Articles tagged with Gut Microbiota
A study by researchers at Umeå University found that diet plays a much stronger role in shaping the intestinal microbiota composition than previously thought. The study also suggested that intestinal defense molecules may help protect against metabolic disorders when consuming an unhealthy Western-style diet.
A study published in Science Translational Medicine suggests that preterm infants' gut microbiomes play a role in the development of dangerous bacterial bloodstream infections. The researchers found that the most common bacteria causing these infections are also commonly found in the gut, and that antibiotics can disrupt the balance of...
An international team of scientists discovered that a severe imbalance in the intestinal microbes and gut microbiome-produced metabolites may directly affect the development and retention of anorexia nervosa. The study suggests that specific gut bacteria produce less vitamin B1, leading to loss of appetite and various symptoms.
A new Cochrane Review found that stool transplantation can increase the number of people recovering from Clostridioides difficile (C. diff) infection by 77%, compared to 40% with standard antibiotic treatment. The study also showed a decrease in side effects with stool transplantation.
A study published in Communications Biology suggests that gut bacteria's digestion of fucose sugar may be behind weaker immune responses to the COVID-19 mRNA vaccine. Individuals with lower T-cell responses had higher expression of genes FOS and ATF3, which are part of a larger group controlling T-cell survival and activity.
A recent Italian study has shed light on how the gut microbiota evolves in infants from birth to three months. The research found that the diversity of gut bacteria increases rapidly in the first few months, with some bacterial families exhibiting marked changes in abundance over time.
A recent study found that over 42% of healthy mothers carrying fecal transplant material tested positive for harmful pathogens, making the procedure risky. The research aims to assess whether postnatal FMT can safely restore normal microbiota in C-section babies.
Researchers found an exceptional number of unknown viruses in the faeces of 647 healthy Danish one-year-olds, representing more than 200 families of yet to be described viruses. These viral species likely have a major impact on whether children develop various diseases later on in life.
A UC Riverside-led study found that reduced PTPN2 activity in intestinal epithelial cells leads to decreased Paneth cell antimicrobial peptide production, disrupting the gut microbiota and increasing E. coli. This loss can serve as a marker of IBD disease.
Researchers found that probiotic bacteria Lactobacillus reuteri stimulates cancer-killing T cells by secreting indole-3-aldehyde, which activates a receptor in CD8 cells. A diet rich in tryptophan enhances the effect of immunotherapy on shrinking tumors and prolonging survival.
A UCalgary study found that a healthy gut microbiome can prevent deadly hospital infections in critically ill patients. The research showed that the gut microbiota and immune system work together to fight infection, with abnormal gut bacteria increasing the risk of severe infections.
Researchers found that a mother's vaginal microbiome composition does not significantly affect the infant stool microbiome in early life. Factors such as breast milk and antibiotic exposure play a larger role in shaping the baby's gut microbiome.
Researchers engineered a strain of E. coli to secrete proteins that block inflammation and inhibit tumor necrosis factor alpha, showing efficacy comparable to injected antibodies in mice with inflammatory bowel disease. The engineered bacteria offer a potential treatment for intestinal-based diseases with reduced side effects.
A recent study published in Frontiers found that maternal vaginal microbiome composition does not significantly influence the development of infants' stool microbiome during the first weeks and months of life. Instead, exposure to breast milk and environmental factors are believed to play a more significant role.
Fruit fly gut remodels itself to accommodate beneficial microbiome species, maintaining long-term stability of the gut environment. The research team identified physical conditions and substances that facilitate colonization by desirable species.
Researchers found that healthy individuals have a median of 16 antimicrobial resistance genes in their gut microbiome, varying across countries and antibiotic use. National antibiotic consumption levels correlate with resistance gene frequencies, highlighting the need for public health strategies to mitigate AMR.
A new study found that eating walnuts may alter the mix of gut microbes in a way that increases the body's production of amino acid L-homoarginine, which has been linked to lower cardiovascular risk. Researchers also discovered higher levels of certain bacteria in the gut of participants on the walnut diet.
A recent study found that moderate exercise duration (≥150 minutes/week) improves gut microbiome richness and diversity, with no significant impact from exercise intensity. Additionally, normal-weight individuals showed the most beneficial changes, while overweight individuals' microbiomes were influenced by poor dietary habits.
A new study found that gut microbes can diagnose gestational diabetes as early as the first trimester of pregnancy. Women with gestational diabetes exhibit differences in gut microbiota, inflammation, and metabolites compared to those without the condition.
A recent study found that certain microbial metabolites are associated with liver fat content in individuals with fatty liver disease. The researchers identified degradation products of amino acids and differences in testosterone levels as potential biomarkers.
