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Science News for January 30, 2004


New mode of action discovered for tamoxifen

Researchers at the University of Iowa have identified a new mode of action for tamoxifen, an anti-estrogen medication used to treat breast cancer. Tamoxifen turns on the tumor suppressor gene maspin, which inhibits tumor invasion and metastasis in normal breast cells.

SourceUniversity of Iowa·JournalClinical Cancer Research·DateJan 30, 2004

Protein Data Bank receives $30 million grant

The Protein Data Bank (PDB) has received a $30 million grant from the federal government to continue its work in unlocking biological secrets. The PDB, an internet-accessible repository of 3-D models of proteins and other macromolecules, will help design new drugs that interact with these molecules.