Articles tagged with Type 2 Diabetes
A recent study published in The Journal of Clinical Endocrinology & Metabolism found that women with type 2 diabetes who take thiazolidinediones are at a higher risk for developing bone fractures. Women over 65 years old were shown to be particularly susceptible, with a 50% increased risk after one year of treatment.
Researchers found that patients with type-2 diabetes struggled with impulse control, particularly resisting high-fat food cues. Cognitive impairment of impulsivity control was the primary explanation for this inability, contributing to chronic lifestyle-related diseases.
African American women living in neighborhoods with lower socioeconomic status are more likely to develop type 2 diabetes. The study found a direct link between neighborhood environment and risk for the disease, with even well-educated women affected.
Researchers at Trinity College Dublin have made significant discoveries about Type 2 diabetes in young adults, shedding light on muscle cell mechanisms that contribute to severe insulin resistance. The study's findings may lead to the development of more targeted treatments for young people with Type 2 diabetes.
Patients with type 2 diabetes who experience subtle brain damage may be at risk of progressive kidney disease and kidney failure, according to a new study. Diabetic patients with silent cerebral infarction were nearly five times more likely to develop serious kidney disease than those without.
A study published in Diabetes Care found that patients with depression are at a 36% higher risk of developing advanced micro-vascular complications, such as end-stage kidney disease or blindness. Depression is also linked to a 25% higher risk of macrovascular complications, including stroke and heart attack.
Research finds that intensive glucose control can lower blood glucose too far, increasing mortality risk in patients with type 2 diabetes. The study suggests that blood glucose level targets should have both upper and lower limits to minimize the risk of hypoglycemia.
Researchers have discovered that environmental cues can lead to breast cancer, while Wnt signaling plays a key role in a rare skin disease. Additionally, chronic morphine use has been found to delay wound healing due to immunosuppression and impaired immune cell recruitment.
A recent study found a diabetes epidemic among First Nations adults, with women in their prime reproductive years disproportionately affected. The incidence of diabetes is more than 4 times higher in First Nations women compared to non-First Nations women.
A team of researchers identified ten new genetic markers associated with biological traits underlying type 2 diabetes and three new variants linked to raised glucose levels. The study helps unravel the complex biology of type 2 diabetes and paves the way for further research on treatments.
Two large-scale studies found 13 new genetic variants influencing blood glucose regulation, insulin resistance, and beta cell function. Five variants increase the risk of type 2 diabetes, highlighting the role of beta cells in disease development.
A study conducted by the University of Chicago found that obstructive sleep apnea (OSA) significantly worsens glucose control in patients with type 2 diabetes. OSA severity is associated with poorer glycemic control and increased HbA1c levels, which can negate the effects of anti-diabetic medications.
Researchers found that people who quit smoking have a 70% increased risk of developing type 2 diabetes in the first six years without cigarettes compared to non-smokers. Weight gain after quitting is suspected to be the cause of this increased risk, which returns to normal after 10 years.
A study published in Archives of Pediatrics & Adolescent Medicine found that childhood blood pressure, body mass index, and glucose levels can predict type 2 diabetes risk nine to 26 years later. Children with high systolic blood pressure, a high body mass index, or low HDL cholesterol are more likely to develop diabetes.
Research suggests that high nicotinamide intake can lead to reactive oxygen species production, insulin resistance, and glucose intolerance. Sweating is identified as an effective way to expel excess nicotinamide from the body, offering a potential preventive and therapeutic intervention for type 2 diabetes.
Researchers at TGen identified genetic markers associated with end-stage renal disease in diabetics, providing hope for early diagnosis and prevention. The study found eight locations along the human genome tied to ESRD, including six potential markers for Type 1 diabetes.
A meta-analysis of 457,922 participants found that drinking regular or decaffeinated coffee lowered diabetes risk by approximately 25%, while those who consumed three to four cups daily had a one-third lower risk. Tea consumption was also associated with a reduced risk, with more cups per day resulting in greater protection.
A newly discovered gene called Brd2 has been found to play a crucial role in regulating body energy balance and protecting against Type 2 diabetes. In mice with a reduced expression of the Brd2 gene, obesity did not lead to diabetes, highlighting the importance of inflammation in this process.
Researchers have discovered a link between a genetic variant and childhood obesity, which may contribute to the development of type 2 diabetes. The study suggests that this gene variant raises the risk of being overweight during childhood, potentially setting the stage for type 2 diabetes in adulthood.
A new Saint Louis University research suggests that individuals with type 2 diabetes and coronary artery disease have a more favorable prognosis when properly managed with medical care. The BARI 2D trial found significant improvements in treatment outcomes for patients receiving intensive medical therapy or bypass surgery.
