Articles tagged with Gut Microbiota
A new study published in iScience found that the co-development of the gut microbiome, immune system, and respiratory system is correlated with a baby's respiratory health. Disruption of any of these systems resulted in greater respiratory morbidity for infants, highlighting the importance of timing in intervening with therapies.
Researchers sequenced the whole genomes of three species of carpenter bees, gaining insights into their gut microbiome, diet, and viral load. They found beneficial bacteria, including Lactobacillus, which protect against fungal pathogens and boost the immune system.
Researchers at MD Anderson Cancer Center found distinct gut microbiome signatures associated with immunotherapy response in patients with newly diagnosed glioblastoma. The study identified a link between gut microbiome signatures and immune checkpoint blockade response in melanoma, NSCLC, and sarcoma.
Research reveals antibiotics can knock out essential gut bacteria, leading to reduced motivation and endurance in athletes. The study found that high-performance mice were more affected by antibiotic treatment, highlighting the microbiome's impact on exercise behaviors.
A recent study published in eLife found that wildlife living in urban environments have picked up some gut bugs from humans, leading to a 'humanization' of their microbiota. The researchers analyzed gut microbiomes in distantly related vertebrates from urban and rural areas and discovered significant differences between the two.
Researchers from UToledo found that a dominant gut bacteria species, Coprococcus comes, can break down quinapril and ramipril, reducing their efficacy. This study provides insights into the impact of gut bacteria on blood pressure medication, potentially leading to new ways to overcome treatment-resistant hypertension.
A new study found that exposure to dogs, particularly from ages 5 to 15, was linked to healthy gut permeability and balance in the gut microbiome. Additionally, growing up in a large family with three or more siblings may also provide protection against Crohn's disease by influencing microbiome composition.
A new study suggests that growing up with dogs and in large families may lower the risk of inflammatory bowel disease. Exposure to dogs, particularly between ages 5-15, was linked to healthy gut permeability and a balanced immune response, which may help protect against Crohn's disease.
A randomized clinical trial found that a specific probiotic supplement accelerated the maturation of the microbiome in extremely preterm infants, leading to reduced intestinal inflammation and improved feeding tolerance. The study also showed potential benefits for reducing the risk of food allergies in these vulnerable infants.
A recent study published by the Murdoch Children's Research Institute found no significant association between caesarean birth and the development of food allergies in infants. The research involved over 2,000 infants and suggested that babies born via caesarean delivery are not at a higher risk of developing food allergies.
Scientists estimate 20% of children and 26% of adults in the US consume high levels of live microorganisms daily. These findings suggest a link between dietary microbes and health outcomes, highlighting the importance of quantifying live microbes consumed through food and supplements.
Scientists discovered that commensal fungi like Candida albicans need to be alive and actively producing proteins to elicit a beneficial immune response. The fungus oscillates between high and low expression of the UME6 gene, signaling its benefits to the body.
Researchers found microbes influence which genes are used for fat digestion and absorption, leading to changes in epithelial cells. The study also showed microbes promote lipid absorption and impact systemic processes like weight gain.
Researchers discovered a link between traumatic brain injuries and changes in the gut microbiome, suggesting a potential diagnostic tool for concussions. The study found two bacterial species that dropped significantly after concussions, indicating a correlation with traumatic brain injury-linked proteins in the blood.
The study found that gut microbiota releases membrane vesicles containing bacterial DNA, which triggers the cytosolic cGAS-STING-IFN-I axis to protect distal organs against viral infections. Antibiotic treatment impairs this ability, making mice more susceptible to viral infections.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
A new study reveals that recurrent urinary tract infections (UTIs) may be caused by an imbalance in the gut microbiome, which can lead to chronic inflammation and increased risk of future UTIs. Antibiotics given to treat UTIs can disrupt the microbiome, making it easier for disease-causing bacteria to spread.
Scientists have found that transplanting faecal microbiota from young mice into old mice can reverse hallmarks of ageing in the gut, eyes, and brain. The study suggests that gut microbes play a role in regulating some of the detrimental effects of ageing, offering a potential solution in the form of gut microbe replacement therapy.
Brazilian researchers have discovered two novel enzyme families in the capybara's gut, which can accelerate the utilization of agroindustrial waste. The enzymes have biotechnological potential and can be used to produce biofuels, biochemicals, and biomaterials.
