Articles tagged with Type 2 Diabetes
A recent study published in Diabetes Care found high levels of oxidative stress in coronary heart disease patients without type 2 diabetes were actually indicative of overt diabetes. This discovery highlights the importance of considering glucose abnormality as a potential underlying condition for heart disease.
A study found that higher levels of liver protein fetuin-A are associated with an increased risk of developing type 2 diabetes in older adults. The researchers measured fetuin-A levels in 519 diabetes-free individuals aged 70-79 years and found a significant association between fetuin-A and the development of diabetes.
A long-term study shows that resveratrol improves bone health, reduces cataracts and cardiovascular dysfunction, and enhances balance and motor coordination in middle-aged mice. The study also found that resveratrol induces gene expression patterns similar to those induced by dietary restriction.
Adults with type 2 diabetes who eat high-fat meals may experience immediate memory declines, but taking antioxidant vitamins with the meal can offset this effect. A study found that consuming healthy foods rich in fruits and vegetables is the best defense against cognitive decline.
Researchers discovered that turmeric-treated mice were less susceptible to developing Type 2 diabetes and showed reduced inflammation in fat tissue and liver. Curcumin's anti-inflammatory properties may lessen insulin resistance and prevent the disease.
A new study published in JAMA found that patients with depression are more likely to develop type-2 diabetes, and those with type-2 diabetes are also at a higher risk for developing depression. The study used data from the Multi-Ethnic Study of Atherosclerosis (MESA) to investigate this connection.
A study published in JAMA found that treated type 2 diabetes is associated with a higher risk of developing depression, while untreated diabetes has no significant link. The study suggests that psychological stress from managing diabetes may contribute to elevated depressive symptoms.
Researchers found a strong association between human herpesvirus 8 (HHV-8) infection and ketosis-prone type 2 diabetes mellitus (DM-2) in persons from sub-Saharan Africa. HHV-8 antibodies were present in 87.7% of patients with DM-2, compared to 15.1% of those without the condition.
Adults with diabetes are more likely to experience hearing loss due to the disease's impact on nerves and blood vessels in the inner ear. Researchers discovered a strong association between high-frequency sound sensitivity and diabetes, which may be linked to nerve damage and increased risk of heart disease.
Women with type 2 diabetes and heart disease have poorer control of both diseases and receive less intensive medical treatment than do men. Women are also more likely to have uncontrolled high blood pressure and poor long-term control of their blood glucose levels compared to men.
A new study found that some patients with type 2 diabetes can maintain good blood sugar control for years using non-insulin oral diabetic medications. The study of 191 veterans showed that 55% of patients remained on oral drugs and achieved improved hemoglobin A1c levels.
A study by the University of Southern California suggests that abdominal fat releases lipids directly to the liver at night, leading to insulin resistance and increasing the risk of type 2 diabetes. The findings highlight the importance of abdominal obesity in the pathogenesis of the disease.
Alogliptin demonstrated significant reductions in hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes, particularly when used as monotherapy or added to existing oral anti-diabetic treatments. The study results suggest alogliptin is a effective treatment option for patients with inadequate blood sugar control.
Recent research highlights the close relationship between type 2 diabetes and sleep apnea, with significant implications for public health and individual well-being. The IDF recommends screening, treatment, and further research to address this link.
Recent research shows a strong connection between type 2 diabetes and sleep apnea, with up to 40% of OSA patients having diabetes. IDF recommends education and screening for both conditions, as well as weight reduction, CPAP treatment, and further research.
Researchers found that intensively lowering blood sugar to near-normal levels did not significantly reduce the risk of major cardiovascular events, but increased the risk of death. The intensive strategy group had a 22% higher risk of death compared to the standard group.
A study of ongoing randomized clinical trials in diabetes reveals that only 20% have primary outcomes important to patients, such as illness, pain, or death. The researchers emphasize the need for a standard set of patient-important outcomes in diabetes trials to improve their informativeness.
A lifestyle intervention trial will determine optimal ways to translate research-developed programs to real-life settings in Chennai, India. The study aims to promote health behaviors, improved diet, weight loss, and increased physical activity to prevent diabetes in those at risk.
A collection of state-of-the-art reports highlights the benefits of self-monitoring blood glucose (SMBG) in achieving improved glucose control. SMBG has been shown to significantly improve glucose control, complements A1C results, and guides patient self-management of diabetes at home.
Research suggests that high-flavanol cocoa can improve blood vessel function in people with type 2 diabetes, rivaling the benefits of exercise and common medications. Flavanols may help increase nitric oxide production, reducing artery stress and promoting cardiovascular health.
