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Science News for January 13, 2004


Gene-disabling techniques simplified by Stanford team

A Stanford team has developed a simplified method for generating siRNA molecules to disable genes, overcoming the technique's limitations in expense and labor. The new protocol allows researchers to create libraries of siRNA molecules for all known genes, enabling the identification of genes that play critical roles in stem cell function.

SourceStanford Medicine·JournalNature Genetics·DateJan 13, 2004

Predicting progression of common cancers

A study published in PLOS Biology discovered a common genetic signature linked to the progression of various cancers, including prostate and liver cell carcinomas. Patients with tumors carrying this signature had an increased risk of metastasis and death compared to those without it.

SourcePLOS·JournalPLOS Biology·DateJan 13, 2004

Gene may be key to evolution of larger human brain

A study led by Bruce Lahn found that the Abnormal Spindle-Like Microcephaly Associated (ASPM) gene shows strong evidence of accelerated evolutionary changes in the primate lineage leading to humans. These changes are most prominent after humans parted ways from chimpanzees, suggesting a possible key role for ASPM in human brain evolution.

SourceHoward Hughes Medical Institute·JournalHuman Molecular Genetics·DateJan 13, 2004

Mars on Earth?

A joint research effort discovered Mars-like soils in Chile's Atacama Desert, which are depleted in organic materials and would have been missed by NASA's Viking missions. The team found that the conditions in this environment represent a limit for microbial life on Earth.

SourceLouisiana State University·JournalScience·DateJan 13, 2004