Articles tagged with Type 2 Diabetes
Dr. von Andrian will focus on setting up a new microscopy model at Joslin to study the interaction between islet cells and immune cells, aiming to develop a simple model for studying islet cells in living animals. He will also collaborate with Joslin researchers on stem cell projects and vascular complications in people with diabetes.
Crestor demonstrates improved lipid profiles and lower LDL-C targets than atorvastatin, achieving higher patient success rates with fewer doses. Crestor also shows effectiveness in reducing apolipoprotein B levels and improving the Apo B:Apo A-I ratio.
Researchers identified a gene called PTPN1 that represses insulin response and is associated with diabetes. The study found a common variant of the gene increases the risk of diabetes in Caucasians, while another form appears protective.
A 12-week physical activity program will be implemented and evaluated in 16 worksites across the US and Canada to assess its effectiveness on promoting physical activity among employees. The study aims to determine the effects of a multilevel intervention aimed at personal goal-setting and ecologically based organizational action.
A new gene marker has been found to increase the risk of heart disease in people with type 2 diabetes. The CD36 gene variant is associated with higher levels of free fatty acids and triglycerides, leading to a 60% increased risk of heart disease.
A pilot study dubbed STAND UP! aims to monitor food intake and physical activity in schools to reduce risk factors for type 2 diabetes among sixth-graders. The program's results will be used to improve the intervention before expanding it to middle schools nationwide.
A three-month study found that patients with type 2 diabetes preferred the prefilled NovoLog(R) Mix 70/30 FlexPen(R) disposable pen due to its ease of use and flexibility. Patients who had never used insulin before reported significant benefits in perceived clinical efficacy.
A significant social gradient in the incidence of type 2 diabetes was observed among civil servants, with men and women in lower employment grades having a higher risk of developing the disease. Effort-reward imbalance was also found to be associated with an increased risk of type 2 diabetes in men.
A study of 91,249 women found a strong association between frequent consumption of sugar-sweetened beverages and increased risk of type 2 diabetes. Women who consumed more sugar-sweetened drinks experienced greater weight gain and higher risk of developing the condition.
Diabetics are susceptible to prolonged inflammation due to infection, leading to cardiovascular disease and poor wound healing. Inhibiting excess TNF may reduce the tendency for prolonged inflammation.
A study found that atorvastatin reduced cardiovascular events, deaths, and strokes by a third in patients with type 2 diabetes without high LDL cholesterol. The results suggest statin therapy may be safe and effective for this patient group.
A new study shows that consuming isolated soy protein can slow down the progression of diabetic kidney disease and improve coronary heart disease in patients with type 2 diabetes. The study found a significant reduction in urinary albumin levels and an improvement in HDL cholesterol levels among participants who consumed soy protein.
A UK study found that a significant proportion of people with type 2 diabetes are managed solely through diet, receiving inadequate monitoring and care. This highlights the need for better routine surveillance and consistency in clinical practice to address the high rate of complications among these patients.
Research finds connection between cytokine IL-4 signaling impairment and type 2 diabetes. Hyperinsulinemia triggers serine phosphorylation, impacting insulin receptor substrates and leading to neuroimmune response.
A meta-analysis found that fluoxetine, orlistat, and sibutramine can achieve modest but statistically significant short-term weight loss in adults with type 2 diabetes. Levels of glycated hemoglobin were also modestly reduced by the medications.
The PROactive study assesses the effect of ACTOS on cardiovascular disease progression in patients with type 2 diabetes. The study examines whether pioglitazone reduces cardiovascular mortality and morbidity in a high-risk population.
A recent study published in the Proceedings of the National Academy of Sciences found that overexpressing a selenium-containing enzyme in mice led to insulin resistance and obesity. The researchers suggest that antioxidants, like selenium, may be harmful by neutralizing free radicals necessary for insulin signaling.
The CARDS trial found that a daily 10mg dose of atorvastatin reduced the risk of serious heart problems by 36% and strokes by 48%. The benefits were observed even in patients with already low LDL-cholesterol levels. This study has significant implications for the cardiovascular health of people with Type 2 diabetes.
A landmark UK study sponsored by Diabetes UK, Department of Health, and Pfizer UK showed that 10mg atorvastatin reduced cardiovascular events by 37% in patients with diabetes without existing CVD. Stroke was substantially reduced by 48% in these patients.
ACTOS therapy has favorable effects on dyslipidemia, including reductions in triglycerides and increases in HDL cholesterol. Additionally, ACTOS was found to have beneficial effects on non-HDL cholesterol and A1C levels.
