCSB researchers has identified changes in cellular metabolism as the triggering factor for Type 2 diabetes. By studying the four types of components that make up cells, they found a 'tipping point' where metabolic threshold is crossed, leading to beta cell failure and insulin regulation issues.
Researchers found metformin improves body mass index (BMI) and fasting glucose levels in obese children at risk for type 2 diabetes. The study's results suggest a potential treatment option for preventing the onset of type 2 diabetes in childhood, offering hope for reducing long-term health risks.
Recent studies suggest that moderate coffee consumption may reduce the risk of developing type 2 diabetes. Epidemiological evidence shows a 25% lower risk associated with three to four cups of coffee per day.
Researchers identified four new genetic regions associated with birth weight, which also link to adult metabolism and disease. The study found that these genetic regions influence blood pressure, height, and type 2 diabetes risk in adulthood.
A new study by USC and University of Oxford researchers indicates that large amounts of high fructose corn syrup (HFCS) in food supplies worldwide may contribute to the rising global epidemic of type 2 diabetes. Countries using HFCS had a 20% higher prevalence of diabetes than those not using it.
Research found that people with diabetes who have adequate vitamin D are less likely to develop clogged arteries. In contrast, insufficient vitamin D leads to immune cells binding to blood vessels and trapping cholesterol.
A study found that patients newly diagnosed with type 2 diabetes often receive little information on diet and physical activity, leading to feelings of isolation. The research highlights the need for easily accessible resources and support to help patients manage their condition.
A pilot program at the University of Ottawa Heart Institute has demonstrated a significant improvement in patient care for diabetic patients. The program resulted in higher notifications to doctors, referrals to community diabetes management programs, and lower average blood sugar levels among in-patients.
A large-scale international study has identified three new gene variants associated with body mass index (BMI) levels in adults, providing fundamental insights into the biology of adult obesity. The study used a versatile gene discovery chip to detect gene variants involved in lipid-related diseases and other disorders.
Old Order Amish children are twice as physically active and three times less likely to be overweight than non-Amish peers. This high level of activity is inversely correlated with their body mass index, suggesting a protective effect against developing Type 2 diabetes.
A study suggests that Type 2 diabetes increases the risk of Barrett's Esophagus (BE) in diabetic men, with a twofold increase compared to non-diabetic men. The risk is higher in men due to differences in fat distribution, which may contribute to the association between Type 2 diabetes and BE.
The new guidelines suggest using a risk calculator to determine the risk level for general population, and recommend no routine screening with blood tests for adults at low or moderate risk of diabetes. For high-risk adults, screening is recommended every 3-5 years using A1C blood test.
Regular exercise can improve fitness levels in people with type 2 diabetes by up to 40% after 12-20 weeks of training. This reduces the impact of the disease on cardiovascular health and decreases mortality risk.
A study has found that nearly half a million people in three East London boroughs are at high risk of developing type 2 diabetes within the next decade. The 'East London Diabetes Belt' maps areas of high risk, highlighting need for targeted public health strategies.
Researchers identified 14 novel biomarkers for type 2 diabetes that can serve as the basis for developing new treatment and prevention methods. These biomarkers provide insight into the complex mechanisms of this disease, which are still not fully understood.
A new study published in The Lancet found that widespread diabetes screening programs do not reduce overall mortality rates. The study, which included over 20,000 patients, also showed no significant difference in mortality rates between screened and non-screened groups.
A study published in Annals of Behavioral Medicine found that gender-specific group therapy reduced depressive symptoms in women with Type 2 diabetes by half compared to usual care. The therapy program, SWEEP, taught participants how blood sugar affects emotions and helped them recognize stress signs.
A study published in Nature reveals that people with type 2 diabetes have a high level of pathogens in their intestines, which can increase resistance to certain medicines. The research also identifies biological indicators that could be used for faster and earlier diagnosis of the disease.
A 5-year, $134 million grant from the National Institute of Health will support a clinical trial examining four glucose-lowering medications for type 2 diabetes treatment. The study aims to determine which therapy most effectively and safely reaches and maintains near normal levels of blood glucose.
A new study published in the Journal of the American Medical Association found that obese individuals with visceral fat are at a higher risk for developing Type 2 diabetes. In contrast, those with excess abdominal subcutaneous fat were not at greater risk. The study, which sampled over 700 obese adults, used imaging methods to determin...
Researchers at Sahlgrenska Academy, University of Gothenburg, have found that metformin is effective in reducing the risk of cardiovascular disease, serious infection, and death in patients with mild kidney impairment. The study suggests that metformin can be prescribed for many more patients with diabetes than previously thought.