A randomized controlled trial found that early intensive insulin therapy improved blood glucose control and β-cell function in patients with newly diagnosed type 2 diabetes. The treatment, which included continuous subcutaneous insulin infusion or multiple daily insulin injections, resulted in higher remission rates and prolonged glyc...
A pilot study will be conducted in Vinh City, Vietnam, to screen people at high-risk for pre-diabetes and diabetes. The screenings will be coupled with community awareness and healthy living programs to promote a lifestyle modification program over three months.
The International Diabetes Federation is funding the STOP Diabetes project to address lifestyle-related metabolic diseases and promote healthy behaviors. The project aims to reduce the risk of type 2 diabetes in women by encouraging healthy behaviors.
Research using a rat model of intrauterine growth retardation found reduced Pdx1 expression in pancreatic beta-cells throughout life following IUGR. The molecular mechanisms affecting Pdx1 expression were reversible in the fetus and after birth, but irreversible in adulthood, providing new insight into diabetes development.
A Kaiser Permanente study found that diabetes more than doubled in six years among teenage and adult women before becoming pregnant. The largest study to date examined 175,000 teenage girls and adult women, revealing significant jumps in pre-pregnancy diabetes in every age, racial, and ethnic group.
Researchers found high levels of E-selectin, white blood cells, and low serum albumin levels are clear predictors of high risk for type 2 diabetes. The study used data from the Western New York Health Study and found that combining these markers increased identification of high-risk patients by 8%.
A recent meta-analysis of 15 studies involving over 70,000 participants identified six new genes linked to type 2 diabetes. The study, published in Nature Genetics, confirms that insulin-producing cells play a crucial role in the disease's development.
Two studies suggest that Diabetinol, a natural citrus supplement, improves blood glucose numbers and LDL-cholesterol levels in people with type 2 diabetes. The supplement shows promise in lowering blood glucose levels after meals and improving heart health, potentially reducing diabetic complications.
Researchers at Michigan Technological University have developed a powerful tool to pinpoint the genes behind inherited illnesses. By analyzing data from over 1,000 people with and without type 2 diabetes, they identified 11 single nucleotide polymorphisms associated with the disease.
Researchers found that people with diabetes have the same high risk for heart attack or stroke as those who've already had a heart attack. The study suggests that all patients with diabetes receiving glucose-lowering treatment are at a particularly high risk of cardiovascular death and disease, regardless of sex and diabetes type.
A new study suggests that taking pioglitazone can help slow the progression of plaque build-up in coronary arteries, which is particularly aggressive in patients with diabetes. The findings have important implications for managing patients with type 2 diabetes and coronary artery disease.
Regular Tai Chi Chuan exercise improves T cell helper function in patients with type 2 diabetes by increasing T-bet transcription factor and IL-12 production, suggesting a potential therapeutic effect. The study also found improved glycemic control, reduced inflammation, and enhanced immune response.
A clinical trial using IVUS technology found that Actos reduced the atherosclerotic burden in coronary arteries compared to glimepiride, and prevented progression. The study adds to the body of cardiovascular data for Actos, showing no evidence of increased risk of heart attack or stroke.
Scientists at the University of Michigan have identified six new genes that play a role in type 2 diabetes, including one also linked to prostate cancer. The study provides insights into the mechanisms controlling glucose levels in the blood, offering potential new methods for preventing or treating the disease.
A collaborative effort by over 90 researchers from 40 centres analysed genetic data from 70,000 people to identify differences in the genetic code that make some individuals more susceptible to type 2 diabetes. The study found six new genes contributing to the risk, bringing the total to sixteen, and provides valuable insights into the...
A team of researchers has discovered six new genetic variants associated with an increased risk of type 2 diabetes, bringing the total number of genetic risk factors to 16. The study used combined genetic data from over 70,000 people and provides new clues to the processes that go wrong when diabetes develops.
A study published in Diabetes Research & Clinical Practice found that people with depression taking antidepressants have a 30% increased risk of developing type 2 diabetes. The risk was highest for those using two types of therapies simultaneously, such as tricyclic antidepressants and selective serotonin reuptake inhibitors.
The UMDNJ-University Hospital has received a grant to tailor interventions and personalize the transition from hospital to outpatient clinic for patients with type 2 diabetes. The project aims to reduce hospital emergency department visits, inpatient readmissions, and improve health-related quality-of-life and metabolic control.
A recent study found that weight loss and major lifestyle changes are more effective in treating type 2 diabetes than intensive insulin therapy. Insulin resistance, caused by high-calorie diets, can lead to organ damage and increase the risk of complications such as heart disease and blindness.
A new study proposes that intestinal dysfunction, specifically in the upper small intestine, may be the source of Type 2 diabetes. Surgical bypass operations can reverse this abnormality, leading to diabetes remission.
