Articles tagged with Type 2 Diabetes
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UCSD researchers have discovered that inflammation from immune cells called macrophages leads to insulin resistance and Type 2 diabetes. By disabling the macrophage inflammatory pathway, insulin resistance can be prevented in mouse models.
A study published in The Lancet found that fenofibrate reduces the frequency of first laser treatment for macular oedema and proliferative DR by 31% and 30%, respectively. These findings suggest additional mechanisms of benefit beyond lipid-lowering effects, potentially additive to blood glucose and blood pressure control.
Researchers have discovered that hyperacidification of the TGN causes increased activity of furin, leading to tissue fibrosis in individuals with CF. Additionally, a new study on EHEC O157:H7 has identified the role of type IV pili in intestinal adherence and immune response.
A study of 38,000 female health professionals found that women with hypertension have a three-fold risk of developing type 2 diabetes compared to those with optimal blood pressure levels. Obesity is also a strong and independent risk factor for the development of type 2 diabetes.
A meta-analysis of seven clinical trials found that rosiglitazone and pioglitazone increased the risk of congestive heart failure in patients with type 2 diabetes or prediabetes. However, these drugs did not increase the risk of cardiovascular death. The authors recommend caution when prescribing TZDs to patients with cardiovascular di...
New research supports the cardiovascular safety of ACTOS (pioglitazone HCI) and its benefits in improving blood glucose and lipid levels. The study found that therapies including pioglitazone are associated with significant reductions in the risk of stroke or myocardial infarction compared to non-thiazolidinedione therapies.
Both aerobic and resistance exercise improved glycemic/blood sugar control in people with type 2 diabetes, with the greatest improvements seen in those who performed both types of exercise. The study found that combining aerobic and resistance training resulted in a significant decrease in A1c value, indicating better blood sugar control.
Researchers found that Metformin improves glucose uptake and survival of early embryos in mice with insulin resistance. The drug may benefit women with type 2 diabetes or polycystic ovary syndrome trying to conceive. Improved embryo quality could lead to more successful pregnancies.
The ADVANCE trial found that a fixed combination of perindopril and indapamide reduced the risk of death from cardiovascular disease by 18% and major macrovascular or microvascular events by 9%. The results suggest that this treatment could be considered routinely for patients with type 2 diabetes to prevent complications.
Scientists have discovered that glucose-sensing neurons play an important role in regulating blood glucose levels in mice with obesity-induced Type 2 diabetes. The study found that defects in these neurons contribute to the disease's progression and may be targeted by novel therapies.
A new study at Joslin Diabetes Center identified a protein called Sirt2 as playing a major role in how fat is produced and stored in the body. Increasing Sirt2 levels may block fat cell differentiation and reduce fat storage.
Researchers at UCLA have identified three inflammatory cytokines as potential biomarkers for predicting Type 2 diabetes in apparently healthy individuals. The study, which involved over 1,600 participants, found that high levels of these cytokines were associated with an increased risk of developing the disease.
Scientists have found a direct link between mitochondrial DNA variants and metabolic markers for type 2 diabetes in rats. The study, published in Genome Research, highlights the role of mitochondrial genome variation in common diseases.
Researchers at Columbia University Medical Center have discovered that the skeleton acts as an endocrine organ, releasing osteocalcin to regulate blood sugar and fat deposition. This hormone boosts insulin sensitivity and enhances insulin-producing cells, preventing type 2 diabetes in mice.
A study of over 10,000 women found that those who were obese prior to pregnancy had a higher risk of giving birth to babies with structural birth defects. The findings suggest a possible mechanism involving alterations in glycemic control, similar to those seen in women with diabetes.
A study published in the Journal of Clinical Investigation reveals that variants of the TCF7L2 gene increase susceptibility to type 2 diabetes by affecting insulin secretion in pancreatic islet cells. The findings provide a mechanism for genetic predisposition and suggest potential therapeutic targets for new treatments.
A randomized clinical trial found that selenium supplementation increased the risk of developing type 2 diabetes by 55%, with higher levels associated with a greater risk. The study suggests that taking high doses of selenium may have detrimental effects in well-nourished populations.
A combination of calcium and vitamin D found in milk may offer protection against type 2 diabetes, with a 15% lower risk among individuals consuming the most dairy. Additionally, magnesium intake from milk products may also reduce type 2 diabetes risk by 15%.
A new study found that measuring retinol-binding protein 4 (RBP4) levels in blood can indicate the amount of visceral fat surrounding abdominal organs. Elevated RBP4 concentrations are linked to insulin resistance, type 2 diabetes, and heart disease risk.
A meta-analysis of 29 studies found that incretin-based therapy improves glycemia, particularly postprandial glycemia, and has a favorable or neutral effect on weight. However, glucagon-like peptide 1 analogues are associated with gastrointestinal adverse effects, while DPP4 inhibitors have an increased risk of infection.
