Articles tagged with Type 2 Diabetes
A new study published in Gastroenterology has found that type 2 diabetes mellitus and insulin use are associated with an increased risk of colorectal cancer among men. The association was not observed in women, suggesting a gender disparity in the link between these conditions.
Researchers found a common denominator between Type 2 diabetes and Alzheimer's disease: PGC-1, a key regulator of glucose. Decreased PGC-1 levels may contribute to Alzheimer's disease progression by promoting beta-secretase degradation.
Researchers have identified a potential target for diabetes drugs by discovering how certain insulin gene mutations cause proinsulin proteins to misfold in pancreatic beta cells. The study found that misfolding of normal proinsulin proteins occurs when mutant protein is present, leading to insulin deficiency and diabetes.
A new consensus statement recommends regular glycemia screening and early identification of patients at metabolic risk to slow or reverse beta-cell decline. The Endocrine Society has launched a website to promote pathophysiology-based clinical practices and aid primary care physicians in interpreting concepts of disease pathogenesis.
A lifestyle intervention has been shown to provide long-term benefits for individuals with type 2 diabetes, leading to significant weight loss and improvements in fitness, hemoglobin A1c levels, and cholesterol profiles. The study suggests that this approach can help prevent long-term complications of the disease.
Research led by Nancy F. Butte and funded by the US Department of Agriculture identifies new genetic biomarkers that may predict type 2 diabetes in children. The study fine-tunes a region on chromosome 13 associated with fasting blood sugar levels, shedding light on predisposition to the disease.
A study by researchers at the University of Warwick has found that short sleep duration is associated with a significant increased risk of developing type 2 diabetes and heart disease. People who sleep less than six hours a night are three times more likely to develop impaired fasting glycaemia, a pre-diabetic state.
A new study has identified three factors linked to cognitive deficits in type 2 diabetes: high blood pressure, balance issues, and poor health reports. These factors contribute to weaker memory and slower cognitive processing in individuals with Type 2 diabetes.
Research reveals that breastfeeding significantly reduces mothers' risk of developing type 2 diabetes later in life. Mothers who did not breastfeed had a 56% lower rate compared to those who breastfed, highlighting the benefits of lactation on maternal health.
Research found that people with insulin resistance and type 2 diabetes are at increased risk of developing brain plaques associated with Alzheimer's disease. The study also discovered a link between abnormal blood sugar control tests and the presence of these plaques.
Four common genetic variants of the PRKCB1 gene are associated with development of end-stage renal disease in Chinese patients with type 2 diabetes. The likelihood for ESRD increased with a greater number of risk alleles, with an adjusted risk six times higher for patients with 4 risk alleles compared to those with 0 or 1.
Researchers found that emodin from Chinese herbs can lower blood glucose and serum insulin levels in mice with diet-induced obesity. The herb's active compound effectively limits the effect of glucocorticoids, which contribute to insulin resistance.
Patients undergoing bariatric surgery showed significant reduction in diabetes medication use, with over 80% eliminating medications one year post-surgery. The study suggests that bariatric surgery may lead to improved glucose control and lower healthcare costs for obese patients with type 2 diabetes.
Researchers found diminished cognitive performance in obese adolescents with type 2 diabetes, as well as subtle brain abnormalities detected by MRI. The study highlights the importance of addressing obesity and inactivity to prevent cognitive deficits.
A study of over 786 cases found that thiazolidinediones, a common diabetes medication, increased the risk of fractures in postmenopausal women and men with diabetes. Higher doses of TZDs were associated with greater fracture risk.
A recent study has discovered that a protein known for its role in type 2 diabetes may also be involved in heart disease and other metabolic disorders. The findings suggest potential drug targets among gene networks, offering new avenues for treatment.
Researchers have discovered a dramatic increase in an enzyme called O-GlcNAcase in the red blood cells of people with diabetes and prediabetes. This enzyme may be used as a diagnostic tool to detect prediabetes at its earliest stages, allowing for potential early intervention.
A simple diagnostic tool predicts type 2 diabetes in Vietnamese individuals based on high systolic blood pressure and waist-to-hip ratio. The prevalence of undiagnosed diabetes is estimated to be around 11% for men and 12% for women, with approximately 350,000 people affected in Ho Chi Minh City.
Researchers discovered 12 new regions on the genome with DNA variants linked to type 2 diabetes, raising hopes for early detection and prevention. The study also revealed surprising overlaps between type 2 diabetes and non-related diseases.
In a study of over 10,000 adults with type 2 diabetes, intensive glucose control did not delay the progression to kidney failure, major vision loss, or advanced peripheral neuropathy. However, it reduced signs of damage, such as decreased protein leakage in urine and lower cataract surgery rates.
