Articles tagged with Type 2 Diabetes
Scientists have identified a major susceptibility gene for type 2 diabetes in Mexican Americans, also affecting two European populations. The discovery provides new approaches to prevention, diagnosis and treatment of the disease.
A new genetic variation in the calpain-10 gene has been identified as a significant contributor to type 2 diabetes. This discovery provides new insight into the origins of the disease and its impact on patients' lives, offering potential therapeutic approaches for treatment.
Researchers found that female mice lacking IRS-2 protein are infertile due to defective ovaries and abnormal hormone production. The study suggests an evolutionarily conserved pathway linking energy metabolism and fertility in humans and animals, with potential implications for diabetes treatment.
Studies show Avandia reduces hepatic fat and increases subcutaneous fat without increasing intra-abdominal fat, a key factor in type 2 diabetes. The medication also decreases plasminogen activator inhibitor-1 levels, associated with cardiovascular risk factors.
Type 2 diabetes accounts for 90% of all cases, with rising costs placing a strain on healthcare resources. Insulin usage and complications are key drivers of increased costs.
The launch of Avandia provides patients with inadequate glycaemic control a new treatment option. Adding Avandia to metformin improves fasting plasma glucose levels in obese patients, reducing the risk of disease progression. This combination therapy also shows promise for patients with mild-to-moderate renal impairment.
Avandia targets both fundamental causes of type 2 diabetes by reducing insulin resistance and improving beta-cell function, providing enhanced glycaemic control. This dual therapeutic approach may delay disease progression and alter outcomes.
A new diet study, funded by Duke University Medical Center, aims to test the hypothesis that reducing fat intake can halt or slow diabetes progression. Participants will consume specially prepared foods with Olestra instead of real fat, allowing researchers to study a low-fat diet independently from a low-calorie diet.
A recent study reveals that primary care practices neglect to counsel diabetic patients on how to self-manage their illness, leading to a lack of comprehensive disease management. Despite this, patients who utilized community resources for support received more medical and counseling-related services from their physicians.
Researchers found that Avandia had a lower rate of elevated alanine aminotransferase (ALT) levels compared to placebo and other treatments. This suggests that Avandia is a valuable option for patients with type 2 diabetes, as it can help improve blood sugar control and potentially slow disease progression.
Researchers found that Avandia improves beta cell function, as measured by proinsulin to insulin ratio, indicating potential benefits for long-term glycemic control and disease progression. The study's results support the use of Avandia in type 2 diabetes treatment and suggest its potential to delay disease progression.
The National Heart, Lung, and Blood Institute recommends a more aggressive approach to treating high blood pressure in patients with type 2 diabetes. This is based on studies showing significant reductions in diabetes-related strokes, small blood vessel damage, and deaths when blood pressure is brought under control.
Researchers link HIV-protease inhibitors to increased diabetes risk due to impaired glucose storage, prompting reevaluation of screening methods and development of new treatments. Up to 83% of patients on the drugs develop excess belly fat and type 2 diabetes.
A nine-year study found that African-American women are 2.4 times more likely to develop diabetes due to lifestyle factors such as poor diet and lack of exercise. The study suggests that adopting a healthier lifestyle can help reduce the risk of developing diabetes in this population.
According to a study published in JAMA, African American women and men are more likely to develop type 2 diabetes than their white counterparts. The researchers found that being overweight was a significant factor in the excess risk for African American women, while high blood pressure was a key contributor for African American men.
A prospective cohort study found that regular exercise can benefit men with type 2 diabetes, while low physical fitness is associated with mortality. Meanwhile, a dangerous combination of blood thinners and intravenous steroids requires daily monitoring to prevent life-threatening bleeding.
Researchers found that taking American ginseng before a meal reduced blood sugar levels in both diabetic and non-diabetic individuals. The study's findings suggest that controlling after-meal blood sugar levels may be an important strategy in managing diabetes and preventing its onset.
A study led by Johns Hopkins found that patients with high blood pressure taking beta blockers were 28% more likely to develop diabetes than those not taking the medication. In contrast, thiazide diuretics were associated with a lower risk of diabetes.
Researchers found that diabetics under specialist care had significantly lower blood glucose levels and higher participation in self-care practices. The effect was particularly notable among patients with lower education levels.