A large national study found that selenium supplements may increase the risk of developing type 2 diabetes, while a leading researcher advises against taking excessive selenium supplements. The study analyzed data from over 1,200 participants and found higher risks among those with higher blood selenium levels at the start of the study.
A new study is providing community pharmacists with education and advice on controlling blood glucose levels through individual glucose meter uploads. The project aims to determine whether lifestyle advice from pharmacists improves glycaemic control and potentially reduces the burden of Type 2 Diabetes on healthcare systems.
Alogliptin, a highly selective DPP-4 inhibitor, demonstrated significant reductions in mean 4-hour plasma glucose levels across multiple doses. The study also showed sustained inhibition of plasma DPP-4 activity and improved glucose control without increased risk of hypoglycemia.
A new study from the University of Illinois found that cytokine resistance contributes to the pathology of type 2 diabetes by impairing the anti-inflammatory response and disrupting insulin-like signaling pathways. This impairment leads to chronic inflammation, which exacerbates health issues in individuals with obesity or diabetes.
Researchers have found a link between low HDL cholesterol and heart disease, suggesting that defective ABCA1 protein may play a role. Additionally, studies have shown that type 2 diabetes patients accumulate high levels of triglyceride-rich lipoprotein in the blood, which can contribute to heart disease.
Early onset type 2 diabetes in adolescents is associated with rapid progression of complications, including hypertension, nephropathy, retinopathy, and psychiatric disorders. The unborn children of pregnant young women are also at increased risk.
A systematic review of rosiglitazone trials suggests a 43% increased risk of heart attack and 64% risk of death from heart attack. However, recent studies DREAM and ADOPT suggest these findings may be overstated, warranting a more considered approach to its safety
A study published in Archives of Internal Medicine found that higher consumption of cereal fiber and magnesium may reduce the risk of type 2 diabetes. Participants who consumed more cereal fiber had a 27% lower risk of developing diabetes compared to those who ate less, while those who consumed more magnesium had a 23% lower risk.
Recent advances in epidemiologic and experimental knowledge have validated health benefits of moderate coffee consumption. Studies suggest that moderate coffee drinking may reduce the risk of Parkinson's disease and Alzheimer's disease, while also lowering the risk of type 2 diabetes.
A UK collaboration of scientists has identified three new genes that predispose individuals to develop type 2 diabetes. The study confirms the link between two previously-identified genes and brings the total number of genes known to be involved in the disease to nine.
A genome-wide search has uncovered three novel regions of human DNA that contain clear genetic risk factors for type 2 diabetes, as well as a genomic region associated with elevated blood triglycerides. The study reveals surprising new avenues for disease research, treatment and prevention.
Researchers have identified at least four new genetic variants associated with increased risk of diabetes and confirmed the existence of six more, boosting the number of known genetic variants to 10. These findings may lead to personalized medicine approaches by exploring how these genetic factors interact with lifestyle factors.
A U of M-led study has identified 10 new genetic risk factors for type 2 diabetes, which could lead to the development of new drugs and more effective treatments. The findings also improve our understanding of how these genetic factors interact with lifestyle factors.
Scientists have identified a strong association between an increase in BMI and a variation of the FTO gene, which carries a 70% higher risk of obesity. The study found that people with two copies of the FTO allele are on average 3kg heavier than those with no copies.
The report estimates that nearly 60% of people with type 2 diabetes have at least one serious health complication, including heart disease, stroke, and chronic kidney disease. Estimated annual healthcare costs for a person with type 2 diabetes complications exceed $10,000.
Researchers discover telomere shortening as a predictor of coronary heart disease in pre-diabetics and Type 2 diabetics. Early indication of telomeres starting to shorten may indicate the onset of diabetes and ultimately predict CAD.
Researchers found that periodontal disease can cause pre-diabetic characteristics and contribute to the progression of Type 2 diabetes. The study used rat models to investigate the relationship between periodontitis and pre-diabetes, highlighting the importance of oral health in preventing diabetes.
A study by Duke University Medical Center found that having both type 2 diabetes and depression significantly increases the risk of death for heart patients. This is because individuals with diabetes who also experience depression may be less motivated to follow their self-care regimen, thereby putting them at a higher risk.
Researchers identified genetic and cellular mechanisms that enable mice with high-fat diets to resist obesity and diabetes, suggesting a role for brown fat cells. The study may lead to new therapies for obesity and prevention of type 2 diabetes.
Researchers mapped genetic makeup of type-2 diabetes in unprecedented detail, identifying four loci that correspond to a 70% genetic background risk. The study also reveals a mutation in the zinc transporter SLC30A8, potentially leading to new treatments for insulin deficiency.
