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Common medication hindering lung cancer treatment

Research found that proton pump inhibitors (PPIs) may reduce the effectiveness of immune checkpoint inhibitor drugs in patients with non-small-cell lung cancer. PPI use was associated with worse survival rates and a significant decrease in the benefit of immune therapy treatment.

SourceFlinders University·JournalBritish Journal of Cancer·TypeObservational study·DateNov 24, 2021

Woodrat microbiomes: It’s who you are that matters most

A University of Utah team analyzed woodrat gut bacteria and found that evolutionary history plays the greatest role in shaping microbiome structure. Diet and geography also influenced microbiome composition, but host relatedness was the strongest predictor in both wild and captive populations.

SourceUniversity of Utah·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 15, 2021

Systemic lupus erythematosus linked to altered gut microbiome

A recent study published in Annals of the Rheumatic Diseases reveals a link between systemic lupus erythematosus and an altered gut microbiome. Researchers at Osaka University identified two species of Streptococcus bacteria significantly increased in SLE patients, which can affect the body's functions by altering plasma metabolites. T...

SourceOsaka University·JournalAnnals of the Rheumatic Diseases·TypeData/statistical analysis·DateOct 27, 2021

Artificial sweeteners disrupt bacterial communication and may influence gut microbiota, Ben-Gurion University of the Negev scientists find

Researchers at Ben-Gurion University of the Negev have discovered that artificial sweeteners can significantly impair bacterial communication. Three out of six tested FDA-approved sweeteners were found to inhibit quorum sensing, a key process for bacteria to communicate with each other.

SourceBen-Gurion University of the Negev·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateOct 7, 2021

Gut bacteria might be an indicator of colon cancer risk

A recent study published in Cell Host & Microbe found that certain gut bacteria are associated with an increased risk of colon cancer. Researchers discovered a correlation between the presence of non-enterotoxigenic Bacteroides fragilis and inflammation in small polyps. The study suggests that normally healthy gut bacteria may adapt to...

SourceUniversity of Washington School of Medicine/UW Medicine·JournalCell Host & Microbe·TypeExperimental study·DateSep 17, 2021

Probiotics prove effective in treating antibiotics-induced dysbiosis in mice

A study by Kazan Federal University found that probiotics administered to antibiotic-treated mice improved behavior, reduced oxidative stress, and restored gut microbiota diversity. The researchers demonstrated a strong link between the gut microbiota and brain functioning, with potential therapeutic benefits for treating dysbiosis-rel...

SourceKazan Federal University·JournalLife·TypeRandomized controlled/clinical trial·DateAug 26, 2021

Species of gut bacteria linked to enhanced cognition and language skills in infant boys

A University of Alberta study found that infant boys with a high Bacteroidetes gut bacterial composition scored higher in cognition and language skills. The researchers believe this association may be due to the production of metabolites called sphingolipids, which are instrumental for neuron formation and structure.

Study identifies gut microbes associated with toxicity to combined checkpoint inhibitors in melanoma patients

A study found specific gut microbiota signatures correlate with high-grade adverse events and response to combined CTLA-4 and PD-1 blockade treatment. The research identified a potential new strategy to treat toxicity while maintaining response through IL-1R inhibition or manipulation of the gut microbiota.

First trial of faecal microbiota transplantation for people with active peripheral psoriatic arthritis shows no advantage

A double-blind trial found that faecal microbiota transplantation did not improve treatment outcomes or reduce symptoms in patients with active peripheral PsA. The study suggests that FMT may not be an effective treatment option for this condition, and future research is needed to explore its potential benefits.

Immunity boost in the gut

A comprehensive review suggests that gut microbiota play a crucial role in immune responses to vaccinations. The study aims to improve vaccine effectiveness by understanding the microbiota's impact on B and T cell immune responses.

SourceFlinders University·JournalNature Reviews Immunology·DateMay 27, 2021

The sea urchin microbiome

Researchers at UC Santa Barbara have deciphered the composition and function of sea urchin microbiomes, revealing significant differences between red and purple species and habitats. The study suggests that sea urchins may be able to produce their own food using microbes in their guts.

SourceUniversity of California - Santa Barbara·JournalLimnology and Oceanography Letters·DateApr 6, 2021

Gut microbiome plays role in autism

A new study has demonstrated a correlation between autism spectrum disorder and changes in the gut microbiome. The researchers found that individuals with autism exhibited differences in gut microbiome composition compared to neurotypical controls, with gastrointestinal symptoms being significantly higher in those with autism. Longitud...

High-fiber diet may play a role in controlling the inflammation associated with COVID-19

Researchers found that high-fiber compounds reduced the expression of a gene and cytokine receptor involved in viral cell entry and inflammation. The findings suggest that high-fiber diets may help control inflammation caused by COVID-19, which can lead to gastrointestinal symptoms and changes in gut microbiota.

Gut microbes may antagonize or assist in anorexia

Researchers found that gut microbes in anorexia patients are less diverse and more abundant in 'harmful' species. Transferring fecal samples from anorexia patients to mice resulted in similar symptoms, suggesting a link between gut bacteria and anorexia symptoms. Targeting the microbiome may be a viable treatment for anorexia.

SourceFrontiers·JournalFrontiers in Psychiatry·DateJan 12, 2021