Researchers at Columbia University Irving Medical Center discovered that beta cells in type 2 diabetes do not die but de-differentiate under stress, suggesting a potential new approach to treatment. By targeting signaling pathways such as Wnt or Notch, scientists may be able to promote re-differentiation of beta cells.
A study published in the New England Journal of Medicine reveals that mutations in the PTEN gene can improve metabolism and increase insulin sensitivity in people with Cowden syndrome. The researchers found that those with Cowden syndrome had higher levels of obesity, but the extra weight was caused by extra fat storage, not muscle mass.
A recent study published in Diabetes Care found that Latinos are more vulnerable to fatty pancreas and Type 2 diabetes due to their ability to store excess fat in the pancreas. This can lead to a reduced capacity for insulin production, increasing the risk of developing the disease.
A new study published today reveals the extent of type 2 diabetes problems in black and minority ethnic populations in the UK. By age 80, approximately half of all South Asians, Africans, and African Caribbean individuals will develop diabetes, with twice as many British South Asian, African, and African Caribbean men and women diagnos...
Researchers at Lund University have developed a new approach that links gene variants to their effect on insulin production in human beta cells. The study explains 25% of variations in blood sugar levels, providing greater insight into the causes of type 2 diabetes.
A study found that even in the normal range, urinary protein excretion increases diabetics' heart risks. Patients may benefit from cardioprotective medications to mitigate this risk.
Researchers have discovered that Grb10 protein plays a crucial role in increasing muscle mass during development, which could lead to new strategies for treating muscle wasting conditions and metabolic disorders. The study found that blocking Grb10 function while mice were in the womb resulted in increased muscle strength and mass.
Cytomegalovirus (CMV) infection is a significant risk factor for type 2 diabetes in the elderly, according to new research. CMV infection can cause inflammation and damage pancreatic cells, leading to insulin resistance and increased glucose levels.
Researchers found that mice exposed to methyl-glyoxal, a heat-processed food compound, developed abdominal weight gain, insulin resistance, and type 2 diabetes. A diet high in MG reduced SIRT1 and AGER1 levels, impairing glucose metabolism.
Researchers have identified 10 new gene regions associated with type 2 diabetes, providing a fuller picture of the disease's genetic underpinnings. The study reveals patterns in genes involved in cell growth, insulin production, and fat cell communication.
A study of 32,002 men found that weight training was associated with a lower risk of type 2 diabetes. Men who engaged in both weight training and aerobic exercise for at least 150 minutes per week had the greatest reduction in risk.
A new study published in Archives of Internal Medicine found that men who engage in weight training regularly may reduce their risk of type 2 diabetes by up to 34%, compared to those who do not. The study also showed that combining weight training with aerobic exercise can further lower the risk, even as high as 59%.
Researchers found that activation of A2b-type adenosine receptor reduces insulin and glucose levels and improves symptoms of high-fat diet-induced type 2 diabetes. The study identified a novel link between A2bAR and insulin signaling, providing new insights into the regulation of glucose and insulin homeostasis.
A new study found South Asians have higher levels of blood sugar than white Europeans, independent of risk factors. This suggests that South Asians should be monitored more closely for type 2 diabetes, as the diagnosis is already higher in this ethnic group.
A 32-country study found that linagliptin, a DPP-4 inhibitor, is effective in improving glycaemic control without weight gain or increased risk of hypoglycemia. The extended trial demonstrated sustained glucose control for up to 102 weeks treatment duration.
A study published in Diabetes found that exercise benefits diabetic hearts by improving energy exchange and resisting oxidative stress. Fatty acids, previously thought to be detrimental, were shown to improve heart function when the heart needs to beat faster.
A new study published in the Canadian Medical Association Journal found a potential link between the use of pioglitazone, a type of thiazolidinedione diabetes medication, and an increased risk of bladder cancer. Researchers analyzed data from over 2.6 million patients to quantify this association.
A UT Southwestern study found that early intensive treatment of type 2 diabetes slows down the progression of the disease by preserving the body's insulin-producing capacity. The intensive treatment regimen was shown to be effective in maintaining steady insulin-producing beta-cell function for three and a half years after diagnosis.
A systematic review of seven studies involving over 32,400 patients found that metformin reduced the risk of any type of cancer by 38% compared to those not taking the medication. The benefits were seen in colon and breast cancer, but not pancreatic cancer.
A new study found that modified bariatric surgery can resolve or improve Type 2 diabetes in obese and diabetic patients, regardless of body mass index (BMI). The procedure showed high success rates in reducing blood sugar levels and eliminating insulin needs.
A new study found an inverse relationship between vitamin D levels and the presence of metabolic syndrome, a group of risk factors that increases the risk of heart disease and Type 2 diabetes. People with high vitamin D levels had a 48% lower risk of having the metabolic syndrome.