Articles tagged with Type 2 Diabetes
A study of over 70,000 type 2 diabetes patients aged 60 and above found that very low blood sugar levels were associated with a small but significant increased risk of death, while those with intermediate levels of control had the best overall outcomes. Researchers emphasized the need for further research to understand the clinical imp...
A recent survey conducted by the American College of Endocrinology found that over half of individuals with type 2 diabetes have experienced low blood sugar, often during daily activities. The study highlights the need for increased education on blood sugar management and symptom recognition to prevent serious consequences.
A study from UNC School of Medicine found that saturated fatty acids activate immune cells to produce inflammatory protein interleukin-1beta, leading to insulin resistance and type 2 diabetes symptoms.
A large study of over 107,000 people in Denmark found that certain insulin secretagogues (ISs) were associated with a higher risk of death from any cause and heart attacks compared to metformin. Metformin was found to be the most effective treatment for preventing cardiovascular diseases.
Researchers identified 54 compounds in maple syrup from Canada with antioxidant activity and potential health benefits, including anti-cancer and anti-inflammatory effects. The study suggests that maple syrup may inhibit enzymes relevant in Type 2 diabetes management.
Research finds micro-RNAs play a role in type 2 diabetes mechanism, blocking insulin's blood-sugar-reducing effect. Obese mice produce excess miRNA-143, which silences genes responsible for insulin activation.
Bariatric surgery has been shown to reduce the risk of heart attack and stroke in patients with diabetes, with 70% remission in two years and 30% remaining 15 years later. The surgery also reduces new cases of diabetes by 80% among obese patients.
Researchers found sitagliptin effective in preventing prediabetes from progressing to diabetes. The drug reduced glucose levels after meals and increased insulin output while decreasing glucagon levels.
A daily pill of pioglitazone prevented type 2 diabetes in more than 70% of participants with obesity and other risk factors. The study also showed a 31% decrease in carotid artery thickening, indicating improved glucose control.
Researchers found that levels of five amino acids, including isoleucine and leucine, can signal future disease risk and indicate candidates for preventive measures. The study used metabolite measurements to identify individuals at elevated risk of developing type 2 diabetes.
The study found that Yi-Qi-Zeng-Min-Tang improves insulin sensitivity, glycaemic control, and dyslipidemia in high-fat diet and low-dose streptozotocin-induced Type 2 diabetic rats. The herbal decoction does not cause weight gain, making it a potential adjunct treatment for patients with insulin resistance.
Researchers identified a 'diabetes belt' of 644 counties in 15 southeastern states with high prevalence rates, linked to sedentary lifestyle, obesity, and non-modifiable factors. Community design changes can promote physical activity and healthy lifestyles to reduce diabetes risk.
Researchers found lower potassium levels associated with higher diabetes risk in African-Americans, who are twice as likely to develop type 2 diabetes. Increasing potassium levels through diet or supplements could potentially prevent the most common form of diabetes.
A multinational study found that a single gene mutation in the HMGA1 gene is responsible for type 2 diabetes in nearly 10 percent of patients of white European ancestry. This defect leads to insulin resistance and type 2 diabetes, providing a potential test to predict disease risk and identify effective treatment options.
Research reveals that specific gene variants, particularly IVS5-13insC, are linked to an increased risk of type 2 diabetes in individuals of white European ancestry. The study's findings suggest that these genetic variations could serve as early predictive markers for insulin resistance and type 2 diabetes.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that individuals with fatty liver were significantly more likely to develop type 2 diabetes than those without. Fatty liver was shown to be an independent risk factor for type 2 diabetes, regardless of insulin resistance levels.
Researchers found that humans can't produce a specific sialic acid molecule, leading to insulin and glucose metabolism problems. This discovery suggests evolutionary changes may have influenced human metabolism and increased diabetes risk.
A La Jolla Institute-led team has identified the primary cellular players in an adenosine-fueled inflammation cascade that contributes to insulin resistance. By using an adenosine receptor blocker, the team prevented the activation of macrophages, leading to improved insulin sensitivity and reduced blood sugar levels in diabetic animals.
The McKesson Foundation has awarded $1.3 million in Mobilizing for Health Research grants to six U.S. institutions to study the use of mobile technology in diabetes care and management. The studies aim to improve patient outcomes and reduce healthcare costs through innovative mobile health solutions.
A study found that gastric bypass surgery resulted in greater weight loss and improved resolution of type 2 diabetes compared to sleeve gastrectomy and lap-band surgery. Additionally, patients who underwent gastric bypass experienced better quality of life outcomes.