Researchers found that Asian Indians have higher insulin resistance and mitochondrial function than Northern Europeans, despite being non-obese. This study suggests that urbanization and diet changes may contribute to the increased risk of type 2 diabetes in Asian Indians.
A new study found elevated markers of blood vessel inflammation in overweight Hispanic children with normal blood glucose levels, increasing their risk for type 2 diabetes and cardiovascular disease. The research highlights the need for obesity prevention strategies tailored to this high-risk population.
The NHLBI has stopped intensive blood glucose lowering treatment in a clinical trial of adults with type 2 diabetes, citing increased risk of death compared to standard treatment. Participants will now receive the less-intensive standard treatment.
Scientists at the University of Cambridge highlight a strong correlation between persistent organic pollutants (POPs) and insulin resistance, leading to adult-onset diabetes. Research suggests that individuals with high POPs levels in their blood are more at risk of developing type 2 diabetes, even if they are thin.
A study found that obese patients with type 2 diabetes who underwent gastric banding surgery had a higher likelihood of achieving diabetes remission compared to those using conventional methods. The surgical group achieved significant weight loss and improved blood glucose control, suggesting intensive weight-loss therapy may be an eff...
A new study found that overweight type 2 diabetes patients who consumed moderate amounts of sugar from carrot cake experienced no adverse changes in blood glucose levels. The study, conducted over 24 days, showed improved insulin sensitivity and balanced energy intake.
A systematic review and meta-analysis found that active smoking is associated with a 44% increased risk of type 2 diabetes. The association was strongest for heavy smokers, suggesting that smoking may contribute to insulin resistance or inadequate compensatory insulin secretion responses.
Scientists at Sirtris developed potent SIRT1 activators, 1000 times more effective than resveratrol, to treat Type 2 Diabetes and age-related diseases. These findings hold promise for a new approach to treating metabolic and other diseases of aging.
Eating high-glycemic index carbohydrates has been associated with an increased risk of developing type 2 diabetes in Chinese and African-American women. Conversely, consuming more cereal fiber may lower this risk. Studies have shown that foods with a higher glycemic index cause rapid spikes and drops in blood glucose levels.
UCSD researchers have discovered that inflammation from immune cells called macrophages leads to insulin resistance and Type 2 diabetes. By disabling the macrophage inflammatory pathway, insulin resistance can be prevented in mouse models.
A study published in The Lancet found that fenofibrate reduces the frequency of first laser treatment for macular oedema and proliferative DR by 31% and 30%, respectively. These findings suggest additional mechanisms of benefit beyond lipid-lowering effects, potentially additive to blood glucose and blood pressure control.
Researchers have discovered that hyperacidification of the TGN causes increased activity of furin, leading to tissue fibrosis in individuals with CF. Additionally, a new study on EHEC O157:H7 has identified the role of type IV pili in intestinal adherence and immune response.
A study of 38,000 female health professionals found that women with hypertension have a three-fold risk of developing type 2 diabetes compared to those with optimal blood pressure levels. Obesity is also a strong and independent risk factor for the development of type 2 diabetes.
A meta-analysis of seven clinical trials found that rosiglitazone and pioglitazone increased the risk of congestive heart failure in patients with type 2 diabetes or prediabetes. However, these drugs did not increase the risk of cardiovascular death. The authors recommend caution when prescribing TZDs to patients with cardiovascular di...
New research supports the cardiovascular safety of ACTOS (pioglitazone HCI) and its benefits in improving blood glucose and lipid levels. The study found that therapies including pioglitazone are associated with significant reductions in the risk of stroke or myocardial infarction compared to non-thiazolidinedione therapies.
Both aerobic and resistance exercise improved glycemic/blood sugar control in people with type 2 diabetes, with the greatest improvements seen in those who performed both types of exercise. The study found that combining aerobic and resistance training resulted in a significant decrease in A1c value, indicating better blood sugar control.
Researchers found that Metformin improves glucose uptake and survival of early embryos in mice with insulin resistance. The drug may benefit women with type 2 diabetes or polycystic ovary syndrome trying to conceive. Improved embryo quality could lead to more successful pregnancies.
The ADVANCE trial found that a fixed combination of perindopril and indapamide reduced the risk of death from cardiovascular disease by 18% and major macrovascular or microvascular events by 9%. The results suggest that this treatment could be considered routinely for patients with type 2 diabetes to prevent complications.
Scientists have discovered that glucose-sensing neurons play an important role in regulating blood glucose levels in mice with obesity-induced Type 2 diabetes. The study found that defects in these neurons contribute to the disease's progression and may be targeted by novel therapies.
A new study at Joslin Diabetes Center identified a protein called Sirt2 as playing a major role in how fat is produced and stored in the body. Increasing Sirt2 levels may block fat cell differentiation and reduce fat storage.