A study of 3,140 patients found pioglitazone to lower blood pressure in both Stage I and Stage II hypertension cases. This effect could reduce cardiovascular disease risk factors in patients with type 2 diabetes.
Studies presented at the American Diabetes Association annual meeting showed ACTOS to be effective in reducing fasting insulin levels and improving A1C levels, with significant benefits seen when used alone or in combination with other oral antidiabetic medications.
Over 60% of type 2 diabetes patients fail to meet recommended glucose treatment goals, increasing risk of complications such as heart disease and blindness. The Control to Goal initiative aims to bridge the gap between guidelines and clinical practice, promoting better diabetes management.
A study highlights the significant risk of cardiovascular disease in women with type 2 diabetes, emphasizing the importance of controlling blood glucose levels, managing cholesterol, and preventing diabetes. The researchers outline strategies for treating diabetic women and CVD, including intensive therapy and lifestyle modifications.
Researchers identified 15 common food habits that significantly impact blood sugar control, surpassing the effectiveness of medication. By adopting these 'do's and avoiding specific 'don'ts,' individuals with diabetes can achieve normal blood sugar levels.
The American College of Physicians recommends statin therapy for adults with type 2 diabetes, regardless of cholesterol levels, due to the high risk of cardiovascular disease. The guidelines also emphasize the importance of monitoring liver function and muscle enzymes only in patients with pre-existing conditions.
Researchers identified four genetic variants strongly associated with type 2 diabetes in Finnish and Ashkenazi Jewish populations. The variants cluster in the regulatory region of the HNF4A gene, influencing insulin secretion in response to glucose.
A large Finnish study found that moderate to high coffee consumption was associated with a lower risk of developing type 2 diabetes. Drinking 3-4 cups of coffee per day was linked to a 29% reduced risk for women and a 27% lower risk for men.
Researchers found that insulin-resistant young offspring of type 2 diabetics have increased muscle cell lipid content and reduced mitochondrial energy production. This study suggests a potential genetic cause of insulin resistance in young people with type 2 diabetes.
Elevated iron stores, particularly plasma ferritin concentration, may predict type 2 diabetes risk in healthy individuals. Healthy women with moderately elevated iron levels were found to have higher baseline intake of heme iron and lower fiber and magnesium consumption.
The XENDOS study found that Xenical significantly reduces the risk of developing type 2 diabetes by 37% compared to lifestyle changes alone and 52% in patients with impaired glucose tolerance. The medication also produces greater long-term weight loss and improves cardiovascular risk factors.
Recent studies show that overweight Hispanic youth are at an increased risk for developing type 2 diabetes and cardiovascular disease. Insulin resistance directly contributes to the development of metabolic syndrome, particularly in those with a family history of diabetes.
A study of Latino children found that nearly three in ten have impaired glucose tolerance, a precursor to type 2 diabetes, while obesity rates are twice those of non-Latino peers. Insulin resistance and metabolic syndrome increase the risk of chronic diseases.
A recent study has found that diabetes case management significantly improves glycemic control among low-income minority populations. The study, which was funded by the California Medi-Cal Managed Care Division and Center for Disease Control and Prevention, involved 362 Medicaid recipients with type 2 diabetes.
A new study finds evidence of genetic linkages to metabolic syndrome in both black and white patients. The researchers also identified chromosomal regions linked to cardiovascular disease and type 2 diabetes risk factors. These findings bring us closer to discovering the actual genes responsible for metabolic syndrome.
A new study finds that obese mice require the MSH hormone to develop diabetes, increasing resistance to insulin. Researchers believe this may lead to more effective preventive treatments for Type 2 Diabetes.
Obese adults who lost 7% of their weight and did moderate-intensity physical exercise for six months improved their major blood vessel function by approximately 80 percent, regardless of type 2 diabetes status. This improvement in blood vessel function reduced the risk of developing arteriosclerosis and coronary heart disease.
A recent study found that patients with a genetic subtype of diabetes have a significantly greater response to sulphonylurea drugs compared to those without a defined cause. This discovery highlights the importance of individualizing treatment for patients with type 2 diabetes, depending on their underlying cause.
A USC study finds that increasing insulin sensitivity can help prevent chronic diseases in Latino children. Overweight children with metabolic syndrome are less physically fit, but improving fitness could deter these diseases.
The study found that gastric bypass surgery significantly improved diabetes outcomes in patients, with nearly all achieving normal blood sugar levels and reducing their reliance on anti-diabetic medications. Patients with shorter disease durations and milder type 2 diabetes saw the greatest improvements in glycemic control.