Researchers at Joslin Diabetes Center have found a molecular pathway that is activated in people with insulin resistance and type 2 diabetes. This pathway holds promise as a target for novel diabetes therapies, offering new hope for patients with the disease.
A new clinical trial at NewYork-Presbyterian Hospital/Weill Cornell Medical Center is testing whether surgery can control Type 2 diabetes as effectively as medical treatment. The study enrolls 50 patients with Type 2 diabetes, comparing gastric bypass to conventional medical therapy and lifestyle modifications.
A study by Purdue University found that diabetes affects not only patients but also their spouses, causing similar distress and depressive symptoms. The research highlights the importance of considering the emotional impact on both individuals in diabetes care.
Women with polycystic ovary syndrome (PCOS) have aberrations in their fat tissue that can lead to insulin resistance and increase the risk of developing type 2 diabetes. The study, published in The Journal of Clinical Endocrinology and Metabolism, found that large fat cells and low levels of adiponectin are strongly associated with ins...
Research at UCLA reveals that coffee's protective effect against type 2 diabetes may be linked to increased SHBG levels. Women who drink four cups of coffee daily are less than half as likely to develop diabetes compared to non-coffee drinkers.
A natural substance in dairy fat, trans-palmitoleic acid, has been identified as a potential factor in reducing the risk of type 2 diabetes. The compound is found in milk, cheese, yogurt, and butter and may mimic the normal biologic role of its produced counterpart, cis-palmitoleic acid.
A new study suggests that consuming an almond-enriched diet can improve insulin sensitivity and decrease LDL-cholesterol levels in individuals with prediabetes. The study found significant improvements in insulin levels, homeostasis model analysis for insulin resistance, and clinically significant reductions in LDL-cholesterol.
A new study found that combining exenatide with insulin provides better blood sugar control in patients with type 2 diabetes, achieving near-normal levels in 60% of participants. Additionally, Byetta recipients lost an average of four pounds during the study, while placebo recipients gained two pounds.
Researchers found a molecular 'switch' called SMRT that turns off protective cellular activities against aging and metabolic diseases. The discovery could lead to new treatments for conditions like type 2 diabetes and heart disease.
A combination of aerobic exercise and resistance training was associated with improved glycemic levels among patients with type 2 diabetes. The level of improvement was not seen among patients who performed either aerobic exercise or resistance training alone. The study found that the combination group had a greater reduction in hemogl...
A systematic review of American Dietetic Association Nutrition Practice Guidelines provides recommendations for registered dietitians to support people with type 1 and type 2 diabetes. The guidelines emphasize consistency in carbohydrate intake, insulin dose adjustment, and cardioprotective nutrition interventions.
Childhood obesity is associated with an increased risk of developing cardiovascular and metabolic disorders in adulthood, including hypertension, elevated cholesterol levels, and insulin resistance. Early intervention and prevention strategies are crucial to minimize this risk.
A University of Alberta study found that including pharmacists in primary care teams leads to significant drops in blood pressure among patients with Type 2 diabetes. The collaboration enables direct discussion between healthcare professionals, resulting in better medication management and reduced cardiovascular risk.
The Endocrine Society releases a clinical practice guideline for the nutritional and endocrine management of adults after bariatric surgery. The guideline features evidence-based recommendations to prevent weight regain and co-morbidities, including type 2 diabetes, polycystic ovarian disease, and fatty liver.
Researchers have found that beta cells in humans do not replicate after age 30, which could lead to breakthroughs in treating type 1 and 2 diabetes. The discovery uses radioactive carbon-14 dating to determine the number of beta cells remains static after this age.
A new study finds that drinking sugary beverages, like soda, daily increases the risk of type 2 diabetes by 26% and metabolic syndrome by 20%. Limiting sugary drink intake can help reduce these conditions.
A new study published in Gastroenterology has found that type 2 diabetes mellitus and insulin use are associated with an increased risk of colorectal cancer among men. The association was not observed in women, suggesting a gender disparity in the link between these conditions.
Researchers found a common denominator between Type 2 diabetes and Alzheimer's disease: PGC-1, a key regulator of glucose. Decreased PGC-1 levels may contribute to Alzheimer's disease progression by promoting beta-secretase degradation.
Researchers have identified a potential target for diabetes drugs by discovering how certain insulin gene mutations cause proinsulin proteins to misfold in pancreatic beta cells. The study found that misfolding of normal proinsulin proteins occurs when mutant protein is present, leading to insulin deficiency and diabetes.
A new consensus statement recommends regular glycemia screening and early identification of patients at metabolic risk to slow or reverse beta-cell decline. The Endocrine Society has launched a website to promote pathophysiology-based clinical practices and aid primary care physicians in interpreting concepts of disease pathogenesis.