High urea levels in chronic kidney failure have been found to be toxic, leading researchers to suggest a potential new treatment strategy. Antioxidant therapy was shown to restore insulin sensitivity in mice with end-stage kidney disease. Similarly, targeting the molecular link Mdm2 may help prevent progression of late-stage metastatic...
A new study by a European research team has found that obese people have high levels of the molecule CXCL5, produced by fatty tissue cells. This discovery could lead to an experimental treatment aimed at inhibiting the action of CXCL5 to protect against type 2 diabetes.
A recent study by Loyola University Health System found that one out of five adults with Type 2 diabetes is morbidly obese. The rate of morbid obesity among people with diabetes increased by 141% between 1976 and 2006, highlighting the growing public health implications.
A consensus statement on diabetes surgery recognizes the legitimacy of surgery as a dedicated treatment for type 2 diabetes in carefully selected patients. The document summarizes evidence showing that bariatric surgery effectively reverses type 2 diabetes, and its findings justify considering surgery as a specific diabetes intervention.
Dr. Bergman's work developed a glucose 'disposition index' that quantifies the nature of interactions between insulin sensitivity and pancreatic secretion, predictive of type 2 diabetes development. The awards ceremony recognizes his contributions to understanding carbohydrate metabolism and identifying risk factors for type 2 diabetes.
A study found that sustained modest weight loss can prevent or lower the incidence of type 2 diabetes in people at high risk, delaying diagnosis by about four years. Lifestyle changes also improved cardiovascular risk factors and were particularly beneficial among older adults.
A decade-long study found that intensive lifestyle changes reduced the rate of developing type 2 diabetes by 34 percent compared to placebo, resulting in a delay of about four years. In contrast, treatment with metformin reduced the risk by 18 percent after 10 years.
A long-term follow-up study found that lifestyle intervention and metformin therapy can persistently delay the onset of type 2 diabetes for at least 10 years. The studies showed a significant reduction in diabetes incidence rates, with lifestyle intervention delaying onset by about 4 years and metformin by 2 years compared to placebo.
Researchers found that intensive lifestyle changes reduced the rate of developing type 2 diabetes in people at high risk by 34 percent over 10 years. Lifestyle changes also lowered blood pressure and triglyceride levels in patients.
Research found that mice lacking a crucial protein for insulin production have lower circulating insulin levels and impaired granule function. The discovery may explain a portion of Type 2 diabetes and help identify rare genetic cases.
The IDF has released important new guidelines to improve the treatment of diabetes globally. The guidelines address critical areas such as pregnancy, self-monitoring blood glucose, and oral health, aiming to tackle the spiraling epidemic of diabetes.
The International Diabetes Federation reports a staggering 285 million people worldwide have diabetes, with the disease disproportionately affecting low and middle-income countries. The number is expected to reach 435 million by 2030, posing a significant threat to global health and economies.
The fixed-dose combination ACTOplus met (pioglitazone HCl and metformin HCl) was shown to be more effective in reducing hemoglobin A1c levels than either component alone, with 64% of patients reaching the goal of ≤7 percent. Additionally, the study found significant reductions in insulin resistance and fasting plasma glucose levels.
A study of 2,285 adults found that neighborhoods with better physical activity resources and access to healthy foods were associated with a 38% lower incidence of type 2 diabetes. The authors conclude that modifying environmental factors may be a key step in arresting the rising epidemic of type 2 diabetes.
Monash researchers found that antioxidants can prevent beneficial effects of ROS on insulin action in early stages of Type 2 diabetes. Elevated ROS levels in genetically-modified mice prevented insulin resistance and diabetes induced by a high-fat diet.
Paired testing, a self-monitored testing approach, enables patients to make informed decisions about their diet and exercise habits. The study found that paired testing can help detect differences between weekend and weekday schedules and habits, facilitating positive patient self-care behaviors.
Exercise counseling combined with fitness center-based training improves muscular strength and exercise capacity in people with type 2 diabetes, comparable to supervised exercise programs. Physical therapists can effectively prescribe this approach for patients with type 2 diabetes.
A new study from the University of Gothenburg reveals that middle-aged women with large abdominal fat cells are at higher risk of developing type 2 diabetes. The study uses waist circumference divided by body height as a predictor, suggesting a simpler and faster way to identify those at risk.
Researchers found that enlarged fat cells and a higher waist-to-height ratio are key indicators of future diabetes in women. The study, published in the FASEB Journal, provides a simple tool for identifying women at risk of developing type 2 diabetes.
Scientists have discovered a genetic variation that impairs the body's muscle cells ability to use insulin effectively, leading to insulin resistance and type 2 diabetes. The study highlights a potential new target for scientists developing treatments for this disease.