A study found African American children exhibited more risk factors for diabetes and cardiovascular disease than white children, despite healthier diets. The authors cautioned that the diets in this study were of poor quality according to national recommendations.
Researchers suggest that a significant majority of people with type 2 diabetes derive little additional benefit from annual eye screening. Instead, every other year or even every third year screening is nearly as beneficial and more cost-effective. This finding could lead to a shift in recommendations for optimal screening intervals.
A recent study found that poorly controlled type 2 diabetic patients are more likely to develop severe periodontal disease, with elevated serum triglycerides contributing to the issue. Reducing cholesterol and serum triglyceride levels through diet and exercise may help improve quality of life and oral health in diabetics.
A large-scale national study will investigate whether weight loss reduces cardiovascular disease and slows atherosclerosis progression in obese people with type 2 diabetes. The 7-year trial, funded by the National Institute of Diabetes and Digestive and Kidney Disorders, aims to enroll 6,000 participants.
A recent study found that nearly half of people with type 2 diabetes stop taking their oral anti-diabetic drugs (OADs), leading to a higher risk of complications such as blindness, amputation, and cardiovascular problems. The study revealed that individuals who discontinued treatment were almost three times more likely to die than thos...
Rosiglitazone reduces insulin resistance by 33% and improves pancreatic function in individuals with type 2 diabetes. The treatment also reduces insulin levels in the blood, potentially alleviating the need for regular insulin injections.
A pan-European study found that type 2 diabetes in Europe is a significant healthcare burden, with total costs exceeding €29 billion and average individual costs more than double those of the general population. Preventing long-term complications through urgent action is crucial to reducing these costs.
Studies suggest that involving individuals with diabetes in their care can improve quality of life and reduce complications. The results highlight the importance of patient education and empowering patients to make informed treatment choices.
Researchers found that rosiglitazone treatment improved glycaemic control and reduced risk factors for coronary heart disease in patients with type 2 diabetes. The medication also showed promise in reducing protein excretion and triglycerides, while improving lipid profiles.
Scientists have identified a genetic defect linked to insulin resistance and adult diabetes, providing a target for potential new treatments. The Q allele of the PC-1 gene is three times more common among insulin-resistant people and twice as frequent among adult diabetics.
Researchers found that resistant mice have higher levels of antioxidant enzymes, which help protect against pancreatic beta-cell destruction. The study suggests a single gene may be responsible for the genetic resistance, and identifying it could lead to therapies to boost natural defenses against diabetes.
Researchers found that stress and coping measures can affect blood sugar control in people with diabetes. The study's biopsychosocial model suggests that psychological factors interact with biological factors to regulate blood sugar levels.
A study of 12,330 men and women aged 45-64 found that those with high levels of white blood cells, albumin, or fibrinogen were at higher risk of developing diabetes. The research suggests that inflammation may play a central role in the development of Type 2 diabetes.
A study of 254 women with Polycystic Ovary Syndrome (PCOS) found that 7.5% had undiagnosed diabetes, compared to 1% in the general population. Insulin resistance is a key factor in PCOS-related glucose intolerance and diabetes risk.
Researchers at Duke University Medical Center found that a low-fat diet can reverse type 2 diabetes in mice by reducing insulin and glucose levels independently of weight loss. The study suggests that foods high in fat, not sugar, are responsible for the onset of diabetes.
The Rockefeller study aims to identify genetic causes of early- and late-onset type 2 diabetes to develop better diagnostic tools and improved drug therapies. The researchers seek individuals with type 2 diabetes and at least one affected family member to participate in the study.
A recent study has found that a mutation in the HNF4alpha gene causes MODY1, a rare form of Type 2 diabetes. The defect impairs glucose homeostasis and glycolysis pathways.
Researchers at Massachusetts General Hospital identified a new rare form of diabetes, MODY4, associated with the ipf-1 gene. The study found that most family members with diabetes carried a single copy of the mutation, highlighting the critical role of this gene in insulin secretion.
An international research group has located a new gene, NIDDM2, linked to type 2 diabetes in Finland. The gene is found in the same region as MODY3, a rare early-onset form of diabetes.