Articles tagged with Type 2 Diabetes
A systematic review of insulin analogues found that they have minimal impact on managing type 1 and 2 diabetes, as well as gestational diabetes. However, rapid-acting insulin analogues may be cost-effective for adults with type 1 diabetes. Experts recommend educational programs to manage sugar levels over insulin analogues.
Researchers have discovered a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. The Wnt signaling pathway is up-regulated in insulin-producing cells of pancreases from adults with type 2 diabetes.
Researchers found a statistically significant inverse relationship between A1C levels and cognitive test scores in people with type 2 diabetes. The study suggests that poorer blood glucose control is strongly associated with poorer memory function.
A large body of science supports the beneficial role eggs play in a healthful diet. However, an association between egg intake and increased incidence of type 2 diabetes was found in a recent study, raising questions about lifestyle factors that may have influenced the results.
A recent study found that CXCL10 is a key factor behind the destruction of insulin-producing β cells in diabetes. The inflammatory marker was found to decrease β cell viability and impair insulin production in isolated human pancreatic cells. This discovery may lead to new treatments for preventing β cell death or restoring lost function.
A multi-center clinical trial is being conducted to investigate the effect of salsalate on blood glucose levels in adults with poorly controlled type 2 diabetes. The study aims to determine if targeting inflammation can lead to an inexpensive way to treat this common form of diabetes.
A new gene variant associated with fasting glucose levels influences insulin secretion via melatonin metabolism, implicating a previously unknown relationship between the sleep-wake rhythm and diabetes. Further studies will explore the role of melatonin in regulating insulin secretion and potentially lead to new treatment options.
A study published in CMAJ found that men with type 2 diabetes have a 3-fold risk of cardiovascular mortality compared to those without either condition. In the long term, however, the two groups had similar mortality risks.
Researchers found that a low-carbohydrate ketogenic diet resulted in a three-fold improvement in type 2 diabetes, with 95% of participants eliminating or reducing diabetes medications. This study suggests that cutting out carbohydrates can lead to significant reductions in blood sugar levels and weight.
Research reveals that adult-onset diabetes slows mental functioning in several ways, with deficits appearing early and persisting into old age. The study found that healthy adults performed significantly better than those with diabetes on executive functioning and processing speed tests.
A study published in JAMA found that a diet high in low-glycemic foods, such as nuts and beans, improved glycemic control and cardiovascular risk factors in patients with type 2 diabetes. The ESC recommends structured lifestyle advice for diabetes management, suggesting it may be as effective as some drug interventions.
A study published in JAMA found that a low-glycemic index diet resulted in greater improvements in glycemic control and reduced cardiovascular risk factors compared to a high-cereal fiber diet. The researchers found that participants on the low-glycemic index diet had lower hemoglobin A1c levels and improved lipid profiles.
A recent study published in the Canadian Medical Association Journal found that long-term use of thiazolidinediones (TZDs) doubles the risk of fractures in women with type 2 diabetes. The study, which analyzed data from 10 previously completed trials, showed a consistent decline in bone mineral density in women exposed to TZD therapy.
Long-term use of diabetes medications like rosiglitazone and pioglitazone increases the risk of bone fractures in women with type 2 diabetes, according to a new study. The risk is doubled compared to men, highlighting the need for alternative treatment options.
Researchers at Children's Hospital of Philadelphia found that overweight siblings of children with type 2 diabetes are four times more likely to have abnormal glucose levels. This discovery highlights the importance of screening and prevention education for these high-risk individuals.
Increasing brisk walking and reducing television watching were found to be inversely associated with a reduced risk of type 2 diabetes. The study's key finding is that vigorous activity is protective against the disease in this high-risk population.
Researchers identified a gene involved in the body's response to the day-night cycle strongly linked to high blood sugar levels and type 2 diabetes. The melatonin receptor is implicated in conditions like jetlag and sleep disorders, suggesting that disrupted sleep patterns are connected to metabolic health.
A study found that genetic variation on chromosome 9p21 and poor glycemic control interact to increase the risk of coronary artery disease in type 2 diabetes patients. The odds of CAD were 4-fold higher for those with two risk gene variants and poor glycemic control compared to those with one variant but good control.
Researchers found that genetic screening for type 2 diabetes is not significantly better than traditional risk factors such as weight, blood pressure, and blood sugar levels. The study identified 18 gene variants associated with increased risk, but the value of genetic screening improved as more risk genes were discovered.
A new study published in JAMA found that low-dose aspirin did not significantly reduce the risk of atherosclerotic events, including coronary and cerebrovascular events, in patients with type 2 diabetes. However, aspirin was effective in reducing fatal coronary and fatal cerebrovascular events.