A Phase II trial led by researchers from the University of Texas MD Anderson Cancer Center demonstrated that adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage non-small cell lung cancer. The treatment also...
Researchers from China conducted a comprehensive review of dual therapy (DT) for H. pylori eradication, highlighting its high efficacy and patient compliance with minimal adverse events. High-dose DT administered over 14 days has emerged as the most effective treatment option.
Researchers at Arizona State University used wastewater-based epidemiology to monitor dietary behavior in a small residential district. The study found significant spikes in phytoestrogen levels and human gut metabolites associated with changes in diet, such as increased isoflavonoid consumption from soy-based foods.
Researchers found that mothers can transfer microbes to their babies via alternative routes, including skin and respiratory tracts. Cesarean-born babies make up for receiving less of their mother's gut microbiome by drinking in breastmilk.
Researchers at the University of Montreal Hospital Research Centre identified two bacterial strains that can either increase or decrease the risk of intestinal leakage after surgery. Modifying patients' gut microbiota before surgery may reduce postoperative complications and improve recovery.
A study by researchers at TUM found that gut bacteria play a crucial role in liver regeneration. The microbiome produces short-chain fatty acids, which are essential for liver cell growth and division. In mice treated with antibiotics, liver regeneration was delayed or not possible, but a
A study by Nagoya University researchers identified three intestinal bacteria - Collinsella, Ruminococcus, and Bifidobacterium - linked to dementia with Lewy bodies. These findings may help diagnose and treat the neurodegenerative disease, with potential therapeutic interventions targeting specific bacteria.
Researchers at the University of Virginia Health System have identified a vital contributor to hyperactive immune responses and neuroinflammation in multiple sclerosis. Blocking this regulator alleviated harmful inflammation in lab mice, suggesting a potential therapeutic target for new treatments.
A new study found that daily prune consumption for 12 months altered the gut microbiome in postmenopausal women, enriching beneficial bacteria like those from the Lachnospiraceae family. This may contribute to improved gut health and reduced inflammation.
Acylated anthocyanins found in purple potatoes, sweet potatoes, and carrots have been shown to reduce type 2 diabetes risk by affecting glucose transporters and enzymes involved in metabolism. These compounds also maintain gut microbiota homeostasis and suppress pro-inflammatory pathways.
A new study discovered that maternal γδ T cells influence the transfer of microorganisms during birth and nursing, impacting lung immune response in newborns. This discovery highlights the role of gut microbiota in modulating lung immunity and has implications for understanding the first breath response.
A UCalgary study has found a significant link between the diversity of fungal species in an infant's gut and their body mass index (BMI) in early childhood. The research also identified other contributing factors, including maternal diet and exposure to antibiotics, as influencing BMI.
Researchers found differences in gut microbiomes of people with ME/CFS compared to healthy controls, indicating a potential role for the microbiome in the disease. Abnormal levels of specific bacteria and metabolites were associated with reduced butyrate production, which is essential for gut health.
A study published in PLOS ONE found that common microbiome analysis techniques can yield erroneous results due to incomplete DNA databases. The researchers used computer simulations to test the consistency of current methods, showing that a large number of detected species are not actually present in the community.
Researchers at Columbia University's Mailman School of Public Health have identified differences in gut microbiomes between people with ME/CFS and healthy controls. Gut bacteria Faecalibacterium prausnitzii and Eubacterium rectale, which are normally health-promoting, were reduced in ME/CFS participants. The study found a deficient mic...
Two studies reveal that ME/CFS is associated with reduced levels of butyrate-producing microbes and differences in gut metabolites. Researchers found distinct changes in the microbiome of patients with short-term and long-term ME/CFS, suggesting a potential link between gut dysbiosis and the disease's severity.
Researchers at Baylor College of Medicine and University of Michigan report that altering gut microbiome is connected to increased oxygen levels in intestine following immune-mediated intestinal damage. Reducing intestinal oxygen levels alleviated the microbial imbalance and reduced the severity of GVHD.
An international study led by the University of Trento revealed that social interactions play a key role in shaping the composition of our microbiomes. The researchers found that adults acquire microbes through close contact with family members, partners, and friends, while infants acquire them later on at birth.
A Phase 2 clinical trial found that a probiotic reduced S. aureus colonization by 96.8% in the stool and 65.4% in the nose. The probiotic Bacillus subtilis was administered orally, surviving passage through the stomach, and did not harm gut microbiota.
A study found that Tibetan Buddhist monks with long-term deep meditation practice had distinct gut microbiome profiles, associated with lower risks of anxiety, depression, and cardiovascular disease. Their gut microbiota was enriched with beneficial bacteria that may influence mental health.
