Articles tagged with Bacterial Pathogens
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Researchers at Stanford University have identified synthetic peptoids as a potential new class of antibiotics, which could overcome the limitations of natural peptides. These manmade molecules show promise in treating bacterial infections, including diabetic foot ulcers, with minimal harm to human cells.
The new device can detect 24 pathogens, including anthrax, plague, and E. coli, and identify them within three minutes, significantly advancing current detection times.
A new study by researchers at the University of Illinois Chicago has identified a crucial enzyme for bacterial growth in blood, offering a potential target for antibiotics. The study found that most E. coli bacteria strains cannot grow in human blood if they lack a specific gene involved in nucleotide biosynthesis.
Brent Christner's team found biological particles in precipitation, which can catalyze freezing at warmer temperatures, affecting precipitation patterns. The discovery has implications for understanding agricultural pathogens and their role in the global warming process.
Researchers have found that the YscJ lipoprotein component determines the location of a key injection device in plague bacteria. This discovery sheds light on how Yersinia pestis causes the bubonic plague and could lead to new treatments.
Researchers at Ohio State University identified two proteins, MprF1 and MprF2, that contribute to bacterial resistance by altering the electrical charge of cell membranes. This finding could lead to the development of new drugs targeting bacterial resistance at its cellular source.
A new animal study suggests small intestinal bacteria overgrowth (SIBO) contributes to nonalcoholic fatty liver disease (NASH) pathogenesis. Treatment with cidomycin alleviates NASH severity by lowering serum ALT, AST, and TNF-α levels.
Researchers have identified the proteins forming the structure of carboxysome microcompartments, a key step in understanding their role in bacterial protection. The discovery may lead to new strategies for targeting these structures, potentially rendering bacteria harmless.
A new study maps emerging disease hotspots worldwide, revealing that human-wildlife conflict and drug-resistant pathogens are major contributors. The research, which analyzed 335 diseases from 1940 to 2004, shows that disease emergence has roughly quadrupled over the past 50 years.
A study published in PNAS identifies intestinal alkaline phosphatase as an enzyme that blocks the action of lipopolysaccharide, a molecule responsible for bacterial toxins' toxic effects. The findings suggest that feeding critically ill patients can prevent infection by stimulating IAP production.
A novel approach strips Staphylococcus aureus of its virulence by blocking pigment formation, which acts as an antioxidant to hinder immune system's ability to kill bacteria. The method reduces bacterial population by 98% in mice infected with S. aureus.
A Vanderbilt University team has discovered a protein that blocks the growth of 'staph' bacteria by sopping up manganese and zinc, offering a new way to treat infections. The protein, calprotectin, is naturally produced by immune cells in response to bacterial infections, making it a potential target for therapeutic interventions.
Researchers at IRB Barcelona have discovered a new control mechanism for genetic code translation in bacteria, which differs from humans. This discovery strengthens the theory that the initial genetic code evolved separately in distinct branches of life, highlighting the plasticity and complexity of the genetic code.
Researchers at Children's Hospital of Pittsburgh have identified interleukin 22 (IL-22) as a crucial factor in the immune response to bacterial pneumonia. The study, published in Nature Medicine, suggests that stimulating the Th17 arm of the immune system may lead to more efficient treatment and prevention of pneumonia.
Researchers have reidentified the main cause of necrotic enteritis in chickens as Clostridium perfringens, producing extracellular toxins that attack the bird's intestines. The discovery of a new toxin, NetB, has led to hope for the development of effective vaccines within two years.
Researchers discover polyphenols in winemaking waste inhibit the ability of bacteria to cause cavities and form biofilms, potentially leading to new treatments for oral diseases. The findings also suggest the compounds may hold clues for lessening the ability of bacteria to cause life-threatening infections.
Researchers have developed a key small molecule inhibitor targeting 'virulence factors' used by bacteria to thrive, offering an alternative means of stopping TB, leprosy, and other bacterial illness. The findings highlight a paradigm shift in infectious disease research beyond antimicrobials like antibiotics.
A Cornell research team used gene chips to study Mycobacterium tuberculosis and found that the bacteria's genes are activated after being engulfed by a macrophage. The study also compared the responses of M. tuberculosis to BCG, finding that BCG may be less capable of protecting itself once inside a macrophage.
A recent breath test can accurately detect SIBO by measuring hydrogen levels in expired air. The disorder has severe systemic consequences including sepsis and multiorgan failure if left untreated.
A study published in PLoS Medicine finds IBCs in cystitis patients, associated with E coli and filamentous bacteria, suggesting a need for longer antibiotic treatment. The researchers collected urine samples from women with cystitis and found IBCs in nearly one in five cases.