Using precise microscopes, University of Missouri researchers identified tumor necrosis factor-α and advanced glycation end products as major contributors to blood vessel dysfunction in type 2 diabetes. This discovery could lead to new treatments for blood vessel diseases and disorders in people with type 2 diabetes.
A new review article highlights the potential of sirtuins to treat diseases of aging such as Type 2 Diabetes and mitochondrial disorders. Early clinical studies suggest that SIRT1 activation may lower glucose and improve insulin sensitivity.
The study found that liraglutide improved blood glucose control compared to glimepiride, with significant reductions in HbA1c levels. Participants receiving liraglutide also experienced weight loss and decreases in systolic blood pressure, making it a promising treatment for type 2 diabetes.
JANUVIA showed longer-term efficacy and safety profile in combination therapy with metformin, improving glycemic control in patients with type 2 diabetes. Additionally, the study demonstrated that JANUVIA provided glycemic control regardless of baseline characteristics.
A new study led by Dr. Keiko Watanabe found that periodontitis accelerates insulin resistance in rats with a high-fat diet. The research will explore the impact of periodontitis on diabetic complications in the retina, aorta and pancreas.
A study published in Diabetes Care found that young men with type-2 diabetes have significantly lower levels of testosterone, which can impact fertility, muscle development, and increase the risk of heart disease. The study also highlights the potential clinical implications of low testosterone in these individuals.
The International Diabetes Federation is funding a two-year study to evaluate the effectiveness of motivational interviewing in improving self-management education for adults with uncontrolled type 2 diabetes. The Baylor Healthcare System project aims to increase program completion rates and long-term diabetes control.
A study of 788 US adults found that those with diabetes had higher levels of arsenic in their urine compared to those without diabetes. Inorganic arsenic from contaminated drinking water may play a role in the development of type 2 diabetes.
A study of 788 US adults found that those with higher arsenic levels in their urine were more likely to develop type 2 diabetes. The researchers also discovered that the presence of certain organic arsenic compounds did not increase diabetes risk.
A recent study published in Diabetes Care found that losing weight soon after a type 2 diabetes diagnosis can lead to better blood pressure and blood sugar control. The study followed over 2,500 adults with type 2 diabetes for four years and showed that those who lost weight were up to twice as likely to achieve their targets.
A new USC study found that overweight Hispanic children are at significant risk for pre-diabetes, with persistent pre-diabetes during growth associated with progression towards type 2 diabetes. The study highlights the importance of regular monitoring of these children to detect potential risks early.
A recent survey found that 94% of doctors recognize the relationship between obstructive sleep apnea (OSA) and type 2 diabetes, but only 47% conduct routine screening. The International Diabetes Federation calls for increased awareness, research, and clinical practices to address treatment.
A Columbia University study found that periodontal disease can be an independent predictor of incident Type 2 diabetes. Over a 20-year follow-up, individuals with elevated levels of periodontal disease were nearly twice as likely to develop Type 2 diabetes compared to those without periodontal disease.
Eating a diet high in sugar-sweetened beverages and low in fruits and vegetables may increase the risk of type 2 diabetes. Consuming more than one soft drink per day or drinking two or more fruit drinks daily increases the risk by 24% and 31%, respectively. In contrast, a low-fat diet does not appear to impact diabetes risk.
A study by Boston University researchers found a significant association between regular consumption of sugar-sweetened soft drinks and fruit drinks with an increased risk for type 2 diabetes in African-American women. The incidence of type 2 diabetes rose with increasing intake of both types of drinks.
A large population-based study of 659,000 women found that almost 20% develop type 2 diabetes within 9 years of pregnancy. The rate of diabetes increased rapidly after delivery, peaking at 9 years. Higher urban statistics and older mothers also increase risk factors for gestational diabetes.
A recent study published in Diabetes Care found high levels of oxidative stress in coronary heart disease patients without type 2 diabetes were actually indicative of overt diabetes. This discovery highlights the importance of considering glucose abnormality as a potential underlying condition for heart disease.
A study found that higher levels of liver protein fetuin-A are associated with an increased risk of developing type 2 diabetes in older adults. The researchers measured fetuin-A levels in 519 diabetes-free individuals aged 70-79 years and found a significant association between fetuin-A and the development of diabetes.
A long-term study shows that resveratrol improves bone health, reduces cataracts and cardiovascular dysfunction, and enhances balance and motor coordination in middle-aged mice. The study also found that resveratrol induces gene expression patterns similar to those induced by dietary restriction.
Adults with type 2 diabetes who eat high-fat meals may experience immediate memory declines, but taking antioxidant vitamins with the meal can offset this effect. A study found that consuming healthy foods rich in fruits and vegetables is the best defense against cognitive decline.