A novel laboratory protocol enables researchers to investigate connections between gut microbes and the brain, shedding light on how microbes influence the central nervous system. The tool allows for comprehensive evaluation of metabolites produced by microbes, providing insights into their role in health and disease.
A recent study suggests that the gut microbiome affects brain behavior, immune cells and neurodegeneration. Altering the gut microbiome could be an effective way to prevent or treat neurodegenerative diseases like Alzheimer’s.
A recent study published in Nature Communications has found a significant imbalance in the gut microbiome of individuals with Parkinson's disease. The researchers discovered that over 30% of micro-organisms and bacterial genes tested had altered abundances, indicating a widespread imbalance in the microbiome.
Research suggests that frequent antibiotic use may heighten the risk of inflammatory bowel disease among older adults. The study found a cumulative risk, with the highest risk observed 1-2 years after antibiotic exposure, particularly for those targeting gut infections.
A study found that patients with severe COVID-19 who suffered progressive lung failure had a different gut microbiome composition compared to those who recovered. The research identified key differences in bacteria and metabolites, including higher levels of Proteobacteria and lower levels of secondary bile acids in dying patients.
Researchers found that people with higher levels of Coprococcus tended to have higher insulin sensitivity, while those with Flavonifractor had lower insulin sensitivity. The study aimed to understand the relationship between microbiome composition and diabetes development.
Research found that approximately 40% of Danish population has gut microbes that extract more energy from food, leading to a higher risk of obesity. This composition of gut microbes is also associated with faster digestion and greater nutrient extraction.
Researchers at Cleveland Clinic found that elevated levels of phenylacetylglutamine, a byproduct of gut microbiome breakdown, increase heart failure risk and severity. This discovery suggests potential approaches to modify PAG-associated risks through diet and beta blocker use.
Eating two ounces of walnuts daily for 16 weeks improved self-reported mental health indicators, had a protective effect against academic stress, and aided sleep quality. Walnuts' bioactive nutrients and phytochemicals may underlie their beneficial effects on mental health.
Researchers at Rutgers University found a link between poor gut health and multiple sclerosis, suggesting that dietary adjustments like increased fiber may slow disease progression. The study also identified fecal Lcn-2 levels as a sensitive marker for detecting unhealthy changes in the gut microbiome of MS patients.
Research from the University of Ottawa finds that oral contraceptives' effects on brain and mood in women may be linked to age of onset and gut microbiome. The study suggests adolescence as a critical period for understanding OCs' impact, as it influences brain development and hormonal changes.
A new study by Arizona State University researchers found that microbiota transfer therapy significantly improved the abundance of beneficial bacteria and normalized altered bacterial gene expression in children with autism. The treatment showed substantial increases in populations of beneficial bacterial species and improvements in ge...
A new study finds that discrimination influences the central and enteric nervous systems, altering the bidirectional signaling between the brain and gut microbiome. This leads to changes in systemic inflammation, emotional arousal, and psychological symptoms across different racial and ethnic groups.
Researchers found that graphene oxide exposure altered the gut microbiome and triggered a type 2 immune response in zebrafish, which could inform strategies to mitigate adverse effects of nanomaterials.
Researchers found that when nursing mother mice are fed a low-fiber diet, their offspring's microbiome is permanently altered, resulting in gut inflammation and obesity. The study suggests that regular fiber intake helps fuel the microbiome, allowing diverse bacteria to thrive.
Researchers uncovered distinct DNA methylation profiles in ocean microbes, shedding light on population dynamics and interactions. The study's findings have significant implications for understanding pathogenicity and developing new approaches to monitoring environmental health.
UC San Diego researchers have developed a self-powered ingestible biosensing system that provides continuous monitoring of gut metabolites, unlocking new understanding of intestinal health and its impact on human health. The battery-free sensor is powered by glucose and can measure glucose levels in the small intestine for up to 14 hours.
Researchers found that dimethyl fumarate treatment increased the proportion of beneficial gut bacteria and reduced pro-inflammatory types, which are associated with MS. The study suggests a potential connection between gut flora and clinical side effects, paving the way for personalized treatment approaches.
A new theory proposes that irritable bowel syndrome (IBS) may be caused by the body's inability to manage gravity. The hypothesis suggests that gravity can compress the spine, decrease flexibility, and cause organs to shift downward, leading to IBS symptoms.
Researchers found that antibiotic treatment led to significant changes in Candida albicans populations, varying by individual's microbiota. The degree of fungal overgrowth depended on the activity of beta-lactamase enzyme produced by endogenous bacteria.