The ACCORD study found that intensive glucose treatment delayed albuminuria onset but didn't reduce microvascular complications like eye disease or kidney failure. However, it increased mortality, weight gain, and severe hypoglycemia risk, prompting a shift to standard therapy.
An international consortium of scientists has identified 12 new gene variants linked to type 2 diabetes, with 11 influencing insulin production and one associated with the X chromosome. This discovery sheds light on the complex pathogenesis of the disease, which affects millions worldwide.
A new study found that rosiglitazone, a medication for treating Type 2 diabetes, is associated with an increased risk of stroke, heart failure, and death compared to pioglitazone. The study analyzed data from over 227,000 patients aged 65 and older who took the medications from 2006 to 2009.
A national study called HEALTHY found that innovative PE programs, healthier food choices, and in-class lessons on healthy lifestyles can benefit children most at-risk for type 2 diabetes. After three years, students in intervention schools had a 21% lower rate of obesity and improved fasting insulin levels compared to comparison schools.
The DURATION-2 study found that once-weekly exenatide improved HbA1c levels by 1.5% compared to 0.9% for sitagliptin and 1.2% for pioglitazone, with significant weight loss in the exenatide group. The findings suggest that exenatide should be considered as an adjunct to metformin for improving glucose control and weight loss.
Diabetes prevalence is set to double by 2030 in sub-Saharan Africa due to rapid urbanization and lifestyle changes. Implementing national diabetes prevention programs involving multiple sectors is crucial to address this public health issue.
A new diabetes drug, dapagliflozin, has been shown to improve blood sugar control in patients who have inadequate control with metformin. The drug acts independently of insulin, promotes excretion of glucose in the urine, and is associated with weight loss and low risk of hypoglycaemia.
A randomized study found that inhaled insulin plus insulin glargine achieved similar blood sugar control as twice-daily premixed biaspart insulin, with less weight gain and hypoglycemia. The treatment also showed a better safety profile, with fewer cough and lung function issues.
The Lancet Editorial emphasizes the need for low-cost and easy-to-implement interventions to address the global type 2 diabetes epidemic. The campaign led by Michelle Obama's Let's Move initiative promotes a three-component approach: nutrition, activity, and children.
Children of mothers with high blood sugar during pregnancy are more likely to have low insulin sensitivity, a risk factor for type 2 diabetes. Obesity does not account for the association, and children exposed to high maternal blood sugar levels in the womb also exhibit exaggerated insulin secretion after meals.
A new study found that low vitamin D levels are associated with poor blood sugar control in patients with Type 2 diabetes. The research, presented at The Endocrine Society's 92nd Annual Meeting, suggests that vitamin D supplementation may improve health outcomes for this prevalent condition.
A new study by Columbia University researchers found that bariatric surgery significantly improves insulin sensitivity in diabetic adults, even with equal weight loss compared to a low-calorie diet. The study suggests hormonal changes may be responsible for the improvements, paving the way for further medical therapies.
A study of 39,765 men and 157,463 women found that consuming five or more servings of white rice per week increases diabetes risk by 17%, whereas eating two or more servings of brown rice per week reduces the risk by 11%. Replacing white rice with brown rice daily could lower diabetes risk by 16%.
Eating five or more servings of white rice per week was associated with an increased risk of type 2 diabetes. Replacing it with brown rice or other whole grains lowered the risk by 16% and 36% respectively.
A new Tel Aviv University study found that Type 2 diabetes doubles the risk of female genital and other cancers. The study recommends screening for colon cancer earlier and more often for diabetic women to save lives.
A study published in The Lancet found that low-dose combination therapy of rosiglitazone and metformin can stop people progressing to type 2 diabetes, with a relative risk reduction of 66% compared to placebo. This strategy could target populations at-risk of diabetes.
Research found that sarcopenia, low skeletal muscle mass and strength, is associated with insulin resistance and high blood-sugar levels in both obese and non-obese individuals. Muscle mass and strength are crucial in preventing type 2 diabetes.
A study of 125,126 Swedish citizens with type 2 diabetes found an increased risk of 24 types of cancer, with the highest rates for pancreatic and liver cell cancers. The researchers also discovered a lower risk of prostate cancer among diabetics with a family history of the disease.
A study found that individuals with a family history of type 2 diabetes gain significantly more weight after consuming excess calories compared to those without such a history. Insulin resistance, a precursor to the disease, was also observed in the genetically prone group.
Women with type 2 diabetes who consumed more whole grains and bran had a lower risk of death from cardiovascular disease and all causes. The study found that high bran intake reduced the risk by 35% for CVD mortality and 28% for overall mortality.