Researchers discovered that turmeric-treated mice were less susceptible to developing Type 2 diabetes and showed reduced inflammation in fat tissue and liver. Curcumin's anti-inflammatory properties may lessen insulin resistance and prevent the disease.
A new study published in JAMA found that patients with depression are more likely to develop type-2 diabetes, and those with type-2 diabetes are also at a higher risk for developing depression. The study used data from the Multi-Ethnic Study of Atherosclerosis (MESA) to investigate this connection.
A study published in JAMA found that treated type 2 diabetes is associated with a higher risk of developing depression, while untreated diabetes has no significant link. The study suggests that psychological stress from managing diabetes may contribute to elevated depressive symptoms.
Researchers found a strong association between human herpesvirus 8 (HHV-8) infection and ketosis-prone type 2 diabetes mellitus (DM-2) in persons from sub-Saharan Africa. HHV-8 antibodies were present in 87.7% of patients with DM-2, compared to 15.1% of those without the condition.
Adults with diabetes are more likely to experience hearing loss due to the disease's impact on nerves and blood vessels in the inner ear. Researchers discovered a strong association between high-frequency sound sensitivity and diabetes, which may be linked to nerve damage and increased risk of heart disease.
Women with type 2 diabetes and heart disease have poorer control of both diseases and receive less intensive medical treatment than do men. Women are also more likely to have uncontrolled high blood pressure and poor long-term control of their blood glucose levels compared to men.
A new study found that some patients with type 2 diabetes can maintain good blood sugar control for years using non-insulin oral diabetic medications. The study of 191 veterans showed that 55% of patients remained on oral drugs and achieved improved hemoglobin A1c levels.
A study by the University of Southern California suggests that abdominal fat releases lipids directly to the liver at night, leading to insulin resistance and increasing the risk of type 2 diabetes. The findings highlight the importance of abdominal obesity in the pathogenesis of the disease.
Alogliptin demonstrated significant reductions in hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes, particularly when used as monotherapy or added to existing oral anti-diabetic treatments. The study results suggest alogliptin is a effective treatment option for patients with inadequate blood sugar control.
Recent research shows a strong connection between type 2 diabetes and sleep apnea, with up to 40% of OSA patients having diabetes. IDF recommends education and screening for both conditions, as well as weight reduction, CPAP treatment, and further research.
Recent research highlights the close relationship between type 2 diabetes and sleep apnea, with significant implications for public health and individual well-being. The IDF recommends screening, treatment, and further research to address this link.
Researchers found that intensively lowering blood sugar to near-normal levels did not significantly reduce the risk of major cardiovascular events, but increased the risk of death. The intensive strategy group had a 22% higher risk of death compared to the standard group.
A study of ongoing randomized clinical trials in diabetes reveals that only 20% have primary outcomes important to patients, such as illness, pain, or death. The researchers emphasize the need for a standard set of patient-important outcomes in diabetes trials to improve their informativeness.
A lifestyle intervention trial will determine optimal ways to translate research-developed programs to real-life settings in Chennai, India. The study aims to promote health behaviors, improved diet, weight loss, and increased physical activity to prevent diabetes in those at risk.
A collection of state-of-the-art reports highlights the benefits of self-monitoring blood glucose (SMBG) in achieving improved glucose control. SMBG has been shown to significantly improve glucose control, complements A1C results, and guides patient self-management of diabetes at home.
Research suggests that high-flavanol cocoa can improve blood vessel function in people with type 2 diabetes, rivaling the benefits of exercise and common medications. Flavanols may help increase nitric oxide production, reducing artery stress and promoting cardiovascular health.
A randomized controlled trial found that early intensive insulin therapy improved blood glucose control and β-cell function in patients with newly diagnosed type 2 diabetes. The treatment, which included continuous subcutaneous insulin infusion or multiple daily insulin injections, resulted in higher remission rates and prolonged glyc...
A pilot study will be conducted in Vinh City, Vietnam, to screen people at high-risk for pre-diabetes and diabetes. The screenings will be coupled with community awareness and healthy living programs to promote a lifestyle modification program over three months.
The International Diabetes Federation is funding the STOP Diabetes project to address lifestyle-related metabolic diseases and promote healthy behaviors. The project aims to reduce the risk of type 2 diabetes in women by encouraging healthy behaviors.
Research using a rat model of intrauterine growth retardation found reduced Pdx1 expression in pancreatic beta-cells throughout life following IUGR. The molecular mechanisms affecting Pdx1 expression were reversible in the fetus and after birth, but irreversible in adulthood, providing new insight into diabetes development.