Researchers at the University of Wisconsin-Madison found that arsenic-tainted wells require tailored treatment approaches, depending on their source and geology. Chlorine disinfection can effectively control pathogenic bacteria but may not address all types of arsenic contamination.
Roman Ganta has received a National Institutes of Health grant to study how to stop Ehrlichia chaffeensis from making animals and people sick. The bacteria can evade the immune system, leading to serious symptoms in humans, particularly those with compromised immune systems.
Researchers at the University of Manchester have pioneered new methods to modify antibiotics' molecular structure, enabling the development of new types of antibiotics capable of combating increasingly resistant bacteria. This innovation provides access to thousands of lipopeptide variants that cannot be produced easily in any other way.
A CU-Boulder technology has been used to identify unexpected bacteria strains in the lung fluid of Denver children suffering from cystic fibrosis. The method uses nucleic acid gene sequencing to rapidly detect and classify pathogens found in the lungs, identifying over 60 species of bacteria in samples from 28 patients.
A new study found that benzethonium chloride is more effective in killing methicillin-resistant Staphylococcus aureus (MRSA) bacteria than other antibacterial products. The compound kills common types of non-hospital MRSA bacteria better than others, with a genuine bactericidal effect against all four tested strains.
A new aerosol launches an immune response in the lungs to wipe out lethal infections, including bacterial and fungal infections. The treatment showed an 83% survival rate against pneumococcal pneumonia in mice treated with the aerosol before exposure.
Anthony Azenabor's research reveals that Chlamydia bacteria can manipulate macrophage cell walls, causing atherosclerosis and disrupting hormone production in the placenta. This discovery could lead to new treatments for both heart disease and infertility by blocking cholesterol signaling.
Researchers at Princeton University have discovered a chemical mechanism used by cholera bacteria to communicate with each other, which can be disrupted to potentially halt the disease's progress.
A new laser technique uses femtosecond pulses to selectively destroy viruses and bacteria, including those causing AIDS and hospital infections. The treatment is non-toxic to human cells, offering a promising solution for disinfection and disease treatment.
Researchers developed a magnetic separation technique that can sort beads hundreds of times smaller than the period at the end of a sentence. This method, called magnetophoresis, uses a rotating magnetic field and microchip to separate tiny magnetic beads based on size within minutes.
Researchers at Purdue and Duke universities developed a technique using a magnetic field to selectively separate tiny magnetic particles, representing a highly sensitive method for diagnosing diseases. The new system can diagnose multiple pathogens in a single sample with high accuracy.
Researchers at Hebrew University of Jerusalem discover a new communication factor that enables bacterial communities to 'talk to each other' and die under stressful conditions. This discovery could lead to the development of a new class of antibiotics targeting Escherichia coli and other pathogenic bacteria.
Common uterine infections can damage ovaries and affect fertility in cows, similar to the impact on humans with sexually transmitted infections like Chlamydia. Researchers found that bacteria can leave toxins in egg-containing follicles, suppressing oestrogen production and preventing ovulation.
Researchers have discovered that French clay can kill several types of bacteria, including MRSA and Mycobacterium ulcerans, which causes the flesh-eating disease Buruli ulcer. The study, led by Lynda Williams at Arizona State University, used laboratory tests to confirm the antibacterial properties of the clay.
Researchers at Yale University discovered that Legionella proteins work together to survive by hijacking cellular compartments. The bacteria manipulate macrophages to transport them to nutrient-rich organelles, where they replicate in high numbers.
Researchers found that red wines, particularly Cabernet, Zinfandel, and Merlot, have anti-microbial properties that defend against food-borne pathogens. The study also showed that grape juice produces similar results, with reseveratrol being a key phytochemical responsible for the findings.
A deficiency of the T-bet protein in dendritic cells has been linked to ulcerative colitis in mice, which can be passed from mother to offspring and between adult animals. This study provides a novel model for the disease, with potential implications for testing new therapies and preventive measures.
Researchers found that Mycobacterium indicus pranii (MIP) is the earliest ancestor of generalist mycobacterial pathogens, including Crohn's disease pathogen M. avium paratuberculosis (MAP). The study suggests that MIP and MAP descended from a common ancestor and infected marine organisms before arriving on soil through bird-droppings.
A new study by Oregon State University microbiologists found that one type of bacteria has mutants that shut down communication systems to avoid sharing nutrients. This allows the lazy bacteria to grow faster and outcompete others, but also reveals a paradox in microbiology and potential strategies for combating bacterial infections.
