Articles tagged with Gut Microbiota
A longitudinal study of infants at risk of developing celiac disease found increased microbial strains and metabolites associated with autoimmune conditions, while decreased protective effects were observed. These preclinical gut microbiome changes may serve as early markers of disease progression.
Newborns are more susceptible to GBS meningitis due to immature gut microbiota and epithelial barriers. This study highlights the critical role of microbiota in protecting against infection, demonstrating its importance in newborn health.
A study found specific gut microbiota signatures correlate with high-grade adverse events and response to combined CTLA-4 and PD-1 blockade treatment. The research identified a potential new strategy to treat toxicity while maintaining response through IL-1R inhibition or manipulation of the gut microbiota.
A double-blind trial found that faecal microbiota transplantation did not improve treatment outcomes or reduce symptoms in patients with active peripheral PsA. The study suggests that FMT may not be an effective treatment option for this condition, and future research is needed to explore its potential benefits.
Researchers found that most IBS patients have visible bacterial biofilms in their gut under endoscopic examination, which can impair gut function. Biofilms can also occur in ulcerative colitis patients, and irrigation therapy shows promise in alleviating symptoms.
Researchers found that diet can alter the breast microbiome to affect breast cancer risk. The study, published in Cancer Research, showed that a high-fat diet led to more aggressive tumors and reduced effectiveness of fish oil supplements.
A comprehensive review suggests that gut microbiota play a crucial role in immune responses to vaccinations. The study aims to improve vaccine effectiveness by understanding the microbiota's impact on B and T cell immune responses.
Researchers found that intermittent fasting lowers blood pressure by altering the gut microbiota composition. The study suggests that gut dysbiosis contributes to hypertension by changing bile acid signaling.
A study published in eLife found that an overgrowth of yeast in the gut within the first few months of life may increase the risk of asthma later on. The period after birth is critical for immune system development and gut microbiome health, and disruptions to gut bacteria can lead to asthma.
Researchers have found a causal link between caesarean section birth and peanut sensitivity in infants, with effects more pronounced in children of Asian descent. Infants born by C-section were eight times more likely to develop peanut allergy by age three compared to those born vaginally.
Research found high dietary intake of animal products, processed foods, and sugary drinks is linked to an 'inflammatory' gut microbiome. Conversely, a diet rich in plant-based foods may promote 'friendly', anti-inflammatory microbes that help control inflammation.
Researchers at UC Santa Barbara have deciphered the composition and function of sea urchin microbiomes, revealing significant differences between red and purple species and habitats. The study suggests that sea urchins may be able to produce their own food using microbes in their guts.
A new study has demonstrated a correlation between autism spectrum disorder and changes in the gut microbiome. The researchers found that individuals with autism exhibited differences in gut microbiome composition compared to neurotypical controls, with gastrointestinal symptoms being significantly higher in those with autism. Longitud...
Researchers found that high-fiber compounds reduced the expression of a gene and cytokine receptor involved in viral cell entry and inflammation. The findings suggest that high-fiber diets may help control inflammation caused by COVID-19, which can lead to gastrointestinal symptoms and changes in gut microbiota.
A new review published in the Journal of Dairy Science suggests that fermented milks may help reduce hypertension by modulating gut microbiota. The researchers propose the development of tailor-made fermented milks to target this effect, which could have significant implications for cardiovascular health.
A new study found that exposure to antibiotics within the first 14 days of life is associated with reduced weight and height in boys up to age six. However, antibiotic use after neonatal period leads to higher body mass index (BMI) in both boys and girls during childhood.
Researchers at Monash University have discovered two novel molecules that provide profound protection in experimental models of asthma and reduce the severity of asthma attacks. These molecules, including one commercially available as a dietary supplement, also show promise in treating respiratory illness associated with COVID-19.
A recent study found no association between gut fungi and Parkinson's disease, contrary to previous studies on the bacterial microbiome. The researchers analyzed fecal samples from 95 PD patients and 57 controls, concluding that fungi were sparse in the gut microbiomes of PD patients.
Researchers found that gut microbes in anorexia patients are less diverse and more abundant in 'harmful' species. Transferring fecal samples from anorexia patients to mice resulted in similar symptoms, suggesting a link between gut bacteria and anorexia symptoms. Targeting the microbiome may be a viable treatment for anorexia.
Research suggests that COVID-19 severity may be influenced by the composition of the gut microbiome, with certain bacteria contributing to inflammatory responses. The study found that patients with COVID-19 had altered gut microbiota compared to healthy individuals, including lower levels of beneficial species.
