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Science News Archive January 2004


Page 1 of 7

New mode of action discovered for tamoxifen

Researchers at the University of Iowa have identified a new mode of action for tamoxifen, an anti-estrogen medication used to treat breast cancer. Tamoxifen turns on the tumor suppressor gene maspin, which inhibits tumor invasion and metastasis in normal breast cells.

SourceUniversity of Iowa·JournalClinical Cancer Research·DateJan 30, 2004

Protein Data Bank receives $30 million grant

The Protein Data Bank (PDB) has received a $30 million grant from the federal government to continue its work in unlocking biological secrets. The PDB, an internet-accessible repository of 3-D models of proteins and other macromolecules, will help design new drugs that interact with these molecules.

A killer microbe as a living antibiotic

Researchers have unraveled the complete genome sequence of Bdellovibrio bacteriovorus, a predatory bacterium that can degrade complex biopolymers in other bacteria. The study may lead to novel anti-microbial substances and the development of a 'living antibiotic' as a potential therapeutic agent.

SourceMax-Planck-Gesellschaft·JournalScience·DateJan 29, 2004

Study finds wide attitude gap on wolves

A recent survey found that attitudes towards wolves in Wisconsin are shaped more by cultural factors than individual experiences. Moderate support exists for wolf recovery statewide, with 73% of residents favoring maintaining or increasing wolf numbers. However, hunters and livestock producers exhibit greater intolerance towards wolves.

SourceWildlife Conservation Society·JournalConservation Biology·DateJan 29, 2004

Death-defying approach devised by Penn scientists to prevent cell apoptosis

Penn scientists use gene-transfer technology to insert extra MRSA into cells, leading to increased protection against oxidative stress and potential treatment for diseases related to aging and the heart. The study's findings suggest that boosting MSRA levels may prevent cell apoptosis and treat disease.

SourceUniversity of Pennsylvania School of Medicine·JournalProceedings of the National Academy of Sciences·DateJan 29, 2004

Home-based therapy beneficial for stroke patients

Therapy-based rehabilitation services for stroke patients living at home reduced the odds of deteriorating in personal activities of daily living (eg. walking, dressing) by 28% and increased the ability of patients to undertake activities of daily living by 14%. These findings suggest that a therapy-based rehabilitation service could b...

SourceThe Lancet_DELETED·JournalThe Lancet·DateJan 29, 2004

Dieters decrease heart risk on moderate fat program

A moderate-fat diet, rich in monounsaturated fats from peanuts and peanut oil, produced a significant reduction in cardiovascular disease risk, with a 14% decrease compared to the low-fat group. The study found that despite weight loss, high fat diets can rebound and cause adverse effects on HDL cholesterol levels during maintenance.

SourcePenn State·JournalAmerican Journal of Clinical Nutrition·DateJan 29, 2004

Teenage girls lacking in vitamin D

A study monitored sun exposure, diet and blood levels of vitamin D in 23 teenage girls from ages 10 to 13 years old. The results showed that almost half of the Bangor area girls had insufficient levels of vitamin D in their blood, with 17% having low levels in September.

Researchers create lung cancer 'cluster bombs'

A team of researchers has developed a novel lung cancer treatment using nanoparticle cluster bombs, which have shown promise in treating cancerous lung cells. The new delivery system could potentially be used to target cancer cells while leaving healthy cells alone.

SourceUniversity of Alberta·JournalInternational Journal of Pharmaceutics·DateJan 29, 2004

A new twist on the mad cow

Researchers at Scripps Research Institute find normal cellular prion protein essential for prion diseases like BSE, and inducing neurotoxicity without scrapie prions triggers catastrophic outcomes. This discovery highlights the complexity of prion pathogenesis and challenges existing therapeutic approaches.

SourceScripps Research Institute·JournalScience·DateJan 29, 2004

Something got me started

The EMBO-launched portal aims to facilitate life scientists' career mobility across Europe by providing a one-stop-shop for funding opportunities, training programs, and job openings. Users can share their research profiles and contribute to the platform through submissions of experience reports on mobility.

How the cellular 'garbage disposal' grinds to a halt to cause Batten disease

A team of researchers at the University of Rochester Medical Center discovered that a genetic defect affects lysosome protein arginine regulation, causing Batten disease. This condition leads to lysosomes malfunctioning and cells swelling with waste, ultimately killing brain cells and resulting in severe medical problems.

SourceUniversity of Rochester Medical Center·JournalProceedings of the National Academy of Sciences·DateJan 28, 2004

AGU journal highlights - 28 January 2004

This AGU journal features research on space weather substorms, with a possible explanation for large magnetic fluctuations during the onset of a space weather substorm. Additionally, high frequency sea ice motion may affect Arctic dynamics, while tropical drought regions in global warming and El Nino teleconnections are also explored.

SourceAmerican Geophysical Union·JournalGeophysical Research Letters·DateJan 28, 2004

No adverse effects of aluminium in vaccines

A meta-analysis of five published trials found that aluminium-containing vaccines were more likely to cause redness and induration in young children and local pain in older children. However, there was no evidence of serious or long-lasting side effects.

SourceThe Lancet_DELETED·JournalThe Lancet Infectious Diseases·DateJan 28, 2004

Call for increase in flu vaccination among young children

Recent studies suggest that pediatric influenza is a significant medical problem, causing excess hospitalizations and antibiotic prescriptions. Experts call for increased efforts to identify and vaccinate high-risk children, as well as educating parents and physicians about the importance of flu vaccination.

SourceThe Lancet_DELETED·JournalThe Lancet Infectious Diseases·DateJan 28, 2004

Brain structure implicated in early onset depression

Researchers found that adolescents with early onset depression had significantly smaller left hippocampuses compared to healthy controls. The study also revealed that those with longer histories of depression had larger hippocampuses, suggesting that initial differences may not be apparent in adult patients.

SourceBMC (BioMed Central)·JournalBMC Medicine·DateJan 28, 2004

Robotic surgery for young heart patients shortens hospital stay and speeds recovery, study indicates

The minimally invasive surgical techniques made possible by the robot system can give the same surgical result as open-chest techniques with less impact on young patients' bodies. Robot-assisted surgery may be a good option for certain defects and reduces hospital stays, operative trauma, cosmetic impact, and overall recovery time.