Articles tagged with Type 2 Diabetes
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A new study by Johns Hopkins Bloomberg School of Public Health reveals that larger waist sizes and higher body fat are strongly associated with an increased risk of developing type 2 diabetes in adult men. The researchers recommend measuring waist circumference instead of waist-to-hip ratio to assess health risk.
Researchers found that the MIF gene is crucial for the development of type 1 diabetes. Specially bred mice without the gene failed to develop diabetes compared to those with it. The finding provides proof of concept for blocking the formation of this protein as a promising approach to fighting diabetes.
Researchers discovered that low-carbohydrate diets led to spontaneous reduction in daily energy consumption and improved glucose levels in obese diabetic patients. The study found no evidence of boredom or metabolic changes as explanations for weight loss.
Research at Joslin Diabetes Center reveals that prenatal undernutrition can lead to impaired insulin production and higher blood glucose levels, setting the stage for type 2 diabetes. The study found that low-birth-weight mice had abnormal insulin secretion patterns, leading to permanent impairment.
Researchers at Joslin Diabetes Center have identified the critical role of two insulin signaling proteins in controlling glucose and lipid metabolism. By knocking out these proteins in liver cells, they found that diabetes results when both signals are simultaneously low, but not when either is individually depleted.
A recent study revealed that nearly one-third of diabetic men suffer from hypogonadism, a condition caused by improper functioning of the pituitary gland or hypothalamus. The high prevalence of low testosterone levels in diabetic patients is concerning and associated with various health issues such as loss of muscle tone, increased abd...
A recent study by Charlotte Ling and colleagues found that aging decreases the expression of PGC-1alpha and PGC-1beta in muscle, increasing insulin resistance and T2DM susceptibility. The age-dependent decrease was partially heritable, suggesting a genetic link to the development of insulin resistance.
A new study examined ACTOS and Avandia's lipid-altering effects in patients with type 2 diabetes. The results suggest looking beyond glycemic effects to potential lipid benefits, which could inform treatment strategies.
Researchers found that pioglitazone significantly reduced carotid artery thickness in just 12-24 weeks, while improving insulin resistance. This regression was independent from metabolic control improvements and correlated with better cardiovascular outcomes for patients with type 2 diabetes.
A study of 1,148 hypertensive patients with type 2 diabetes found that tight blood pressure control reduced the incidence of diabetic retinopathy and visual loss by 47% over seven years. The researchers discovered a lower risk of microaneurysms and blindness in the tight BP control group compared to those with less stringent policies.
A study found that people with type 2 diabetes are not being optimally managed for their cardiovascular risk. Fewer than 25% of patients were on medication needed to control high cholesterol and less than 50% received treatment for high blood pressure.
Dr. von Andrian will focus on setting up a new microscopy model at Joslin to study the interaction between islet cells and immune cells, aiming to develop a simple model for studying islet cells in living animals. He will also collaborate with Joslin researchers on stem cell projects and vascular complications in people with diabetes.
Crestor demonstrates improved lipid profiles and lower LDL-C targets than atorvastatin, achieving higher patient success rates with fewer doses. Crestor also shows effectiveness in reducing apolipoprotein B levels and improving the Apo B:Apo A-I ratio.
Researchers identified a gene called PTPN1 that represses insulin response and is associated with diabetes. The study found a common variant of the gene increases the risk of diabetes in Caucasians, while another form appears protective.
A 12-week physical activity program will be implemented and evaluated in 16 worksites across the US and Canada to assess its effectiveness on promoting physical activity among employees. The study aims to determine the effects of a multilevel intervention aimed at personal goal-setting and ecologically based organizational action.
A new gene marker has been found to increase the risk of heart disease in people with type 2 diabetes. The CD36 gene variant is associated with higher levels of free fatty acids and triglycerides, leading to a 60% increased risk of heart disease.
A pilot study dubbed STAND UP! aims to monitor food intake and physical activity in schools to reduce risk factors for type 2 diabetes among sixth-graders. The program's results will be used to improve the intervention before expanding it to middle schools nationwide.
A three-month study found that patients with type 2 diabetes preferred the prefilled NovoLog(R) Mix 70/30 FlexPen(R) disposable pen due to its ease of use and flexibility. Patients who had never used insulin before reported significant benefits in perceived clinical efficacy.
A significant social gradient in the incidence of type 2 diabetes was observed among civil servants, with men and women in lower employment grades having a higher risk of developing the disease. Effort-reward imbalance was also found to be associated with an increased risk of type 2 diabetes in men.