A recent study published in Diabetes Technology and Therapeutics demonstrated that Diachrome safely improves blood glucose levels and cholesterol metabolism in people with type 2 diabetes. The 30-day study showed a significantly greater reduction in glucose levels, suggesting potential benefits for improved blood sugar control.
A new study aims to improve diabetes management by linking patients' glucose levels to their pharmacists. Half of the participants will share their data with their pharmacist for lifestyle advice, while the other half will manage it themselves.
A new study found a genetic link between the 'diabetes gene' (calpain-10) and polycystic ovary syndrome (PCOS), which affects up to five percent of females. The study suggests that specific variants of the CAPN10 gene may contribute to PCOS susceptibility, providing hope for diagnosis and treatment.
A study at the University of Illinois Chicago found that pioglitazone significantly slowed the thickening of carotid artery walls, reducing the risk of heart attack. The medication was shown to be effective regardless of age, sex, or diabetes duration.
A new clinical trial, CHICAGO, demonstrated that pioglitazone (ACTOS) reduced the progression of carotid intima-media thickness (CIMT), a surrogate marker for heart attack and stroke, by 0.013 mm. The study also showed improved glycemic control, decreased triglycerides, and increased HDL-C levels with ACTOS treatment.
The proportion of people with type 2 diabetes in Asia has increased rapidly, with younger age groups developing the condition and suffering longer from chronic complications. The region's healthcare systems are under threat as a result.
A Finnish study found that intensive lifestyle interventions can sustainably reduce the risk of developing type 2 diabetes. After four years, participants showed a 36% reduction in relative risk, attributed to achieving weight loss and increased physical activity.
A new study published in the Journal of Periodontology found that periodontal therapy decreases lipid peroxide levels in diabetic patients, reducing oxidative stress. This reduction is comparable to that seen in nondiabetic patients, suggesting a potential benefit for patients with Type 2 diabetes.
Rimonabant reduces bodyweight and improves blood glucose control in patients with type 2 diabetes. The study suggests that rimonabant could be used as a new treatment option for patients who have not responded to standard treatments.
A major national study found that about 154,000 of 80.7 million children and adolescents nationwide had diabetes in 2001. Non-Hispanic white children had the highest diabetes rate, with type 1 diabetes being the most common form.
Researchers found that increasing leptin production in the hypothalamus helps regulate insulin secretion, keeping blood glucose levels normal. Gene therapy successfully reversed type 2 diabetes in diabetic mice, even after a high-fat diet.
A study at the University of Chicago Medical Center found that short or poor quality sleep is associated with reduced control of blood-sugar levels in African Americans with diabetes. The research suggests that improving sleep duration and quality may be an inexpensive way to improve health outcomes for patients with type 2 diabetes.
A new study suggests that taking rosiglitazone, a medication for type 2 diabetes, can prevent the disease in people at high risk. The three-year trial found that this combination reduced the risk by about two-thirds, preventing around 144 cases of diabetes per 1000 people.
The partnership aims to address pediatric health concerns through groundbreaking scientific research and monitoring disease, with the goal of finding long-term solutions for childhood obesity and type 2 diabetes. The collaboration will also support increased awareness and education on these critical health issues.
ACTOS demonstrated significant improvements in reducing the risk of heart attacks, strokes, and cardiovascular death in high-risk patients with type 2 diabetes. The study showed a 23% reduction in heart attacks and an 18% reduction in combined risk of cardiovascular death, nonfatal heart attack, or nonfatal stroke.
Researchers at Washington University School of Medicine successfully transplanted pig pancreatic primordia into rats with type 2 diabetes, curing the condition without the need for immune suppression drugs. The approach, similar to one that cured type 1 diabetes in previous studies, uses embryonic cells to produce insulin.
New analyses of the PROactive Study found that ACTOS (pioglitazone HCl) significantly reduced the risk of recurrent stroke in high-risk patients with type 2 diabetes, with a 47% reduction in incidence and a 28% decrease in combined risk of death, MI, or stroke.
Researchers have identified two chemical compounds, PBA and TUDCA, that alleviate ER stress and restore normal glucose homeostasis in type 2 diabetic mice. These compounds also improved insulin response, reduced fatty liver disease, and prevented JNK activation, offering a potential new approach to treating metabolic syndrome.
A low-fat vegan diet has been shown to treat type 2 diabetes more effectively than a standard diabetes diet, with significant improvements in blood sugar control and weight loss. The diet also appears to have favorable effects on cholesterol levels and kidney function.
A study found that youth-onset type 2 diabetes is associated with a substantially increased risk of end-stage kidney disease and death between 25-55 years old. Participants with early-onset diabetes had a significantly higher incidence rate of kidney disease compared to those with older-onset diabetes.