A large-scale international study found strong associations between specific gut microbes, dietary habits, and cardiometabolic disease risk. Participants who consumed a healthy, plant-based diet had higher levels of beneficial gut microbes.
Research reveals that an imbalance in gut bacteria can cause depressive-like behaviors by reducing essential lipid metabolites. Transferring healthy gut bacteria from one animal to another can restore normal brain function and alleviate depression.
Researchers analyzed ten cancer patients with refractory melanoma and found that fecal microbiota transplant improved patient outcomes in three out of ten cases. The treatment was safe and feasible, suggesting a potential role in overcoming resistance to anti-PD-1 immunotherapy.
Research reveals significant microbial changes in women with polycystic ovary syndrome, associated with metabolic health. The study also found differences in microbiome profile between pre-diabetic and healthy women, shedding light on the causes of the condition.
Researchers identified distinct gut microbiome signatures in individuals with major depressive disorder (MDD), including higher levels of Bacteroides and lower levels of Blautia. A biomarker-based diagnostic tool may help physicians diagnose MDD, providing a companion to clinical interviews.
Researchers discovered that black bears' gut microbiomes are surprisingly simple and consistent throughout the intestinal tract. This finding has practical applications for wildlife researchers, as a fecal sample can provide insight into the entire gut microbiome.
Researchers found significant differences in gut microbiome and metabolite profiles between COPD patients and healthy individuals. The study suggests that stool sampling could be used to non-invasively diagnose and monitor for COPD.
A European study confirms that altered intestinal microbiota increases the production of imidazole propionate, a molecule that prevents insulin's blood sugar-lowering effects. Elevated levels of imidazole propionate are also found in prediabetes, suggesting it may contribute to disease progression.
Researchers found that children born by caesarean section have an increased risk of developing asthma if their gut microbiota still carries a caesarean signature at age 1 year. This study proposes restoring the perturbed microbiome to potentially prevent asthma development in high-risk children.
A University of Gothenburg study shows that a molecule from gut bacteria, imidazole propionate, reduces the efficacy of metformin in lowering blood glucose. The study found high levels of imidazole propionate associated with impaired metformin action in type 2 diabetes patients.
Researchers discovered that the gut's local immune system creates antibodies tailored to specific microbiota, challenging the long-held assumption of a non-specific approach. This finding has significant implications for understanding the relationship between the immune system and the composition of our microbiomes.
A new study suggests that gut bacteria are partially responsible for metabolic changes leading to weight gain in women after chemotherapy treatment. The research found that the pre-treatment microbiome of patients who gained weight was different from those who did not, and fecal transplantation resulted in glucose intolerance in germ-f...
A probiotic bacterial species significantly worsens multiple sclerosis severity in a mouse model. The study reveals the critical role of Lactobacillus reuteri in modulating disease risk, with colonized mice exhibiting more severe symptoms.
Researchers found caesarean section and prolonged labour influence infant gut microbiome, linked to childhood obesity and allergic sensitization. The study identified specific bacteria and metabolic pathways involved in these health outcomes.
The AGA Fecal Microbiota Transplantation National Registry reported that FMT led to a cure of C. difficile infection in 90% of patients across 20 North American FMT practice sites, with few serious side effects. The study included 259 patients enrolled between December 2017 and September 2019.
A study of 270 overweight women found no link between gut microbiota composition and the incidence of gestational diabetes. However, the combination of fish oil and probiotics was shown to modulate gut microbiota in women who did not develop gestational diabetes. Further research is needed to confirm these findings.
A study found that patients with metastatic kidney cancer who had a greater variety of gut microbes responded better to immunotherapy, and that eating a high-fiber diet may help improve treatment outcomes. The researchers suggest that modulating the gut microbiome during therapy could impact responses to therapy.
A new technology allows scientists to study the role of gut bacteria in health by taking samples anywhere in the gastrointestinal tract. The non-invasive tool, a drug-like capsule, can collect intestinal fluid containing bacteria and protect it for analysis.
Gut microbiome plays a crucial role in cancer growth, particularly in the colon where high levels of metabolites from antioxidant-rich foods accelerate bowel cancer. In contrast, small intestines have fewer bacteria and may convert cancer-driving proteins into super-suppressors.
A new study found that children with newly-diagnosed type 1 diabetes have a distinct gut microbiome composition associated with poorer blood sugar control. The researchers used machine learning analysis and genetic analysis to identify this link, highlighting the importance of gut health in disease development.