Researchers discovered insulin's properties reduce inflammation in fat tissue, a key factor in developing insulin resistance and type 2 diabetes. Identifying the inflammatory molecule IL-6 and protein PKCdelta improved understanding of signalling mechanisms that can lead to medicines to reduce inflammation and related disorders.
A new study found that PARL protein levels decline with age, contributing to muscle defects and insulin resistance. The researchers suggest increasing PARL levels may bring metabolic benefits, potentially leading to a new drug target for age-related diseases.
The Biodesign Institute project seeks to discover and validate molecular signs to predict who will develop diabetes before symptoms appear. By analyzing blood samples from over 700 patients, researchers hope to identify new biomarkers that can identify those at risk for developing diabetes and heart disease.
Researchers found that men with metabolic syndrome had twice as low blood H2S levels as lean men, while those with diabetes had four times lower levels. This reduction in H2S was associated with higher blood pressure, increased insulin resistance and damage to small blood vessels.
A new study published in The Lancet found that injected liraglutide is more effective than oral sitagliptin at controlling blood glucose levels in people with type 2 diabetes who have inadequate control on standard treatment metformin. Liraglutide was well tolerated with minimal risk of hypoglycaemia.
A study found that healthy children from South Asian and African-Caribbean groups in the UK showed increased precursors of diabetes risk, similar to adult disparities. Researchers observed these patterns in children as young as 9 and 10 years old, suggesting ethnic differences persist into childhood.
A recent study published in the Journal of Clinical Endocrinology Metabolism found that modest weight loss can reverse many of the damaging changes seen in immune cells of obese people. This reversal is achieved through an 80% reduction of pro-inflammatory T-helper cells and reduced activation of other circulating immune cells.
A new Europe-wide strategy for preventing type 2 diabetes has been developed, recommending lifestyle changes such as weight loss and increased physical activity to prevent the disease. The guidelines aim to halve the incidence of type 2 diabetes by implementing evidence-based prevention programs across European countries.
A recent study found two genetic regions associated with lower birth weight, one of which is also linked to an increased risk of type 2 diabetes. The research analyzed over 38,000 Europeans and showed that individuals with a specific gene variant were 25% more likely to develop diabetes if they had low birth weight.
An international expert group recommends individualized treatment for patients with type 2 diabetes, citing the need to address underlying physiological and genetic differences. The recommendations aim to improve glycemic control, minimize risk, and reduce diabetes complications by tailoring therapies to specific patient subgroups.
Research shows that initiating type 2 diabetes screening in the US population at ages 30-45 and repeating it every 3-5 years is cost-effective. This approach can prevent heart attacks, diabetes-related microvascular complications, and improve quality of life while keeping costs below $10,500 per quality-adjusted life-year.
Researchers at Boston Children's Hospital have identified a new strategy to treat type 2 diabetes by activating a cellular pathway that fails in obese individuals. The approach normalizes blood glucose levels in severely obese and diabetic mice, suggesting potential benefits for human treatment.
Researchers delayed onset of type 2 diabetes in rats by relocating a portion of the small intestine, identifying biochemical changes that may contribute to this effect. The study's findings suggest bariatric surgery may improve type 2 diabetes without relying on weight loss.
The University of Copenhagen is set to establish a leading international research center for basic metabolic research, thanks to a historic $160 million donation from the Novo Nordisk Foundation. The Center will conduct research into Type 2 diabetes and other lifestyle diseases, aiming to make a significant impact on global health trends.
Researchers found that an experimental oral drug lowered blood sugar levels and reduced inflammatory proteins in diabetic mice. The study suggests that targeting the MIF protein could be a viable therapeutic approach to treating Type 2 diabetes.
The ACCORD trial showed that targeting normal systolic blood pressure levels did not significantly reduce the risk of fatal or nonfatal cardiovascular disease events. Treating multiple lipids with combination drug therapy also did not provide additional benefits over treatment with statin alone.
Researchers at McMaster University found that interval training can be an effective and time-efficient way to reduce the risk of Type 2 diabetes. The study involved eight to 12 one-minute bouts of exercise with rest intervals, resulting in a total of 20-25 minutes per session.
A new study by Duke University Medical Center scientists identifies a mechanism linking meal anticipation to Type 2 diabetes. Ankyrin-B gene mutation impairs insulin secretion, increasing blood sugar levels.
Researchers discovered mitochondrial protein and gene anomalies in young obese subjects with type 2 diabetes, leading to insulin resistance and reduced physical exercise response. The study highlights the need for specific treatments for each patient subtype.
A study of over 19,500 Chinese participants found that frequent napping is associated with a higher prevalence of type 2 diabetes and impaired fasting glucose. The observed associations were unaltered even after removing participants with potential health issues, suggesting that napping may increase the risk of diabetes.