A study led by Kobe University researchers found that idiopathic autism is caused by epigenetic abnormalities in hematopoietic cells, leading to immune dysregulation and brain-gut axis disorders. The study used BTBR mice as a model and identified histone deacetylase HDAC1 as a common mechanism underlying these pathologies.
Research finds that intestinal inflammation liberates chemicals that nourish E. coli's growth and promote inflammation, highlighting new treatment targets for Crohn's disease. The study identifies key compounds that feed E. coli, such as phospholipids and amino acids, and shows that these compounds can enhance the bacteria's virulence.
The 9th World Congress on Targeting Microbiota 2022 will focus on recent advances in the microbiota field and therapeutic strategies. Key findings include research on probiotic strains, natural mineral waters, and extracellular vesicles.
Scientists discovered that bacteria adapt their gene expression to evade bacteriophages in the gut environment, reducing susceptibility to infection. This finding paves the way for improved use of phages in therapeutic purposes.
Researchers at Institut Pasteur have found that hypothalamic neurons can directly detect variations in bacterial activity, adapting appetite and body temperature accordingly. This discovery could lead to new treatments for diabetes and obesity.
A recent study published in Nature Microbiology found that chlorine water treatment does not disrupt the normal population of beneficial bacteria in children's developing gut microbiomes. The study suggests that chlorination can actually help reduce disease incidence and limit antibiotic use while keeping microbiomes healthy.
Researchers found varied diversity of gut microbiomes among brown bears at three national parks in Alaska, with Katmai showing the most diversity due to its diverse food sources. The study advances understanding of wildlife habitat, diet, and gut microbiome diversity.
Researchers found that a certain gut bacterium can break down quinapril, an ACE inhibitor used to treat high blood pressure, reducing its effectiveness. The study suggests that the same drug may not be suitable for everyone due to unique gut microbial compositions.
Researchers have engineered probiotic bacteria to produce the dopamine precursor L-DOPA, a potential treatment for Parkinson's disease. The new approach eliminates side effects and reduces treatment complications, offering a promising alternative to existing treatments.
A study published in Nutrients found distinct bacteria and metabolomes associated with each personality trait, including mental energy and physical fatigue. The research team discovered unique gut bacteria profiles for different energy and fatigue traits.
The Experimental Biology (EB) 2022 meeting features live presentations and a moderated Q&A session on groundbreaking studies. The virtual press conference reveals potential treatments for Parkinson's disease, COVID-19 vaccine-associated side effects, and alleviating food allergies.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
A study of nearly 15,000 US nurses found that significant antibiotic use in midlife is associated with increased risk of cognitive decline later in life. The researchers suggest that this may be related to changes in the gut microbiome, which can impact brain function and overall health.
Researchers at Université Laval found that yogurt's health benefits for obesity may be due to its impact on the gut microbiota and production of branched chain hydroxy acids (BCHA). The study, published in Nature Communications, suggests that BCHA can help improve fasting glucose and liver function in obese mice.
A new tool called vibration of effects (VoE) has been developed to analyze the reliability of reported links between gut microbes and various diseases. The tool found that a third of reported microbe-disease associations were inconsistent, with outcomes changing depending on study design and variable inclusion.
A recent study published in Nature Medicine has confirmed the link between a healthy gut microbiome and the response to cancer immunotherapy. The study found that certain bacterial species, such as Bifidobacterium pseudocatenulatum, Roseburia spp., and Akkermansia muciniphila, are associated with a better immune response.
Researchers discovered that gut bacteria can awaken dormant viruses by producing colibactin, leading to cell-killing infections. This finding suggests a possible link between colibactin-producing bacteria and cancer, potentially benefiting the bacteria's own survival.
Researchers analyzed the gut microbiome of 1,241 middle-aged individuals and found that about half of the bacterial species were modified by drug treatment, while 75% of disturbances occurred in early stages of overweight and type 2 diabetes. The study suggests that an imbalanced gut microbiome may play a role in heart disease development
A study found that specific bacterial groups from the Lachnospiraceae family were associated with an increased risk of developing type 2 diabetes. The research used machine learning techniques and analyzed fecal samples from a large Finnish population cohort, identifying microbial biomarkers that predicted disease incidence.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
Researchers discovered that nerves in the intestines regulate gut acidity to maintain a healthy balance of gut bacteria. They used zebrafish with genetic mutations to study the connection between the enteric nervous system and microbial communities.