A study of 91,249 women found a strong association between frequent consumption of sugar-sweetened beverages and increased risk of type 2 diabetes. Women who consumed more sugar-sweetened drinks experienced greater weight gain and higher risk of developing the condition.
Diabetics are susceptible to prolonged inflammation due to infection, leading to cardiovascular disease and poor wound healing. Inhibiting excess TNF may reduce the tendency for prolonged inflammation.
A study found that atorvastatin reduced cardiovascular events, deaths, and strokes by a third in patients with type 2 diabetes without high LDL cholesterol. The results suggest statin therapy may be safe and effective for this patient group.
A new study shows that consuming isolated soy protein can slow down the progression of diabetic kidney disease and improve coronary heart disease in patients with type 2 diabetes. The study found a significant reduction in urinary albumin levels and an improvement in HDL cholesterol levels among participants who consumed soy protein.
A UK study found that a significant proportion of people with type 2 diabetes are managed solely through diet, receiving inadequate monitoring and care. This highlights the need for better routine surveillance and consistency in clinical practice to address the high rate of complications among these patients.
Research finds connection between cytokine IL-4 signaling impairment and type 2 diabetes. Hyperinsulinemia triggers serine phosphorylation, impacting insulin receptor substrates and leading to neuroimmune response.
A meta-analysis found that fluoxetine, orlistat, and sibutramine can achieve modest but statistically significant short-term weight loss in adults with type 2 diabetes. Levels of glycated hemoglobin were also modestly reduced by the medications.
The PROactive study assesses the effect of ACTOS on cardiovascular disease progression in patients with type 2 diabetes. The study examines whether pioglitazone reduces cardiovascular mortality and morbidity in a high-risk population.
A recent study published in the Proceedings of the National Academy of Sciences found that overexpressing a selenium-containing enzyme in mice led to insulin resistance and obesity. The researchers suggest that antioxidants, like selenium, may be harmful by neutralizing free radicals necessary for insulin signaling.
A study of 3,140 patients found pioglitazone to lower blood pressure in both Stage I and Stage II hypertension cases. This effect could reduce cardiovascular disease risk factors in patients with type 2 diabetes.
Studies presented at the American Diabetes Association annual meeting showed ACTOS to be effective in reducing fasting insulin levels and improving A1C levels, with significant benefits seen when used alone or in combination with other oral antidiabetic medications.
The CARDS trial found that a daily 10mg dose of atorvastatin reduced the risk of serious heart problems by 36% and strokes by 48%. The benefits were observed even in patients with already low LDL-cholesterol levels. This study has significant implications for the cardiovascular health of people with Type 2 diabetes.
A landmark UK study sponsored by Diabetes UK, Department of Health, and Pfizer UK showed that 10mg atorvastatin reduced cardiovascular events by 37% in patients with diabetes without existing CVD. Stroke was substantially reduced by 48% in these patients.
ACTOS therapy has favorable effects on dyslipidemia, including reductions in triglycerides and increases in HDL cholesterol. Additionally, ACTOS was found to have beneficial effects on non-HDL cholesterol and A1C levels.
Over 60% of type 2 diabetes patients fail to meet recommended glucose treatment goals, increasing risk of complications such as heart disease and blindness. The Control to Goal initiative aims to bridge the gap between guidelines and clinical practice, promoting better diabetes management.
A study highlights the significant risk of cardiovascular disease in women with type 2 diabetes, emphasizing the importance of controlling blood glucose levels, managing cholesterol, and preventing diabetes. The researchers outline strategies for treating diabetic women and CVD, including intensive therapy and lifestyle modifications.
Researchers identified 15 common food habits that significantly impact blood sugar control, surpassing the effectiveness of medication. By adopting these 'do's and avoiding specific 'don'ts,' individuals with diabetes can achieve normal blood sugar levels.
The American College of Physicians recommends statin therapy for adults with type 2 diabetes, regardless of cholesterol levels, due to the high risk of cardiovascular disease. The guidelines also emphasize the importance of monitoring liver function and muscle enzymes only in patients with pre-existing conditions.
Researchers identified four genetic variants strongly associated with type 2 diabetes in Finnish and Ashkenazi Jewish populations. The variants cluster in the regulatory region of the HNF4A gene, influencing insulin secretion in response to glucose.
A large Finnish study found that moderate to high coffee consumption was associated with a lower risk of developing type 2 diabetes. Drinking 3-4 cups of coffee per day was linked to a 29% reduced risk for women and a 27% lower risk for men.
Researchers found that insulin-resistant young offspring of type 2 diabetics have increased muscle cell lipid content and reduced mitochondrial energy production. This study suggests a potential genetic cause of insulin resistance in young people with type 2 diabetes.