A lifestyle intervention has been shown to provide long-term benefits for individuals with type 2 diabetes, leading to significant weight loss and improvements in fitness, hemoglobin A1c levels, and cholesterol profiles. The study suggests that this approach can help prevent long-term complications of the disease.
Research led by Nancy F. Butte and funded by the US Department of Agriculture identifies new genetic biomarkers that may predict type 2 diabetes in children. The study fine-tunes a region on chromosome 13 associated with fasting blood sugar levels, shedding light on predisposition to the disease.
A study by researchers at the University of Warwick has found that short sleep duration is associated with a significant increased risk of developing type 2 diabetes and heart disease. People who sleep less than six hours a night are three times more likely to develop impaired fasting glycaemia, a pre-diabetic state.
A new study has identified three factors linked to cognitive deficits in type 2 diabetes: high blood pressure, balance issues, and poor health reports. These factors contribute to weaker memory and slower cognitive processing in individuals with Type 2 diabetes.
Research reveals that breastfeeding significantly reduces mothers' risk of developing type 2 diabetes later in life. Mothers who did not breastfeed had a 56% lower rate compared to those who breastfed, highlighting the benefits of lactation on maternal health.
Research found that people with insulin resistance and type 2 diabetes are at increased risk of developing brain plaques associated with Alzheimer's disease. The study also discovered a link between abnormal blood sugar control tests and the presence of these plaques.
Four common genetic variants of the PRKCB1 gene are associated with development of end-stage renal disease in Chinese patients with type 2 diabetes. The likelihood for ESRD increased with a greater number of risk alleles, with an adjusted risk six times higher for patients with 4 risk alleles compared to those with 0 or 1.
Researchers found that emodin from Chinese herbs can lower blood glucose and serum insulin levels in mice with diet-induced obesity. The herb's active compound effectively limits the effect of glucocorticoids, which contribute to insulin resistance.
Patients undergoing bariatric surgery showed significant reduction in diabetes medication use, with over 80% eliminating medications one year post-surgery. The study suggests that bariatric surgery may lead to improved glucose control and lower healthcare costs for obese patients with type 2 diabetes.
Researchers found diminished cognitive performance in obese adolescents with type 2 diabetes, as well as subtle brain abnormalities detected by MRI. The study highlights the importance of addressing obesity and inactivity to prevent cognitive deficits.
A study of over 786 cases found that thiazolidinediones, a common diabetes medication, increased the risk of fractures in postmenopausal women and men with diabetes. Higher doses of TZDs were associated with greater fracture risk.
A recent study has discovered that a protein known for its role in type 2 diabetes may also be involved in heart disease and other metabolic disorders. The findings suggest potential drug targets among gene networks, offering new avenues for treatment.
Researchers have discovered a dramatic increase in an enzyme called O-GlcNAcase in the red blood cells of people with diabetes and prediabetes. This enzyme may be used as a diagnostic tool to detect prediabetes at its earliest stages, allowing for potential early intervention.
A simple diagnostic tool predicts type 2 diabetes in Vietnamese individuals based on high systolic blood pressure and waist-to-hip ratio. The prevalence of undiagnosed diabetes is estimated to be around 11% for men and 12% for women, with approximately 350,000 people affected in Ho Chi Minh City.
Researchers discovered 12 new regions on the genome with DNA variants linked to type 2 diabetes, raising hopes for early detection and prevention. The study also revealed surprising overlaps between type 2 diabetes and non-related diseases.
The ACCORD study found that intensive glucose treatment delayed albuminuria onset but didn't reduce microvascular complications like eye disease or kidney failure. However, it increased mortality, weight gain, and severe hypoglycemia risk, prompting a shift to standard therapy.
In a study of over 10,000 adults with type 2 diabetes, intensive glucose control did not delay the progression to kidney failure, major vision loss, or advanced peripheral neuropathy. However, it reduced signs of damage, such as decreased protein leakage in urine and lower cataract surgery rates.
A new study found that rosiglitazone, a medication for treating Type 2 diabetes, is associated with an increased risk of stroke, heart failure, and death compared to pioglitazone. The study analyzed data from over 227,000 patients aged 65 and older who took the medications from 2006 to 2009.
An international consortium of scientists has identified 12 new gene variants linked to type 2 diabetes, with 11 influencing insulin production and one associated with the X chromosome. This discovery sheds light on the complex pathogenesis of the disease, which affects millions worldwide.
A national study called HEALTHY found that innovative PE programs, healthier food choices, and in-class lessons on healthy lifestyles can benefit children most at-risk for type 2 diabetes. After three years, students in intervention schools had a 21% lower rate of obesity and improved fasting insulin levels compared to comparison schools.