Researchers at Tel Aviv University found that a specific type of bacteria, Weissella, becomes dominant in the gut microbiomes of locusts when they form swarms. This change may provide the bacteria with an evolutionary advantage, allowing them to spread and infect more locusts.
Prunes have been found to help prevent or delay bone loss in postmenopausal women by reducing inflammation and oxidative stress. This is due to their potential to alter the gut microbiome, which can lead to lower levels of pro-inflammatory cytokines and markers of oxidative damage.
Researchers at Oregon Health & Science University have made a groundbreaking connection between the gut microbiome and cognitive decline in an animal model of Alzheimer's disease. Fecal implants induced significant behavioral and cognitive changes in mice, offering new avenues for treating or forestalling dementia.
A University of Ottawa review provides the first field-wide summary of how pesticide exposure affects social bee gut microbiotas. The study found that pesticides disturb microbial communities, leading to a loss of benefits and potential decline in bee health and performance.
A UC Davis Health study found that taking bile acids or treatments regulating their production levels can help control psoriasis inflammation. Bile acids inhibited skin inflammation by stopping immune T cells from producing proinflammatory protein IL-17A and blocking immune cell movement to the site.
Researchers at TUM discover that intestinal bacteria interact with Paneth cells in the gut mucus layer, leading to chronic inflammation. This finding may lead to new treatments for IBD.
Beneficial gut microbes transfer genes to acquire vitamin B12, increasing their ability to survive. This process, called bacterial sex, allows them to form a tube that DNA can pass through to another cell, demonstrating the horizontal gene exchange among microbes.
A study by UConn Health and Washington University School of Medicine found that eating more meat correlates with worse MS symptoms, altered gut bacteria, and increased immune cells. The research identified key bacteria and metabolites associated with the disease, providing new insights into its causes.
A new study reveals that microbes in the guts of hibernating ground squirrels play a crucial role in recycling nutrients and maintaining muscle mass. The discovery could have significant implications for humans with muscle-wasting disorders and astronauts on extended space voyages.
Researchers found a distinct microbial profile associated with long COVID symptoms, including fatigue, muscle weakness, and insomnia. Patients with long COVID had a less diverse and abundant gut microbiome compared to those without the condition.
A study found that a daily supplement of urolithin A improved muscle function and reduced inflammation in older adults. The supplement, produced by gut bacteria, was shown to stimulate mitophagy, a process that recycles damaged mitochondria.
Researchers discovered that Black women have a greater relative abundance of Actinobacteria, associated with reduced insulin sensitivity and elevated inflammation. The study highlights the importance of understanding the role of gut microbiome in cardiometabolic health disparities among Black women.
Researchers found that giant pandas' gut microbiota shifts in season, helping them gain weight and store fat. The team used a fecal transplant experiment to show that the metabolic product of Clostridium butyricum can upregulate lipid synthesis and storage.
A recent study reveals significant differences between the gut microbiomes of male and female American minks, suggesting a surprising sexual distinction in carnivores. The findings have implications for future wildlife research, as analyzing fecal samples may not provide accurate assessments of population sex.
A recent study by researchers at Case Western Reserve University found that Candida tropicalis fungus can trigger chronic inflammation in the gut microbiome of Crohn's disease patients. This imbalance of fungi and bacteria can create a predisposition to inflammatory bowel disease.
A high-fiber diet has been shown to improve the response of melanoma patients to immunotherapy by influencing the gut microbiome. Patients who consumed at least 20 grams of dietary fiber per day lived longer without their cancer progressing, compared to those who consumed less fiber.
Patients with sufficient fiber intake had improved progression-free survival and response to immunotherapy in melanoma. A high-fiber diet was associated with slower tumor growth and increased CD4+ T cells in pre-clinical models, supporting the potential benefits of dietary interventions on cancer treatment outcomes.
A study published in Annals of the Rheumatic Diseases found that crAss-like phages, a component of the gut virome, are less abundant in individuals with autoimmune diseases. This discovery may lead to the development of targeted therapies to manage autoimmune conditions.
Researchers found high levels of toxic metabolites produced by gut bacteria in MS patients' cerebrospinal fluid and plasma. The discovery suggests a potential therapeutic target for developing new MS therapies.
Researchers found fecal transplants increase IL-25, reducing tissue inflammation and boosting immune system response to C. difficile infections. The transplants also promote beneficial microbial diversity, helping patients heal from life-threatening diarrhea.