Elevated iron stores, particularly plasma ferritin concentration, may predict type 2 diabetes risk in healthy individuals. Healthy women with moderately elevated iron levels were found to have higher baseline intake of heme iron and lower fiber and magnesium consumption.
The XENDOS study found that Xenical significantly reduces the risk of developing type 2 diabetes by 37% compared to lifestyle changes alone and 52% in patients with impaired glucose tolerance. The medication also produces greater long-term weight loss and improves cardiovascular risk factors.
A study of Latino children found that nearly three in ten have impaired glucose tolerance, a precursor to type 2 diabetes, while obesity rates are twice those of non-Latino peers. Insulin resistance and metabolic syndrome increase the risk of chronic diseases.
Recent studies show that overweight Hispanic youth are at an increased risk for developing type 2 diabetes and cardiovascular disease. Insulin resistance directly contributes to the development of metabolic syndrome, particularly in those with a family history of diabetes.
A recent study has found that diabetes case management significantly improves glycemic control among low-income minority populations. The study, which was funded by the California Medi-Cal Managed Care Division and Center for Disease Control and Prevention, involved 362 Medicaid recipients with type 2 diabetes.
A new study finds evidence of genetic linkages to metabolic syndrome in both black and white patients. The researchers also identified chromosomal regions linked to cardiovascular disease and type 2 diabetes risk factors. These findings bring us closer to discovering the actual genes responsible for metabolic syndrome.
A new study finds that obese mice require the MSH hormone to develop diabetes, increasing resistance to insulin. Researchers believe this may lead to more effective preventive treatments for Type 2 Diabetes.
Obese adults who lost 7% of their weight and did moderate-intensity physical exercise for six months improved their major blood vessel function by approximately 80 percent, regardless of type 2 diabetes status. This improvement in blood vessel function reduced the risk of developing arteriosclerosis and coronary heart disease.
A recent study found that patients with a genetic subtype of diabetes have a significantly greater response to sulphonylurea drugs compared to those without a defined cause. This discovery highlights the importance of individualizing treatment for patients with type 2 diabetes, depending on their underlying cause.
A USC study finds that increasing insulin sensitivity can help prevent chronic diseases in Latino children. Overweight children with metabolic syndrome are less physically fit, but improving fitness could deter these diseases.
The study found that gastric bypass surgery significantly improved diabetes outcomes in patients, with nearly all achieving normal blood sugar levels and reducing their reliance on anti-diabetic medications. Patients with shorter disease durations and milder type 2 diabetes saw the greatest improvements in glycemic control.
A study of 1,728 non-diabetic men and women found that those who engaged in regular physical activity were less likely to develop type 2 diabetes. The researchers suggest that adopting a program of moderate-intensity exercise can play a significant role in preventing the disease.
A Mayo Clinic study found that middle-aged and older adults who engage in regular aerobic exercise can maintain increased insulin sensitivity for up to four days after their last workout. However, this effect is not seen in those over 40, highlighting the importance of frequent exercise for preventing or treating Type 2 diabetes.
A recent study found that diabetes prevalence increased globally between 1993 and 1999. However, mortality rates from diabetes decreased by 3% during this period. The researchers suggest that earlier treatment and improved healthcare may contribute to the decline in mortality rates.
A study by Joslin Diabetes Center has identified a family of metabolic genes associated with type 2 diabetes risk. The research found that 55 genes showed altered activity in both people with diabetes and those at high risk for prediabetes, suggesting a continuum from normal to diabetic states.
Researchers found that 30% of diabetic patients with kidney disease do not exhibit common symptoms like protein in urine and eye disease. The current approach of screening for these symptoms alone is insufficient, and a blood test measuring kidney function directly is recommended.
A study found that prenatal exposure to a diabetic environment from mothers with type 1 diabetes is associated with increased occurrence of impaired glucose tolerance and a defective insulin secretory response in adult offspring. This effect was observed independently of genetic predisposition to type 2 diabetes.
A study found that regular physical activity, especially brisk walking, significantly reduces the risk of cardiovascular disease and death in men with diabetes. Diabetic men who were in the third highest category of total physical activity reduced their risk by 36 percent.
A new study suggests that type 1 diabetics can develop insulin resistance, increasing their risk of heart disease. Insulin resistance occurs when the body fails to use insulin properly, leading to high blood sugar levels and a greater risk of cardiovascular events.
A University of Pittsburgh study examines the effects of gastric bypass surgery on type 2 diabetes in 1,150 patients over a five-year period. The results show that diabetes resolves after an average of 62 days following surgery, with patients experiencing significant weight loss and improvement in glucose levels.