A new species of darkling beetle larvae discovered in East Asia can degrade polystyrene, a material notoriously difficult to decompose. The larvae's unique gut flora contains a simple group of bacterial species that oxidize and change the surface property of polystyrene.
A team of researchers identified that the intestinal flora (microbiota) of each host determines the maintenance of antibiotic-resistant bacteria in the gut. The study found that resistance has different interactions depending on the individual's microbiota, with some individuals showing a high ability to survive without antibiotics.
The study found that oat and rye bran fibres support beneficial gut microbiota growth, improving cholesterol metabolism, gut barrier function, and reducing liver inflammation. Diets enriched with either bran type attenuated weight gain associated with a high-fat diet.
A new study uses stool microbiomes to predict cirrhosis risk in patients with nonalcoholic fatty liver disease. Researchers found a unique signature that distinguishes cirrhosis from other causes of the disease, potentially leading to an accurate, non-invasive diagnostic tool.
Researchers at UMass Amherst find TiO2 nanoparticles alter gut microbiota, causing inflammation and changes in liver protein expression. The study suggests long-term exposure to foodborne TiO2 NPs may have adverse health effects, particularly in obese mice.
A new study reveals that poor oral health can exacerbate gut inflammation in IBD patients, potentially leading to reduced quality of life and surgery. The research suggests that promoting oral health could improve clinical outcomes in IBD, making it a crucial aspect of total body health.
The study found that statin therapy was associated with a decrease in the prevalence of Bact2 enterotype, which is linked to inflammatory bowel disease and depression. The researchers suggest that statins may be used to alter the gut microbiota, leading to new treatment options for cardiovascular disease.
Researchers found that parasite infection was strongly associated with the overall composition of the microbiome, which could accurately predict a person's country and lifestyle. The study also discovered that the presence of four soil-transmitted gut parasites tended to co-occur at a higher rate than chance.
A recent study by the American Society of Agronomy found that reusing chicken litter can deter growth of pathogens like Salmonella. Researchers discovered 'good' bacteria in used poultry litter can hinder Salmonella growth, providing new information on the relationship between litter environment and microbiome.
Researchers identified a new gut-brain connection in ALS, finding that altering the gut microbiome can prevent or improve disease symptoms in mice with a common genetic mutation. The study suggests that the gut microbiome may influence disease severity and could be a target for therapy.
Researchers studied 45 female colobus monkeys in Ghana to understand the impact of social groupings and distance on their gut microbiomes. They found that individuals from different groups with closer social connections had more similar gut microbiomes, suggesting microbes can be transmitted during occasional encounters.
Research finds statin-treated individuals have lower prevalence of gut microbiota dysbiosis compared to non-treated obese individuals. The study suggests that statins may modulate harmful gut inflammation, potentially leading to a healthier microbiome.
Taking antibiotics with opioids may exacerbate addiction by altering brain responses to opioids, according to research on rats depleted of their gut microbiome. The study found that a weakened microbiome intensified opioid intoxication while reducing withdrawal effects.
Researchers at the Australian Centre for Digestive Diseases have successfully treated Crohn's disease in patients, achieving prolonged remission of 3-23 years. The treatment uses a combination of specific antibiotics and Faecal Microbiota Transfer (FMT) to repopulate the gut with healthy bacteria.
A study found that infants who started on solid foods at or before three months of age showed changes in gut bacteria and bacterial byproducts, which may predispose them to being overweight later in childhood. The researchers also found a delayed impact of early solid food introduction on short-chain fatty acid concentrations.
Researchers found that propionic acid reduced relapse rates and disability progression in MS patients, with initial MRI studies suggesting reduced brain atrophy. The gut microbiome plays a crucial role in immune regulation, and altering its composition may lead to innovative dietary measures to complement existing therapies.
Researchers at Texas A&M University have discovered a previously unknown response to indole in the beneficial gut bacteria E. coli, which seems to both repel and attract bacteria. The Janus response displays sophistication and could lead to a better understanding of the complexities of the gut microbiome.
A new research tool allows biologists to watch in real time the cell renewal process that keeps gut tissue healthy, as well as the interactions between bacterial species that make up the microbiome. Researchers discovered regional differences in microbiome stability that mimic the regionality of stem cell activity.
A mother's gut microbiota can influence her offspring's energy homeostasis and metabolism. Research using mouse models suggests that targeting the maternal microbiota could be a preemptive strategy to protect against metabolic diseases.
Researchers identified a unique collection of gut bacteria associated with pulmonary arterial hypertension (PAH), predicting its presence with 83% accuracy. This discovery may lead to new therapies targeting the digestive system and improving PAH diagnosis.