A study of 1,728 non-diabetic men and women found that those who engaged in regular physical activity were less likely to develop type 2 diabetes. The researchers suggest that adopting a program of moderate-intensity exercise can play a significant role in preventing the disease.
A Mayo Clinic study found that middle-aged and older adults who engage in regular aerobic exercise can maintain increased insulin sensitivity for up to four days after their last workout. However, this effect is not seen in those over 40, highlighting the importance of frequent exercise for preventing or treating Type 2 diabetes.
A recent study found that diabetes prevalence increased globally between 1993 and 1999. However, mortality rates from diabetes decreased by 3% during this period. The researchers suggest that earlier treatment and improved healthcare may contribute to the decline in mortality rates.
A study by Joslin Diabetes Center has identified a family of metabolic genes associated with type 2 diabetes risk. The research found that 55 genes showed altered activity in both people with diabetes and those at high risk for prediabetes, suggesting a continuum from normal to diabetic states.
Researchers found that 30% of diabetic patients with kidney disease do not exhibit common symptoms like protein in urine and eye disease. The current approach of screening for these symptoms alone is insufficient, and a blood test measuring kidney function directly is recommended.
A study found that prenatal exposure to a diabetic environment from mothers with type 1 diabetes is associated with increased occurrence of impaired glucose tolerance and a defective insulin secretory response in adult offspring. This effect was observed independently of genetic predisposition to type 2 diabetes.
A study found that regular physical activity, especially brisk walking, significantly reduces the risk of cardiovascular disease and death in men with diabetes. Diabetic men who were in the third highest category of total physical activity reduced their risk by 36 percent.
A new study suggests that type 1 diabetics can develop insulin resistance, increasing their risk of heart disease. Insulin resistance occurs when the body fails to use insulin properly, leading to high blood sugar levels and a greater risk of cardiovascular events.
A University of Pittsburgh study examines the effects of gastric bypass surgery on type 2 diabetes in 1,150 patients over a five-year period. The results show that diabetes resolves after an average of 62 days following surgery, with patients experiencing significant weight loss and improvement in glucose levels.
A unique program, ENERGY, has been established to reduce childhood obesity and type 2 diabetes among elementary school students. The program incorporates science education enrichment activities to promote healthy eating and active living.
The American College of Physicians recommends aiming for blood pressure levels less than 135/80 mm Hg in patients with type 2 diabetes. Thiazide diuretics and ACE inhibitors can be used as first-line agents to control blood pressure, but patients may need multiple medications.
The ACCORD clinical trial enrolls 10,000 adults with type 2 diabetes to test the effects of intensively controlling blood sugar along with aggressive control of blood pressure and lipids. The study aims to address the significant public health challenge of cardiovascular disease in people with type 2 diabetes.
A new study aims to investigate the effects of intensively controlling blood sugar, blood pressure, and lipid levels on cardiovascular disease risk in adults with type 2 diabetes. The ACCORD study will test three medical treatment strategies to determine their impact on CVD risk.
A Pittsburgh study found that even among those with normal weight, excess fat distribution in the body increases insulin resistance and type 2 diabetes risk. The study of elderly men and women with normal glucose tolerance showed that two-thirds of those with type 2 diabetes were not obese.
A new study from the Liverpool Diabetic Eye Study has proposed optimal screening intervals for diabetic eye disease, based on incidence data. The findings suggest that patients with no baseline retinopathy should be screened every 3 years, while those with background retinopathy can be screened annually.
A large study of over 17,000 Dutch adults found that those who drank seven or more cups of coffee a day were 50% less likely to develop type-2 diabetes. The study suggests that components of coffee other than caffeine may be beneficial for glucose metabolism, but long-term effects are unknown.
Regular aerobic and weight-lifting activities can help diabetics control blood sugar and lower blood pressure, also providing cardiovascular benefits. Exercise training reduces total and abdominal fat, leading to improvements in insulin sensitivity, blood pressure, and blood vessel function.
The InnoLet system features a dosing dial and reversible dose mechanism, making it easier for patients to administer accurate doses. Clinical studies show that 95% of participants rated the device as 'very easy' or 'easy' to use.
The XENDOS study found that 28.3% of obese individuals had undetected or untreated diabetes or pre-diabetes. Xenical-treated patients experienced significant weight loss and improved cardiovascular risk factors compared to lifestyle intervention alone.
The XENDOS study demonstrates that Xenical plus lifestyle intervention is more effective than lifestyle intervention alone in preventing or delaying the development of type 2 diabetes. Significant and sustained weight loss was achieved with Xenical, which also improved cardiovascular risk factors.