Researchers at EPFL have developed a nanoparticle vaccine that delivers vaccines more effectively with fewer side effects, at a fraction of the cost. The technology targets dendritic cells to trigger a strong immune response, and has potential applications for diseases like hepatitis and malaria.
Researchers will develop a faster, more sensitive biosensor to detect bacterial infections in human clinical fluid samples. The goal is to enable point-of-care diagnostics and aid antibiotic treatment selection within two hours.
Researchers have found that bacteria living in red poultry mites could be targeted to prevent Salmonella and other pathogen spread in chickens. The discovery offers a potential new approach to combat the devastating impact of these blood-sucking pests on poultry and human health.
Researchers at Johns Hopkins Medicine have developed a new method to eliminate viruses from blood using low-power lasers. The technique selectively targets and destroys viruses while preserving normal human cells.
Scientists developed a microchip that can identify 56 virulence genes in E. coli bacteria and 54 antimicrobial resistance genes in gram-negative bacteria, speeding up diagnosis and treatment of infections. The chip will enable large-scale monitoring of bacterial pathogens and search for important genes in other pathogens.
Bacteria and nematode worms work together to kill insects using insecticidal toxins. The toxins, found in Photorhabdus luminescens, are also found in human pathogens Yersinia pestis and Yersinia pseudotuberculosis.
A 2-year survey in Ireland aims to determine how the bacteria enters the food chain. Scientists analyzed 1,800 pig tissue samples and found non-disease causing Yersinia enterocolitica in 12 samples and disease-causing genes in 15 samples.
Researchers found that SWCNTs can kill bacteria like E. coli by severely damaging their cell walls, and this effect is only seen when there is direct contact between the nanotubes and the bacteria.
A recent study discovered that certain bacteria, including Brucella species responsible for the flu-like disorder Brucellosis, require sunlight to enhance their virulence. The researchers found that disabling the light-sensing molecule in these bacteria led to a significant drop in their ability to cause disease.
Researchers discovered that bacteria can sense light using a protein structure called an LOV domain, which is also present in plants. This finding suggests that light may play a crucial role in bacterial life, allowing them to regulate their virulence and potentially leading to new therapeutic targets.
Scientists are studying Streptococcus pneumoniae bacteria grown in space to understand how it adapts and potentially poses a threat to long-duration space travelers. The bacteria were brought back from orbit frozen in 'zero-g mode' for analysis, providing valuable insights into its behavior in microgravity.
Researchers have created synthetic antibiotics called Teflon AMPs that are more resistant to bacterial defenses than their natural counterparts. These compounds mimic the immune system's early line of defense and show promise in battling a range of infections, including those caused by antibiotic-resistant bacteria.
Cornell researchers demonstrate a new way to make nanoresonators vibrate 'in the plane' – side to side. This technique shakes off extraneous materials, allowing only tightly bound pathogens to be detected. The ability to excite in-plane motion also has applications in making nanoscale gyroscopes and nano optics.
Researchers from Case Western Reserve University found that blocking receptors responding to bacterial infections can nearly halve preterm deaths in mice. A synthetic TLR4 antagonist appears safe for mice mothers and pups.
A recent study published in The ISME Journal reveals that a specific group of E. coli bacteria is associated with chronic intestinal inflammation in patients with Crohn's disease. Researchers found an increased level of invasive E. coli bacteria in inflamed areas of the small intestine, suggesting a potential causal link to the disease.
A recent study by Stanford scientists found that sand at beaches along the California coast contains fecal indicator bacteria, contradicting the common belief that they occur naturally. The researchers detected human-specific genetic markers in enterococci bacteria at a popular beach in Monterey, Calif.
Research by Dr James Chin and colleagues reveals that antibiotics not only kill bad bacteria but also maintain a pool of resistant genes within microbial communities. This means that subsequent therapy with another antibiotic may be ineffective due to increased resistance.
Researchers describe a single bacterial protein, AvrPtoB, that can overcome plant defenses and evade immune response. The study suggests that the evolution of this protein is an example of the 'arms race' between pathogens and plants.
A new grant will enable researchers to test a diagnostic technique that determines the environmental source of Buruli ulcer. The disease, caused by Mycobacterium ulcerans, can lead to severe infections and is difficult to cure without removing infected tissue.
A viral infection in 1990 reprogrammed the genetic machinery of a strep bacteria strain, creating a deadly form of
Researchers at Hauptman-Woodward Institute have solved the structure of a novel protein in Pseudomonas, a bacterium that causes cystic fibrosis and tuberculosis. The discovery may lead to the development of new antibiotics to prevent infection in patients with CF and TB.