A breakthrough discovery identifies a new gene called Insulin Receptor Substrate 1 (IRS1) that affects how the body responds to insulin, leading to insulin resistance. The study found a single-nucleotide polymorphism in the IRS1 gene that reduces its activity by 40%, making it harder for insulin to work effectively.
A study found that most people with type 2 diabetes do not meet recommended dietary guidelines, which can lead to cardiovascular disease. The researchers suggest ongoing nutritional education and counseling are crucial for managing energy intake and maintaining metabolic control.
A new molecule has been discovered that can treat type 2 diabetes and reduce weight gain by activating the protein TGR5. The study found that INT-777, a selective TGR5 activator, increases GLP-1 secretion and energy expenditure, leading to improved blood sugar control and weight loss.
Pittsburgh researchers have found a molecular link between insulin resistance and inflammation, suggesting a novel target for diabetes treatment. The study reveals that protein Fox01 stimulates inflammatory white blood cells, leading to increased production of cytokine IL-1B, which interferes with insulin signaling.
A recent study at UT Southwestern Medical Center suggests that taking insulin as the initial treatment for type 2 diabetes can be just as effective as other options, reducing low-blood-sugar events and weight gain. Insulin-based therapy has been shown to improve patient satisfaction and overall quality of life.
Researchers found that a specific gene variant, CDKAL1, is associated with both lower birth weight and an increased risk of developing type 2 diabetes in childhood. The study suggests a genetic link between prenatal events and the development of diabetes in later life.
Researchers at Yale University have made a groundbreaking discovery that reducing levels of an enzyme in the brain decreases appetites and increases energy levels. The study found that blocking this enzyme leads to weight loss and a decreased risk of type 2 diabetes in mice, providing new hope for treating metabolic disorders.
A Monash University study has discovered a critical link between obesity and Type 2 diabetes, revealing that fat cells release PEDF, which triggers insulin resistance. Blocking PEDF reverses these effects, suggesting a potential breakthrough in treating the disease.
A meta-analysis of 13 studies found a consistent inverse association between adiponectin levels and type 2 diabetes risk across various ethnic groups. Higher adiponectin levels were associated with a lower risk of developing the condition.
A new study identifies a genomic fragment that reduces the effect of a type 2 diabetes risk gene in mice. The researchers found that this fragment, known as a 'jumping gene,' diminishes the activity of the risk gene Zfp69. In overweight individuals with diabetes, the human equivalent of this gene is highly active.
A recent major study has found that children and young people with type 1 diabetes are more likely to be overweight or obese than those without diabetes. The research, which compared data from over 11,000 children and youths, also highlights significant differences in weight problems among different racial and ethnic groups.
A study of 1,008 patients with obstructive sleep apnea found a significant association between REM-related OSA and type 2 diabetes, with adjusted odds ratios up to 2.8 times higher in middle-aged participants. The researchers suggest that REM-related OSA may be an early marker for type 2 diabetes, especially in women and younger patients.
Temple University's School of Podiatric Medicine has received a $650,000 NIH grant to test the effectiveness of a personalized, visual diabetic foot education strategy. The program aims to improve health literacy and empower patients to make better decisions about their foot care.
A study published in the World Journal of Gastroenterology found that type 2 diabetes mellitus is an independent risk factor for hepatocellular carcinoma. The research revealed a direct association between HCC and insulin/sulphanylureas treatment, as well as an inverse relationship with metformin therapy.
A recent study found that liraglutide significantly improves glycaemic control compared to exenatide, while also being better tolerated. Liraglutide reduces HbA1c levels by 1.12%, compared to 0.79% for exenatide, and promotes similar weight loss.
A study published in The Lancet found that metabolic changes, including increased fasting glucose levels and decreased insulin sensitivity, occur several years before the onset of type 2 diabetes. By identifying these changes, it may be possible to delay or even prevent diabetes diagnosis.
A recent phase II study found aleglitazar to be safe and well-tolerated, reducing HbA1c levels in patients with type 2 diabetes. The medication also showed a favorable lipid profile without significant cardiovascular risks.
A study found that rosiglitazone, used in combination with standard diabetes treatments, does not increase cardiovascular disease or death risk but doubles the risk of heart failure and fractures, mainly in women. The study included 4447 patients with type 2 diabetes.
Researchers from USC's Keck School of Medicine presented new findings on the role of exercise in preventing post-exercise hypoglycemia and ways to modulate pancreatic beta cell mass to prevent type 2 diabetes. The studies aim to improve diabetes treatment guidelines, including medication timing and exercise recommendations.
A groundbreaking new study is exploring the effectiveness of a high-protein diet in preventing type 2 diabetes in overweight adolescents. The research, funded by the MBF Foundation, will investigate whether a lower-carbohydrate and increased protein diet can delay or prevent the progression to insulin resistance.